Interleukin-6 promotes a sustained loss of endothelial barrier function via Janus kinase-mediated STAT3 phosphorylation and de novo protein synthesis

Regulation of endothelial barrier function by p120-catenin∙VE-cadherin interaction

(2017) Joshua P. Garrett et al.   MOLECULAR BIOLOGY OF THE CELL

Selective Role of Vinculin in Contractile Mechanisms of Endothelial Permeability

(2016) Anna A. Birukova et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Forces and mechanotransduction in 3D vascular biology

(2016) Matthew L Kutys et al.   CURRENT OPINION IN CELL BIOLOGY

Endothelial STAT3 Activation Increases Vascular Leakage Through Downregulating Tight Junction Proteins: Implications for Diabetic Retinopathy

(2016) Jang-Hyuk Yun et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Src Family Kinases Modulate the Loss of Endothelial Barrier Function in Response to TNF-α: Crosstalk with p38 Signaling

(2016) Alejandro P. Adam et al.   PLoS One

New insights in the control of vascular permeability

(2015) Marianna Trani et al.   CURRENT OPINION IN HEMATOLOGY

Anti–IL-6 neutralizing antibody modulates blood-brain barrier function in the ovine fetus

(2015) Jiyong Zhang et al.   FASEB JOURNAL

Regulation of Endothelial Adherens Junctions by Tyrosine Phosphorylation

(2015) Alejandro Pablo Adam   MEDIATORS OF INFLAMMATION

Tumor Necrosis Factor Disrupts Claudin-5 Endothelial Tight Junction Barriers in Two Distinct NF-κB-Dependent Phases

(2015) Paul R. Clark et al.   PLoS One

Shear Stress–Initiated Signaling and Its Regulation of Endothelial Function

(2014) Jing Zhou et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Phosphatases and kinases as regulators of the endothelial barrier function

(2014) Verena Küppers et al.   CELL AND TISSUE RESEARCH

Toward a new STATe: The role of STATs in mitochondrial function

(2014) Jeremy A. Meier et al.   SEMINARS IN IMMUNOLOGY

The Role of IL-6Trans-Signaling in Vascular Leakage: Implications for Ovarian Hyperstimulation Syndrome in a Murine Model

(2013) Lin-Hung Wei et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The putative JAK-STAT inhibitor AG490 exacerbates LPS-fever, reduces sickness behavior, and alters the expression of pro- and anti-inflammatory genes in the rat brain

(2013) Jelena Damm et al.   NEUROPHARMACOLOGY

p120-Catenin prevents neutrophil transmigration independently of RhoA inhibition by impairing Src dependent VE-cadherin phosphorylation

(2012) Pilar Alcaide et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Janex-1, a JAK3 inhibitor, ameliorates tumor necrosis factor‑α‑induced expression of cell adhesion molecules and improves myocardial vascular permeability in endotoxemic mice

(2012) Kyung Kang   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Measurement of local permeability at subcellular level in cell models of agonist- and ventilator-induced lung injury

(2012) Oleksii Dubrovskyi et al.   LABORATORY INVESTIGATION

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Multi-tasking: nuclear transcription factors with novel roles in the mitochondria

(2012) Karol Szczepanek et al.   TRENDS IN CELL BIOLOGY

Amplification of the response to Toll-like receptor ligands by prolonged exposure to interleukin-6 in mice: Implication for the pathogenesis of macrophage activation syndrome

(2011) Raffaele Strippoli et al.   ARTHRITIS AND RHEUMATISM

Robo4-dependent Slit signaling stabilizes the vasculature during pathologic angiogenesis and cytokine storm

(2011) Nyall R London et al.   CURRENT OPINION IN HEMATOLOGY

Interleukin-6 signalling: More than Jaks and STATs

(2011) René Eulenfeld et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Interleukin-6 mediates pulmonary vascular permeability in a two-hit model of ventilator-associated lung injury

(2011) Ozlem U. Gurkan et al.   EXPERIMENTAL LUNG RESEARCH

Mitochondrial-targeted Signal Transducer and Activator of Transcription 3 (STAT3) Protects against Ischemia-induced Changes in the Electron Transport Chain and the Generation of Reactive Oxygen Species

(2011) Karol Szczepanek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interleukin-6 in Sepsis and Capillary Leakage Syndrome

(2011) Alexander Krüttgen et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Serious Adverse Events During Ruxolitinib Treatment Discontinuation in Patients With Myelofibrosis

(2011) Ayalew Tefferi et al.   MAYO CLINIC PROCEEDINGS

Cytoprotection by the modulation of mitochondrial electron transport chain: The emerging role of mitochondrial STAT3

(2011) Karol Szczepanek et al.   MITOCHONDRION

Activated STAT3 is a mediator and biomarker of VEGF endothelial activation

(2010) Shao-Hua Chen et al.   CANCER BIOLOGY & THERAPY

TNF-  Signals Through PKC /NF- B to Alter the Tight Junction Complex and Increase Retinal Endothelial Cell Permeability

(2010) C. A. Aveleira et al.   DIABETES

Unphosphorylated STAT3 modulates alpha7 nicotinic receptor signaling and cytokine production in sepsis

(2010) Geber Peña et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Src-induced Tyrosine Phosphorylation of VE-cadherin Is Not Sufficient to Decrease Barrier Function of Endothelial Monolayers

(2010) Alejandro P. Adam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

JAK2 inhibition prevents innate immune responses and rescues animals from sepsis

(2010) Geber Peña et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Sepsis and Endothelial Permeability

(2010) Warren L. Lee et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interleukin 6 in autoimmune and inflammatory diseases: a personal memoir

(2010) Toshio HIRANO   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Stat3 promotes directional cell migration by regulating Rac1 activity via its activator  PIX

(2009) T. S. Teng et al.   JOURNAL OF CELL SCIENCE

Mitochondrial STAT3 Supports Ras-Dependent Oncogenic Transformation

(2009) D. J. Gough et al.   SCIENCE

Function of Mitochondrial Stat3 in Cellular Respiration

(2009) J. Wegrzyn et al.   SCIENCE

Small epitope-linker modules for PCR-based C-terminal tagging inSaccharomyces cerevisiae

(2009) Minoru Funakoshi et al.   YEAST

Inhibition of Janus Kinase 2 and Signal Transduction and Activator of Transcription 3 Protect Against Cecal Ligation and Puncture-Induced Multiple Organ Damage and Mortality

(2009) Liu Hui et al.   JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE

Vascular permeability, vascular hyperpermeability and angiogenesis

(2008) Janice A. Nagy et al.   ANGIOGENESIS

Nonclinical Antiangiogenesis and Antitumor Activities of Axitinib (AG-013736), an Oral, Potent, and Selective Inhibitor of Vascular Endothelial Growth Factor Receptor Tyrosine Kinases 1, 2, 3

(2008) D. D. Hu-Lowe et al.   CLINICAL CANCER RESEARCH

Divergent roles of endothelial NF-κB in multiple organ injury and bacterial clearance in mouse models of sepsis

(2008) Xiaobing Ye et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Anti-inflammatory activity profile of JANEX-1 in preclinical animal models

(2007) Fatih M. Uckun et al.   BIOORGANIC & MEDICINAL CHEMISTRY