Article
Medicine, Research & Experimental
Fatemeh Koohi, Davood Khalili, Mohammad Ali Mansournia, Farzad Hadaegh, Hamid Soori
Summary: The study identified seven distinct multi-trajectories of blood lipid levels and found that individuals with rising triglyceride levels over time, even with optimal LDL-C levels, faced a significantly increased risk of cardiovascular disease. Despite the decline in LDL-C levels, there remained a considerable residual risk for CVD, emphasizing the importance of monitoring and potentially lowering triglyceride concentrations to reduce this risk.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Leonie Schoch, Lina Badimon, Gemma Vilahur
Summary: Increasing doubt has been raised over the HDL-cholesterol hypothesis, with evidence pointing towards the complexity and molecular changes in HDL particles. Chemical modifications, compositional changes, and miRNA cargo have been identified as factors contributing to the ineffectiveness of HDL particles. Overcoming challenges is crucial to bringing hope to HDL-targeted approaches.
Article
Endocrinology & Metabolism
Genki Kobayashi, Hiroshi Okada, Masahide Hamaguchi, Kazushiro Kurogi, Hiroaki Murata, Masato Ito, Michiaki Fukui
Summary: This study investigated the association between LDL cholesterol, HDL cholesterol, and LDL/HDL ratio and the incidence of diabetes, and identified the cut-off values for incident diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Nicholas A. Marston, Robert P. Giugliano, Giorgio E. M. Melloni, Jeong-Gun Park, Valerie Morrill, Michael A. Blazing, Brian Ference, Evan Stein, Erik S. Stroes, Eugene Braunwald, Patrick T. Ellinor, Steven A. Lubitz, Christian T. Ruff, Marc S. Sabatine
Summary: This study found that the number of apoB-containing lipoproteins plays a crucial role in predicting cardiovascular risk independently of cholesterol or TG content. Lowering the concentration of all apoB-containing lipoproteins should be the primary focus of therapeutic strategies.
Review
Biochemistry & Molecular Biology
Saeed Aslani, Bahman Razi, Danyal Imani, Keyhan Mohammadi, Tannaz Jamialahmadi, Zeljko Reiner, Amirhossein Sahebkar
Summary: A systematic review and meta-analysis showed that statin therapy effectively lowered levels of total cholesterol, LDL-C, and TG, and increased levels of HDL-C in patients with different CVDs.
CURRENT MEDICINAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Enrica Rossini, Federico Biscetti, Maria Margherita Rando, Elisabetta Nardella, Andrea Leonardo Cecchini, Maria Anna Nicolazzi, Marcello Covino, Antonio Gasbarrini, Massimo Massetti, Andrea Flex
Summary: Atherosclerotic cardiovascular disease remains a leading cause of morbidity and mortality in high-income countries, although its impact is decreasing. Statins are effective in reducing LDL cholesterol and the risk of mortality, but are under-prescribed or under-dosed due to concerns about side effects. Personalized treatment decisions should be made based on individual considerations and shared decision-making.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Eleni Papadopoulou, Alina Nicolescu, Line S. Haug, Trine Hus, Calin Deleanu, Hubert Dirven, Birgitte Lindeman
Summary: This study explores the association between serum PFAS concentrations and lipoprotein subclasses. After adjusting for confounders, the adjusted models found positive associations between several PFASs and cholesterol concentrations in large to medium sized HDL and medium sized LDL particles. Significant associations were observed between certain PFASs and cholesterol in large to medium LDL particle sizes among women. The study also found that most PFASs tended to be associated with a reduction in VLDL particle number and VLDL triglyceride.
ENVIRONMENTAL POLLUTION
(2022)
Article
Multidisciplinary Sciences
Jae-Chan Ryu, Jae-Han Bae, Sang Hee Ha, Boseong Kwon, Yunsun Song, Deok Hee Lee, Bum Joon Kim, Dong-Wha Kang, Sun U. U. Kwon, Jong S. S. Kim, Jun Young Chang
Summary: This study investigated the association between changes in lipid profiles and the risk of in-stent restenosis. The results showed that improvement of HDL-C levels, TC/HDL-C ratio, and LDL-C/HDL-C ratio were associated with a decreased risk of in-stent restenosis.
Review
Toxicology
Charles A. German, James K. Liao
Summary: Statins not only reduce LDL-C through inhibition of the key rate-limiting step in the cholesterol biosynthetic pathway, but also improve serum clearance by upregulating the expression of LDL receptors. They may exert various pleiotropic effects, such as improving plaque stability, reducing inflammation and thrombosis, decreasing oxidative stress, and improving endothelial function and vascular tone. However, they also have potential harmful pleiotropic effects, including increased risk of muscle-related side effects, diabetes, hemorrhagic stroke, and cognitive decline.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Multidisciplinary Sciences
Juana Maria Sanz, Andrea D'Amuri, Domenico Sergi, Sharon Angelini, Valeria Fortunato, Elda Favari, Giovanni Vigna, Giovanni Zuliani, Edoardo Dalla Nora, Angelina Passaro
Summary: Familial Hypercholesterolemia (FH) is associated with high LDL cholesterol and premature cardiovascular disease. This study aimed to investigate the impact of FH on cholesterol efflux capacity (CEC) and its relationship with lipoprotein subfraction distribution. The results showed that FH patients had higher concentrations of all LDL subfractions, a shift towards small HDL subfractions, and increased CEC compared to controls.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Sang Jun Lee, Se-Eun Kim, Tae-Hwa Go, Dae Ryong Kang, Ho-Seong Jeon, Young-In Kim, Dong-Hyuk Cho, Young Jun Park, Jung-Hee Lee, Jun-Won Lee, Young-Jin Youn, Sang-Hyun Kim, Jang Young Kim, Sung Gyun Ahn
Summary: This study investigated the synergistic association between low-density lipoprotein cholesterol (LDL-C) and remnant cholesterol (remnant-C) levels with incident cardiovascular disease (CVD) in a large Korean population. The results showed that individuals with high levels of both LDL-C and remnant-C had a higher risk of CVD compared to those with normal levels. Additionally, elevated remnant-C levels, independent of LDL-C levels, were associated with an increased risk of CVD.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Clinical Neurology
Zhirong Yang, Duncan Edwards, Stephen Burgess, Carol Brayne, Jonathan Mant
Summary: This study investigated the potential associations between blood LDL-C, HDL-C, and triglycerides and post-stroke dementia. The results showed that higher LDL-C levels were associated with an increased risk of dementia, while lower triglyceride levels were associated with a decreased risk. There was no association between HDL-C levels and dementia.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Oncology
Giovanna Revilla, Lidia Cedo, Mireia Tondo, Antonio Moral, Jose Ignacio Perez, Rosa Corcoy, Enrique Lerma, Victoria Fuste, T. Srivinasa Reddy, Francisco Blanco-Vaca, Eugenia Mato, Joan Carles Escola
Summary: Cholesterol is crucial for various functions in endocrine-related cells, including hormone and steroid production. While LDL-cholesterol and HDL-cholesterol were not consistently associated with endocrine-related cancer risk, LDL receptor plays a critical role in endocrine-related tumor cells by enhancing circulating LDL-C uptake.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Youhyun Song, Hye Sun Lee, Su Jung Baik, Soyoung Jeon, Donghee Han, Su-Yeon Choi, Eun Ju Chun, Hae-Won Han, Sung Hak Park, Jidong Sung, Hae Ok Jung, Ji Won Lee, Hyuk-Jae Chang
Summary: The study results indicate that Martin's LDL-C estimation equation performs well in estimating direct LDL-C, showing superiority in both the general population and dyslipidaemia populations. Regardless of the TG levels, MLDL has better performance compared to other equations. For individuals with mild-to-moderate hypertriglyceridaemia, Martin's equation may be the optimal choice for LDL-C estimation and ASCVD risk assessment.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Mahmoud A. Alomari, Hanan Khalil, Omar F. Khabour, Karem H. Alzoubi
Summary: The study revealed a relationship between BDNF and lipid profile, suggesting the importance of BDNF for lipid metabolism in patients with Parkinson's disease.