A STAT4 variant increases liver fibrosis risk in Caucasian patients with chronic hepatitis B

The membrane-bound O-acyltransferase domain-containing 7 variant rs641738 increases inflammation and fibrosis in chronic hepatitis B

(2017) Khaled Thabet et al.   HEPATOLOGY

IFN-λ3, not IFN-λ4, likely mediates IFNL3–IFNL4 haplotype–dependent hepatic inflammation and fibrosis

(2017) Mohammed Eslam et al.   NATURE GENETICS

Fibrosis is not just fibrosis - basement membrane modelling and collagen metabolism differs between hepatitis B- and C-induced injury

(2016) M. J. Nielsen et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Intrahepatic NK cells function suppressed in advanced liver fibrosis

(2016) Xiaoyan Li et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Genetic variation in STAT4 predicts response to interferon-α therapy for hepatitis B e antigen-positive chronic hepatitis B

(2016) De-Ke Jiang et al.   HEPATOLOGY

Polymorphisms in STAT4 are not associated with treatment response and spontaneous clearance of hepatitis C virus in europeans

(2016) Anastasia Asimakopoulos et al.   HEPATOLOGY

MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C

(2016) Khaled Thabet et al.   Nature Communications

Re-evaluation of hepatitis B virus clinical phases by systems biology identifies unappreciated roles for the innate immune response and B cells

(2015) Thomas Vanwolleghem et al.   HEPATOLOGY

STAT4 genetic polymorphisms association with spontaneous clearance of hepatitis B virus infection

(2015) Yanjun Lu et al.   IMMUNOLOGIC RESEARCH

Estimations of worldwide prevalence of chronic hepatitis B virus infection: a systematic review of data published between 1965 and 2013

(2015) Aparna Schweitzer et al.   LANCET

A global reference for human genetic variation

(2015) Richard A. Gibbs et al.   NATURE

Interferon-λ rs12979860 genotype and liver fibrosis in viral and non-viral chronic liver disease

(2015) Mohammed Eslam et al.   Nature Communications

Genetic variations in STAT4,C2,HLA-DRB1 and HLA-DQ associated with risk of hepatitis B virus-related liver cirrhosis

(2015) De-Ke Jiang et al.   Scientific Reports

Systematic review with meta-analysis: do interferon lambda 3 polymorphisms predict the outcome of interferon-therapy in hepatitis B infection?

(2014) E. Galmozzi et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Review article: genetic factors that modify the outcome of viral hepatitis

(2014) A. F. Stättermayer et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

STAT4 Knockout Mice Are More Susceptible to Concanavalin A–Induced T-Cell Hepatitis

(2014) Yan Wang et al.   AMERICAN JOURNAL OF PATHOLOGY

IFNL3 mediates interaction between innate immune cells: Implications for hepatitis C virus pathogenesis

(2013) Kate S O’Connor et al.   Innate Immunity

Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus–related hepatocellular carcinoma

(2012) De-Ke Jiang et al.   NATURE GENETICS

Cytokines and STATs in Liver Fibrosis

(2012) Xiaoni Kong et al.   Frontiers in Physiology

NKp46-mediated killing of human and mouse hepatic stellate cells attenuates liver fibrosis

(2011) Chamutal Gur et al.   GUT

Suppression of innate immunity (natural killer cell/interferon-γ) in the advanced stages of liver fibrosis in mice

(2011) Won-Il Jeong et al.   HEPATOLOGY

Understanding the Host Genetics of Chronic Hepatitis B and C

(2011) Mark Thursz et al.   SEMINARS IN LIVER DISEASE

Natural Killer Cell Functional Dichotomy in Chronic Hepatitis B and Chronic Hepatitis C Virus Infections

(2009) Barbara Oliviero et al.   GASTROENTEROLOGY

Natural killer T cells regulate the homing of chemokine CXC receptor 3-positive regulatory T cells to the liver in mice

(2008) Tania Santodomingo-Garzon et al.   HEPATOLOGY