Review
Physiology
Siska Wilantri, Hanna Grasshoff, Tanja Lange, Timo Gaber, Luciana Besedovsky, Frank Buttgereit
Summary: Research on 24-h rhythms over the past four decades has revealed their significance for immunity and various diseases through genetic, molecular, and physiological findings. Disruption and misalignment of circadian rhythms have been linked to diseases and abnormal physiological functioning, highlighting their fundamental importance to mammals. This article provides an overview of the molecular regulation of 24-h rhythms, their impact on immunity, the detrimental effects of misalignment, the association between pathological rhythms and rheumatoid arthritis (RA), and the potential use of chronobiological rhythms for chronotherapy in inflammatory autoimmune diseases like RA.
Article
Pharmacology & Pharmacy
Sandrine Dulong, Lucas Eduardo Botelho de Souza, Jean Machowiak, Benoit Peuteman, Gaelle Duvallet, Deborah Boyenval, Elise Roth, Afag Asgarova, Yunhua Chang, Xiao-Mei Li, Adlen Foudi, Annabelle Ballesta
Summary: This study investigated the sex- and timing-related factors of hematopoietic toxicities induced by oxaliplatin in mice. The results showed that there were significant circadian rhythms in the counts of white blood cells and bone marrow cellularity in both sexes at different time points.
Review
Cell Biology
Ana R. Neves, Tania Albuquerque, Telma Quintela, Diana Costa
Summary: There is clear evidence of the correlation between circadian rhythm dysregulation and disease origin/development, and clock-related therapies have emerged as significant progress in the clinical field.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Food Science & Technology
Huijun Cheng, Zenghui Liu, Guohuo Wu, Chi-Tang Ho, Daxiang Li, Zhongwen Xie
Summary: The circadian rhythm is crucial in regulating daily physiological activities and metabolic homeostasis. Dietary patterns and compounds can modulate peripheral clocks and metabolic processes through various molecular mechanisms, providing potential targets for preventing metabolic disorders. Further research is needed to clarify the exact mechanisms connecting feeding patterns and dietary compounds with metabolic processes and circadian rhythm.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Review
Oncology
Ana Amiama-Roig, Eva M. Verdugo-Sivianes, Amancio Carnero, Jose-Ramon Blanco
Summary: The circadian clock plays a crucial role in regulating biological rhythms and its alteration during aging is associated with age-related pathologies, including cancer. Understanding the impact of circadian rhythms on cancer therapy and utilizing chronotherapy to optimize treatment timing shows promise in improving treatment outcomes.
Review
Genetics & Heredity
Suengwon Lee, Christian I. Hong
Summary: Circadian rhythms play a crucial role in regulating cellular and physiological processes in mammals. The master clock, located in the hypothalamus, coordinates peripheral clocks and allows organisms to align with external conditions. Recent studies have shown that peripheral clocks can function independently from the master clock, and disruption of circadian rhythms is associated with various human diseases. However, the molecular mechanisms underlying the relationship between circadian rhythms and human diseases are still largely unknown. Advances in technology, such as 3-dimensional organoids, provide new opportunities to study complex circadian clock-related diseases.
FRONTIERS IN GENETICS
(2022)
Review
Pharmacology & Pharmacy
Claire O. Kisamore, Brittany D. Elliott, A. Courtney Devries, Randy J. Nelson, William H. Walker II
Summary: Circadian rhythms are internal manifestations of the 24-h solar day that synchronize biological and behavioral processes to improve adaptive function and survival. Chronotherapy optimizes drug administration based on circadian rhythms to achieve maximum therapeutic efficacy and minimize side effects. This review examines the evidence for chronotherapeutic treatment for solid tumors, including chrono-chemotherapy, chrono-radiotherapy, and alternative chronotherapeutics, and discusses areas for further research and challenges in the field.
Editorial Material
Dermatology
Andrea Luengas-Martinez, Ralf Paus, Mudassar Iqbal, Laura Bailey, David W. Ray, Helen S. Young
Summary: This article reviews the relationship between psoriasis and circadian rhythms, suggesting that psoriasis is driven by circadian rhythms. The authors recommend investigating the specific circadian components of psoriasis to develop a novel personalized treatment strategy for psoriasis. They also propose that circadian oscillations of VEGF-A could enhance the efficacy and tolerability of a novel anti-VEGF-A therapeutic approach.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Clinical Neurology
Sui-yi Xu, Ling Li, Wen-xiu Sun, Jia-yu Shen, Chang-xin Li
Summary: This article presents a case study where agomelatine showed promising results as a prophylactic treatment for hypnic headache.
FRONTIERS IN NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xiaomeng Liu, Niuben Cao, Xinchan Liu, Yu Deng, Yu Xin, Ruobing Fu, Xirui Xin, Yubo Hou, Weixian Yu
Summary: Circadian rhythms play a crucial role in regulating the body's homeostasis, and circadian rhythm disorders can have detrimental effects on metabolic and immune functions. However, the relationship between circadian rhythm disorders and periodontitis has not been well studied. This research aimed to investigate the role of the circadian rhythm control gene BMAL1 in periodontitis. The results showed that downregulation of BMAL1 in circadian rhythm disorder-induced periodontitis led to significant alveolar bone resorption, increased osteoclast differentiation, upregulation of the inflammatory signaling molecule NF-kappa B, elevated apoptosis and oxidative stress levels in periodontal tissues. This study suggests that BMAL1 is a key regulator in periodontitis exacerbated by circadian rhythm disorders, highlighting a potential avenue for periodontitis treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Evrim Yildirim, Rachel Curtis, Dae-Sung Hwangbo
Summary: Biological clocks are essential mechanisms that synchronize physiological and behavioral processes with external cues to ensure organisms' fitness and survival. While the central clock in the brain drives daily activity rhythms, peripheral tissues have their own clock systems generating metabolic and physiological rhythms. The fruit fly Drosophila melanogaster has been a widely studied model organism for investigating the mechanism and functions of circadian clocks.
Article
Cell Biology
Sabrina Klemz, Thomas Wallach, Sandra Korge, Mechthild Rosing, Roman Klemz, Bert Maier, Nicholas C. Fiorenza, Irem Kaymak, Anna K. Fritzsche, Erik D. Herzog, Ralf Stanewsky, Achim Kramer
Summary: In organisms with circadian clocks, the post-translational modifications of clock proteins, particularly phosphorylation, play a crucial role in controlling circadian rhythms. Protein phosphatase 4 (PPP4) and its regulatory subunit PPP4R2 have been identified as critical components in mammals and Drosophila, affecting the circadian system by regulating phosphorylation and transactivation activity of CLOCK/BMAL1.
GENES & DEVELOPMENT
(2021)
Review
Cell Biology
Namasthee Harris-Gauthier, Shashank Bangalore Srikanta, Nicolas Cermakian
Summary: Living organisms have evolved to synchronize and adapt to daily environmental cycles through circadian rhythms. These rhythms are driven by a molecular clock composed of clock genes and proteins, which regulate the expression of numerous genes. Ubiquitination and deubiquitination play important roles in the regulation of clock proteins and their functions within the circadian clock.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Review
Andrology
Wei-Zhen Zhu, Qi-Ying He, De-Chao Feng, Qiang Wei, Lu Yang
Summary: The circadian clock is associated with better adaptation to changes in the external environment. Disruption of the circadian rhythm plays a critical role in the tumorigenesis of many cancers, including prostate cancer. Integrating the circadian rhythm into PCa research can provide a deeper understanding of PCa mechanisms and offer new treatment options for patients with PCa.
ASIAN JOURNAL OF ANDROLOGY
(2023)
Review
Endocrinology & Metabolism
Ferdinando Fusco, Nicola Longo, Marco De Sio, Davide Arcaniolo, Giuseppe Celentano, Marco Capece, Roberto La Rocca, Francesco Mangiapia, Gianluigi Califano, Simone Morra, Carmine Turco, Gianluca Spena, Lorenzo Spirito, Giovanni Maria Fusco, Luigi Cirillo, Luigi De Luca, Luigi Napolitano, Vincenzo Mirone, Massimiliano Creta
Summary: The impact of circadian desynchrony on spermatogenesis is significant but current evidence is insufficient due to study heterogeneity.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Correction
Infectious Diseases
G. Clement Dobbins, Amit Patki, Dongquan Chen, Hemant K. Tiwari, Curtis Hendrickson, William J. Britt, Karen Fowler, Jake Y. Chen, Suresh B. Boppana, Shannon A. Ross
BMC INFECTIOUS DISEASES
(2020)
Article
Cell Biology
Keshav K. Singh, Gyaneshwer Chaubey, Jake Y. Chen, Prashanth Suravajhala
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2020)
Article
Immunology
Huixian Hong, Min Gao, Qi Wu, Philomena Yang, Shanrun Liu, Hao Li, Peter D. Burrows, Daniel Cua, Jake Y. Chen, Hui-Chen Hsu, John D. Mountz
JOURNAL OF IMMUNOLOGY
(2020)
Article
Cell Biology
Kazunari Nohara, Eunju Kim, Marvin Wirianto, Eugenia Mileykovskaya, William Dowhan, Zheng Chen, Seung-Hee Yoo
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2020)
Article
Multidisciplinary Sciences
Eric Zhang, Thanh Nguyen, Meng Zhao, Son Hai Dang, Jake Y. Chen, Weihua Bian, Gregory P. Walcott
Article
Cell Biology
Syed Aun Muhammad, Hiba Ashfaq, Sidra Zafar, Fahad Munir, Muhammad Babar Jamshed, Jake Chen, Qiyu Zhang
BMC MOLECULAR AND CELL BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Zongliang Yue, Eric Zhang, Clark Xu, Sunny Khurana, Nishant Batra, Son Do Hai Deng, James J. Cimino, Jake Y. Chen
Summary: PAGER-CoV is a new web-based database that assists biomedical researchers in interpreting coronavirus-related functional genomic study results using a vast collection of PAGs. By exploring relationships between PAGs, users can gain deeper insights into the research information. This database can help researchers find molecular biology mechanisms and tailored therapeutics for treating COVID-19 patients.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Medical Informatics
Thanh Nguyen, Tongbin Zhang, Geoffrey Fox, Sisi Zeng, Ni Cao, Chuandi Pan, Jake Y. Chen
Summary: This study demonstrated the use of clinical information and electronic medical records to support precision medicine research and clinical decision-making on complex diseases. Through integration of public omic databases and advanced machine learning techniques, the study successfully addressed issues such as patient stratification, significant associations between clinical information and diseases, and potential linkages between clinical information and genomic data.
BMC MEDICAL INFORMATICS AND DECISION MAKING
(2021)
Article
Biochemistry & Molecular Biology
Eunju Kim, Kazunari Nohara, Marvin Wirianto, Gabriel Jr Jr Escobedo, Ji Ye Lim, Rodrigo Morales, Seung-Hee Yoo, Zheng Chen
Summary: The study investigated the effects of the natural compound NOB on circadian, metabolic, and amyloid characteristics in an AD mouse model, finding that NOB improved sleep duration, oxygen consumption, CO2 production, cold tolerance, and altered expression of core clock genes and metabolic genes. Furthermore, NOB attenuated the expression of AD-related genes, reduced APP protein levels, and strongly ameliorated Aβ pathology in the cortex, suggesting the circadian clock as a modifiable target for AD.
Article
Biochemistry & Molecular Biology
Jong Han Lee, Bingzhong Xue, Zheng Chen, Yuxiang Sun
Summary: This study demonstrates that GHS-R regulates energy homeostasis by altering feeding patterns, and differentially modulates feeding patterns in a site- and diet-dependent manner.
Article
Genetics & Heredity
Ji Ye Lim, Eunju Kim, Collin M. Douglas, Marvin Wirianto, Chorong Han, Kaori Ono, Sun Young Kim, Justin H. Ji, Celia K. Tran, Zheng Chen, Karyn A. Esser, Seung-Hee Yoo
Summary: This study illustrates the pivotal role of the circadian E3 ligase FBXL21 in sarcomere structure and muscle differentiation by regulating MYOZ1 degradation and NFAT2 signaling, providing important insights into the regulatory mechanisms of the skeletal muscle biological clock.
Review
Neurosciences
Radomir M. Slominski, Chander Raman, Jake Y. Chen, Andrzej T. Slominski
Summary: During oncogenesis, tumors can affect local and systemic homeostasis by producing cytokines, immune mediators, neurotransmitters, and other substances. They can control the central neuroendocrine and immune systems to promote their own growth and expansion.
TRENDS IN NEUROSCIENCES
(2023)
Article
Genetics & Heredity
Thanh Minh Nguyen, Jacob John Jeevan, Nuo Xu, Jake Y. Chen
Summary: The Polar Gini Curve is a method for characterizing cluster markers by analyzing single-cell RNA sequencing data, which helps users understand the shape and density distribution of cells in a particular cluster. By combining gene expression and spatial information, it can detect uniformity patterns within clustered cells and identify biomarkers with consistent gene expression patterns across clusters.
GENOMICS PROTEOMICS & BIOINFORMATICS
(2021)
Article
Clinical Neurology
Chorong Han, Marvin Wirianto, Eunju Kim, Mark J. Burish, Seung-Hee Yoo, Zheng Chen
Summary: The study revealed that the anti-arrhythmic drug moricizine can lengthen the circadian period, leading to changes in cardiac gene expression and cellular oscillators.
Proceedings Paper
Computer Science, Artificial Intelligence
James J. Cimino, Wayne H. Liang, Jelai Wang, Dongmei Sun, John D. Osborne, Amy Y. Wang, S. Louis Bridges, Matt Wyatt, Jake Y. Chen
2020 IEEE 21ST INTERNATIONAL CONFERENCE ON INFORMATION REUSE AND INTEGRATION FOR DATA SCIENCE (IRI 2020)
(2020)
Review
Physiology
Minyu Zhang, Biyang Xiao, Xiaoqi Chen, Bingming Ou, Songtao Wang
Summary: Non-alcoholic fatty liver disease (NAFLD) is closely related to bile acid and gut microbiota disorders. Exercise plays an important role in maintaining the homeostasis of the enterohepatic circulation and the health of the host gut microbiota by regulating the composition and function of the bile acid pool in the enterohepatic axis. Exercise has been recommended as a first-line intervention for NAFLD, and regulating bile acids through exercise may be a promising treatment strategy.