Tumour compartment transcriptomics demonstrates the activation of inflammatory and odontogenic programmes in human adamantinomatous craniopharyngioma and identifies the MAPK/ERK pathway as a novel therapeutic target

Molecular Analyses Reveal Inflammatory Mediators in the Solid Component and Cyst Fluid of Human Adamantinomatous Craniopharyngioma

(2017) Andrew M Donson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Interleukin-6 induces an epithelial-mesenchymal transition phenotype in human adamantinomatous craniopharyngioma cells and promotes tumor cell migration

(2017) Jie Zhou et al.   Molecular Medicine Reports

New outlook on the diagnosis, treatment and follow-up of childhood-onset craniopharyngioma

(2017) Hermann L. Müller et al.   Nature Reviews Endocrinology

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma

(2017) Jose Mario Gonzalez-Meljem et al.   Nature Communications

METRIC phase III study: Efficacy of trametinib (T), a potent and selective MEK inhibitor (MEKi), in progression-free survival (PFS) and overall survival (OS), compared with chemotherapy (C) in patients (pts) with BRAFV600E/K mutant advanced or metastatic melanoma (MM).

(2017) Caroline Robert et al.   JOURNAL OF CLINICAL ONCOLOGY

Cytokine Profile in Gout: Inflammation Driven by IL-6 and IL-18?

(2016) Nara Gualberto Cavalcanti et al.   IMMUNOLOGICAL INVESTIGATIONS

Adamantinomatous and papillary craniopharyngiomas are characterized by distinct epigenomic as well as mutational and transcriptomic profiles

(2016) Annett Hölsken et al.   Acta Neuropathologica Communications

Imaging Invasion: Micro-CT imaging of adamantinomatous craniopharyngioma highlights cell type specific spatial relationships of tissue invasion

(2016) John R. Apps et al.   Acta Neuropathologica Communications

Sonic Hedgehog pathway is upregulated in adamantinomatous craniopharyngiomas

(2015) D. C. Gomes et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Adamantinomatous craniopharyngioma: pathology, molecular genetics and mouse models

(2015) Juan Pedro Martinez-Barbera et al.   JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

Molecular and cellular pathogenesis of adamantinomatous craniopharyngioma

(2015) Juan Pedro Martinez-Barbera   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Activated WNT signaling in postnatal SOX2-positive dental stem cells can drive odontoma formation

(2015) Guilherme M. Xavier et al.   Scientific Reports

Identification of targets for rational pharmacological therapy in childhood craniopharyngioma

(2015) Jacob M Gump et al.   Acta Neuropathologica Communications

Insights into the Infiltrative Behavior of Adamantinomatous Craniopharyngioma in a New Xenotransplant Mouse Model

(2014) Christina Stache et al.   BRAIN PATHOLOGY

Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma

(2014) Andrew D. Rhim et al.   CANCER CELL

Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas

(2014) Priscilla K Brastianos et al.   NATURE GENETICS

Adamantinomatous Craniopharyngioma Containing Teeth

(2014) Narlin Bennet Beaty et al.   NEW ENGLAND JOURNAL OF MEDICINE

Stromal response to Hedgehog signaling restrains pancreatic cancer progression

(2014) J. J. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sox2+ Stem/Progenitor Cells in the Adult Mouse Pituitary Support Organ Homeostasis and Have Tumor-Inducing Potential

(2013) Cynthia Lilian Andoniadou et al.   Cell Stem Cell

Abnormal Ras signaling in Costello syndrome (CS) negatively regulates enamel formation

(2013) Alice F. Goodwin et al.   HUMAN MOLECULAR GENETICS

Identification of novel pathways involved in the pathogenesis of human adamantinomatous craniopharyngioma

(2012) Cynthia L. Andoniadou et al.   ACTA NEUROPATHOLOGICA

BMP Activity Is Required for Tooth Development from the Lamina to Bud Stage

(2012) Y. Wang et al.   JOURNAL OF DENTAL RESEARCH

Pathology and pathogenesis of craniopharyngiomas

(2012) Sarah J. Larkin et al.   Pituitary

Signaling Networks Regulating Tooth Organogenesis and Regeneration, and the Specification of Dental Mesenchymal and Epithelial Cell Lineages

(2012) M. Jussila et al.   Cold Spring Harbor Perspectives in Biology

Immunohistochemical expression of podoplanin in so-called hard ^|^alpha;-keratin-expressing tumors, including calcifying cystic odontogenic tumor, craniopharyngioma, and pilomatrixoma

(2012) Kentaro Kikuchi et al.   Journal of Oral Science

EGFR Signaling Regulates Tumor Cell Migration in Craniopharyngiomas

(2011) A. Holsken et al.   CLINICAL CANCER RESEARCH

Increased Wingless (Wnt) signaling in pituitary progenitor/stem cells gives rise to pituitary tumors in mice and humans

(2011) C. Gaston-Massuet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Current Status of Understanding the Pathogenesis and Management of Patients With NOMID/CINCA

(2011) Raphaela Goldbach-Mansky   Current Rheumatology Reports

Expression of aberrant β-catenin and impaired p63 in craniopharyngiomas

(2010) J. Cao et al.   BRITISH JOURNAL OF NEUROSURGERY

Toothy craniopharyngioma: a literature review and case report of craniopharyngioma with extensive odontogenic differentiation and tooth formation

(2010) Craig Muller et al.   CHILDS NERVOUS SYSTEM

β-catenin Initiates Tooth Neogenesis in Adult Rodent Incisors

(2010) F. Liu et al.   JOURNAL OF DENTAL RESEARCH

A tumor-specific cellular environment at the brain invasion border of adamantinomatous craniopharyngiomas

(2010) Stefanie Burghaus et al.   VIRCHOWS ARCHIV

Long-term efficacy of the interleukin-1 receptor antagonist anakinra in ten patients with neonatal-onset multisystem inflammatory disease/chronic infantile neurologic, cutaneous, articular syndrome

(2009) Bénédicte Neven et al.   ARTHRITIS AND RHEUMATISM

Target Gene Activation of the Wnt Signaling Pathway in Nuclear β-Catenin Accumulating Cells of Adamantinomatous Craniopharyngiomas

(2008) Annett Hölsken et al.   BRAIN PATHOLOGY

Is interleukin-1 a good or bad ‘guy’ in tumor immunobiology and immunotherapy?

(2008) Ron N. Apte et al.   IMMUNOLOGICAL REVIEWS