3D Visualization of the Temporal and Spatial Spread of Tau Pathology Reveals Extensive Sites of Tau Accumulation Associated with Neuronal Loss and Recognition Memory Deficit in Aged Tau Transgenic Mice

Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain

(2015) Nicole Maphis et al.   BRAIN

The preclinical phase of the pathological process underlying sporadic Alzheimer’s disease

(2015) Heiko Braak et al.   BRAIN

ScaleS: an optical clearing palette for biological imaging

(2015) Hiroshi Hama et al.   NATURE NEUROSCIENCE

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

(2015) Hirohide Asai et al.   NATURE NEUROSCIENCE

Loss of GPR3 reduces the amyloid plaque burden and improves memory in Alzheimer’s disease mouse models

(2015) Yunhong Huang et al.   Science Translational Medicine

Microglial internalization and degradation of pathological tau is enhanced by an anti-tau monoclonal antibody

(2015) Wenjie Luo et al.   Scientific Reports

Inside Alzheimer brain with CLARITY: senile plaques, neurofibrillary tangles and axons in 3-D

(2014) Kunie Ando et al.   ACTA NEUROPATHOLOGICA

Whole-Brain Imaging with Single-Cell Resolution Using Chemical Cocktails and Computational Analysis

(2014) Etsuo A. Susaki et al.   CELL

iDISCO: A Simple, Rapid Method to Immunolabel Large Tissue Samples for Volume Imaging

(2014) Nicolas Renier et al.   CELL

Microglia display modest phagocytic capacity for extracellular tau oligomers

(2014) Petra Majerova et al.   Journal of Neuroinflammation

Soluble pathological tau in the entorhinal cortex leads to presynaptic deficits in an early Alzheimer’s disease model

(2013) Manuela Polydoro et al.   ACTA NEUROPATHOLOGICA

ClearT: a detergent- and solvent-free clearing method for neuronal and non-neuronal tissue

(2013) T. Kuwajima et al.   DEVELOPMENT

Lateral entorhinal cortex is critical for novel object-context recognition

(2013) David I.G. Wilson et al.   HIPPOCAMPUS

Lateral entorhinal cortex is necessary for associative but not nonassociative recognition memory

(2013) David I.G. Wilson et al.   HIPPOCAMPUS

Structural and molecular interrogation of intact biological systems

(2013) Kwanghun Chung et al.   NATURE

CLARITY for mapping the nervous system

(2013) Kwanghun Chung et al.   NATURE METHODS

Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer's disease

(2013) Usman A Khan et al.   NATURE NEUROSCIENCE

SeeDB: a simple and morphology-preserving optical clearing agent for neuronal circuit reconstruction

(2013) Meng-Tsen Ke et al.   NATURE NEUROSCIENCE

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

Perirhinal cortex represents nonspatial, but not spatial, information in rats foraging in the presence of objects: Comparison with lateral entorhinal cortex

(2012) Sachin S. Deshmukh et al.   HIPPOCAMPUS

Who fans the flames of Alzheimer's disease brains? Misfolded tau on the crossroad of neurodegenerative and inflammatory pathways

(2012) Norbert Zilka et al.   Journal of Neuroinflammation

Three-dimensional imaging of solvent-cleared organs using 3DISCO

(2012) Ali Ertürk et al.   Nature Protocols

Propagation of Tau Pathology in a Model of Early Alzheimer's Disease

(2012) Alix de Calignon et al.   NEURON

Trans-Synaptic Spread of Tau Pathology In Vivo

(2012) Li Liu et al.   PLoS One

Chemical Clearing and Dehydration of GFP Expressing Mouse Brains

(2012) Klaus Becker et al.   PLoS One

Human P301L-Mutant Tau Expression in Mouse Entorhinal-Hippocampal Network Causes Tau Aggregation and Presynaptic Pathology but No Cognitive Deficits

(2012) Julie A. Harris et al.   PLoS One

Tau-Induced Defects in Synaptic Plasticity, Learning, and Memory Are Reversible in Transgenic Mice after Switching Off the Toxic Tau Mutant

(2011) A. Sydow et al.   JOURNAL OF NEUROSCIENCE

Scale: a chemical approach for fluorescence imaging and reconstruction of transparent mouse brain

(2011) Hiroshi Hama et al.   NATURE NEUROSCIENCE

Amygdala atrophy is prominent in early Alzheimer's disease and relates to symptom severity

(2011) Stéphane P. Poulin et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

Genetic background modifies neurodegeneration and neuroinflammation driven by misfolded human tau protein in rat model of tauopathy: implication for immunomodulatory approach to Alzheimer's disease

(2010) Zuzana Stozicka et al.   Journal of Neuroinflammation

The Caudal Medial Entorhinal Cortex: a Selective Role in Recollection-Based Recognition Memory

(2010) M. M. Sauvage et al.   JOURNAL OF NEUROSCIENCE

Post-training reversible inactivation of the hippocampus enhances novel object recognition memory

(2010) A. M.M. Oliveira et al.   LEARNING & MEMORY

Human misfolded truncated tau protein promotes activation of microglia and leukocyte infiltration in the transgenic rat model of tauopathy

(2009) Norbert Zilka et al.   JOURNAL OF NEUROIMMUNOLOGY

Microglial activation in brain lesions with tau deposits: Comparison of human tauopathies and tau transgenic mice TgTauP301L

(2008) Atsushi Sasaki et al.   BRAIN RESEARCH

Memory loss in Alzheimer’s disease: implications for development of therapeutics

(2008) Carl A Gold et al.   Expert Review of Neurotherapeutics