Review
Immunology
Ye Qiu, Gaoneng Fang, Feng Ye, Wen Zeng, Mengxin Tang, Xuan Wei, Jinglu Yang, Zhengtu Li, Jianquan Zhang
Summary: This study describes the pathogen spectrum and treatment strategies among patients with AIGA positivity. Non-tuberculous mycobacteria (NTM) is the most common pathogen, with 41.2% of patients experiencing recurrence and/or persistent infection. Rituximab and cyclophosphamide are common treatment options, and most patients achieve remission.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Dermatology
Mingwei Ma, Shufeng Wei, Dan Yin, Weizhong Li, Chen Li
Summary: SAPHO syndrome is a rare disease characterized by osteoarticular and cutaneous manifestations. In this case report, a rare case of SAPHO syndrome complicated with Sweet's syndrome is presented, highlighting the importance of understanding the interplay between these two diseases and the potential implications for treatment.
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
(2023)
Article
Dermatology
F. Bellinato, M. Maurelli, P. Gisondi, G. Girolomoni
Summary: This study found that patients with acquired perforating dermatoses (APDs) had significantly elevated levels of cutaneous advanced glycation end-products (AGEs), suggesting a potential pathophysiological role of AGEs in the mechanisms involved in certain APDs.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2022)
Article
Immunology
Vera Goda, Gergely Krivan, Andrea Kulcsar, Marton Gonczi, Szabolcs Tasnady, Zsolt Matula, Ginette Nagy, Gabriella Beko, Mate Horvath, Ferenc Uher, Zoltan Szekanecz, Istvan Valyi-Nagy
Summary: This study evaluated the immune response of CVID patients receiving booster vaccination with BNT162b2 against SARS-CoV-2. The results showed that the vaccine can increase antibody levels and T cell response in CVID patients, but the response levels are still lower compared to healthy individuals.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Dermatology
Salin Kiratikanon, Phichayut Phinyo, Rujira Rujiwetpongstorn, Jayanton Patumanond, Veeraphol Tungphaisal, Pongsak Mahanupab, Romanee Chaiwarith, Napatra Tovanabutra, Siri Chiewchanvit, Mati Chuamanochan
Summary: A study found that Sweet syndrome is more common in adult patients with immunodeficiency accompanied by non-tuberculous mycobacterial infection. Lymphadenopathy, pustular lesions, and leukocytosis are important predictors for AOID-associated Sweet syndrome. AOID may increase the prevalence of SS and there might be a potential causal relationship with dNTMI.
JOURNAL OF DERMATOLOGY
(2022)
Article
Immunology
Joseph Jelinski, Monika M. Kowatsch, Marc-Alexandre Lafrance, Alice Berger, Jannie Pedersen, Hiva Azizi, Yue Li, Florine Scholte, Alejandro Gomez, Natasha Hollett, Toby Le, Matthew Wade, Hugues Fausther-Bovendo, Marc-Antoine de la Vega, George Babuadze, Ara Xiii, Claude Lamarre, Trina Racine, Chil-Yong Kang, Xiao-Jian Yao, Galit Alter, Eric Arts, Keith R. Fowke, Gary P. Kobinger
Summary: Despite the 40-year global HIV pandemic, no licensed vaccine has been developed for high-risk populations. However, a novel recombinant vesicular stomatitis virus (rVSV) vector vaccine expressing modified HIV envelope glycoproteins and Ebola virus glycoprotein successfully prevented SHIV infection in 60% of non-human primates (NHPs). Resistance to infection was associated with specific immune responses, including CD69 and CD154 upregulation, increased IL-2 production, and reduced IFN-γ response, providing insights into potential correlates of protection.
EMERGING MICROBES & INFECTIONS
(2023)
Article
Medicine, General & Internal
Amel Awad IbnIdris Rodwan, Abdel Gaffar A. Mohammed, Mohammed Elmujtba Adam Essa, Atif Elhadi Abdalla Babker, Ali Mohamed Abdelsatir, Elnour Mohammed Elagib
Summary: This report presents a rare case of neutrophilic dermatosis in a patient with seronegative rheumatoid arthritis. The patient did not respond well to steroid treatment but showed significant improvement after receiving cyclosporin.
CLINICAL CASE REPORTS
(2022)
Article
Allergy
Ankit Srivastava, Longlong Luo, Warangkana Lohcharoenkal, Florian Meisgen, Lorenzo Pasquali, Andor Pivarcsi, Eniko Sonkoly
Summary: IFN-γ suppresses miR-149 to prime keratinocytes for inflammatory responses, leading to skin inflammation.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Immunology
Helen Ferreira, Mayara Abud Mendes, Mayara Garcia de Mattos Barbosa, Eliane Barbosa de Oliveira, Anna Maria Sales, Milton Ozorio Moraes, Euzenir Nunes Sarno, Roberta Olmo Pinheiro
Summary: The study evaluated the effect of multidrug therapy on skin cell phenotype and Mycobacterium leprae-specific immune response in multibacillary leprosy cases, indicating that CXCL10 (IP-10) could be a good marker for monitoring treatment efficacy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Wen-I. Lee, Yao-Fan Fang, Jing-Long Huang, Huey-Ling You, Meng-Ying Hsieh, Wan-Ting Huang, Chi-Jou Liang, Chen-Chen Kang, Ting-Shu Wu
Summary: It is not uncommon to find the presence of anti-interferon-gamma autoantibodies (AutoAbs-IFN-gamma) in patients with persistent non-tuberculous mycobacterial (NTM) infections characteristic of adult-onset immunodeficiency syndrome. The immune disturbances in this disorder are still not well understood. By quantifying the levels of AutoAbs-IFN-gamma and comparing them with healthy controls, it was found that the abnormal distribution of immune cell subpopulations may be correlated with the presence of AutoAbs-IFN-gamma.
JOURNAL OF CLINICAL IMMUNOLOGY
(2023)
Article
Immunology
Yi-Chun Chen, Shao-Wen Weng, Jing-Ya Ding, Chen-Hsiang Lee, Cheng-Lung Ku, Wen-Chi Huang, Huey-Ling You, Wan-Ting Huang
Summary: Patients with anti-IFN-gamma antibodies exhibit immune dysfunction, with T cell exhaustion and adaptive NK cells leading to specific clinical and pathological features.
JOURNAL OF CLINICAL IMMUNOLOGY
(2022)
Article
Immunology
Ondrej Vladyka, Petra Vrabcova, Michaela Reiterova, Zuzana Parackova, Robert Haesler, Anna Sediva, Tomas Kalina, Adam Klocperk
Summary: The aim of this study was to investigate the impact of thymic dysplasia on the phenotypic and functional characteristics of T cells in patients with 22q11.2 deletion syndrome. The results showed a strong Th1 bias in T cell populations, accompanied by accelerated maturation of T cells into memory stages. In vitro experiments also revealed that IL-7 further reduced naive T cells and increased cytokine production.
CLINICAL IMMUNOLOGY
(2023)
Article
Cell Biology
Kyle J. Gellatly, James P. Strassner, Kingsley Essien, Maggi Ahmed Refat, Rachel L. Murphy, Anthony Coffin-Schmitt, Amit G. Pandya, Andrea Tovar-Garza, Michael L. Frisoli, Xueli Fan, Xiaolan Ding, Evangeline E. Kim, Zainab Abbas, Patrick McDonel, Manuel Garber, John E. Harris
Summary: The study revealed that cytokine signaling plays a critical role in the progression of vitiligo, while regulatory T cells also participate in inhibiting disease development. The CCL5-CCR5 signaling pathway acts as a chemokine circuit between effector CD8(+) T cells and Tregs.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Infectious Diseases
Jana Ihlow, Edward Michaelis, Selina Greuel, Verena Heynol, Annika Lehmann, Helena Radbruch, Jenny Meinhardt, Florian Miller, Hermann Herbst, Victor Max Corman, Joerg Westermann, Lars Bullinger, David Horst, Ann-Christin von Bruenneck, Sefer Elezkurtaj
Summary: The study revealed that severe COVID-19 pneumonia with bacterial infection may lead to sepsis-related immunodeficiency. Additionally, lymphocytopenia in COVID-19 patients is accompanied by B cell depletion in hematopoietic tissue, which could impact the durability of the humoral immune response to SARS-CoV-2.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Fuquan Lin, Wenting Hu, Wen Xu, Miaoni Zhou, Ai-E. Xu
Summary: This study investigated potential biomarkers of vitiligo through autologous cultured pure melanocyte transplantation in 36 patients. It found that levels of CXCL9 and CXCL10 in blister fluid samples were significantly associated with active vitiligo diagnosis and treatment response prediction. Specifically, a high CXCL9 level correlated with ineffective treatment responses and CXCL9 was a predictor of treatment effectiveness.
SCIENTIFIC REPORTS
(2021)
Article
Dermatology
J. Triwatcharikorn, T. Puaratana-arunkon, P. Punyaratabandhu, P. Mongkolpathumrat, S. Palapinyo, S. Buranapraditkul, P. Rerknimitr, J. Klaewsongkram
Summary: Patients who develop an immediate allergic reaction within 4 hours of COVID-19 vaccine injection are not recommended to receive the same vaccine again; however, for CoronaVac vaccine, immediate urticaria should not be a contraindication for the second dose, as successful revaccination is possible.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2022)
Letter
Dermatology
P. Rerknimitr, T. Puaratanaarunkon, C. Wongtada, N. Wittayabusarakam, S. Krithin, L. Paitoonpong, C. Kumtornrut, S. J. Kerr, P. Asawanonda, W. Jantarabenjakul, J. Klaewsongkram
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Rheumatology
Chanidapa Wongtada, Stephen J. Kerr, Pawinee Rerknimitr
Summary: The lupus band test performed on non-lesion skin can be valuable for diagnosing systemic lupus erythematosus, especially in cases with insufficient clinical and serological profiles.
Article
Acoustics
V. Schreiber, C. Hurst, F. da Silva Costa, R. Stoke, J. Turner, S. Kumar
Summary: This study compared the screening performance of SMFM biometric criteria with ISUOG/Delphi consensus criteria for fetal growth restriction (FGR) detection. The results showed that both criteria were effective in predicting infants with low birth weight, but had limited predictive ability for adverse neonatal outcomes.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Environmental Sciences
Dhammika Leshan Wannigama, Mohan Amarasiri, Parichart Hongsing, Cameron Hurst, Charin Modchang, Sudarat Chadsuthi, Suparinthon Anupong, Phatthranit Phattharapornjaroen, Ali Hosseini S. M. Rad, Stefan Fernandez, Angkana T. Huang, Naris Kueakulpattana, Chanikan Tanasatitchai, Porames Vatanaprasan, Thammakorn Saethang, Sirirat Luk-in, Robin James Storer, Puey Ounjai, Naveen Kumar Devanga Ragupathi, Phitsanuruk Kanthawee, Daisuke Sano, Takashi Furukawa, Kazunari Sei, Asada Leelahavanichkul, Talerngsak Kanjanabuch, Nattiya Hirankarn, Paul G. Higgins, Anthony Kicic, Tanittha Chatsuwan, Alexander D. McLellan, Shuichi Abe
Summary: The study detected monkeypox viral DNA in wastewater samples from various locations in Bangkok, suggesting that wastewater could be a complementary source for detecting viral DNA and predicting outbreaks.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Nursing
Jyai Allen, Yu Gao, Julie Germain, Michelle O'Connor, Cameron Hurst, Sue Kildea
Summary: This study assessed the impact of implementing the Thompson method on direct breastfeeding at hospital discharge and exclusive breastfeeding at 3-months of age. The results showed that the implementation of the Thompson method improved direct breastfeeding trends at hospital discharge and reduced the risk of exclusive breastfeeding discontinuation at 3-months.
INTERNATIONAL JOURNAL OF NURSING STUDIES
(2023)
Article
Allergy
J. L. Robinson, K. L. Gatford, C. P. Hurst, V. L. Clifton, J. L. Morrison, M. J. Stark
Summary: Asthma in pregnant women in Australia affects about 17% of pregnancies and is associated with negative perinatal outcomes. Revised guidelines in South Australia aim to improve asthma management during pregnancy based on severity. This study explores whether the revised guidelines have reduced the impact of maternal asthma on adverse perinatal outcomes.
Article
Dermatology
Nunthanach Chuenboonngarm, Thanaporn Puaratanaarunkon, Chanudda Washrawirul, Jidapa Triwatcharikorn, Bussabong Chancheewa, Chinathip Theerawattanawit, Yuda Chongpison, Pawinee Rerknimitr, Jettanong Klaewsongkram
Summary: In this study, we identified age, neutrophil-to-lymphocyte ratio (NLR), systemic infection, and SCAR phenotype as factors predicting in-hospital mortality in SCAR patients. Using these factors, we developed a simple and accurate model for predicting mortality rates in SCAR patients.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Urology & Nephrology
Dong Yu, Eva Malacova, Cameron Hurst, Monica Suet Ying Ng, Andrew John Mallett
Summary: This study evaluates the clinical outcomes of kidney transplant recipients and finds that monogenic primary kidney disease is associated with lower rates of recurrence and graft failure. Donor relatedness has no effect on transplant outcomes.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2023)
Article
Dermatology
Jidapa Triwatcharikorn, Yada Itthipanichpong, Chanudda Washrawirul, Nunthanach Chuenboonngarm, Yuda Chongpison, Suthep Udomsawaengsup, Patchaya Boonchaya-Anant, Pawinee Rerknimitr
Summary: This prospective study aimed to evaluate the prevalence and changes of skin signs in morbidly obese patients after post-bariatric surgery (BaS). The study found that BaS provided improvements in various skin manifestations, but was also associated with the occurrence of telogen effluvium. Biophysical changes in skin properties were observed, including decreased sebum production on the face and decreased elasticity.
JOURNAL OF DERMATOLOGY
(2023)
Letter
Infectious Diseases
Dhammika Leshan Wannigama, Mohan Amarasiri, Phatthranit Phattharapornjaroen, Cameron Hurst, Charin Modchang, Sudarat Chadsuthi, Suparinthon Anupong, Kazuhiko Miyanaga, Longzhu Cui, Stefan Fernandez, Angkana T. Huang, Puey Ounjai, Ratana Tacharoenmuang, Naveen Kumar Devanga Ragupathi, Daisuke Sano, Takashi Furukawa, Kazunari Sei, Asada Leelahavanichkul, Talerngsak Kanjanabuch, Paul G. Higgins, Asuka Nanbo, Anthony Kicic, Andrew C. Singer, Tanittha Chatsuwan, Sam Trowsdale, Aisha Khatib, Kenji Shibuya, Shuichi Abe, Hitoshi Ishikawa, Parichart Hongsing
LANCET INFECTIOUS DISEASES
(2023)
Article
Multidisciplinary Sciences
Dhammika Leshan, Aye Mya Sithu Shein, Cameron Hurst, Peter N. Monk, Parichart Hongsing, Phatthranit Phattharapornjaroen, William Graham Fox Ditcham, Puey Ounjai, Thammakorn Saethang, Naphat Chantaravisoot, Pattama Wapeesittipan, Sirirat Luk-in, Sasipen Sae-Joo, Sumanee Nilgate, Ubolrat Rirerm, Chanikan Tanasatitchai, Naris Kueakulpattana, Matchima Laowansiri, Tingting Liao, Rosalyn Kupwiwat, Rojrit Rojanathanes, Natharin Ngamwongsatit, Somkanya Tungsanga, Asada Leelahavanichkul, Naveen Kumar Devanga Ragupathi, Vishnu Nayak Badavath, S. M. Ali Hosseini, Talerngsak Kanjanabuch, Nattiya Hirankarn, Robin James Storer, Longzhu Cui, Mohan Amarasiri, Hitoshi Ishikawa, Paul G. Higgins, Stephen M. Stick, Anthony Kicic, Tanittha Chatsuwan, Shuichi Abe
Summary: The novel aztreonam-Ca-EDTA or ceftazidime-avibactam-Ca-EDTA combinations show favorable efficacy and safety in treating carbapenemase-positive Klebsiella pneumoniae (CPKp) infections.
Article
Multidisciplinary Sciences
Dhammika Leshan Wannigama, Mohan Amarasiri, Parichart Hongsing, Cameron Hurst, Charin Modchang, Sudarat Chadsuthi, Suparinthon Anupong, Phatthranit Phattharapornjaroen, S. M. Ali Hosseini Rad, Stefan Fernandez, Angkana T. Huang, Porames Vatanaprasan, Dylan John Jay, Thammakorn Saethang, Sirirat Luk-in, Robin James Storer, Puey Ounjai, Naveen Kumar Devanga Ragupathi, Phitsanuruk Kanthawee, Daisuke Sano, Takashi Furukawa, Kazunari Sei, Asada Leelahavanichkul, Talerngsak Kanjanabuch, Nattiya Hirankarn, Paul G. Higgins, Anthony Kicic, Andrew C. Singer, Tanittha Chatsuwan, Sam Trowsdale, Shuichi Abe, Alexander D. McLellan, Hitoshi Ishikawa
Summary: This study analyzed wastewater samples from 186 urban and rural subdistricts in nine provinces of Thailand to detect SARS-CoV-2 RNA variants. The results showed that wastewater RNA concentrations could be used to estimate real-time incidence and predict outbreaks earlier than official reports.
Article
Biology
Wei Qian, Elvina Viennet, Kathryn Glass, David Harley, Cameron Hurst
Summary: This study predicts the incidence rates of Ross River virus (RRV) in three cities in Queensland, Australia, using mosquito abundance data and other variables. The results demonstrate the value of mosquito data in predicting RRV incidence, with excellent predictive results in Brisbane and Redlands.
Article
Medicine, Research & Experimental
Aye Mya Sithu Shein, Dhammika Leshan Wannigama, Cameron Hurst, Peter N. Monk, Mohan Amarasiri, Vishnu Nayak Badavath, Phatthranit Phattharapornjaroen, William Graham Fox Ditcham, Puey Ounjai, Thammakorn Saethang, Naphat Chantaravisoot, Wanwara Thuptimdang, Sirirat Luk-in, Sumanee Nilgate, Ubolrat Rirerm, Chanikan Tanasatitchai, Naris Kueakulpattana, Matchima Laowansiri, Tingting Liao, Rosalyn Kupwiwat, Rojrit Rojanathanes, Natharin Ngamwongsatit, Arsa Thammahong, Hitoshi Ishikawa, Daniel Pletzer, Asada Leelahavanichkul, Naveen Kumar Devanga Ragupathi, Pattama Wapeesittipan, S. M. Ali Hosseini Rad, Talerngsak Kanjanabuch, Robin James Storer, Kazuhiko Miyanaga, Longzhu Cui, Hiroshi Hamamoto, Paul G. Higgins, Anthony Kicic, Tanittha Chatsuwan, Parichart Hongsing, Shuichi Abe
Summary: This study tested the efficacy of a combination therapy using phage and an adjuvant in treating multidrug-resistant Pseudomonas aeruginosa infections. The results showed that intranasal inhalation of phage along with CaEDTA successfully resensitized the bacteria to specific antibiotics, indicating its potential as a therapy for respiratory tract infections.
BIOMEDICINE & PHARMACOTHERAPY
(2023)