Review
Medicine, General & Internal
Ying X. Gue, Young-Hoon Jeong, Mohamed Farag, Nikolaos Spinthakis, Diana A. Gorog
Summary: Despite advancements in treatment, ACS patients still face the risk of recurrent thrombotic events, with impaired endogenous fibrinolysis playing a major role. Global assessment and personalized antithrombotic therapy based on fibrinolytic status may improve long-term outcomes in ACS.
JOURNAL OF CLINICAL MEDICINE
(2021)
Editorial Material
Engineering, Chemical
Meenesh R. Singh, Diana Azevedo
Summary: The special issue titled Women in Chemical Engineering released by Chemical Engineering Research and Design aims to recognize and showcase top women researchers across the globe who are conducting pioneering research in their field of study. This issue features contributions from 17 outstanding women researchers in the research areas of catalysis, separation, process systems, pharmaceuticals, energy, and environmental science and engineering.
CHEMICAL ENGINEERING RESEARCH & DESIGN
(2022)
Review
Ecology
Giorgio Matassi, Pedro Martinez
Summary: In this review essay, the twelve contributions in the Special Issue of Frontiers in Ecology and Evolution on the topic of the brain-computer analogy are summarized and linked to selected concepts through a graphical summary. The authors all recognize the importance of semantics in the debate, but the distinction between metaphor and analogy is missing. The authors also suggest the development of evolutionary theories of the brain and discuss the role of metaphors and analogies in the creative process.
FRONTIERS IN ECOLOGY AND EVOLUTION
(2023)
Review
Cell Biology
Masoom Raza, Naveen Kumar, Uttara Nair, Gehna Luthra, Ushosi Bhattacharyya, Smruthi Jayasundar, Rama Jayasundar, Seema Sehrawat
Summary: Precision medicine has revolutionized cancer therapy by targeting unique biomarkers in different types of cancers, leading to more efficient treatment. Despite challenges posed by tumor heterogeneity, the development of precision medicine allows for the discovery and utilization of various gene mutations to design more targeted therapies. It also helps in identifying potential cross-cancer therapeutic benefits based on similarities in signaling pathways and machinery.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Oncology
Lin Fang, Yang Yao, Xin Guan, Yuanyu Liao, Bojun Wang, Luying Cui, Shuling Han, Haoyi Zou, Dan Su, Yue Ma, Biao Liu, Yao Wang, Rui Huang, Yuli Ruan, Xuefan Yu, Yuanfei Yao, Chao Liu, Yanqiao Zhang
Summary: This study developed a scoring system called Regulatory-Immunoscore (RIS) to predict the recurrence risk and treatment responsiveness of colorectal cancer (CRC) patients. The density of CD8(+) and FOXP3(+) T cells in the tumor and invasive margin was analyzed using immunohistochemistry and digital pathology.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Editorial Material
Multidisciplinary Sciences
Liam Drew
Summary: Mind-altering drugs are having a significant impact on medicine, but the way they actually work is still unknown. A series of imaging studies could shed light on this mystery.
Review
Immunology
Cai-Ping Sun, Huan-Rong Lan, Xing-Liang Fang, Xiao-Yun Yang, Ke-Tao Jin
Summary: Cancer immunotherapy modulates the immune system to treat diseases, but conventional animal and in vitro models fail to accurately simulate the tumor immune microenvironment. More physiomimetic cancer models, such as patient-derived organoids, are needed to evaluate the efficacy of immunotherapy agents. The dynamic interactions between neoplastic cells and non-neoplastic host components in the tumor immune microenvironment play a crucial role in carcinogenesis, tumor metastasis, cancer progression, and drug resistance. Tumor organoids can effectively recapitulate the tumor immune microenvironment and be used for testing immunotherapy agents and personalized cancer immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Kathryn Maxson Jones, Jennifer R. Morgan
Summary: This paper employs history of science methods to present the history of lampreys in neurobiology, focusing on their role in understanding spinal cord regeneration mechanisms. The large neurons and basal vertebrate characteristics of lampreys have attracted researchers, leading to new insights and discoveries in the field. The lamprey model has provided valuable information about CNS regeneration and the intrinsic factors that promote or hinder it.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Engineering, Biomedical
David Caballero, Catarina M. Abreu, Ana C. Lima, Nuno N. Neves, Rui L. Reis, Subhas C. Kundu
Summary: Traditional cancer treatment approaches are becoming obsolete, leading to more patients failing to respond to treatments. Personalized genetic profiling offers a more accurate method of treatment, but still faces issues like low local drug efficacy. Efforts are now focused on developing precision medicine-based strategies to improve cancer treatment efficiency.
Editorial Material
Biochemistry & Molecular Biology
Alessandro Passardi, Emanuela Scarpi, Paola Ulivi
Summary: This editorial summarizes six scientific papers on molecular and translational research on colorectal cancer, contributing to the current understanding of potential biomarkers and treatment targets. It aims to identify new strategies to improve diagnostic and therapeutic approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Genetics & Heredity
Tosso Leeb
Summary: Wolves were the first animals to be domesticated by humans, and thousands of generations of dog breeding have resulted in more than 350 recognized breeds with distinct morphological, behavioral, and disease predisposition differences. The domestication and breeding of dogs can be seen as a significant genetic experiment for humans, providing unique research opportunities. This special issue, titled Canine Genetics 2, focuses on the importance of canine genetics and includes reports on genetic diseases in dogs, as well as research on wild canids, genetic diversity, and canine morphology.
Editorial Material
Oncology
Maheetha Bharadwaj, Mounica Vallurupalli, Franklin W. Huang
Summary: The article calls for improving access to precision oncology therapies in lower- and middle-income countries, highlighting lack of diagnostic ability, trained providers, and drug availability as significant barriers to cancer care delivery. It draws upon lessons from international efforts in oncology and infectious disease to make this urgent call to action.
Editorial Material
Biochemistry & Molecular Biology
Elizabeth S. S. Yeh
Summary: This special issue includes nine original contributions on various human cancers, covering topics such as cancer stem cell function, cancer immunology, and glycosylation. It addresses critical barriers in curing cancer, including metastasis and resistance to therapeutics.
Review
Biochemistry & Molecular Biology
Alessia Vignoli, Emanuela Risi, Amelia McCartney, Ilenia Migliaccio, Erica Moretti, Luca Malorni, Claudio Luchinat, Laura Biganzoli, Leonardo Tenori
Summary: Precision oncology focuses on selecting the optimal therapy for individual patients with breast cancer, who need appropriate stratification for maximizing survival and quality of life. Gene-expression tools assist in estimating risk and benefit from chemotherapy, while NMR metabolomics has shown promising results in BC research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Joaquin Mateo, Lotte Steuten, Philippe Aftimos, Fabrice Andre, Mark Davies, Elena Garralda, Jan Geissler, Don Husereau, Iciar Martinez-Lopez, Nicola Normanno, Jorge S. Reis-Filho, Stephen Stefani, David M. Thomas, C. Benedikt Westphalen, Emile Voest
Summary: Precision medicine is reshaping cancer care, but accessibility to all patients remains a challenge. This Perspective highlights the importance of addressing the challenges in implementing precision oncology, including equal access to genomics tests, robust evidence for new drugs and technologies, interpretation of genomics data by physicians, and empowering patients in shared decision-making.
Article
Chemistry, Medicinal
Eric A. Wold, Erik J. Garcia, Christopher T. Wild, Joanna M. Miszkiel, Claudia A. Soto, Jianping Chen, Konrad Pazdrak, Robert G. Fox, Noelle C. Anastasio, Kathryn A. Cunningham, Jia Zhou
JOURNAL OF MEDICINAL CHEMISTRY
(2020)
Article
Psychiatry
Michelle A. Land, Divya Ramesh, Aaron L. Miller, Richard B. Pyles, Kathryn A. Cunningham, F. Gerard Moeller, Noelle C. Anastasio
FRONTIERS IN PSYCHIATRY
(2020)
Article
Neurosciences
Irma E. Cisneros, Kathryn A. Cunningham
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Substance Abuse
Kabir B. Nigam, Lisa K. Straub, Edward A. Zuniga, Aysha Sami, Kathryn A. Cunningham, Noelle C. Anastasio, F. Gerard Moeller, James M. Bjork
Summary: This study investigated the neural circuit characteristics and effects of behavioral control in patients with cocaine use disorder, revealing attenuated covert features of attention and proactive control in these patients, which may partially account for their susceptibility to relapse due to poor executive function.
DRUG AND ALCOHOL DEPENDENCE
(2021)
Review
Pharmacology & Pharmacy
Nicholas M. Barnes, Gerard P. Ahern, Carine Becamel, Joel Bockaert, Michael Camilleri, Severine Chaumont-Dubel, Sylvie Claeysen, Kathryn A. Cunningham, Kevin C. Fone, Michael Gershon, Giuseppe Di Giovanni, Nathalie M. Goodfellow, Adam L. Halberstadt, Rachel M. Hartley, Gherici Hassaine, Katharine Herrick-Davis, Ruud Hovius, Enza Lacivita, Evelyn K. Lambe, Marcello Leopoldo, Finn Olav Levy, Sarah C. R. Lummis, Philippe Marin, Luc Maroteaux, Andrew C. McCreary, David L. Nelson, John F. Neumaier, Adrian Newman-Tancredi, Hugues Nury, Alexander Roberts, Bryan L. Roth, Anne Roumier, Gareth J. Sanger, Milt Teitler, Trevor Sharp, Carlos M. Villalon, Horst Vogel, Stephanie W. Watts, Daniel Hoyer
Summary: This review provides a comprehensive account of the classification and function of 5-hydroxytryptamine receptors, including how they are targeted for therapeutic benefit.
PHARMACOLOGICAL REVIEWS
(2021)
Article
Behavioral Sciences
Brionna D. Davis-Reyes, Ashley E. Smith, Jimin Xu, Kathryn A. Cunningham, Jia Zhou, Noelle C. Anastasio
Summary: The concept of impulse control, originating from early psychiatry, has evolved into a multidimensional endophenotype underlying various neuropsychiatric disorders. Evidence suggests that dysfunction in glutamate neurotransmission drives cognitive and behavioral aspects of impulsivity. Pharmacological approaches targeting GluR signaling, such as ketamine and AMPAR positive allosteric modulation, may effectively normalize impulsivity and improve neuropsychiatric disorders characterized by aberrant impulse control.
BEHAVIOURAL PHARMACOLOGY
(2021)
Article
Neurosciences
Caitlin R. Schlagal, Tiffany J. Dunn, Pei Xu, Daniel E. Felsing, Christina R. Merritt, Sanjana Manja, Robert G. Fox, Shelly A. Buffington, George Saade, Kelly T. Dineley, Yongjia Yu, Kathryn A. Cunningham, Ping Wu
Summary: The use of opioids by pregnant women has increased significantly since 2004, leading to a rise in neonatal opioid withdrawal syndrome (NOWS) and other neurological deficits in offspring. A novel mouse model was developed to study the consequences of maternal opioid use on fetal neurodevelopment, revealing critical changes in brain development and behavioral anomalies in adolescent offspring. These findings suggest a teratogenic effect of prenatal opioid exposure.
Article
Psychiatry
Sade E. Johns, Lori Keyser-Marcus, Antonio Abbate, Edward Boone, Benjamin Van Tassell, Kathryn A. Cunningham, Noelle C. Anastasio, Justin L. Poklis, Tatiana Ramey, F. Gerard Moeller
Summary: The study demonstrated the safety of administering the 5-HT2CR agonist lorcaserin with cocaine in patients with CocUD, but it showed a lack of efficacy in reducing the reinforcing effects of cocaine. This suggests a disconnect between the effects of 5-HT2CR agonists on craving and cocaine choice in human cocaine users.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Neurosciences
I. E. Cisneros, K. A. Cunningham
Summary: The Covid-19 pandemic has exacerbated the drug overdose and substance use disorder epidemic, with social isolation, economic distress, and mental health issues disproportionally affecting vulnerable populations, potentially leading to instability in central nervous system functioning and the development of neuropsychiatric symptoms.
Article
Neurosciences
James M. Kasper, Ashley E. Smith, Sierra N. Miller, Ara, William K. Russell, Kathryn A. Cunningham, Jonathan D. Hommel
Summary: The neurotransmitter neuromedin U (NMU) and its receptor were found to regulate motivation for cocaine, affecting GABA release and c-Fos expression, leading to reduced breakpoints for cocaine. Using viral transsynaptic studies, it was discovered that NMU impacts the GABAergic pathway from the dorsal raphe nucleus to the nucleus accumbens shell to the ventral pallidum. These findings advance understanding of the neurochemical regulation of pathways specific to cocaine self-administration.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Cell Biology
Eun-Seon Yoo, Li Li, Lin Jia, Caleb C. Lord, Charlotte E. Lee, Shari G. Birnbaum, Claudia R. Vianna, Eric D. Berglund, Kathryn A. Cunningham, Yong Xu, Jong-Woo Sohn, Chen Liu
Summary: The study shows that Htr2c in Sim1 neurons plays a role in promoting food intake and counteracting the effects of serotonergic appetite suppressants. Moreover, activation of PVH Htr2c suppresses hunger while inhibition promotes feeding.
Meeting Abstract
Biochemistry & Molecular Biology
Leah M. Salinsky, Robert Fox, Noelle Anastasio, Kathryn A. Cunningham
Article
Psychiatry
Liangsuo Ma, Kathryn A. Cunningham, Noelle C. Anastasio, James M. Bjork, Brian A. Taylor, Albert J. Arias, Brien P. Riley, Andrew D. Snyder, F. Gerard Moeller
Summary: Patients with Cocaine Use Disorder (CUD) exhibit diverse symptoms and unpredictable responses to treatment, emphasizing the importance of identifying biobehavioral signatures to predict success in clinical trials. This study utilized a task-based behavioral and pharmacogenetic-fMRI approach to investigate craving and attentional bias in CUD patients. The findings suggest that the wild-type 5-HT2CR gene is necessary for the efficacy of the serotonin antagonist mirtazapine in reducing activated effective connectivity in CUD patients.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Pharmacology & Pharmacy
Christina R. Merritt, Irma E. Cisneros, Obdulia Covarrubias-Zambrano, Sonja J. Stutz, Massoud Motamedi, Stefan H. Bossmann, Kathryn A. Cunningham
Summary: This article discusses the challenges physicians face in treating pain patients and highlights the lack of quantifiable, objective methods of measuring pain in clinical settings. The study uses an animal model to investigate the relationship between circulating regulators of the inflammatory response and objective behavioral responses to inflammatory pain. The findings suggest that certain cytokines and matrix metalloproteinases may serve as predictive biomarkers for inflammation-associated locomotor impairment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Christina R. Merritt, Ashley E. Smith, Kamil Khanipov, George Golovko, Kelly T. Dineley, Noelle C. Anastasio, Kathryn A. Cunningham
Summary: The lack of FDA-approved medications for the treatment of cocaine use disorder (CUD) has contributed to the increase in drug overdose deaths involving cocaine. This study used next-generation sequencing to identify specific genes associated with cue-evoked cocaine-seeking behavior in the medial prefrontal cortex (mPFC) of rats. The findings provide potential candidates for future pharmacotherapeutics aimed at maintaining abstinence in CUD.
FRONTIERS IN PHARMACOLOGY
(2022)