Article
Biochemistry & Molecular Biology
Maria Quiterio, Sandra Simoes, Andreia Ascenso, Manuela Carvalheiro, Ana Paula Leandro, Isabel Correia, Ana Silveira Viana, Pedro Faisca, Lia Ascensao, Jesus Molpeceres, Maria Manuela Gaspar, Catarina Pinto Reis
Summary: Insulin, a peptide hormone, plays an important role in wound healing. Research shows that insulin-loaded nanoparticles exhibit controlled release characteristics in vitro, and demonstrate good safety in cell experiments and preliminary animal assays.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Multidisciplinary
Linye Jiang, Jie Luo, Dawei Hong, Shuhong Guo, Shuyi Wang, Bizhong Zhou, Shiyu Zhou, Jingyan Ge
Summary: Poly(lactic-co-glycolic acid) (PLGA) is an FDA-approved polymer known for its biocompatibility and biodegradability. PLGA-based nanoparticles (NPs) have shown potential as drug delivery systems, but their lack of selectivity to cancer cells limits their clinical application. This review summarizes passive and active tumor-targeting strategies using PLGA NPs for drug delivery, and discusses new challenges and opportunities for further research.
Article
Pharmacology & Pharmacy
Cheng-Han Tsai, Le Ngoc Hoang, Chun Che Lin, Liang-Chen Pan, Chiao-Li Wu, I-Chan Lin, Peng-Yuan Wang, Ching-Li Tseng
Summary: Posterior eye diseases, such as age-related macular degeneration and diabetic retinopathy, are difficult to treat due to ineffective drug delivery. In this study, self-assembling nanoparticles made from gelatin-epigallocatechin gallate (EGCG) and surface-decorated with hyaluronic acid (HA) were successfully used for drug delivery to the retinal/choroidal area. The nanoparticles, characterized by a positive surface and HA decoration, showed high drug delivery efficiency to the posterior eye through eye drops and subconjunctival injection.
Article
Pharmacology & Pharmacy
Camila Folle, Natalia Diaz-Garrido, Elena Sanchez-Lopez, Ana Maria Marques, Josefa Badia, Laura Baldoma, Marta Espina, Ana Cristina Calpena, Maria Luisa Garcia
Summary: The study focused on developing surface-functionalized poly(lactic-co-glycolic acid) nanoparticles loaded with thymol for topical treatment against acne. The nanoparticles demonstrated anti-inflammatory, antioxidant, and wound healing activities, with surface modifications playing a significant role in influencing their therapeutic effects.
Article
Pharmacology & Pharmacy
Ana Lopez-Machado, Natalia Diaz, Amanda Cano, Marta Espina, Josefa Badia, Laura Baldoma, Ana Cristina Calpena, Martina Biancardi, Eliana B. Souto, Maria Luisa Garcia, Elena Sanchez-Lopez
Summary: The study successfully incorporated lactoferrin into nanoparticles, achieving a monodisperse population with prolonged release profile of lactoferrin. These nanoparticles exhibited significantly enhanced anti-inflammatory efficacy, both in cell culture and preclinical assays.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Dan Yun, Dengyuan Liu, Jinlin Liu, Yanyi Feng, Hongyu Chen, Simiao Chen, Qingchun Xie
Summary: This study proposes a simplified surface modification strategy using cRGDyK peptide (RGD)-modified PLGA nanoparticles (NPs) loaded with paclitaxel. The results show that the modified NPs have excellent in vitro drug release properties and cellular uptake ability, leading to increased efficacy and reduced toxicity of the antitumor drug. In a mouse model experiment, the RGD-modified NPs exhibit a higher tumor weight suppression rate, demonstrating their promising potential in cancer therapy.
Article
Pharmacology & Pharmacy
Duygu Deniz Akolpoglu Basaran, Ufuk Gunduz, Aysen Tezcaner, Dilek Keskin
Summary: Skin regeneration is a crucial issue in tissue engineering, and developing effective biomaterials for enhanced regeneration while meeting the healing requirements is a challenge. This study encapsulated heparin in PLGA nanoparticles and incorporated them into Ser/Gel nanofibers to create a controlled release system promoting skin tissue regeneration. Sericin addition slowed down scaffold degradation, and the scaffold with a Ser/Gel ratio of 1/2 was considered the most promising candidate due to its proper fiber morphology, high water retention, and low degradation degree.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Multidisciplinary Sciences
Cigdem Cetin Aluc, Bahar Gok, Serda Kecel-Gunduz, Yasemin Budama-Kilinc
Summary: Glycyrrhizic acid (GA) is a component of licorice roots with various therapeutic properties. In this study, GA-loaded nanoparticles were prepared and evaluated for their efficacy and safety. Molecular docking analysis revealed the mechanism of GA binding to MMPs. The results suggest that GA nanoparticles could be a potential candidate for topical anti-aging skincare products.
Article
Pharmacology & Pharmacy
Aneta Kalvodova, Kristyna Dvorakova, Eliska Petrova, Bozena B. B. Michniak-Kohn, Jarmila Zbytovska
Summary: Due to the complex pathophysiology of skin diseases, a complex approach is required for their treatment. Topical corticosteroids, which are conventionally used, have low effectiveness and often lead to local or systemic side effects. Nanoformulation of potent anti-inflammatory drugs has been chosen as an optimal strategy for enhancing the topical delivery of corticosteroids. In this study, we formulated hydrocortisone (HC) and hydrocortisone-17-butyrate (HCB) into three different systems - lipid nanocapsules (LNC), polymeric nanoparticles (PNP), and ethosomes (ETZ). These systems were characterized and tested for their efficiency in delivering HC and HCB to ex vivo skin samples. The results showed that ETZ was the most effective delivery system for both transdermal and dermal drug targeting, but also had a profound effect on the skin barrier with limited restoration. LNC and PNP had significant effects in dermal delivery with minimal transdermal penetration, especially in the case of HCB.
Article
Chemistry, Multidisciplinary
In Kyu Lee, Su Jung You, Young Jin Yun, Jae Kwang Kim, Dae Hyeok Yang, Heung Jae Chun, Jaehoon Ko, Youngjoo Koh
Summary: Thrombin-conjugated PLGA (THR-PLGA) electrospun meshes were prepared through reagent-free surface modification. In vitro studies and a rat tail injury model were used to evaluate their hemostatic efficacy. The results showed that the THR-PLGA samples had improved hemostatic efficacy, reduced inflammatory response, and the formation of a protective fibrous layer.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2023)
Article
Engineering, Biomedical
Kuan Jiang, Xingyan Fan, Yang Hu, Shengyu Yao, Yu Liu, Changyou Zhan, Weiyue Lu, Gang Wei
Summary: This study achieved effective tumor inhibition and prevention of metastases through topical instillation by conjugating a cell-penetrating peptide, 89WP, with melphalan. The conjugated melphalan and other small molecules were absorbed by the eye via a non-corneal pathway, resulting in a prolonged residence duration in the retina.
Article
Pharmacology & Pharmacy
Umesh D. Laddha, Sanjay J. Kshirsagar, Layba S. Sayyad, Musab T. Ahmed, Sachin S. Gaikwad, Pavan B. Udavant, Abhijeet D. Kulkarni
Summary: Diabetic retinopathy is the most severe complication of diabetes that leads to blindness. The current treatment methods are invasive and associated with pain. This study developed surface-modified PLGA nanoparticles of Curcumin for targeted treatment of diabetic retinopathy. The optimized nanoparticles showed satisfactory results in in vitro and in vivo experiments.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Feipeng Yang, Maleen Cabe, Hope A. Nowak, Kelly A. Langert
Summary: In this study, different size groups of poly(lactic-co-glycolic) acid (PLGA) nanoparticles and chitosan-PLGA nanoparticle counterparts were prepared by adjusting key formulation parameters. The effects of size and surface modification on drug loading and release were investigated, and changes in mucoadhesion were quantified.
Article
Chemistry, Multidisciplinary
Anna Badia, Anna Duarri, Anna Salas, Jordi Rosell, Joana Ramis, Muriel Freixanet Gusta, Eudald Casals, Miguel A. Zapata, Victor Puntes, Josep Garcia-Arumi
Summary: A formulation for ocular topical delivery containing small biocompatible cerium oxide nanoparticles (CeO(2)NPs) has shown antioxidant and neuroprotective effects, reducing oxidative stress and inhibiting neovascularization related to AMD disease.
Article
Chemistry, Physical
Huaxing Dai, Qianyu Yang, Rong Sun, Yue Zhang, Qingle Ma, Yifan Shen, Beilei Wang, Yitong Chen, Jialu Xu, Bo Tian, Fang Xu, Chao Wang
Summary: This study demonstrates that accumulation of silica nanoparticles in the liver can induce resistance to immune checkpoint blockade therapy by affecting T cell frequency and tumor infiltration. The findings provide a new mechanism insight into ICB resistance.
