Article
Biochemistry & Molecular Biology
Nagi M. El-Shafai, Mamdouh S. Masoud, Mohamed M. Ibrahim, Mohamed S. Ramadan, Gaber A. M. Mersal, Ibrahim M. El-Mehasseb
Summary: This study focuses on improving the loading and release efficiency of sofosbuvir drug (SOF) for anti-hepatitis C virus (HCV) by combining it with beta-cyclodextrin (beta CD) basket to form a novel self-assembly beta CD-SOF. The drug is then loaded onto chitosan nanoparticles (Cs NPs) to create a hybrid composite named Cs@beta CD-SOF. Through various characterization methods, it is confirmed that Cs@beta CD-SOF has a loading efficiency of 94.54% and exhibits high release efficiency.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Pharmacology & Pharmacy
Sebastian Quintana-Contardo, Orlando Donoso-Gonzalez, Erika Lang, Ariel R. R. Guerrero, Michael Noyong, Ulrich Simon, Marcelo J. J. Kogan, Nicolas Yutronic, Rodrigo Sierpe
Summary: The antineoplastic drug Dacarbazine was encapsulated in beta-cyclodextrin to improve solubility and stability. When combined with plasmonic gold nanoparticles and polyethylene glycol, it exhibited controlled release and potential for drug delivery.
Review
Chemistry, Applied
Somaye Rashki, Kasra Asgarpour, Hossein Tarrahimofrad, Maryam Hashemipour, Mohammad Saeid Ebrahimi, Hadis Fathizadeh, Ahmad Khorshidi, Haroon Khan, Zeynab Marzhoseyni, Masoud Salavati-Niasari, Hamed Mirzaei
Summary: Chitosan nanomaterials have gained attention in biomedicine for their high levels of biodegradability and biocompatibility, along with antimicrobial effects. Functional modification with other natural compounds, metallic antimicrobial particles, and antibiotics can enhance the efficiency of chitosan in wound dressing with antimicrobial activity. The antibacterial effect of chitosan is mainly associated with the leakage of intracellular content due to malfunction and altered permeability of the negatively charged cell membrane, on which chitosan is adsorbed. Additionally, chitosan nanoparticles possess favorable features of nanoparticles and their chitosan base, thereby exhibiting strengthened antibacterial potential. Polycations in chitosan nanoparticles target negatively charged bacterial membranes, resulting in a stronger effect on bacterial cells compared to pure chitosan.
CARBOHYDRATE POLYMERS
(2021)
Article
Spectroscopy
Nagi M. El-Shafai, Ahmed I. Nada, Mahmoud A. Farrag, Kahdr Alatawi, Adel I. Alalawy, Salhah D. Al-Qahtani, Ibrahim M. El-Mehasseb
Summary: The aim of this study was to create a novel hybrid nanocomposite (Cs@Pyc.SOF) by combining the hepatitis C virus (HCV) drug sofosbuvir with the nano antioxidant pycnogenol and nano biomolecules like chitosan nanoparticles. The nanocomposite was characterized using various techniques, and the results showed high loading efficiency and release rate, as well as good viability against tested cell lines.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Biochemistry & Molecular Biology
Li Ming Lim, Kunn Hadinoto
Summary: This study found that hydroxypropyl starch is a suitable mucoadhesive polysaccharide for high-payload buccal film applications, with excellent CUR release characteristics and stability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Nagi M. El-Shafai, Shaymaa Shawky, Ibrahim M. El-Mehasseb, Maged A. El-Kemary
Summary: The research focused on the application of sandwich nanohybrid of nano-PVA and nano-chitosan in water treatment and drug adsorption, revealing their potential effects through tests on photocatalytic activity and release efficiency. Additionally, studies on cytotoxicity and antioxidant properties were conducted.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Physical
Rajaram Rajamohan, Mika Sillanpaa, Angaiah Subramania
Summary: Nanofibrous mats and cyclodextrins are essential components in drug releasing systems, with cyclodextrins playing a key role in enhancing drug release profile by forming inclusion complexes. This study focused on analyzing the drug release profile of benzocaine using electrospun PVdF nanofibrous mats, with and without beta-cyclodextrin, demonstrating enhanced drug release ability with the presence of beta-CD due to increased solubility of benzocaine.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Environmental Sciences
Afsana Sheikh, Sahim Aziz Hazari, Nagashekhara Molugulu, Saad Ali Alshehri, Shadma Wahab, Amirhossein Sahebkar, Prashant Kesharwani
Summary: This article investigates the potential of chitosan nanoparticles loaded with gallic acid (GA) for the treatment of psoriasis. The study found that coating the nanoparticles with hyaluronic acid (HA) slightly increased the particle size but enhanced their inhibitory effect on cells. In vivo experiments demonstrated the potential of HA-modified nanoparticles in restricting psoriasis. Further research should explore the application of HA-modified nanoparticles in the treatment of other skin-related conditions.
ENVIRONMENTAL RESEARCH
(2023)
Article
Biophysics
Mohammad Akrami-Hasan-Kohal, Mahnaz Eskandari, Atefeh Solouk
Summary: The study developed a sustained release formulation using dexamethasone sodium phosphate-loaded chitosan nanoparticles embedded in silk fibroin hydrogel. The scanning electron microscopy showed the prepared drug delivery system had a properly interconnected porous structure, indicating potential for drug delivery applications.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Polymer Science
Islam M. Minisy, Nehal A. Salahuddin, Mohamad M. Ayad
Summary: Chitosan/polyaniline nanofibers were successfully prepared and loaded with ketoprofen. The drug release kinetics were studied using various models, showing that the drug release mechanism follows anomalous non-Fickian diffusion.
Article
Chemistry, Applied
Huong Thi Hoang, Trung Thang Vu, Viswanathan Karthika, Sung-Han Jo, Yi-Jun Jo, Jeong-Woo Seo, Chul-Woong Oh, Sang-Hyug Park, Kwon Taek Lim
Summary: A physically and chemically double-crosslinked hydrogel derived from chitosan oligosaccharide/alginate was developed for the delivery of ketoprofen. The hydrogel showed outstanding hydrophobic drug loading and sustained release, as well as pH responsiveness, making it a potential candidate for hydrophobic drug delivery.
CARBOHYDRATE POLYMERS
(2022)
Review
Pharmacology & Pharmacy
Chong Yu, Shuai Wang, Wing-Fu Lai, Dahong Zhang
Summary: Bladder cancer (BC) is the most common cancer of the urinary system and non-muscle-invasive bladder cancer (NMIBC) accounts for the majority of cases. Patients with NMIBC have a good survival rate but are at high risk for tumor recurrence and progression. The use of antitumor agents instilled into the bladder is the standard treatment for NMIBC, but their efficacy is limited due to chemo-resistance and poor drug retention. Chitosan-based nanoparticles offer a promising solution by enhancing drug penetration and improving biomedical applications in bladder cancer treatment.
Review
Biochemistry & Molecular Biology
Cha Yee Kuen, Mas Jaffri Masarudin
Summary: Lung cancer is one of the most common and lethal cancer diseases worldwide. Chitosan nanoparticle (CNP) systems, as a nano-particulate delivery vehicle, have emerged as a promising approach for lung cancer treatment. This review discusses the advantages, challenges, opportunities, drug release mechanisms, and mathematical kinetic models of CNP systems.
Review
Chemistry, Applied
Saman Sargazi, Bazla Siddiqui, Maimoona Qindeel, Abbas Rahdar, Muhammad Bilal, Razieh Behzadmehr, Shekoufeh Mirinejad, Sadanand Pandey
Summary: In recent years, gene therapy based on miRNA has emerged as a potential technique for treating co-morbidities. Chitosan, as an effective carrier for miRNA delivery, has been widely utilized. This review discusses the recent progress and future prospects of using chitosan and its derivatives to deliver and detect miRNAs, with a focus on cancer.
CARBOHYDRATE POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Fenghui Qiao, Zhiqi Jiang, Wen Fang, Jingzhi Sun, Qiaoling Hu
Summary: In this study, dual responsive nanoparticles were developed for drug delivery. The nanoparticles were able to release drug under the acidic tumor microenvironment and in the presence of mannitol. The nanoparticles were composed of chitosan, heparin, and poly(vinyl alcohol), and they exhibited dynamic covalent bonds and various functional groups for drug release.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Yi Cheng, Rui Sun, Muye He, Miao Zhang, Xinyu Hou, Yuji Sun, Jie Wang, Jiajun Xu, Hai He, Hongtao Wang, Minbo Lan, Yuzheng Zhao, Yi Yang, Xianjun Chen, Feng Gao
Summary: The study presents a novel treatment strategy for overcoming the therapeutic barrier in breast cancer using a combination of a light-switchable transgene system and losartan. The researchers developed a nanoparticle drug delivery system for targeted and responsive delivery of therapeutic genes to tumor sites. In vivo studies showed improved tumor penetration, inhibited tumor growth, and increased survival rate. This combination strategy provides a promising method for clinical treatment of breast cancer.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Geosciences, Multidisciplinary
Chunhui Zhang, Wanyi Zhang, Yan Liu, Jinjiao Yao, Renchao Wan, Huwei Li, Xinyu Hou, Chengjun Zhang
Summary: The grain size analysis and end-member modeling of clastic fractions in the Selin Co basin sedimentary sequence have revealed the variations of aeolian activity in the central Tibetan Plateau since 3,900 cal yr BP. The results indicate that the aeolian activity occurred under dry and cold conditions, with three strong aeolian activity intervals. Comparison with other records suggests that solar insolation, weakening Indian summer monsoon, and the strengthening westerlies have a direct relationship with the aeolian activity in the central Tibetan Plateau.
FRONTIERS IN EARTH SCIENCE
(2022)
Article
Geosciences, Multidisciplinary
Jun Lin, Xinyu Hou, Guojun Cai, Songyu Liu
Summary: This study presents a framework for uncertainty analysis of the ultimate axial bearing capacity of piles evaluated by the UniCone method in layered soils. The effects of spatial variability of CPTU data and variations of empirical correlation coefficients on the ultimate axial bearing capacity of piles are evaluated. The proper identification of different soil units is crucial for estimating the failure probability of pile capacity.
FRONTIERS IN EARTH SCIENCE
(2022)
Article
Geosciences, Multidisciplinary
Zhang Chengjun, Zhang Wanyi, Cheng Dingshu, Yang Na, Hou Xinyu, Li Huwei, Zhang Xiaojing, Ramamoorthy Ayyamperumal
Summary: This study investigates the sediment record of Sugan Lake in the Qaidam Basin to understand the Holocene climate variations in the region. It reveals that during the Holocene Megathermal Maximum, there was high evaporation and sparse terrestrial vegetation due to high temperatures, resulting in a SO42--type water characteristic. After ca. 5800 cal a BP, there was a shift to Cl-type water and intensified aeolian activities. Between 5800 and 3580 cal a BP, a higher lake level and cool and wet conditions were inferred, with the weakening of the East Asian Summer Monsoon (EASM) and intensification of the westerly jet. After 3580 cal a BP, colder and drier conditions prevailed, possibly due to the strengthening of the mid-latitude westerly circulation. However, the EASM briefly prevailed at around 3580-3000 cal a BP and 1800-810 cal a BP. The Little Ice Age fluctuations between 580 and 280 cal a BP were characterized by cold/dry, cold/wet, and cold/dry conditions, accompanied by increased aeolian activities and risen lake levels.
Article
Engineering, Electrical & Electronic
Xinyu Hou, Zhihui Wang, Yugang Su, Zhe Liu, Zhipeng Deng
Summary: This paper proposes a power supply solution for online monitoring equipment in high-voltage transmission lines, utilizing a dual-frequency dual-load multirelay magnetic coupling wireless power transfer (MC-WPT) system with a shared power channel. The MC-WPT system provides selective power distribution for different loads and maintains a constant current output characteristic. By introducing a dual-frequency inverter and compensation network, cross interference is reduced, and operating frequencies with constant current output characteristics are obtained. Experimental results confirm the effectiveness of constant current output characteristics and selective power distribution for the two power channels.
IEEE TRANSACTIONS ON POWER ELECTRONICS
(2022)
Review
Chemistry, Physical
Lang Guo, Pengcheng Zuo, Zequn Zhang, Qianwen Zhang, Mengya Zhao, Xinyu Hou, Junsheng Wu, Bowei Zhang
Summary: This study presents the preparation methods and microstructural characteristics of Cu-Ni-Sn alloys, discusses the influence of alloying elements such as Si, Ti, and Nb on their microstructure and properties, and explores the effects of plastic deformation and heat treatment. The findings of this study can provide valuable insight for the development of high-performance Cu-Ni-Sn alloys.
Article
Engineering, Electrical & Electronic
Xinyu Hou, Hongsheng Hu, Yugang Su, Zhe Liu, Zhipeng Deng, Renwei Deng
Summary: A multirelay wireless power transfer (WPT) system with double-sided LCC compensation network is proposed for online monitoring equipment on high-voltage transmission lines. The system achieves constant-voltage or constant-current output characteristics, and does not use ferrite materials. Three working modes are proposed based on the resonance conditions of the compensation networks and relay coils. The CC and CV output characteristics in each mode are analyzed and compared through simulation.
IEEE JOURNAL OF EMERGING AND SELECTED TOPICS IN POWER ELECTRONICS
(2023)
Article
Economics
Xinyu Hou, Puyang Sun
Summary: State monopoly hinders market integration, and the dismantling of the monopoly can promote market integration. This study empirically analyzes the market reform in China's edible salt market, and finds that the dissolution of state monopoly leads to nationwide market integration.
ECONOMICS OF TRANSITION AND INSTITUTIONAL CHANGE
(2023)
Editorial Material
Clinical Neurology
Quan Li, Xinyu Hou, Jun Li, Jia Bian
ACTA NEUROLOGICA BELGICA
(2023)
Article
Mathematics, Interdisciplinary Applications
Liying Li, Xinyu Hou, Lixia Niu
Summary: Based on uncertain market demand, this paper studies the sharing strategy of each main body of the closed-loop supply chain for demand prediction information and introduces the variable of advertising effect into the model. A manufacturer-led Stackelberg game model based on a two-level closed-loop supply chain is constructed. The manufacturer advertising mode and the retailer advertising mode are set up, and the influence of information sharing is discussed in each advertising mode. The results show that certain conditions should be met to achieve a win-win situation by sharing information, and the advertising effect has positive impacts on various aspects of the supply chain.
DISCRETE DYNAMICS IN NATURE AND SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Muye He, Yuji Sun, Yi Cheng, Jie Wang, Miao Zhang, Rui Sun, Xinyu Hou, Jiajun Xu, Hai He, Hongtao Wang, Zeting Yuan, Minbo Lan, Yuzheng Zhao, Yi Yang, Xianjun Chen, Feng Gao
Summary: Individualized immunotherapy using neoantigen-specific T cells has shown promising results in tumor clearance. However, the immunosuppressive tumor microenvironment poses a challenge to achieve complete tumor eradication. In this study, a spatiotemporally controlled transgene system, combined with tumor neoantigen labeling, was developed to enhance immunological function and recruit T cells to infiltrate tumor tissue. The use of a nanoparticle delivery system improved the efficiency of neoantigen delivery and tumor targeting ability. This approach achieved good tumor inhibition and prolonged survival, highlighting its potential for tumor immunotherapy.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Neurosciences
Qi-Min Zheng, Zi-Rui Zhou, Xin-Yu Hou, Ning Lv, Yu-Qiu Zhang, Hong Cao
Summary: Using RNA sequencing technology, we investigated the transcriptomic profiles in the medial prefrontal cortex (mPFC) of mice with chronic pain. Our findings revealed differentially expressed genes (DEGs) in the ipsilateral and contralateral mPFC of mice with chronic constriction injury (CCI) model, indicating the involvement of immune- and inflammation-related processes. Further analysis showed the enrichment of genes involved in neuroactive ligand-receptor interaction signaling pathway and Parkinson's disease pathway, which are known to be associated with chronic neuralgia and cognitive dysfunction.
NEUROMOLECULAR MEDICINE
(2023)
Article
Construction & Building Technology
Shuangfeng Guo, Bikai Wang, Peng Zhang, Shengnian Wang, Zihao Guo, Xinyu Hou
Summary: This study investigates the influences of key shield parameters on tunneling-induced ground settlements by considering the dynamic excavation process. Advanced machine learning with principal component analysis is used to evaluate the nonlinear relationships between ground settlements and multiple parameters in soil-rock composite ground. Nonlinear relationships of excavation characteristic parameters are developed through correlation analysis to quantify shield machine performance in mixed ground. The predictive model based on Light-GBM shows good agreement with in-site measurements and can be used to optimize excavation schemes.
TUNNELLING AND UNDERGROUND SPACE TECHNOLOGY
(2023)
Article
Environmental Studies
Xueming Li, Yishan Song, He Liu, Xinyu Hou
Summary: In this study, we integrated the enhanced vegetation index, points of interest, surface temperature, and night light data to extract the built-up area in Dalian. The method using the HSI-POI-LST index achieved the highest accuracy and provided richer spatial details compared to other data types. This method offers more choices for assessing small-scale urban built-up areas in future research.
Article
Oncology
Yuexian Wei, Zubiao Niu, Xinyu Hou, Mengzhe Liu, Yuqi Wang, Yongan Zhou, Chenxi Wang, Qunfeng Ma, Yichao Zhu, Xinyue Gao, Peiyun Li, Shuo Gao, Sibo Zhan, Zi Yang, Yanhong Tai, Qiuju Shao, Jianlin Ge, Jilei Hua, Lihua Gao, Qiang Sun, Hong Jiang, Hongyan Huang
Summary: This study investigated the profiling of cell-in-cell structures (CICs) in non-small cell lung cancer (NSCLC) tissues and found that the presence of CICs is associated with the prognosis of NSCLC patients. CICs were more frequently present in adenocarcinoma and lymphocyte-in-tumor (LiT) was more common in the upper lobe of the lung. Univariate and multivariate analyses revealed that heCICs and lymph node invasion were independent factors associated with the overall survival of NSCLC.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)