Review
Pharmacology & Pharmacy
Hassan A. Albarqi, Anuj Garg, Mohammad Zaki Ahmad, Abdulsalam A. Alqahtani, Ismail A. Walbi, Javed Ahmad
Summary: Glaucoma is a chronic degenerative eye disease that leads to irreversible vision loss due to high intraocular pressure. Traditional ocular drug delivery systems have low bioavailability, making glaucoma therapy challenging. Chitosan-based nanoparticulate systems have shown promise in overcoming these limitations. This manuscript reviews recent research on chitosan-based nanoparticulate systems for glaucoma treatment, discussing their significance in improving drug residence time and ocular bioavailability. It also analyzes the impact of chitosan-based nanomedicine on corneal permeability, ocular bioavailability, and therapeutic performance of loaded antiglaucoma agents.
Article
Pharmacology & Pharmacy
Simise S. Sikhondze, Pedzisai A. Makoni, Roderick B. Walker, Sandile M. M. Khamanga
Summary: In this study, a once-daily-dosed chitosan-coated metronidazole (MTZ)-loaded solid lipid nanoparticles (SLNs) for ocular delivery were developed to improve the residence time and release of the drug in the eye, which may reduce patient non-adherence.
Article
Chemistry, Medicinal
Beatriz Silva, Lidia M. Goncalves, Berta Sao Braz, Esmeralda Delgado
Summary: This study investigates the delivery of EPO beta to the eye through subconjunctival administration of chitosan-hyaluronic acid-EPO beta nanoparticles. The results show that these nanoparticles can efficiently deliver EPO beta into the retina without adverse effects. This nanoformulation could be a promising tool for treating retinopathies.
Article
Pharmacology & Pharmacy
Linh Phuong Ta, Erika Bujna, Szilard Kun, Dimitris Charalampopoulos, Vitaliy V. Khutoryanskiy
Summary: The study focused on the importance of prolonged gastrointestinal retention for probiotics delivery. Different formulations of alginate microparticles were prepared using electrospray technique, with chitosan-coated microparticles showing the highest mucoadhesive property. A novel in vitro wash-off mucoadhesion test setup was successfully validated for evaluating the performance of these probiotic formulations.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Sadaf Ejaz, Bridget Hogg, Delyan R. Hristov, David J. Brayden, Muhammad Imran, Sourav Bhattacharjee
Summary: Crosslinked chitosan nanocarriers entrapping coumarin-6 with or without surface mannosylation were synthesized and evaluated for their cytotoxicity, cellular uptake, permeation, and mucin adhesion. Results showed that mannosylated and non-mannosylated nanocarriers exhibited similar biocompatibility in cell experiments, but differed in cellular uptake. Additionally, chitosan nanocarriers enhanced adhesion to porcine gut mucin through increased cationic charge density.
Article
Pharmacology & Pharmacy
A. Abruzzo, B. Giordani, A. Miti, B. Vitali, G. Zuccheri, T. Cerchiara, B. Luppi, F. Bigucci
Summary: The study designed chitosan nanoparticles and evaluated their use as mucoadhesive and/or mucopenetrating systems for vancomycin delivery. The nanoparticles showed sizes ranging from 150 nm to 350 nm with good polydispersity index and positive zeta-potential, allowing for fast and complete release of vancomycin while maintaining antibacterial activity.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Gye Hwa Shin, Jun Tae Kim
Summary: In this study, curcumin nanosuspensions coated with chitosan and oligochitosan were prepared using ultrasonic homogenization technique. The encapsulation efficiencies ranged from 80% to 90%, and mucin adsorption significantly increased after coating. The findings suggest that these nanosuspensions can serve as mucoadhesive carriers for efficient delivery of water insoluble compounds.
Review
Pharmacology & Pharmacy
Beatriz Silva, Berta Sao Braz, Esmeralda Delgado, Lidia Goncalves
Summary: In recent years, there has been a growing scientific interest in topical ocular delivery targeting the posterior segment of the eye, as it is a non-invasive and well-tolerated administration route with fewer side effects. Improving corneal permeability or prolonging precorneal retention time can enhance intraocular bioavailability of drugs. Nanosystems utilizing mucoadhesive polymers or colloidal particles have emerged as promising strategies for more efficient treatment of ocular diseases.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Mariacristina Gagliardi, Sara Chiarugi, Chiara De Cesari, Giulia Di Gregorio, Alessandra Diodati, Laura Baroncelli, Marco Cecchini, Ilaria Tonazzini
Summary: The study presents a method to obtain stable and cytocompatible crosslinked chitosan nanoparticles for intranasal drug delivery. The nanoparticles showed a stable size and surface charge, and exhibited good cytocompatibility in vitro. This synthetic system has potential as a drug carrier for intranasal delivery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Multidisciplinary
Ridhdhi S. Dave, Taylor C. Goostrey, Maya Ziolkowska, Sofia Czerny-Holownia, Todd Hoare, Heather Sheardown
Summary: There is a growing demand for effective treatments for ocular conditions, with topical administration being the preferred method despite its drawbacks. Nanoparticles with tunable mucoadhesion and/or mucopenetration show potential to overcome these drawbacks and improve ocular bioavailability, reduce toxicity, and increase ocular retention. Recent advances in developing nanocarriers with tunable mucoadhesion and mucopenetration for drug delivery to the eye are highlighted in the current review.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Biochemistry & Molecular Biology
Renas Rzgar Jalal, Twana Mohammed M. Ways, Mahmoud H. Abu Elella, Diyar Ahmed Hassan, Vitaliy V. Khutoryanskiy
Summary: Mucoadhesive nanoparticles based on methacrylated chitosan (MeCHI) were designed and compared with unmodified chitosan nanoparticles for the delivery of ciprofloxacin. The MeCHI nanoparticles showed smaller particle size, lower polydispersity index, higher encapsulation efficiency, and sustained drug release compared to their chitosan counterpart. The mucoadhesion study also demonstrated that the ciprofloxacin-loaded MeCHI nanoparticles had better retention on the mucosal surface.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Polymer Science
Syed Sarim Imam, Sultan Alshehri, Mohammed M. Ghoneim, Ameeduzzafar Zafar, Omar Awad Alsaidan, Nabil K. Alruwaili, Sadaf Jamal Gilani, Md. Rizwanullah
Summary: The review discusses the loading of phytochemicals in biodegradable and biocompatible nanoparticles based on chitosan for improved bioavailability and bioactivity. Chitosan's properties such as mucoadhesiveness, non-toxicity, stability in harsh gastrointestinal conditions, and enhanced intestinal permeability make it suitable for oral delivery of phytochemicals.
Article
Pharmacology & Pharmacy
Muhammet Davut Arpa, Neslihan Ustundag Okur, Mehmet Koray Gok, Saadet Ozgumusc, Erdal Cevher
Summary: In this study, buccal patches were prepared using chitosan glutamate (Chi-Glu) and novel chitosan azelate (Chi-Aze) to enhance the bioavailability of TZN. Chi-Aze patches showed longer integrity and higher drug permeability compared to Chi-Glu patches. In vivo studies revealed that buccal formulation with Chi-Aze showed approximately 3 times higher bioavailability than the orally administered commercial product.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Engineering, Biomedical
Mitchell Ross, Lindsay Sheardown, Benjamin Muirhead, Jonathan Mofford, Jennifer (JingYuan) Tian, Heather Sheardown
Summary: A platform of mucoadhesive and thermogelling eyedrops was developed for the treatment of various ocular conditions. The materials used were highly tunable, allowing for the delivery of different therapeutic agents. The safety and tolerability of the eyedrops was demonstrated in both in vitro and in vivo studies.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2023)
Review
Chemistry, Medicinal
Viliana Gugleva, Velichka Andonova
Summary: The challenge faced by researchers in achieving sufficient ocular bioavailability is due to the complex structure of the eye and its protective physiological mechanisms. Low viscosity eye drops and short ocular residence time contribute to low drug concentration at the target site. Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) are being developed as drug delivery platforms to overcome these challenges and enhance ocular bioavailability. They are biocompatible, biodegradable, and can be sterilized and scaled-up. Surface modifications can prolong ocular residence time, enhance penetration, and improve performance.
Article
Chemistry, Multidisciplinary
Satish Manchanda, Pravat K. Sahoo, Dipak K. Majumdar
NANOTECHNOLOGY REVIEWS
(2016)
Review
Chemistry, Medicinal
Sachin Kumar, Faizana Fayaz, Faheem Hyder Pottoo, Sakshi Bajaj, Satish Manchanda, Himangini Bansal
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2020)
Review
Chemistry, Medicinal
Bhumika Kumar, Mukesh Pandey, Faizana Fayaz, Tareq Abu Izneid, Faheem Hyder Pottoo, Satish Manchanda, Anjali Sharma, Pravat Kumar Sahoo
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2020)
Article
Plant Sciences
Sakshi Bajaj, Shivkanya Fuloria, Vetriselvan Subramaniyan, Dhanalekshmi Unnikrishnan Meenakshi, Sharad Wakode, Avneet Kaur, Himangini Bansal, Satish Manchanda, Sachin Kumar, Neeraj Kumar Fuloria
Summary: The study isolated two phytoisols, SA-1 and SA-4, from Swertia alata C.B Clarke and found that SA-4 exhibited more effective COX-1/COX-2 inhibitory activity and significant gastric tolerance in ulcerogenic study compared to SA-1. This research concludes that compound SA-4 has significant anti-inflammatory activity and less irritant property over gastric mucosa with minimal ulcerogenicity.
Article
Nanoscience & Nanotechnology
Hemlata Kaurav, Satish Manchanda, Kamal Dua, Deepak N. Kapoor
NANO HYBRIDS AND COMPOSITES
(2018)
Article
Polymer Science
Amit Arya, Dharam Pal Pathak, Dipak K. Majumdar, Satish Manchanda
DESIGNED MONOMERS AND POLYMERS
(2016)