Review
Immunology
Bernd Heinrich, Firouzeh Korangy
Summary: Innate lymphoid cells (ILCs) are a heterogeneous population of the innate immune system that play a crucial role in maintaining immune homeostasis. They exhibit high plasticity, allowing them to quickly respond to changes in their microenvironment. ILCs can transdifferentiate into different subsets in the tumor microenvironment, influencing the immune response and tumor therapy. This review summarizes the functional and plastic heterogeneity of ILCs in homeostasis and disease, with a focus on tumor-driven plasticity and the impact of ILC-induced inflammation on the tumor microenvironment and anti-tumor immunity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Kun-Yu Teng, Anthony G. Mansour, Zheng Zhu, Zhiyao Li, Lei Tian, Shoubao Ma, Bo Xu, Ting Lu, Hanyu Chen, David Hou, Jianying Zhang, Saul J. Priceman, Michael A. Caligiuri, Jianhua Yu
Summary: This study demonstrates the effectiveness of PSCA CAR_s15 NK cells in suppressing pancreatic cancer both in vitro and in vivo, without causing systematic toxicity. These findings provide a strong rationale for further clinical development.
Review
Oncology
Sizhe Liu, Vasiliy Galat, Yekaterina Galat, Yoo Kyung Annie Lee, Derek Wainwright, Jennifer Wu
Summary: NK cells, as a specialized immune effector cell type, play a critical role in immune activation against abnormal cells. Unlike T cell activation, NK cell activation is governed by interactions between NK receptors and target cells, leading to significant attention in cancer immunotherapy. Many efforts are focused on developing and engineering NK cell-based cancer immunotherapy.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2021)
Review
Immunology
Nina B. Horowitz, Imran Mohammad, Uriel Y. Moreno-Nieves, Ievgen Koliesnik, Quan Tran, John B. Sunwoo
Summary: Innate lymphoid cells (ILCs) play an important role in antitumor immunity, but their behavior in the context of cancer is not fully understood. Humanized mouse models serve as excellent tools for studying these pathways and interactions between ILCs and tumors.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Fay C. Magnusson, Ilham Bahhar
Summary: While cancer immunotherapy has been used in clinics for over a century, limited understanding of the tumor microenvironment and mechanisms involved has hindered its practical application. However, immune checkpoint inhibitors and CAR-T cell therapies have revolutionized cancer treatment in the past two decades, proving the viability of immunotherapies. This article focuses on the role of ILCs, particularly helper ILCs, in tumor development and the potential of using them as immunotherapy for cancer.
Review
Pharmacology & Pharmacy
Hobin Seo, Amisha Verma, Megan Kinzel, Qiutong Huang, Douglas J. J. Mahoney, Nicolas Jacquelot
Summary: Reinvigorating the killing function of tumor-infiltrating immune cells through targeting regulatory molecules has improved the prognosis of cancer patients. Recent investigations suggest that tissue-resident innate lymphoid cells (ILCs), in addition to T lymphocytes, can benefit from immunotherapy. This article discusses the expression of immune checkpoint on ILCs and how their effector function is modulated by checkpoint blockade-based therapies, exploring potential to impede tumor growth and disease progression.
Article
Critical Care Medicine
Jaideep Dhariwal, Aoife Cameron, Ernie Wong, Malte Paulsen, Maria-Belen Trujillo-Torralbo, Ajerico Del Rosario, Eteri Bakhsoliani, Tatiana Kebadze, Mark Almond, Hugo Farne, Leila Gogsadze, Julia Aniscenko, Batika M. J. Rana, Trevor T. Hansel, David J. Jackson, Onn Min Kon, Michael R. Edwards, Roberto Solari, David J. Cousins, Ross P. Walton, Sebastian L. Johnston
Summary: The study found that after experimental rhinovirus challenge, ILC2 levels were significantly higher in patients with asthma compared to healthy subjects, as well as the ILC2:ILC1 ratio. ILC2 may play an important role in virus-induced asthma exacerbations.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Immunology
Margaux Vienne, Marion Etiennot, Bertrand Escaliere, Justine Galluso, Lionel Spinelli, Sophie Guia, Aurore Fenis, Eric Vivier, Yann M. Kerdiles
Summary: NK cells are known to have cytotoxic effects on tumor cell lines, but their specific roles in primary tumor detection and elimination remain unclear. ILC1 play an active role in inhibiting the antitumoral immune response, suggesting the need to evaluate the tumor infiltration of ILC1 and NK cells to optimize immune harnessing in cancer therapies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yetao Wang, Lawrence Lifshitz, Noah J. Silverstein, Esther Mintzer, Kevin Luk, Pamela StLouis, Michael A. Brehm, Scot A. Wolfe, Steven G. Deeks, Jeremy Luban
Summary: Innate lymphoid cells (ILCs) are a diverse population of cells that include NK cells and play important roles in tissue homeostasis and repair, inflammation, and protection from infection. This study used transcriptional and chromatin profiling to investigate the interplay between human blood ILCs and their responses to HIV-1 infection. The findings reveal the existence of four main ILC subsets in human blood and provide insights into how HIV-1 infection disrupts NK cells and their homeostatic function.
Article
Oncology
Carminia Maria Della Corte, Morena Fasano, Vincenza Ciaramella, Flora Cimmino, Robert Cardnell, Carl M. Gay, Kavya Ramkumar, Lixia Diao, Raimondo Di Liello, Giuseppe Viscardi, Vincenzo Famiglietti, Davide Ciardiello, Giulia Martini, Stefania Napolitano, Concetta Tuccillo, Teresa Troiani, Erika Martinelli, Jing Wang, Lauren Byers, Floriana Morgillo, Fortunato Ciardiello
Summary: In this study, we evaluated the efficacy and immune effects of cetuximab plus avelumab combination treatment in NSCLC patients who had previously responded to PD-1 inhibitors. The results showed that this combination treatment can induce anti-tumor activity and activate the ADCC mediated by NK cells as well as the STING pathway.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Review
Oncology
Matthew R. Lordo, Steven D. Scoville, Akul Goel, Jianhua Yu, Aharon G. Freud, Michael A. Caligiuri, Bethany L. Mundy-Bosse
Summary: AML is an aggressive form of blood cancer with poor survival rates. Patients with AML often have defects in their immune system, particularly in NK cells. Recent studies are shedding light on the role of other ILC family members in AML, enhancing our understanding of AML treatment.
Article
Allergy
Andrzej Eljaszewicz, Fiorella Ruchti, Urszula Radzikowska, Anna Globinska, Tadech Boonpiyathad, Anna Gschwend, Hideaki Morita, Arthur Helbling, Stefania Arasi, Helga Kahlert, Nadine Berek, Andreas Nandy, Mubeccel Akdis, Christoph Willers, Marcin Moniuszko, Cezmi A. Akdis, Milena Sokolowska
Summary: This study found that AIT treatment can induce changes in the composition and heterogeneity of circulating innate immune cells, bringing them to the level observed in healthy individuals. Monitoring of ILCs, monocytes, and DCs during AIT may serve as a novel biomarker strategy.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Cell Biology
Eilis Russell, Melissa J. Conroy, Martin P. Barr
Summary: Lung cancer, with NSCLC as the majority, is the leading cause of cancer-related deaths worldwide. Early lung cancer often presents with no symptoms, leading to late-stage diagnosis. Despite current treatments, many patients experience tumor relapse or develop therapeutic resistance, highlighting the need for more effective therapies.
Article
Immunology
Iracema Luisa Quintino-de-Carvalho, Marcela Helena Goncalves-Pereira, Michele Faria Ramos, Bruno Henrique Goncalves de Aguiar Milhim, Ultimo Libanio Da Costa, Erika Goncalves Santos, Mauricio Lacerda Nogueira, Helton Da Costa Santiago
Summary: ILCs and NK cells are important sources of inflammatory cytokines during acute dengue infection, with distinct profiles associated with different clinical forms.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Immunology
Joey H. Li, Timothy E. O'Sullivan
Summary: NK cell dysfunction is a common occurrence during tumor development due to immunosuppressive mechanisms. Understanding the spatiotemporal dynamics of these mechanisms is crucial for optimizing NK cell therapy for cancer.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Samuel S. Widodo, Ryan A. Hutchinson, Yitong Fang, Stefano Mangiola, Paul J. Neeson, Phillip K. Darcy, Alexander D. Barrow, Christopher M. Hovens, Marija Dinevska, Stanley S. Stylli, Theo Mantamadiotis
Summary: Recent developments in cancer immunotherapy offer hope for cancer patients, but difficult to treat cancers such as malignant brain cancer still present challenges, with immune cells in the tumor microenvironment playing a crucial role in regulating tumor immune suppression.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Hematology
Huan Cao, Andreas Neerincx, Bernard de Bono, Ursula Lakner, Catherine Huntington, John Elvin, Emma Gudgin, Clare Pridans, Mark A. Vickers, Brian Huntly, John Trowsdale, Alexander D. Barrow
Summary: The monoclonal antibody A9E8 specific for Siglec-15 stains myeloid leukaemia cell lines and blasts from AML patients, but shows minimal expression on healthy donor cells, indicating therapeutic potential for AML treatment. Additionally, after binding, A9E8 is rapidly internalised into K562 cells, suggesting an efficient mechanism for targeted therapy.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Review
Oncology
Samuel S. Widodo, Marija Dinevska, Liam M. Furst, Stanley S. Stylli, Theo Mantamadiotis
Summary: The prognosis for patients with GBM is very poor despite current standard treatments. The immunosuppressive tumour microenvironment hinders the development of effective immunotherapies for GBM, and understanding the role of IL-10 in GBM is crucial for improving immunotherapy.
BRITISH JOURNAL OF CANCER
(2021)
Article
Immunology
Yuhan Sun, Alexander James Sedgwick, Yaseelan Palarasah, Stefano Mangiola, Alexander David Barrow
Summary: The activation of NK cells by PDGF-DD and the expression of KLR family receptors are associated with a more favorable prognosis in low-grade glioma patients, suggesting their important clinical role in immune surveillance.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Michael O'Rawe, Ethan J. Kilmister, Theo Mantamadiotis, Andrew H. Kaye, Swee T. Tan, Agadha C. Wickremesekera
Summary: Glioblastoma (GB) is an aggressive brain tumor with poor prognosis despite extensive research. The renin-angiotensin system (RAS) plays a critical role in influencing cancer stem cells and tumor microenvironment in GB. Targeting RAS with existing medications presents a potential new therapeutic strategy for GB treatment.
Article
Immunology
Yuhan Sun, Alexander James Sedgwick, Md Abdullah-Al-Kamran Khan, Yaseelan Palarasah, Stefano Mangiola, Alexander David Barrow
Summary: The activation of NK cell function in bladder cancer is regulated by cytokines and secreted factors. IL-2-expanded NK cell phenotype is associated with improved prognosis, while PDGF-DD-activated NK cell phenotype is associated with poor prognosis. High expression of activating NK cell receptors correlates with IL-2-expanded NK cell phenotype and improved prognosis in bladder cancer.
FRONTIERS IN IMMUNOLOGY
(2021)
Editorial Material
Immunology
Nicolas Jacquelot, Emilie Narni-Mancinelli, Alexander D. Barrow
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Dylan Jones, Clarissa A. Whitehead, Marija Dinevska, Samuel S. Widodo, Liam M. Furst, Andrew P. Morokoff, Andrew H. Kaye, Katharine J. Drummond, Theo Mantamadiotis, Stanley S. Stylli
Summary: Glioblastoma is a highly invasive and destructive brain tumor, and current standard treatments often fail to effectively eliminate it. In this study, we investigate the effects of several FDA-approved drugs on the invasion and viability of GBM cells. We found that these drugs can reduce cell invasion and viability, suggesting their potential as therapeutic options for GBM.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Oncology
Marija Dinevska, Samuel S. Widodo, Liam Furst, Lucero Cuzcano, Yitong Fang, Stefano Mangiola, Paul J. Neeson, Phillip K. Darcy, Robert G. Ramsay, Ryan Hutchinson, Fabienne MacKay, Michael Christie, Stanley S. Stylli, Theo Mantamadiotis
Summary: Tumor microenvironment in malignant astrocytoma undergoes changes in cell composition, cell signaling activation, and extracellular matrix deposition during disease progression. Targeting the extracellular matrix and cell signaling activation will be critical in designing personalized therapy.
Review
Oncology
Padmashree Rao, Liam Furst, Deborah Meyran, Chelsea Mayoh, Paul J. Neeson, Rachael Terry, Dong-Anh Khuong-Quang, Theo Mantamadiotis, Paul G. Ekert
Summary: Pediatric brain tumors are the most common solid tumor in children, and current treatments include surgery, chemotherapy, and radiotherapy. Immunotherapy, especially CAR T cell therapy, may provide new avenues for improved outcomes.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Sarah A. Cain, Bernard Pope, Stefano Mangiola, Theo Mantamadiotis, Katharine J. Drummond
Summary: This study aimed to identify somatic mutations and copy number alterations associated with grade progression in meningiomas. Through targeted next-generation sequencing, mutations and CNAs associated with different grade progression were found. NF2 mutations played an important role in grade progression.
Article
Oncology
Clarissa A. Whitehead, Haoyun Fang, Huaqi Su, Andrew P. Morokoff, Andrew H. Kaye, Eric Hanssen, Cameron J. Nowell, Katharine J. Drummond, David W. Greening, Laura J. Vella, Theo Mantamadiotis, Stanley S. Stylli
Summary: In this study, it was found that glioblastoma cells promote invadopodia activity by secreting small extracellular vesicles (sEVs) containing matrix metalloproteinase MMP-2. Additionally, the invasiveness of cells and sEV secretion were increased after radiotherapy/temozolomide treatment. These findings reveal a relationship between sEVs and invadopodia, providing important insights into the functional capacity of sEVs in promoting glioblastoma cell invasion.
Article
Developmental Biology
Tom C. Karagiannis, Christian Orlowski, Katherine Ververis, Eleni Pitsillou, Gulcan Sarila, Samuel T. Keating, Laura J. Foong, Stefanie Fabris, Christina Ngo-Nguyen, Neha Malik, Jun Okabe, Andrew Hung, Theo Mantamadiotis, Assam El-Osta
Summary: This study investigates the role of phosphorylated histone H2AX (gamma H2AX) as a marker of DNA double-strand breaks (DSBs) and its implication in stem cell differentiation. The research establishes a mouse embryonic stem cell (mESC) differentiation model and examines the dynamics of gamma H2AX foci during the process. The findings reveal that gamma H2AX serves as a versatile marker of DSBs and may have a role as a biomarker in stem cell differentiation.
CELLS & DEVELOPMENT
(2024)
Review
Biochemistry & Molecular Biology
Simon Haron, Ethan J. Kilmister, Paul F. Davis, Stanley S. Stylli, Theo Mantamadiotis, Andrew H. Kaye, Sean R. Hall, Swee T. Tan, Agadha C. Wickremesekera
Summary: The Renin-Angiotensin System (RAS) plays a crucial role in both CNS tumors and degenerative diseases by regulating various signaling pathways that affect cellular functions and the development of diseases.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2021)
