Review
Immunology
Andrew Getahun
Summary: This review article focuses on the B cell-intrinsic mechanisms that prevent the activation of autoreactive B cells in the periphery. It discusses the establishment of inhibitory signaling circuits, specifically the Lyn-SHIP-1-SHP-1 axis, and how disruptions of these circuits can contribute to the development of autoimmunity.
IMMUNOLOGICAL REVIEWS
(2022)
Article
Microbiology
Marissa A. Berry, Ekaterina P. Andrianova, Igor B. Zhulin
Summary: Chemosensory systems in bacteria and archaea are complex and multi-protein pathways that allow rapid cellular response to environmental changes. CheA histidine kinase, a central component of these systems, lacks a sensor domain and relies on dedicated chemoreceptors for sensing. This study provides a genomic survey of CheA domain composition from thousands of bacteria and archaea, revealing variations and deviations from the canonical architecture. It lays the foundation for better classification of CheA homologs and identifies targets for experimental investigations.
MICROBIOLOGY SPECTRUM
(2023)
Review
Medicine, General & Internal
Jiawen Chen, Yafei Li, Chong Du, Tianwen Wei, Tiankai Shan, Liansheng Wang
Summary: Protein kinases play a crucial role in cardiovascular diseases and their study is of great significance for heart repair and treatment.
CHINESE MEDICAL JOURNAL
(2022)
Article
Multidisciplinary Sciences
Caralyn E. Flack, John S. Parkinson
Summary: Our study provides important insights into the molecular signaling mechanisms of transmembrane chemoreceptors in Escherichia coli, offering valuable clues for further research in this area.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biochemistry & Molecular Biology
Hui-Liang Zhang, Xiao-Chuan Wang, Rong Liu
Summary: Zinc is crucial for human growth and development, particularly in regulating the mechanisms of neurodegenerative diseases.
Review
Medicine, Research & Experimental
Xia Zhao, Li Xiong, Lingyu She, Liwei Li, Ping Huang, Guang Liang
Summary: Protein tyrosine phosphatases (PTPs) play a significant role in the pathogenesis of Alzheimer's disease (AD) and are closely related to the accumulation of abnormally phosphorylated proteins.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Malathi Bheri, Swati Mahiwal, Sibaji K. Sanyal, Girdhar K. Pandey
Summary: Protein phosphorylation and dephosphorylation are important reversible post-translational modifications, with protein phosphatases playing a key role in signaling networks. The classification and mechanism of phosphatases in plant systems still require further investigation.
Article
Biochemistry & Molecular Biology
Elizabet Monteagudo-Cascales, Alvaro Ortega, Felix Velando, Bertrand Morel, Miguel A. Matilla, Tino Krell
Summary: Bacterial signal transduction systems are typically activated by the binding of signal molecules to receptor ligand binding domains (LBDs), such as the NIT LBD. The NIT domain is found in over 15,000 receptors from 30 bacterial phyla and 19 eukaryotic phyla, and it is a part of seven receptor families involved in transcription control, chemotaxis, or second messenger regulation.
MOLECULAR MICROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Xiaoyu Guo, Xue Ding, Juan Dong
Summary: In this study, the authors found that BSL proteins in Arabidopsis have different functions in the cell cortex and nucleus, regulating stomatal formation through the activation or deactivation of different signaling pathways.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Emmanuel Baudouin, Juliette Puyaubert, Patrice Meimoun, Melisande Blein-Nicolas, Marlene Davanture, Michel Zivy, Christophe Bailly
Summary: This study investigated the remodeling of Arabidopsis seed phosphoproteome during imbibition using stable isotope dimethyl labeling and nanoLC-MS/MS analysis. The study identified a large repertoire of phosphopeptides and phosphoproteins involved in seed germination control, including protein kinases and key regulators like DOG1. Gene ontology analysis revealed their involvement in various biological processes. The study provides evidence of the major role of phosphosignaling in the regulation of Arabidopsis seed germination.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Haichao Feng, Yu Lv, Tino Krell, Ruixin Fu, Yunpeng Liu, Zhihui Xu, Wenbin Du, Qirong Shen, Nan Zhang, Ruifu Zhang
Summary: Bacteria have evolved multiple signal transduction systems to adapt to changing environmental conditions. The chemoreceptor McpA of Bacillus velezensis SQR9 has been found to directly bind to 13 chemoattractants. Structural biology studies and mutagenesis experiments have identified key amino acid residues that play roles in recognizing multiple ligands. This discovery reveals a mechanism in which a single chemoreceptor can integrate diverse signals through two modules.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biochemistry & Molecular Biology
Marjorie Lapouge, Sylvain Meloche
Summary: Most of our understanding about the involvement of SRC-family tyrosine kinases in cancer comes from studies on the SRC oncogene. However, recent research has highlighted the important role of YES signaling in cancer development, metastasis, therapy resistance, and poor outcomes. Abnormal expression or activity of YES is frequently observed in human cancers, making it a potential target for specific cancer subtypes. This review discusses the critical role of YES in cancer and the challenges of translating preclinical findings into effective YES-targeted therapies.
Review
Microbiology
Aakriti Gangwal, Nishant Kumar, Nitika Sangwan, Neha Dhasmana, Uma Dhawan, Andaleeb Sajid, Gunjan Arora, Yogendra Singh
Summary: Protein phosphorylation is a universal mechanism that regulates cellular responses in all domains of life. Bacillus species, particularly with the availability of bacterial genome sequences, proteomics, and functional studies, have provided insights into the role of protein kinases and phosphatases in different physiological states of the organism. Phosphorylation of specific amino acid residues can alter protein activity, structure, and protein-protein interactions, ultimately impacting downstream pathways. This review summarizes the current knowledge of Bacillus signaling, focusing on the role of protein phosphorylation in physiological processes.
FEMS MICROBIOLOGY REVIEWS
(2023)
Article
Multidisciplinary Sciences
Vadim M. Gumerov, Ekaterina P. Andrianova, Miguel A. Matilla, Karen M. Page, Elizabet Monteagudo-Cascales, Annette C. Dolphin, Tino Krell, Igor B. Zhulin
Summary: This study identifies a common amino acid recognition mechanism in bacteria, archaea, and humans, which may lead to improvements in drug targeting pain and neurobiological disorders.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Microbiology
Richard J. Lamont, Daniel P. Miller, Juhi Bagaitkar
Summary: Epithelial cells serve as both a barrier and an interactive interface with microbial colonization. The study of cellular microbiology has provided insights into epithelial cell physiology, bacterial colonization and pathogenic strategies, and innate host responses.
FEMS MICROBIOLOGY REVIEWS
(2023)
Article
Cell Biology
Michael W. Murrey, James H. Steer, Eloise L. Greenland, Julie M. Proudfoot, David A. Joyce, Fiona J. Pixley
JOURNAL OF CELL SCIENCE
(2020)
Article
Oncology
Ashleigh R. Poh, Amy R. Dwyer, Moritz F. Eissmann, Ashwini L. Chand, David Baloyan, Louis Boon, Michael W. Murrey, Lachlan Whitehead, Megan O'Brien, Clifford A. Lowell, Tracy L. Putoczki, Fiona J. Pixley, Robert J. J. O'Donoghue, Matthias Ernst
CANCER IMMUNOLOGY RESEARCH
(2020)
Review
Endocrinology & Metabolism
Amy R. Dwyer, Thu H Truong, Julie H. Ostrander, Carol A. Lange
JOURNAL OF MOLECULAR ENDOCRINOLOGY
(2020)
Review
Immunology
Steven E. Mutsaers, Fiona J. Pixley, Cecilia M. Prele, Gerard F. Hoyne
CURRENT OPINION IN IMMUNOLOGY
(2020)
Review
Geriatrics & Gerontology
L. Duong, H. G. Radley, B. Lee, D. E. Dye, F. J. Pixley, M. D. Grounds, D. J. Nelson, C. Jackaman
Summary: As individuals age, their health deteriorates, leading to an increased risk of diseases such as cancer. The process of immunosenescence is characterized by changes in immune function, including an imbalance between pro-inflammatory and anti-inflammatory factors. Macrophages, key inflammatory cells, play a significant role in aging processes, potentially impacting the severity of age-related diseases such as cancer and injury repair.
Article
Multidisciplinary Sciences
Natalia G. Sampaio, Lise Chauveau, Jonny Hertzog, Anne Bridgeman, Gerissa Fowler, Jurgen P. Moonen, Maeva Dupont, Rebecca A. Russell, Marko Noerenberg, Jan Rehwinkel
Summary: Research has identified MDA5 as a cellular sensor for SARS-CoV-2 infection that induces type I and III IFNs, which can inhibit viral replication, but does not affect the induction of IL6 and TNF.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Raymond K. H. Yip, Joel S. Rimes, Bianca D. Capaldo, Francois Vaillant, Kellie A. Mouchemore, Bhupinder Pal, Yunshun Chen, Elliot Surgenor, Andrew J. Murphy, Robin L. Anderson, Gordon K. Smyth, Geoffrey J. Lindeman, Edwin D. Hawkins, Jane E. Visvader
Summary: The study demonstrates the preferential homing of mouse mammary tumor cells to specific blood vessels within the bone marrow during the metastasis process, with the tumor cells remodeling the local vasculature by producing granulocyte-colony stimulating factor. This hijacking of the host microenvironment by tumor cells leads to the formation of a pro-tumorigenic niche in the bone marrow, highlighting the importance of targeting this metastatic niche to inhibit blood vessel remodeling and reduce bone metastasis burden.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Ashleigh R. Poh, Christopher G. Love, David Chisanga, James H. Steer, David Baloyan, Michael Chopin, Stephen Nutt, Jai Rautela, Nicholas D. Huntington, Nima Etemadi, Megan O'Brien, Ryan O'Keefe, Lesley G. Ellies, Christophe Macri, Justine D. Mintern, Lachlan Whitehead, Gangadhara Gangadhara, Louis Boon, Ashwini L. Chand, Clifford A. Lowell, Wei Shi, Fiona J. Pixley, Matthias Ernst
Summary: Genetic ablation or therapeutic inhibition of the myeloid-specific hematopoietic cell kinase (HCK) enhances the response to immunotherapy by modifying the tumor microenvironment and promoting immune cell activation.
Review
Cardiac & Cardiovascular Systems
Reece Parry, Kamran Majeed, Fiona Pixley, Graham Scott Hillis, Roslyn Jane Francis, Carl Johann Schultz
Summary: Cardiovascular disease remains a major cause of death and disability worldwide, with inflammation being a significant component of atherosclerosis. Macrophages play a central role in atherosclerotic inflammation. Some anti-inflammatory therapies have shown effectiveness in reducing cardiovascular events, but there are limitations. Colchicine has been added to societal guidelines for the prevention of recurrent cardiovascular events in high-risk patients with chronic coronary syndromes. Functional imaging methods may offer a non-invasive and relatively inexpensive way to identify patients who will benefit most from novel anti-inflammatory therapies.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2022)
Review
Immunology
Kellie A. Mouchemore, Robin L. Anderson
Summary: G-CSF has been reported to play a pro-tumour role in cancer by mainly affecting neutrophils and MDSCs, suppressing T cells in the presence of G-CSF. Recent studies have also highlighted other tumour-promoting effects of G-CSF on myeloid cells, raising concerns about its impact on anti-cancer treatments like immune checkpoint blockade.
SEMINARS IN IMMUNOLOGY
(2021)
Article
Oncology
Amy R. Dwyer, Carlos Perez Kerkvliet, Raisa Krutilina, Hilaire C. Playa, Deanna N. Parke, Warner A. Thomas, Branden A. Smeester, Branden S. Moriarity, Tiffany N. Seagroves, Carol A. Lange
Summary: Research shows that in triple-negative breast cancer, the PTK6-driven signaling pathway mediates cell migration via RhoA and AhR signaling pathways, and plays a crucial role in lung metastasis.
MOLECULAR CANCER RESEARCH
(2021)
Article
Oncology
Amy R. Dwyer, Thu H. Truong, Carlos Perez Kerkvliet, Kiran Paul, Peter Kabos, Carol A. Sartorius, Carol A. Lange
Summary: Phospho-PR-B collaborates with IRS-1 to promote the outgrowth of endocrine-resistant and stem-like breast cancer cells. Activation of p-PR can lead to tamoxifen insensitivity. Targeting the crosstalk between phospho-PR and IRS-1 may block the emergence of endocrine resistance.
BRITISH JOURNAL OF CANCER
(2021)
Article
Oncology
Carlos Perez Kerkvliet, Amy R. Dwyer, Caroline H. Diep, Robert H. Oakley, Christopher Liddle, John A. Cidlowski, Carol A. Lange
BREAST CANCER RESEARCH
(2020)
Article
Endocrinology & Metabolism
Thu H. Truong, Amy R. Dwyer, Caroline H. Diep, Hsiangyu Hu, Kyla M. Hagen, Carol A. Lange
