Copper-Promoted One-Pot Trifluoromethylation of Aromatic Amines with Togni′s Reagent

A structure-guided optimization of pyrido[2,3- d ]pyrimidin-7-ones as selective inhibitors of EGFR L858R/T790M mutant with improved pharmacokinetic properties

(2017) Lei Yu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Tetrahydroisoquinoline-7-carboxamide Derivatives as New Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors

(2017) Zhen Wang et al.   ACS Medicinal Chemistry Letters

Palladium-Catalyzed Trifluoromethylation of (Hetero)Arenes with CF3 Br

(2016) Kishore Natte et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Amine-free melanin-concentrating hormone receptor 1 antagonists: Novel 1-(1H-benzimidazol-6-yl)pyridin-2(1H)-one derivatives and design to avoid CYP3A4 time-dependent inhibition

(2016) Hideyuki Igawa et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Highly mono-selective ortho-trifluoromethylation of benzamides via 8-aminoquinoline assisted Cu-promoted C–H activations

(2016) Liang Hu et al.   CHEMICAL COMMUNICATIONS

Continuous Flow Homolytic Aromatic Substitution with Electrophilic Radicals: A Fast and Scalable Protocol for Trifluoromethylation

(2016) Júlia L. Monteiro et al.   CHEMISTRY-A EUROPEAN JOURNAL

Ligand-dependent formation of ion-pair CuI/CuIII trifluoromethyl complexes containing bisphosphines

(2016) Song-Lin Zhang et al.   DALTON TRANSACTIONS

Molecular Engineering of Mechanochromic Materials by Programmed C–H Arylation: Making a Counterpoint in the Chromism Trend

(2016) Jie Wu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Simple and Clean Photoinduced Aromatic Trifluoromethylation Reaction

(2016) Lu Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper-free Sandmeyer cyanation of arenediazonium o-benzenedisulfonimides

(2016) Margherita Barbero et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The application of NCTS (N-cyano-N-phenyl-p-toluenesulfonamide) in palladium-catalyzed cyanation of arenediazonium tetrafluoroborates and aryl halides

(2016) Jizhen Li et al.   TETRAHEDRON LETTERS

Access to a new class of synthetic building blocks via trifluoromethoxylation of pyridines and pyrimidines

(2016) Pengju Feng et al.   Chemical Science

Redox-ligand sustains controlled generation of CF3 radicals by well-defined copper complex

(2016) Jérémy Jacquet et al.   Chemical Science

Trifluoromethylation of haloarenes with a new trifluoro-methylating reagent Cu(O2CCF2SO2F)2

(2016) Gang Zhao et al.   RSC Advances

Visible-Light Photoredox-Catalyzed Semipinacol-Type Rearrangement: Trifluoromethylation/Ring Expansion by a Radical-Polar Mechanism

(2015) Basudev Sahoo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Carbon Trifluoromethylation Reactions of Hydrocarbon Derivatives and Heteroarenes

(2015) Concepción Alonso et al.   CHEMICAL REVIEWS

Core-structure-inspired asymmetric addition reactions: enantioselective synthesis of dihydrobenzoxazinone- and dihydroquinazolinone-based anti-HIV agents

(2015) Shen Li et al.   CHEMICAL SOCIETY REVIEWS

Direct Aromatic CH Trifluoromethylation via an Electron-Donor-Acceptor Complex

(2015) Yuanzheng Cheng et al.   CHEMISTRY-A EUROPEAN JOURNAL

Core Perylene Diimide Designs via Direct Bay- andortho-(Poly)trifluoromethylation: Synthesis, Isolation, X-ray Structures, Optical and Electronic Properties

(2015) Tyler T. Clikeman et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Trifluoromethylpyrazoles as anti-inflammatory and antibacterial agents: A review

(2015) Kamalneet Kaur et al.   JOURNAL OF FLUORINE CHEMISTRY

Copper-Promoted Trifluoromethanesulfonylation and Trifluoromethylation of Arenediazonium Tetrafluoroborates with NaSO2CF3

(2015) Ke Zhang et al.   JOURNAL OF ORGANIC CHEMISTRY

Catalytic Trifluoromethylation of Aryl- and Vinylboronic Acids by 2-Cyclopropyl-1-(trifluoromethyl)benzo[b]thiophenium Triflate

(2015) Sadayuki Arimori et al.   ORGANIC LETTERS

Trifluoromethyl-Substituted Sulfonium Ylide: Rh-Catalyzed Carbenoid Addition to Trifluoromethylthioether

(2015) Yafei Liu et al.   ORGANIC LETTERS

Direct C–H Trifluoromethylation of Glycals by Photoredox Catalysis

(2015) Bang Wang et al.   ORGANIC LETTERS

A scalable and operationally simple radical trifluoromethylation

(2015) Joel W. Beatty et al.   Nature Communications

Sandmeyer cyanation of arenediazonium tetrafluoroborate using acetonitrile as a cyanide source

(2015) Wenbin Xu et al.   Organic Chemistry Frontiers

One-Pot Sandmeyer Trifluoromethylation and Trifluoromethylthiolation

(2014) Bilguun Bayarmagnai et al.   ADVANCED SYNTHESIS & CATALYSIS

A Universal Procedure for the [18F]Trifluoromethylation of Aryl Iodides and Aryl Boronic Acids with Highly Improved Specific Activity

(2014) Dion van der Born et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Exceedingly Fast Copper(II)-Promotedortho CH Trifluoromethylation of Arenes using TMSCF3

(2014) Ming Shang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Trifluoromethylation of arenediazonium salts with fluoroform-derived CuCF3in aqueous media

(2014) Anton Lishchynskyi et al.   CHEMICAL COMMUNICATIONS

Addition of CF3 across unsaturated moieties: a powerful functionalization tool

(2014) Estíbaliz Merino et al.   CHEMICAL SOCIETY REVIEWS

Stable but Reactive Perfluoroalkylzinc Reagents: Application in Ligand-Free Copper-Catalyzed Perfluoroalkylation of Aryl Iodides

(2014) Kohsuke Aikawa et al.   CHEMISTRY-A EUROPEAN JOURNAL

An Easy Route to (Hetero)arylboronic Acids

(2014) William Erb et al.   CHEMISTRY-A EUROPEAN JOURNAL

Recent advances in the trifluoromethylation methodology and new CF3-containing drugs

(2014) Wei Zhu et al.   JOURNAL OF FLUORINE CHEMISTRY

Copper-Mediated Perfluoroalkylation of Heteroaryl Bromides with (phen)CuRF

(2014) Michael G. Mormino et al.   ORGANIC LETTERS

Sandmeyer Trifluoromethylation

(2014) Lukas Gooßen et al.   SYNTHESIS-STUTTGART

Conversion of Aromatic Amino into Trifluoromethyl Groups through a Sandmeyer­-Type Transformation

(2014) Jianbo Wang et al.   SYNTHESIS-STUTTGART

Discovery of Potent Parthenolide-Based Antileukemic Agents Enabled by Late-Stage P450-Mediated C—H Functionalization

(2013) Joshua N. Kolev et al.   ACS Chemical Biology

Iron-Catalysed Borylation of Arenediazonium Salts to Give Access to Arylboron DerivativesviaAryl(amino)boranes at Room Temperature

(2013) Ludovic D. Marciasini et al.   ADVANCED SYNTHESIS & CATALYSIS

Sandmeyer Trifluoromethylation of Arenediazonium Tetrafluoroborates

(2013) Grégory Danoun et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rapid and Efficient Trifluoromethylation of Aromatic and Heteroaromatic Compounds Using Potassium Trifluoroacetate Enabled by a Flow System

(2013) Mao Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Silver-catalysed trifluoromethylation of arenes at room temperature

(2013) Sangwon Seo et al.   CHEMICAL COMMUNICATIONS

CuCl-catalyzed ortho trifluoromethylation of arenes and heteroarenes with a pivalamido directing group

(2013) Shangjun Cai et al.   CHEMICAL COMMUNICATIONS

Trifluoromethylation of heterocycles in water at room temperature

(2013) James C. Fennewald et al.   GREEN CHEMISTRY

Probing the Role of the Vancomycin E-Ring Aryl Chloride: Selective Divergent Synthesis and Evaluation of Alternatively Substituted E-Ring Analogues

(2013) Joseph R. Pinchman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Comparative Study on Performances of Trimethyl-Sulfonium and Trimethyl-Ammonium Based Ionic Liquids in Molecular Solvents as Electrolyte for Electrochemical Double Layer Capacitors

(2013) Erwan Coadou et al.   Journal of Physical Chemistry C

Copper-Promoted Sandmeyer Trifluoromethylation Reaction

(2013) Jian-Jun Dai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Silver-Mediated Trifluoromethylation of Aryldiazonium Salts: Conversion of Amino Group into Trifluoromethyl Group

(2013) Xi Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fluoroform-Derived CuCF3for Low-Cost, Simple, Efficient, and Safe Trifluoromethylation of Aryl Boronic Acids in Air

(2012) Petr Novák et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tamed Arene and Heteroarene Trifluoromethylation

(2012) Tatiana Besset et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper-catalyzed trifluoromethylation of aryl- and vinylboronic acids with generation of CF3-radicals

(2012) Yang Li et al.   CHEMICAL COMMUNICATIONS

The New Age of Electrophilic Perfluoro­alk­ylation Reactions

(2012) Yohan Macé et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis, Structures, and Properties of Thieno[3,2-b]thiophene and Dithiophene Bridged Isoindigo Derivatives and Their Organic Field-effect Transistors Performance

(2012) Ti Wu et al.   Journal of Physical Chemistry C

Pd(II)-Catalyzed Ortho Trifluoromethylation of Arenes and Insights into the Coordination Mode of Acidic Amide Directing Groups

(2012) Xing-Guo Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Merging Visible-Light Photocatalysis and Transition-Metal Catalysis in the Copper-Catalyzed Trifluoromethylation of Boronic Acids with CF3I

(2012) Yingda Ye et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Practical Method for the Cu-Mediated Trifluoromethylation of Arylboronic Acids with CF3 Radicals Derived from NaSO2CF3 and tert-Butyl Hydroperoxide (TBHP)

(2012) Yingda Ye et al.   ORGANIC LETTERS

Rhenium-Catalyzed Trifluoromethylation of Arenes and Heteroarenes by Hypervalent Iodine Reagents

(2012) Esteban Mejía et al.   ACS Catalysis

A General Strategy for the Perfluoroalkylation of Arenes and Arylbromides by Using Arylboronate Esters and [(phen)CuRF]

(2011) Nichole D. Litvinas et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Broadly Applicable Copper Reagent for Trifluoromethylations and Perfluoroalkylations of Aryl Iodides and Bromides

(2011) Hiroyuki Morimoto et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper-Mediated Trifluoromethylation of Heteroaromatic Compounds by Trifluoromethyl Sulfonium Salts

(2011) Cheng-Pan Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper-mediated trifluoromethylation of arylboronic acids by trifluoromethyl sulfonium salts

(2011) Cheng-Pan Zhang et al.   CHEMICAL COMMUNICATIONS

Aromatic Trifluoromethylation with Metal Complexes

(2011) Olesya A. Tomashenko et al.   CHEMICAL REVIEWS

Room Temperature Aryl Trifluoromethylation via Copper-Mediated Oxidative Cross-Coupling

(2011) Todd D. Senecal et al.   JOURNAL OF ORGANIC CHEMISTRY

Direct Cupration of Fluoroform

(2011) Alessandro Zanardi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper-Catalyzed Direct C–H Oxidative Trifluoromethylation of Heteroarenes

(2011) Lingling Chu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalysis for fluorination and trifluoromethylation

(2011) Takeru Furuya et al.   NATURE

Trifluoromethylation of arenes and heteroarenes by means of photoredox catalysis

(2011) David A. Nagib et al.   NATURE

Copper-Catalyzed Trifluoromethylation of Aryl and Vinyl Boronic Acids with An Electrophilic Trifluoromethylating Reagent

(2011) Tianfei Liu et al.   ORGANIC LETTERS

Silver-Mediated Trifluoromethylation of Arenes Using TMSCF3

(2011) Yingda Ye et al.   ORGANIC LETTERS

Innate C-H trifluoromethylation of heterocycles

(2011) Y. Ji et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct Conversion of Arylamines to Pinacol Boronates: A Metal-Free Borylation Process

(2010) Fanyang Mo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Discovery and Characterization of Sulfoxaflor, a Novel Insecticide Targeting Sap-Feeding Pests

(2010) Yuanming Zhu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Electrophilic trifluoromethylation of arenes and N-heteroarenes using hypervalent iodine reagents

(2010) Matthias S. Wiehn et al.   JOURNAL OF FLUORINE CHEMISTRY

Pd(II)-Catalyzedortho-Trifluoromethylation of Arenes Using TFA as a Promoter

(2010) Xisheng Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper-Mediated Oxidative Trifluoromethylation of Boronic Acids

(2010) Lingling Chu et al.   ORGANIC LETTERS

The Palladium-Catalyzed Trifluoromethylation of Aryl Chlorides

(2010) E. J. Cho et al.   SCIENCE

Direct C2-trifluoromethylation of indole derivatives catalyzed by copper acetate

(2010) Ryo Shimizu et al.   TETRAHEDRON LETTERS

Nucleophilic Trifluoromethylation of Imines under Acidic Conditions

(2008) Vitalij V. Levin et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Active Trifluoromethylating Agents from Well-Defined Copper(I)−CF3Complexes

(2008) Galyna G. Dubinina et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fluorine in medicinal chemistry

(2007) Sophie Purser et al.   CHEMICAL SOCIETY REVIEWS

Halo- and Azidodediazoniation of Arenediazonium Tetrafluoroborates with Trimethylsilyl Halides and Trimethylsilyl Azide and Sandmeyer-Type Bromodediazoniation with Cu(I)Br in [BMIM][PF6] Ionic Liquid§

(2007) Abigail Hubbard et al.   JOURNAL OF ORGANIC CHEMISTRY