Article
Immunology
Yi Zhang, Lei Li, Genevieve Genest, Wei Zhao, Dan Ke, Sabrina Bartolucci, Nils Pavey, Tho-Alfakar Al-Aubodah, Duncan Lejtenyi, Bahar Torabi, Moshe Ben-Shoshan, Bruce Mazer, Ciriaco A. Piccirillo
Summary: In this study, the induction of specific T-REG cells during oral immunotherapy (OIT) in children with cow's milk protein (CMP) allergy was found to be effective in promoting tolerance and reducing Th2 responses. The expansion of these T-REG cells correlated with successful desensitization to CMP and may be a potential marker for predicting the time to reach maintenance phase in OIT.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Kathryn A. Knoop, Keely G. McDonald, Chyi-Song Hsieh, Phillip Tarr, Rodney D. Newberry
Summary: Atopic disorders are on the rise in Western societies, characterized by immune responses to environmental triggers. Early life exposure to diet and microbes shapes the intestinal Treg population significantly. Tregs developed early in life play a crucial role in restraining systemic inflammatory responses into adulthood.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Natalia M. Krajewska, Remi Fiancette, Ye H. Oo
Summary: Immune-mediated cholangiopathies are characterized by the destruction of bile ducts, leading to liver inflammation and fibrosis. Regulatory T cells (Tregs) play a crucial role in these diseases, but their function can be impaired by the inflamed microenvironment. Mast cells (MCs) are also involved in the pathogenesis by releasing pro-inflammatory mediators. MCs can indirectly influence Treg function and there are also direct interactions between MCs and Tregs. Understanding the crosstalk between Tregs and MCs is important for the progression of autoimmune cholangiopathy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Yiran Qiu, Shouyu Ke, Jieqiong Chen, Zhizhen Qin, Wenle Zhang, Yaqin Yuan, Dehua Meng, Gang Zhao, Kejin Wu, Bin Li, Dan Li
Summary: This review summarizes the latest findings on the dynamic connections and reciprocal regulations of non-lymphoid Treg cell subsets in the immune escape of tumour cells in solid tumors, providing new insights for the development of next-generation engineered T cell-based immune treatments for solid tumors.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Shareni Jeyamogan, Joseph R. Leventhal, James M. Mathew, Zheng Jenny Zhang
Summary: Solid organ transplantation (SOT) and vascularized composite allotransplantation (VCA) are the gold-standard treatments for end-stage organ failure and complex tissue defects. However, ischemia reperfusion injury (IRI) is a major factor that can negatively impact transplant outcomes. CD4+CD25+FOXP3+ regulatory T cells (Tregs) have immunomodulatory potential and can prevent and mitigate IRI. Increasing the number of Tregs and targeted delivery can improve the outcomes of SOT and VCA.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Guirong Liu, Manman Liu, Junjuan Wang, Yao Mou, Huilian Che
Summary: The increasing prevalence of food allergies has spurred research on novel treatment strategies like EPIT, which has shown potential in inducing immune tolerance. Treg cells play a key role in immune tolerance induced by EPIT but further exploration is needed to understand its mechanism.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Kazuyuki Kasahara, Naoto Sasaki, Hilman Zulkifli Amin, Toru Tanaka, Sayo Horibe, Tomoya Yamashita, Ken-Ichi Hirata, Yoshiyuki Rikitake
Summary: This study demonstrates that Foxp3(+) Tregs can suppress pro-inflammatory CD4(+) T cell immune responses to control the development of atherosclerosis under hypercholesterolemia.
Article
Multidisciplinary Sciences
Kazuyuki Kasahara, Naoto Sasaki, Hilman Zulkifli Amin, Toru Tanaka, Sayo Horibe, Tomoya Yamashita, Ken-ichi Hirata, Yoshiyuki Rikitake
Summary: Foxp3+ Tregs play a crucial role in the control of atherosclerosis by suppressing pro-inflammatory CD4+ T cell immune responses. Depletion of Foxp3+ Tregs aggravates inflammation and worsens atherosclerosis under hypercholesterolemia.
Review
Immunology
Juyeun Lee, Dongkyun Kim, Booki Min
Summary: Foxp3(+) regulatory T (Treg) cells are crucial for immune regulation and tolerance, and tissue resident Treg cells play a central role in regulating tissue homeostasis, inflammation, and repair.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Allergy
Kirstin Jansen, Lacin Cevhertas, Siyuan Ma, Pattraporn Satitsuksanoa, Mubeccel Akdis, Willem van de Veen
Summary: B cells play a central role in the immune system by producing antibodies, and they also have the capacity to regulate immune responses through various mechanisms. Regulatory B cells suppress inflammatory responses in autoimmune diseases, allergies, infections, transplants, and cancer, with key suppressive molecules like cytokines and cell membrane-bound molecules playing important roles. Regulatory B cells can be induced by different stimuli and play a role in altering inflammatory responses in various diseases.
Review
Cell Biology
Jianhui Wu, Bowen Ren, Daochao Wang, Hui Lin
Summary: This review discusses the role and mechanisms of regulatory T cells (Tregs) in skeletal muscle repair and regeneration, as well as new strategies for Treg immunotherapy in skeletal muscle diseases.
CELL DEATH & DISEASE
(2022)
Article
Biology
Severine Menoret, Laurent Tesson, Severine Remy, Victor Gourain, Celine Serazin, Claire Usal, Aude Guiffes, Vanessa Chenouard, Laure-Helene Ouisse, Malika Gantier, Jean-Marie Heslan, Cynthia Fourgeux, Jeremie Poschmann, Carole Guillonneau, Ignacio Anegon
Summary: In this study, a Foxp3-EGFP rat transgenic line was created to genetically tag CD4(+) and CD8(+) FOXP3(+) regulatory T cells. CD4(+)EGFP(+) Treg were found to be 5-10 times more frequent than CD8(+)EGFP(+) Treg. RNAseq analysis provided insights into the transcriptome of CD8(+) Treg, allowing for a better understanding of their phenotype and function.
Article
Immunology
Pooja Mehta, Victoire Gouirand, Devi P. Boda, Jingxian Zhang, Sofia Gearty, Bahar Zirak, Margaret M. Lowe, Sean Clancy, Ian Boothby, Kelly M. Mahuron, Adam Fries, Matthew F. Krummel, Parminder Mankoo, Hsin-Wen Chang, Jared Liu, Joshua M. Moreau, Tiffany C. Scharschmidt, Adil Daud, Esther Kim, Isaac M. Neuhaus, Hobart W. Harris, Wilson Liao, Michael D. Rosenblum
Summary: The study identifies LAYN (layilin) as preferentially expressed on a subset of activated Tregs in human skin, with a role in facilitating Treg adhesion and limiting their suppressive capacity. This mechanism may influence Treg motility and immune regulation in nonlymphoid tissues, potentially guiding therapeutic strategies for immune modulation.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Immunology
Dandan Yang, Xueqiang Zhao, Xin Lin
Summary: Bcl10 plays a critical role in the development and function of regulatory T (Treg) cells, deficiency of which leads to impaired development and suppressive function of Treg cells, even causing lethal autoimmunity. Bcl10-deficient Treg cells can undergo conversion into proinflammatory cells and decrease in effector Treg cell populations. The study provides genetic evidence that Bcl10 is essential for Treg cell development and function.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Cell Biology
Daniel S. Shin, Sneha Ratnapriya, Creel Ng Cashin, Lucy F. Kuhn, Rod A. Rahimi, Robert M. Anthony, James J. Moon
Summary: Self-antigen-specific T cells are regulated through tolerance mechanisms, but tissue injury can disrupt this regulation and trigger autoimmunity. Using mouse models of lung injury, we found that acute injury leads to the expansion of CD4+ regulatory T cells (Tregs) that specifically recognize self-antigen. Conventional CD4+ T cells with the same self-antigen specificity remained unresponsive even after Treg ablation. Therefore, the self-antigen-specific CD4+ T cell repertoire plays a regulatory role in limiting tissue damage and autoimmunity during acute injury.
Review
Immunology
Elena Martin-Orozco, Ana Sanchez-Fernandez, Irene Ortiz-Parra, Maria Ayala-San Nicolas
FRONTIERS IN IMMUNOLOGY
(2019)
Editorial Material
Immunology
Antje Blumenthal, Elena Martin-Orozco, Jere W. McBride, Dennis A. Carson, Malini Sen
FRONTIERS IN IMMUNOLOGY
(2020)
Review
Environmental Sciences
Azahara Maria Garcia-Serna, Elena Martin-Orozco, Trinidad Hernandez-Caselles, Eva Morales
Summary: This article summarizes the evidence on how the prenatal and perinatal environment can shape the immune cell populations and cytokines at birth in humans, including factors such as season of birth, mode of delivery, exposure to common allergens, a farming environment, pet ownership, and exposure to tobacco smoking and pollutants. Reported disruptions in the immune system at birth may play a role in the development of asthma and related allergic manifestations later in life.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Environmental Sciences
Azahara M. Garcia-Serna, Trinidad Hernandez-Caselles, Pedro Jimenez-Guerrero, Elena Martin-Orozco, Virginia Perez-Fernandez, Esther Cantero-Cano, Maria Munoz-Garcia, Carmen Ballesteros-Meseguer, Irene Perez de los Cobos, Luis Garcia-Marcos, Eva Morales
Summary: The study suggests that prenatal exposure to traffic-related air pollution may impact the numbers of NK cells, T cells, and Th1 cells in cord blood, especially during early and late gestation.
ENVIRONMENTAL RESEARCH
(2021)
Article
Public, Environmental & Occupational Health
Eva Morales, Maria Alcantara-Lopez, Juan Cabezas-Herrera, Teresa de Diego, Trinidad Hernandez-Caselles, Pedro Jimenez-Guerrero, Elvira Larque, Concepcion Lopez-Soler, Carmen Martinez-Gracia, Antonela Martinez-Torres, Elena Martin-Orozco, Jaime Mendiola, Anibal Nieto-Diaz, Jose A. Noguera, Virginia Perez-Fernandez, M. Teresa Prieto-Sanchez, Carme Salvador-Garcia, Manuel Sanchez-Solis, Marina Santaella-Pascual, Rosa A. Sola-Martinez, Alberto Torres-Cantero, Genoveva Yague-Guirao, Matilde Zornoza-Moreno, Luis Garcia-Marcos
Summary: The NELA cohort study aims to unravel the developmental origins of asthma by investigating the impact of maternal obesity, nutrition, air pollution, endocrine disruptors, and maternal psychological stress on asthma susceptibility, using biological samples to assess potential mechanisms.
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
(2022)
Article
Allergy
Azahara M. Garcia-Serna, Elena Martin-Orozco, Pedro Jimenez-Guerrero, Trinidad Hernandez-Caselles, Virginia Perez-Fernandez, Esther Cantero-Cano, Maria Munoz-Garcia, Maria Dolores Molina-Ruano, Encarna Rojo-Atenza, Luis Garcia-Marcos, Eva Morales
Summary: This study found that gestational exposure to traffic-related air pollutants may increase the detection rate of pro-inflammatory, Th2-related, and T regulatory cytokines in newborns, which may influence their immune system responses later in life.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Letter
Gastroenterology & Hepatology
Nicholas D. Weber, Javier Martinez-Garcia, Gloria Gonzalez-Aseguinolaza
JOURNAL OF HEPATOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Javier Martinez-Garcia, Angie Molina, Gloria Gonzalez-Aseguinolaza, Nicholas D. Weber, Cristian Smerdou
Summary: Gene therapy shows promising results in treating cholestatic diseases, but challenges remain in translating this therapy to clinical practice and developing strategies for other types of cholestasis.
Article
Pediatrics
Azahara M. Garcia-Serna, Eva Morales, Ester Cantero-Cano, Maria Norte-Munoz, Ma Angeles Gil-Buendia, Josefa Velazquez-Marin, Trinidad Hernandez-Caselles, Virginia Perez-Fernandez, Antonia E. Martinez-Torres, Luis Garcia-Marcos, Elena Martin-Orozco
Summary: The cytokine signatures in newborns are influenced by sex and season of birth, with male newborns showing higher levels of certain cytokines and summer-born children displaying increased immune response. These signatures may be associated with the development of clinical outcomes in the future.
PEDIATRIC RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Javier Martinez-Garcia, Manuela Molina, Leticia Odriozola, Angie Molina, Gloria Gonzalez-Aseguinolaza, Nicholas D. Weber, Cristian Smerdou
Summary: This study evaluated the functionality and bile acid-mediated regulation of minimal versions of the human and mouse BSEP promoters. The minimal mouse BSEP promoter (imPr) showed higher expression and inducibility compared to the minimal human promoter (ihPr) and full-length BSEP promoters in human hepatic cells. The imPr promoter was efficiently regulated by administration of a bile acid-enriched diet in mice receiving an AAV8 vector. The optimized imPr promoter with additional IR-1 repeats provided higher levels of expression both in vitro and in vivo.
CELL AND BIOSCIENCE
(2022)
Article
Oncology
Guillermo Herrador-Canete, Marta Zalacain, Sara Labiano, Virginia Laspidea, Montserrat Puigdelloses, Lucia Marrodan, Marc Garcia-Moure, Marisol Gonzalez-Huarriz, Javier Marco-Sanz, Iker Ausejo-Mauleon, Daniel de la Nava, Reyes Hernandez-Osuna, Javier Martinez-Garcia, Noelia Silva-Pilipich, Elisabeth Gurucega, Ana Patino-Garcia, Ruben Hernandez-Alcoceba, Cristian Smerdou, Marta M. Alonso
Summary: The usage of Semliki Forest virus (SFV) vectors expressing galectin-3 inhibitors as therapeutic tools showed promising results in reducing tumor progression and improving immune responses in pediatric osteosarcoma patients.
MOLECULAR THERAPY-ONCOLYTICS
(2022)
Editorial Material
Immunology
Elena Martin-Orozco, Lisheng Wang, Shilpak Chatterjee, Brent A. Hanks
FRONTIERS IN IMMUNOLOGY
(2022)
Meeting Abstract
Biotechnology & Applied Microbiology
Angie Molina, Leticia Odriozola, Laia Trigueros-Motos, Manuela Molina, Javier Martinez-Garcia, Cristian Smerdou, Gloria Gonzalez-Aseguinolaza, Nicholas D. Weber
Meeting Abstract
Biotechnology & Applied Microbiology
Guillermo Herrador-Canete, Marta Zalacain, Sara Labiano, Javier Martinez-Garcia, Ruben Hernandez-Alcoceba, Ana Patino, Cristian Smerdou, Marta M. Alonso
Meeting Abstract
Gastroenterology & Hepatology
Nicholas D. Weber, Leticia Odriozola, Javier Martinez-Garcia, Veronica Ferrer, Anne Douar, Bernard Benichou, Cristian Smerdou, Gloria Gonzalez-Aseguinolaza
JOURNAL OF HEPATOLOGY
(2019)