Using the Drosophila Nephrocyte to Model Podocyte Function and Disease

A Drosophila model system to assess the function of human monogenic podocyte mutations that cause nephrotic syndrome

(2017) Yulong Fu et al.   HUMAN MOLECULAR GENETICS

Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency

(2017) Svjetlana Lovric et al.   JOURNAL OF CLINICAL INVESTIGATION

A Personalized Model of COQ2 Nephropathy Rescued by the Wild-Type COQ2 Allele or Dietary Coenzyme Q 10 Supplementation

(2017) Jun-yi Zhu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice

(2017) Pazit Beckerman et al.   NATURE MEDICINE

Drosophila imaginal disc growth factor 2 is a trophic factor involved in energy balance, detoxification and innate immunity

(2017) Vaclav Broz et al.   Scientific Reports

SPARC–Dependent Cardiomyopathy inDrosophilaCLINICAL PERSPECTIVE

(2016) Paul S. Hartley et al.   Circulation-Cardiovascular Genetics

APOL1-G1 in Nephrocytes Induces Hypertrophy and Accelerates Cell Death

(2016) Yulong Fu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

APOL1–Mediated Cell Injury Involves Disruption of Conserved Trafficking Processes

(2016) Etty Kruzel-Davila et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

MAGI2Mutations Cause Congenital Nephrotic Syndrome

(2016) Agnieszka Bierzynska et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Modeling Monogenic Human Nephrotic Syndrome in theDrosophilaGarland Cell Nephrocyte

(2016) Tobias Hermle et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Megalin and cubilin in proximal tubule protein reabsorption: from experimental models to human disease

(2016) Rikke Nielsen et al.   KIDNEY INTERNATIONAL

SPARC–Dependent Cardiomyopathy inDrosophilaCLINICAL PERSPECTIVE

(2016) Paul S. Hartley et al.   Circulation-Cardiovascular Genetics

MiniCORVET is a Vps8-containing early endosomal tether in Drosophila

(2016) Péter Lőrincz et al.   eLife

KANK deficiency leads to podocyte dysfunction and nephrotic syndrome

(2015) Heon Yung Gee et al.   JOURNAL OF CLINICAL INVESTIGATION

Genetic testing in steroid-resistant nephrotic syndrome: when and how?

(2015) Svjetlana Lovric et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Knockdown of InR gene in ventral nephrocytes promotes resistance to toxic stress in Drosophila melanogaster females

(2015) O. V. Andreenkova et al.   RUSSIAN JOURNAL OF GENETICS

Diet-Induced Podocyte Dysfunction in Drosophila and Mammals

(2015) Jianbo Na et al.   Cell Reports

Klf15 Is Critical for the Development and Differentiation of Drosophila Nephrocytes

(2015) Jessica R. Ivy et al.   PLoS One

Genetic bases and clinical manifestations of coenzyme Q10 (CoQ10) deficiency

(2014) Maria Andrea Desbats et al.   JOURNAL OF INHERITED METABOLIC DISEASE

A Single-Gene Cause in 29.5% of Cases of Steroid-Resistant Nephrotic Syndrome

(2014) C. E. Sadowski et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

V-ATPase/mTOR Signaling Regulates Megalin-Mediated Apical Endocytosis

(2014) Eva Maria Gleixner et al.   Cell Reports

Src64B phosphorylates Dumbfounded and regulates slit diaphragm dynamics: Drosophila as a model to study nephropathies

(2013) A. S. Tutor et al.   DEVELOPMENT

ARHGDIA mutations cause nephrotic syndrome via defective RHO GTPase signaling

(2013) Heon Yung Gee et al.   JOURNAL OF CLINICAL INVESTIGATION

ADCK4 mutations promote steroid-resistant nephrotic syndrome through CoQ10 biosynthesis disruption

(2013) Shazia Ashraf et al.   JOURNAL OF CLINICAL INVESTIGATION

An In Vivo Functional Analysis System for Renal Gene Discovery in Drosophila Pericardial Nephrocytes

(2013) F. Zhang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A Drosophila Model of High Sugar Diet-Induced Cardiomyopathy

(2013) Jianbo Na et al.   PLoS Genetics

Krüppel-like Factor 15 (KLF15) Is a Key Regulator of Podocyte Differentiation

(2012) Sandeep K. Mallipattu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cubilin and Amnionless Mediate Protein Reabsorption in Drosophila Nephrocytes

(2012) F. Zhang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Functional Study of Mammalian Neph Proteins in Drosophila melanogaster

(2012) Martin Helmstädter et al.   PLoS One

The Drosophila nephrocyte

(2011) Ross L Cagan   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

TTC21B contributes both causal and modifying alleles across the ciliopathy spectrum

(2011) Erica E Davis et al.   NATURE GENETICS

The novel endosomal membrane protein Ema interacts with the class C Vps–HOPS complex to promote endosomal maturation

(2010) Sungsu Kim et al.   JOURNAL OF CELL BIOLOGY

Bringing together components of the fly renal system

(2009) Barry Denholm et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Sns and Kirre, the Drosophila orthologs of Nephrin and Neph1, direct adhesion, fusion and formation of a slit diaphragm-like structure in insect nephrocytes

(2009) S. Zhuang et al.   DEVELOPMENT

Flying podocytes

(2009) Matias Simons et al.   KIDNEY INTERNATIONAL

Macromolecular uptake in Drosophila pericardial cells requires rudhira function

(2008) Debjani Das et al.   EXPERIMENTAL CELL RESEARCH

Analysis of the Cell Adhesion Molecule Sticks-and-Stones Reveals Multiple Redundant Functional Domains, Protein-Interaction Motifs and Phosphorylated Tyrosines That Direct Myoblast Fusion in Drosophila melanogaster

(2008) K. S. Kocherlakota et al.   GENETICS

Rolling blackout is required for bulk endocytosis in non-neuronal cells and neuronal synapses

(2008) N. Vijayakrishnan et al.   JOURNAL OF CELL SCIENCE

The insect nephrocyte is a podocyte-like cell with a filtration slit diaphragm

(2008) Helen Weavers et al.   NATURE