Differential IL-1 signaling induced by BMPR2 deficiency drives pulmonary vascular remodeling

Targeting Vascular Remodeling to Treat Pulmonary Arterial Hypertension

(2017) A.A. Roger Thompson et al.   TRENDS IN MOLECULAR MEDICINE

Role of interleukin-1 receptor 1/MyD88 signalling in the development and progression of pulmonary hypertension

(2016) Aurélien Parpaleix et al.   EUROPEAN RESPIRATORY JOURNAL

MicroRNA-140-5p and SMURF1 regulate pulmonary arterial hypertension

(2016) Alexander M.K. Rothman et al.   JOURNAL OF CLINICAL INVESTIGATION

Low-Dose FK506 (Tacrolimus) in End-Stage Pulmonary Arterial Hypertension

(2015) Edda Spiekerkoetter et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Bone Morphogenetic Protein Receptor Type II Deficiency and Increased Inflammatory Cytokine Production. A Gateway to Pulmonary Arterial Hypertension

(2015) Elaine Soon et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Elafin Reverses Pulmonary Hypertension via Caveolin-1–Dependent Bone Morphogenetic Protein Signaling

(2015) Nils P. Nickel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

New Molecular Targets of Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension

(2015) Christophe Guignabert et al.   CHEST

Neutrophil Elastase Promotes Interleukin-1β Secretion from Human Coronary Endothelium

(2015) Mabruka Alfaidi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction between Bone Morphogenetic Protein Receptor Type 2 and Estrogenic Compounds in Pulmonary Arterial Hypertension

(2014) Joshua P. Fessel et al.   Pulmonary Circulation

FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension

(2013) Edda Spiekerkoetter et al.   JOURNAL OF CLINICAL INVESTIGATION

Blocking Macrophage Leukotriene B4 Prevents Endothelial Injury and Reverses Pulmonary Hypertension

(2013) W. Tian et al.   Science Translational Medicine

BMP type II receptor deficiency confers resistance to growth inhibition by TGF-β in pulmonary artery smooth muscle cells: role of proinflammatory cytokines

(2012) Rachel J. Davies et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Inhibition of tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) reverses experimental pulmonary hypertension

(2012) Abdul G. Hameed et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases

(2012) Charles A. Dinarello et al.   NATURE REVIEWS DRUG DISCOVERY

Interleukin-1β inhibition and the prevention of recurrent cardiovascular events: Rationale and Design of the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS)

(2011) Paul M Ridker et al.   AMERICAN HEART JOURNAL

Paigen Diet–Fed Apolipoprotein E Knockout Mice Develop Severe Pulmonary Hypertension in an Interleukin-1–Dependent Manner

(2011) Allan Lawrie et al.   AMERICAN JOURNAL OF PATHOLOGY

Cytoskeletal defects in Bmpr2-associated pulmonary arterial hypertension

(2011) Jennifer A. Johnson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Signal Transducers and Activators of Transcription-3/Pim1 Axis Plays a Critical Role in the Pathogenesis of Human Pulmonary Arterial Hypertension

(2011) Roxane Paulin et al.   CIRCULATION

S100A4 and Bone Morphogenetic Protein-2 Codependently Induce Vascular Smooth Muscle Cell Migration via Phospho–Extracellular Signal-Regulated Kinase and Chloride Intracellular Channel 4

(2009) Edda Spiekerkoetter et al.   CIRCULATION RESEARCH

Interleukin-6 Overexpression Induces Pulmonary Hypertension

(2008) M. Kathryn Steiner et al.   CIRCULATION RESEARCH