Review
Pharmacology & Pharmacy
Pankaj Bhatt, Vipin Kumar, Vetriselvan Subramaniyan, Kandasamy Nagarajan, Mahendran Sekar, Suresh Chinni, Gobinath Ramachawolran
Summary: Natural polymers have gained attention in drug delivery due to their biocompatibility and biodegradability. However, their surface properties often limit their use. Plasma treatment can overcome these limitations by improving the properties of natural polymers. This review provides an overview of recent advances in plasma modification of natural polymer-based drug delivery systems.
Article
Polymer Science
Anh-Minh Nguyen-Huu, Ngoc Thuy Trang Le, Pham Nguyen Dong Yen, Yern Chee Ching, Dai Hai Nguyen
Summary: Quercetin has been extensively studied in drug delivery systems, and this study aims to use simplistic micelles to solve the problem of complicated systems. PEGylated-cholesterol micelles were prepared and characterized, and the results showed promising features of the nano-micelles as a drug delivery system.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Chemistry, Physical
Yuling Zhang, Zuoping Li, Zhihao Zhao, Youping Li, Zhiyong Liu, Shiguo Sun
Summary: Mesoporous carbon (MCNs) nanomaterials, as a new inorganic material, combine the advantages of a mesoporous structure and carbonaceous composition, and have shown superior properties compared with traditional mesoporous silica and other carbon-based materials. However, their application in the biomedical field is limited due to poor hydrophilicity and potential toxicity. This review discusses the modified strategies of MCNs nanomaterials and their effects on biocompatibility, as well as the challenges and opportunities in developing and translating these nanomaterials.
Article
Pharmacology & Pharmacy
Kashif Hussain, Abdul Jabbar, Khwaja Ali Hasan, Muneeb Ali, Zaheer Ul-Haq, Muhammad Raza Shah, Saeed Ahmad Khan, Md Abdur Rashid, Mohsin Kazi, Muhammad Naseer Abbas
Summary: Due to the low solubility of hydrophobic drugs, nonionic surfactants are used to improve their solubility by entrapping them in lipid bilayers. Two newly synthesized nonionic surfactants, NODNH-16 and NODNH-18, were characterized and demonstrated good drug entrapment efficiency. They also showed biocompatibility and low blood hemolysis, making them safe for use. The antifungal potential of niosomes loaded with amphotericin B has been evaluated, showing promising fungicidal activity and providing a safe vehicle system for drug delivery.
Review
Nanoscience & Nanotechnology
Monireh Esmaeili Rad, Caner Soylukan, Prabir Kumar Kulabhusan, Beyza Nur Gunaydin, Meral Yuce
Summary: The nanomaterial and toolkit have potential applications in improving human health and well-being, particularly in drug delivery systems. Current research focuses on using nanoscale materials as carriers to deliver therapeutic agents, addressing issues with conventional drug delivery systems. Although this technology shows promise, there are challenges to overcome in terms of safety, toxicity, efficacy, and delivery capacity.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Biochemistry & Molecular Biology
Sara Hooshmand, Seyed Mohammad Gheibi Hayat, Ahmad Ghorbani, Mehrdad Khatami, Kimya Pakravanan, Majid Darroudi
Summary: Nanocarriers improve the properties of traditional drugs, and magnetic nanoparticles show potential in drug delivery applications.
CURRENT MEDICINAL CHEMISTRY
(2021)
Review
Engineering, Biomedical
Wei Yuan, Dandan Xia, Shuilin Wu, Yufeng Zheng, Zhenpeng Guan, Julietta Rau
Summary: Zinc and its alloys have been proposed as candidate materials for biodegradable metals (BMs) due to their corrosion behavior and biocompatibility. However, surface treatment for Zn-based BMs is desired to better control their degradation behavior. This review summarizes the current surface modification methods of Zn-based alloys, the recent progress in biomedical Zn-based BMs and their surface modification strategies, and proposes future perspectives for designing bio-functionalized coatings on Zn-based BMs for orthopedic and cardiovascular applications.
BIOACTIVE MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Qi-Zhi Zhong, Joseph J. Richardson, Ai He, Tian Zheng, Rene P. M. Lafleur, Jianhua Li, Wen-Ze Qiu, Denzil Furtado, Shuaijun Pan, Zhi-Kang Xu, Ling-Shu Wan, Frank Caruso
Summary: By employing a co-assembly strategy with quinone and polyamine building blocks, we have developed a method to precisely control the structure and properties of coatings on various materials, including thickness, adhesion, wettability, and zeta potential. The properties of the films can be tuned by increasing the length of the amine building blocks, and the films can be post-functionalized to form diverse nanostructures for various applications.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Engineering, Biomedical
Tong Li, Xian-Mao Lu, Ming-Rong Zhang, Kuan Hu, Zhou Li
Summary: Peptide-based self-assembly nanomaterials, with diverse structures and functionalities, play a significant role in bioapplications. This review provides an overview of the recent advances in peptide-based self-assembly nanostructures, focusing on the driving forces and assembly mechanisms. It also summarizes the synthesis, properties, and applications of functional peptide nanomaterials. The challenges and future prospects of peptide-based nanomaterials are discussed.
BIOACTIVE MATERIALS
(2022)
Review
Engineering, Biomedical
Mohammad Mehdi Sabzehmeidani, Mahmood Kazemzad
Summary: This article discusses the coating techniques of metal-organic frameworks (MOFs) for medical applications, focusing on surface modification for medical implants. It summarizes the various coating methods and their effects on improving the properties of alloy surfaces and enhancing antibacterial and corrosion resistance.
BIOMATERIALS RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Nisar Ul Khaliq, Juyeon Lee, Joohyeon Kim, Yejin Kim, Sohyeon Yu, Jisu Kim, Sangwoo Kim, Daekyung Sung, Hyungjun Kim
Summary: Cancer remains a major global health challenge, and traditional chemotherapy often leads to side effects and drug resistance, necessitating the development of alternative treatments like gene therapy. Mesoporous silica nanoparticles (MSNs) offer numerous advantages as gene delivery carriers, including high loading capacity, controlled drug release, and easy surface functionalization. They are biodegradable and biocompatible, making them promising candidates for drug delivery applications. Recent studies have reviewed the use of MSNs for delivering therapeutic nucleic acids to cancer cells and discussed their potential as a tool for cancer therapy. The major challenges and future interventions of MSNs as gene delivery carriers for cancer therapy are also discussed.
Article
Pharmacology & Pharmacy
Julian David Friedl, Arne Matteo Jorgensen, Nguyet-Minh Nghyen Le, Christian Steinbring, Andreas Bernkop-Schnuerch
Summary: This study aimed to evaluate the application of different polyhydroxy surfaces in SEDDS to overcome the limitations associated with conventional PEG-based SEDDS surfaces for intracellular drug delivery. The results showed that replacing PEG-surfactants with polyhydroxy surfactants can improve the performance of SEDDS and promote drug delivery.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Materials Science, Multidisciplinary
Jaebum Park, Michael J. McShane
Summary: Nanoscale bio-polymer coatings play a crucial role in medical device applications, and chemically crosslinking can reduce the diffusivity of glucose, effectively controlling the permeation of small molecules and enhancing biomimetic properties.
Article
Chemistry, Physical
Shubhankar Dube, Deepak Rawtani, Nitasha Khatri, Garvita Parikh
Summary: This article comprehensively reviews the potential and issues of HNTs as drug carriers, and discusses their safety across different cell lines and model organisms. Furthermore, it provides insights into the impact of HNTs' surface chemistry and release kinetics on therapeutic efficacy, as well as unexplored areas in current research.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Zhen Xu, Tianhui Shi, Fengye Mo, Wenqian Yu, Yu Shen, Qunying Jiang, Fuan Wang, Xiaoqing Liu
Summary: In this study, programmable DNA-protein superstructures were successfully assembled through biomimetic assembly, by combining programmable polymer DNA wire with alkaline protein protamine to form densely packed DNA nanospheres. These DNA-protein superstructures exhibited specifically high affinity and stability, enabling high cancer cell selectivity and reduced side effects.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Ravi Prakash, Ishwar Chandra Maurya, Pankaj Srivastava, Sourov Mondal, Biswajit Ray, Pralay Maiti
Summary: This study improves the electrical conductivity of graphene-tagged polyurethane through chemical attachment and functionalization, making it suitable for applications in gel electrolytes such as solar cells. The combination of these materials shows high power conversion efficiency, attributed to improved light harvesting behavior, conductivity, and reduced electron-hole pair recombination.
NANOSCALE ADVANCES
(2022)
Article
Chemistry, Multidisciplinary
Reshu Bhardwaj, Om Prakash, Shivam Tiwari, Preeti Maiti, Sandipta Ghosh, Ram Kumar Singh, Pralay Maiti
Summary: Carfentrazone-ethyl is embedded in guar gum to prepare a polymer-herbicide conjugate gel formulation for sustained release of the active ingredient. The study demonstrates that the gel formulation shows strong interactions in the polymer-herbicide conjugate system, leading to enhanced weed mortality and reduced plant regeneration compared to conventional herbicides.
Correction
Chemistry, Multidisciplinary
Karun Kumar Jana, Om Prakash, Vinod K. Shahi, Devesh K. Avasthi, Pralay Maiti
Article
Polymer Science
Shruti Pandey, Pralay Maiti, Karun K. K. Jana, Dipak Rana, Vinod K. K. Aswal
Summary: Polyurethane nanocomposites with varying concentrations of nanotalc and Cloisite 30B as fillers were prepared by hot melt extrusion. TEM images showed good dispersion of 30B but moderate agglomeration in nanotalc composite. The mechanical, thermal, and gas barrier properties of the nanocomposites were better in 30B due to its greater interaction and good dispersion.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Chemistry, Medicinal
Maram Habashi, Pradeep S. Chauhan, Suresh Vutla, Sudipta Senapati, Mykhailo Diachkov, Ali EL-Husseini, Brigitte Guerin, William D. Lubell, Shai Rahimipour
Summary: Transient soluble oligomers of amyloid-beta (A beta) are toxic in Alzheimer's disease (AD). The peptide CP-2 self-assembles into nanotubes and exhibits anti-amyloidogenic activity by engaging soluble oligomers. Substituting certain residues with aza-amino acid counterparts improves the ability to mitigate A beta aggregation and toxicity. Specifically, [azaNle3]-1 and [azaHse6]-1 significantly decrease A beta oligomer levels and alleviate symptoms in a transgenic AD model.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Polymer Science
Ravi Prakash, Santanu Das, Pralay Maiti
Summary: Functionalization of multi-walled carbon nanotubes (CNTs) was conducted to obtain CNT-tagged polyurethane (PU-CNT) through ultrasonication, chemical attachment, and chain extension. Spectroscopic techniques confirmed the functionalization of CNTs and polymer and thermal measurements revealed improved thermal stability and conductivity. Quantum dots of CuInS2 were synthesized and characterized for potential use in solar cells. Solar cell devices with Au as counter electrode achieved an enhanced power conversion efficiency of 0.81% due to reduced electron-hole pair recombination and improved hole transportation.
Article
Nanoscience & Nanotechnology
Shivam Tiwari, Anupama Devi, Dipesh Kumar Dubey, Pralay Maiti
Summary: A flexible and easily processable polymer composite is developed from naturally occurring piezoelectric materials for efficient energy-harvesting applications. The induced electroactive phases in tomato peel (TP)-and cotton (CTN)-based poly(vinylidene fluoride) (PVDF) composites have been explored through structural, thermal, and morphological analyses. The CTN-based composite shows higher output voltage and current compared to the TP-based composites due to significant induction of the piezoelectric phase in the presence of suitable electroactive cotton, demonstrating its potential as an efficient and sustainable biomechanical energy harvester.
ACS APPLIED BIO MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Manojit Das, Arijit Jana, Rajat Mishra, Swapan Maity, Pralay Maiti, Sushanta Kumar Panda, Rahul Mitra, Amit Arora, Peter Samora Owuor, Chandra Sekhar Tiwary
Summary: Direct ink writing (DIW) additive manufacturing is a versatile 3D printing technique that can print a variety of materials with well-engineered ink. DIW has great potential in tissue engineering for repairing and regenerating deformed or missing organs or tissues.
ACS APPLIED BIO MATERIALS
(2023)
Article
Thermodynamics
Shivam Tiwari, Dipesh Kumar Dubey, Om Prakash, Santanu Das, Pralay Maiti
Summary: Carbon nanofibers (CNF) have been functionalized to enhance their surface property and applied in energy harvesting applications. Electrospun composite fibers with electroactive filler show improved properties compared to the pristine poly(vinylidene fluoride) (PVDF), and computational studies analyze the role of structural conformations and the effect of the filler. The device developed from the electrospun scaffold demonstrates high efficiency in generating output voltage and current through different modes, attributed to the mechanistic pathway of charge generation and transformation of non-piezo to piezo-active parts.
Review
Energy & Fuels
Sunil Kumar, Pralay Maiti
Summary: This review focuses on functional polymers for electrolytes, the interface between photosensitizers and polymers, thermodynamic interactions, and power conversion efficiencies of third generation (3G) photovoltaic devices. Functional polymers offer a potential avenue for the development of stable and efficient photovoltaic reactions at low cost based on dyes, quantum dots, and perovskite-sensitized solar conversion systems.
Article
Chemistry, Multidisciplinary
Neelam Gupta, Swapan Maity, Anamika, Ravi Prakash Behere, Prabhash Mahata, Biswajit Maiti, Pralay Maiti, Biplab Kumar Kuila
Summary: In this study, two soluble and highly fluorescent triazine-based conjugated polymer networks (TCPNs) were synthesized by conjugating a thiophene unit with a triazine ring through a phenyl linker. The effect of introducing alkyl and oligoethylene glycol side chains on the TCPNs' solubility, optical properties, conductivity, and biological activities was investigated. Additionally, non-oxidative doping of the TCPNs was achieved through the reaction with a Lewis acid, leading to significant optical switching and conductivity changes. These TCPNs also demonstrated stability and gelation after doping, and exhibited abilities for fluorescence imaging and cancer cell inhibition. This study highlights the potential applications of triazine-based conjugated polymer networks in electronic, optoelectronic, cell imaging, and chemotherapeutic fields.
NEW JOURNAL OF CHEMISTRY
(2023)
Review
Medicine, Research & Experimental
Swikriti Tripathi, Subham Shekhar Mandal, Sudepta Bauri, Pralay Maiti
Summary: 3D bioprinting is an emerging innovative technology that combines engineering, manufacturing, art, education, and medicine to revolutionize biomedical applications. It involves incorporating cells with biocompatible materials to create tissue or organ models for in vivo applications. However, there are challenges related to material selection, cell types, and their growth and differentiation factors.
Review
Nanoscience & Nanotechnology
Sudepta Bauri, Swikriti Tripathi, Avishek Mallick Choudhury, Subham Sekhar Mandal, Hans Raj, Pralay Maiti
Summary: The concept of theranostics is groundbreaking in cancer remedy as it combines therapeutic and diagnostic elements in one approach. Nanocarriers play a vital role in this method, but also face various challenges. Different nanomaterials have been integrated to enhance the therapeutic efficacy and diagnostic ability.
ACS APPLIED NANO MATERIALS
(2023)
Article
Materials Science, Biomaterials
Sourov Mondal, Archana Kumari, Kheyanath Mitra, Abhineet Verma, Satyen Saha, Biswajit Maiti, Ranjeet Singh, Partha Pratim Manna, Pralay Maiti, Hironobu Watanabe, Masami Kamigaito, Biswajit Ray
Summary: A new acrylamide monomer and polymer have been synthesized and their properties have been controlled by varying the copolymer composition. The LCST and T-g of the polymers are found to be dependent on their composition, and the polymers exhibit good thermal stability. Additionally, the properties of the copolymers are affected by concentration and external additives. The copolymers can serve as nano-carriers for drugs and demonstrate promising anti-tumor activity.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Review
Medicine, Research & Experimental
Aparna Shukla, Pralay Maiti
Summary: Nanomedicine is a powerful tool for developing innovative drug carriers with greater efficacy and fewer side effects in cancer treatment. This review discusses different nanocarriers, their routes of administration, and the effect of dimensional properties on chemotherapy. It also highlights emerging therapies, such as photothermal, photodynamic, immunotherapy, chemodynamic, and gas therapy, and their advantages compared to conventional molecular anticancer therapies.
