Formal [3 + 2] cycloaddition of α-unsubstituted isocyanoacetates and methyleneindolinones: enantioselective synthesis of spirooxindoles

The Application of N-Protected 3-Vinylindoles in Chiral Phosphoric Acid-Catalyzed [3+2] Cyclization with 3-Indolylmethanols: Monoactivation of the Catalyst to Vinyliminium

(2016) Tao Fan et al.   ADVANCED SYNTHESIS & CATALYSIS

Chiral phosphoric acid catalyzed enantioselective 1,3-dipolar cycloaddition reaction of azlactones

(2016) Zhenhua Zhang et al.   CHEMICAL COMMUNICATIONS

Catalytic asymmetric chemoselective 1,3-dipolar cycloadditions of an azomethine ylide with isatin-derived imines: diastereo- and enantioselective construction of a spiro[imidazolidine-2,3′-oxindole] framework

(2016) Yue-Ming Wang et al.   CHEMICAL COMMUNICATIONS

Enantioselective Synthesis of Indole-Annulated Medium-Sized Rings

(2016) Lin Huang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Thiourea–Quaternary Ammonium Salt Catalyzed Asymmetric 1, 3-Dipolar Cycloaddition of Imino Esters To Construct Spiro[pyrrolidin-3,3′-oxindoles]

(2016) Jia-Xing Zhang et al.   ORGANIC LETTERS

Organocatalytic Diels-Alder Reaction of 2-Vinylindoles with Methyleneindolinones: An Efficient Approach to Functionalized Carbazolespirooxindoles

(2015) Lin-Jie Huang et al.   ADVANCED SYNTHESIS & CATALYSIS

Direct Catalytic Enantio- and Diastereoselective Ketone Aldol Reactions of Isocyanoacetates

(2015) Raquel de la Campa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Brønsted Acid Catalyzed Asymmetric Diels–Alder Reactions: Stereoselective Construction of Spiro[tetrahydrocarbazole-3,3′-oxindole] Framework

(2015) Yang Wang et al.   JOURNAL OF ORGANIC CHEMISTRY

Asymmetric [3 + 2] Cycloaddition of Methyleneindolinones with N,N′-Cyclic Azomethine Imines Catalyzed by a N,N′-Dioxide–Mg(OTf)2 Complex

(2015) Chengkai Yin et al.   JOURNAL OF ORGANIC CHEMISTRY

Diastereo- and Enantioselective Construction of 3,3′-Pyrrolidinyldispirooxindole Framework via Catalytic Asymmetric 1,3-Dipolar Cycloadditions

(2015) Wei Dai et al.   JOURNAL OF ORGANIC CHEMISTRY

Asymmetric Annulation of Donor–Acceptor Cyclopropanes with Dienes

(2015) Hao Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic Divergent Synthesis of 3H or 1H Pyrroles by [3 + 2] Cyclization of Allenoates with Activated Isocyanides

(2015) Jia-Yu Liao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ligand Control of Diastereodivergency in Asymmetric Inverse Electron Demand Diels–Alder Reaction

(2015) Xiaoyu Hao et al.   ACS Catalysis

Direct Catalytic Enantio- and Diastereoselective Mannich Reaction of Isocyanoacetates and Ketimines

(2014) Irene Ortín et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

PyBidine-Cu(OTf)2-Catalyzed Asymmetric [3+2] Cycloaddition with Imino Esters: Harmony of Cu-Lewis Acid and Imidazolidine-NH Hydrogen Bonding in Concerto Catalysis

(2014) Takayoshi Arai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highly Diastereo- and Enantioselective Silver-Catalyzed Double [3+2] Cyclization of α-Imino Esters with Isocyanoacetate

(2014) Pan-Lin Shao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent advances in the synthesis of biologically active spirooxindoles

(2014) Maria M.M. Santos   TETRAHEDRON

Highly enantioselective synthesis of chiral 7-ring O- and N-heterocycles by a one-pot nitro-Michael–cyclization tandem reaction

(2013) Renate Rohlmann et al.   CHEMICAL COMMUNICATIONS

Catalytic [4+2] Cyclization of α,β-Unsaturated Acyl Chlorides with 3-Alkylenyloxindoles: Highly Diastereo- and Enantioselective Synthesis of Spirocarbocyclic Oxindoles

(2012) Li-Tao Shen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organocatalytic stereocontrolled synthesis of 3,3′-pyrrolidinyl spirooxindoles by [3+2] annulation of isocyanoesters with methyleneindolinones

(2012) Liang-Liang Wang et al.   CHEMICAL COMMUNICATIONS

Enantioselective synthesis of 3,3′-dihydropyrryl-spirooxindoles via an organocatalytic three-component reaction

(2012) Wen-Tao Wei et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

N-Heterocyclic Carbene-Catalyzed Cyclization of Unsaturated Acyl Chlorides and Ketones

(2011) Li-Tao Shen et al.   ADVANCED SYNTHESIS & CATALYSIS

Enantioselective Michael/Cyclization Reaction Sequence: Scaffold-Inspired Synthesis of Spirooxindoles with Multiple Stereocenters

(2011) Yiming Cao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

N-Heterocyclic Carbene Catalysis: Enantioselective Formal [2+2] Cycloaddition of Ketenes and N-Sulfinylanilines

(2011) Teng-Yue Jian et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A highly organocatalytic stereoselective double Michael reaction: efficient construction of optically enriched spirocyclic oxindoles

(2011) Liang-Liang Wang et al.   CHEMICAL COMMUNICATIONS

Core Structure-Based Design of Organocatalytic [3+2]-Cycloaddition Reactions: Highly Efficient and Stereocontrolled Syntheses of 3,3′-Pyrrolidonyl Spirooxindoles

(2011) Bin Tan et al.   CHEMISTRY-A EUROPEAN JOURNAL

Asymmetric Formal [3+2] Cycloaddition Reaction of Isocyanoesters to 2-Oxobutenoate Esters by a Multifunctional Chiral Silver Catalyst

(2011) Jin Song et al.   CHEMISTRY-A EUROPEAN JOURNAL

Highly Enantioselective γ-Amination of α,β-Unsaturated Acyl Chlorides with Azodicarboxylates: Efficient Synthesis of Chiral γ-Amino Acid Derivatives

(2011) Li-Tao Shen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A New Family of Cinchona-Derived Amino Phosphine Precatalysts: Application to the Highly Enantio- and Diastereoselective Silver-Catalyzed Isocyanoacetate Aldol Reaction

(2011) Filippo Sladojevich et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

CH activation and CH2 double activation of indolines by radical translocation: Understanding the chemistry of the indolinyl radical

(2011) David C. Harrowven et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Enantioselective Synthesis of 2,3-Dihydro-1H-benzo[b]azepines: Iridium-Catalyzed Tandem Allylic Vinylation/Amination Reaction

(2010) Hu He et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Formal [3+2] Cycloaddition of Ketenes and Oxaziridines Catalyzed by Chiral Lewis Bases: Enantioselective Synthesis of Oxazolin-4-ones

(2010) Pan-Lin Shao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highly organocatalytic asymmetric Michael–ketone aldol–dehydration domino reaction: straightforward approach to construct six-membered spirocyclic oxindoles

(2010) Liang-Liang Wang et al.   CHEMICAL COMMUNICATIONS

Enantioselective Synthesis of Indole-Fused Dihydropyranones via Catalytic Cycloaddition of Ketenes and 3-Alkylenyloxindoles

(2010) Hui Lv et al.   JOURNAL OF ORGANIC CHEMISTRY

Highly enantioselective synthesis and cellular evaluation of spirooxindoles inspired by natural products

(2010) Andrey P. Antonchick et al.   Nature Chemistry

Three New Indole Alkaloids fromTrigonostemon lii

(2010) Cheng-Jian Tan et al.   ORGANIC LETTERS

Enantioselective [4+2] cycloaddition of ketenes and 9,10-phenanthrenequinone catalyzed by N-heterocyclic carbenes

(2010) Pan-Lin Shao et al.   TETRAHEDRON LETTERS

Organocatalytic Synthesis of Spiro[pyrrolidin-3,3′-oxindoles] with High Enantiopurity and Structural Diversity

(2009) Xiao-Hua Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric Synthesis of Medium-Sized Rings by Intramolecular Au(I)-Catalyzed Cyclopropanation

(2009) Iain D. G. Watson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Synthesis of β-Trifluoromethyl-β-lactones via NHC-Catalyzed Ketene−Ketone Cycloaddition Reactions

(2009) Xiao-Na Wang et al.   ORGANIC LETTERS

Asymmetric Syntheses of Oxindole and Indole Spirocyclic Alkaloid Natural Products

(2009) Barry Trost et al.   SYNTHESIS-STUTTGART

[4+2] Cycloaddition of Ketenes withN-Benzoyldiazenes Catalyzed by N-Heterocyclic Carbenes

(2008) Xue-Liang Huang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rh-Catalyzed Carbonyl Hydroacylation:  An Enantioselective Approach to Lactones

(2008) Zengming Shen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

N-Heterocyclic carbene catalysed β-lactam synthesis

(2008) Nicolas Duguet et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

(2008) S. Shangary et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chiral N-Heterocyclic Carbene Catalyzed Staudinger Reaction of Ketenes with Imines:  Highly Enantioselective Synthesis ofN-Boc β-Lactams

(2007) Yan-Rong Zhang et al.   ORGANIC LETTERS