Article
Biochemistry & Molecular Biology
Sebastian Wimmer, Lisa Deloch, Michael Hader, Anja Derer, Fridolin Grottker, Thomas Weissmann, Markus Hecht, Antoniu-Oreste Gostian, Rainer Fietkau, Benjamin Frey, Udo S. Gaipl
Summary: Following radiotherapy, the HPV status may not distinctly predict immunological responses, highlighting the importance of individualized ICM expression in selecting patients for targeted immune therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Alexandra Ruth Glathar, Akinsola Oyelakin, Christian Gluck, Jonathan Bard, Satrajit Sinha
Summary: The heterogeneity of head and neck squamous cell carcinoma (HNSCC) is reflected in its diverse etiology, including Human Papillomavirus-positive (HPV+) HNSCC subtypes. One aggressive subtype of HPV+ HNSCC is characterized by elevated expression of genes involved in keratinization, which is regulated by the oncogenic transcription factor Delta Np63. The TP63 gene locus is frequently targeted by HPV integration, and HPV oncoproteins drive Delta Np63 expression, suggesting a functional link between Delta Np63 and HPV+ HNSCC that has not been explored. This study demonstrates that HPV+ HNSCCs can be classified based on Delta Np63 expression levels, and an associated gene signature profile is derived. The study also identifies crucial Delta Np63-bound super-enhancers that likely mediate subtype-specific gene expression in HPV+ HNSCC, anchored by the PI3K-mTOR pathway. These findings highlight the importance of Delta Np63 as a key regulator of oncogenic pathways in a specific subtype of HPV+ HNSCC, and suggest its potential as a biomarker for patient stratification and treatment choices.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Kirsty Taylor, Jinfeng Zou, Marcos Magalhaes, Marc Oliva, Anna Spreafico, Aaron R. Hansen, Simon S. McDade, Vicky M. Coyle, Mark Lawler, Elena Elimova, Scott V. Bratman, Lillian L. Siu
Summary: Immune checkpoint blockade is an important treatment for recurrent/metastatic head and neck squamous cell cancer, but only a subset of patients benefit from it. Monitoring plasma circulating tumor DNA (ctDNA) levels and changes during treatment can help assess disease burden and predict patient outcomes. This study showed that early changes in ctDNA after one cycle of treatment can predict progression-free survival and overall survival in patients with recurrent/metastatic head and neck squamous cell cancer.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Oncology
Guangxu Xuan, Xin Zhang, Min Zhang, Minghang Yu, Yujie Zhou, Xiaosong He, Xiaopeng Hu, Xi Wang, Liangfa Liu
Summary: This study found that the expression of NTF2 was significantly increased in HNSCC tissue and high expression levels were associated with poor prognosis. NTF2 was found to be involved in epithelial cell growth, skin differentiation, keratosis, and estrogen metabolism. The expression of NTF2 was negatively correlated with immune infiltrations and correlated with immune checkpoint blockade responses. Experimental verifications confirmed the promoting effects of NTF2 on the proliferation and migration of tumor cells.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Yuchen Shen, Xinyu Li, Deming Wang, Liming Zhang, Xiao Li, Lixin Su, Xindong Fan, Xitao Yang
Summary: This study aimed to identify a novel prognostic biomarker for head and neck squamous cell carcinoma (HNSCC) based on tumor immunology-related alternative splicing (AS). Through the establishment of an AS-related risk model, the researchers found that Collagen Type III Alpha 1 Chain (COL3A1) is a reliable biomarker for predicting the prognosis of HNSCC patients. COL3A1 expression levels were elevated in HNSCC tissues compared to normal tissues and were associated with HNSCC differentiation and T stage. Additionally, COL3A1 was found to be better at evaluating immune cell infiltrations and activities in HNSCC lesions compared to the risk model.
Article
Oncology
Elia Lombardo, Julia Hess, Christopher Kurz, Marco Riboldi, Sebastian Marschner, Philipp Baumeister, Kirsten Lauber, Ulrike Pflugradt, Axel Walch, Martin Canis, Frederick Klauschen, Horst Zitzelsberger, Claus Belka, Guillaume Landry, Kristian Unger
Summary: A explainable convolutional neural network classifier, DeepClassPathway, is proposed to predict HPV status and identify molecular pathways driving classifier decisions in head and neck cancer patients. The classification performance achieved high accuracy and highlighted key pathways for HPV positive and negative patients.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Immunology
Wanzun Lin, Yanyan Xu, Jing Gao, Haojiong Zhang, Yun Sun, Xianxin Qiu, Qingting Huang, Lin Kong, Jiade J. Lu
Summary: The study identifies B7-H3 as a novel biomarker for head and neck squamous cell carcinoma (HNSCC), predicting prognosis and response to immunotherapy; high expression of B7-H3 is associated with poor prognosis, immunotherapy resistance, and contributes to an immunosuppressive microenvironment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Sashi Kandel, Pratik Adhikary, Guangfu Li, Kun Cheng
Summary: The blockade of the TIM3/Gal9 pathway shows promising therapeutic potential in cancer treatment, by enhancing immune response and overcoming immune resistance. TIM3 and Gal9 may also serve as prognostic and predictive biomarkers in different types of cancers.
Article
Oncology
Benedikt Schmidl, Michael Siegl, Melanie Boxberg, Fabian Stoegbauer, Daniel Jira, Christof Winter, Leonhard Stark, Anja Pickhard, Barbara Wollenberg, Markus Wirth
Summary: The NOTCH1 gene mutation is common in squamous cell carcinoma in the head and neck. This study found that a high expression of NOTCH1 is associated with reduced survival in these patients. In vitro experiments showed that knocking down NOTCH1 reduces migration and proliferation of cancer cells. This suggests that NOTCH1 is involved in the migration and proliferation of head and neck squamous cell carcinoma and could be a prognostic marker.
Article
Oncology
Sara Varatanovic, Stefan Stoiber, Markus Haas, Alexander Lein, Lorenz Kadletz-Wanke, Faris F. Brkic
Summary: MK0752 shows potential as a therapeutic agent for HPV-positive HNSCC by exhibiting antineoplastic effects and inducing apoptosis. Further investigation is needed to validate these findings and understand the underlying mechanisms.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Neil Shende, Jingyue Xu, Wei Tse Li, Jeffrey Liu, Jaideep Chakladar, Kevin T. Brumund, Weg M. Ongkeko
Summary: This study investigated the effects of smoking and HPV infection on eRNA expression in HNSCC tumors. The research found a substantial number of differentially expressed eRNA in each patient cohort, with some dysregulated eRNA correlated to patient survival, clinical variables, immune pathways, and genomic alterations. Additionally, dysregulated eRNA near key HNSCC-related oncogenes were identified, providing potential insights into the relationship between eRNA expression, enhancer activity, and nearby gene dysregulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Mingyuan Zou, Huina Wu, Meiling Zhou, Feng Xiao, GuliNazhaer Abudushalamu, Yuming Yao, Fengfeng Zhao, Wei Gao, Xuejiao Yan, Xiaobo Fan, Guoqiu Wu
Summary: Immunotherapy is a promising treatment for HNSCC, but only a small percentage of patients benefit from it. Identifying molecular markers for prognosis and predicting immunotherapy response is important. CLEC10A plays a role in enhancing immune cells' antitumor activity. This study analyzed CLEC10A expression in HNSCC and its association with tumor progression, HPV status, and patient survival. Low CLEC10A expression correlated with advanced clinical stage and poor prognosis, while higher expression correlated with immune infiltration and immunotherapy response.
CELLULAR IMMUNOLOGY
(2022)
Article
Oncology
Ruben Rodriguez-Bautista, Claudia H. Caro-Sanchez, Paula Cabrera-Galeana, Gerardo J. Alanis-Funes, Everardo Gutierrez-Millan, Santiago Avila-Rios, Margarita Matias-Florentino, Gustavo Reyes-Teran, Jose Diaz-Chavez, Cynthia Villarreal-Garza, Norma Y. Hernandez-Pedro, Alette Ortega-Gomez, Luis Lara-Mejia, Claudia Rangel-Escareno, Oscar Arrieta
Summary: Triple-negative breast cancer (TNBC) is a highly aggressive and heterogeneous disease with seven subtypes based on gene expression patterns. The immunomodulatory (IM) subtype showed distinct immune microenvironment and specific genomic alterations, providing potential guidance for immune-based therapy in this subgroup of patients.
Review
Oncology
Sharon Changshan Wu, Karl Munger
Summary: Cancer/testis antigens show potential as therapeutic targets and prognostic biomarkers in head and neck squamous cell carcinoma, warranting further study to elucidate their role in the pathogenesis of these cancers. Their differential expression in HPV-positive HNSCC may mechanistically contribute to the genesis and clinical characteristics of these cancers, making them attractive targets for immunotherapies. These antigens, historically linked to diverse cancers, are increasingly implicated in various hallmarks of cancer, suggesting potential as cancer drivers.
Article
Immunology
Linyang Gan, Huan Chen, Xiaowei Liu, Li Zhang
Summary: This study investigated the incidence of immune-related adverse events (irAEs) of immune checkpoint inhibitor therapy and reported the clinical features, management, and outcomes of ophthalmic irAEs. Medical records of 962 patients who received ICI therapy were retrospectively reviewed, and 248 patients (25.8%) experienced irAEs. The first-year incidences of total irAEs and ophthalmic irAEs were 23.5% and 1.1% respectively. The most common ICI received was pembrolizumab (38.8%).
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Guiquan Zhu, Bangrong Cao, Xinhua Liang, Longjiang Li, Yaying Hao, Wanrong Meng, Chuanshi He, Linlin Wang, Ling Li
Summary: This study revealed the mechanisms by which hypoxic cancer cells induce CAF-like differentiation through secreting sEVs and TGF-beta, with miRNAs delivered by sEVs playing a crucial role in this process. Elevated levels of miR-192/215 in HNSCC tissue-derived sEVs indicated a hypoxic and aggressive cancer stroma, and miR-215 in tumor tissue-derived sEVs was associated with poor overall survival in HNSCC patients. The findings suggest that sEVs serve as a messenger to transfer miRNAs from cancer cells to fibroblasts, contributing to the remodeling of the hypoxic tumor microenvironment and indicating the potential of cancer tissue-derived sEVs as biomarkers.
Review
Oncology
Siyao Deng, Wenjing Ye, Shichuan Zhang, Guiquan Zhu, Peng Zhang, Yanqiong Song, Fanglei Duan, Jinyi Lang, Shun Lu
Summary: This case report describes a patient with Fanconi anemia who developed oral tongue cancer and experienced severe bone marrow failure after receiving cisplatin/radiation treatment. Genetic testing revealed novel mutations in the FANCA gene inherited from the patient's parents. Despite successful symptom relief with reduced-dose radiotherapy, the patient eventually died of disease progression.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Oncology
Wei Dai, Wenhong Feng, Yuanqiang Zhang, Xin Shelley Wang, Yangjun Liu, Cecilia Pompili, Wei Xu, Shaohua Xie, Yaqin Wang, Jia Liao, Xing Wei, Run Xiang, Bin Hu, Bo Tian, Xiaozun Yang, Xiang Wang, Ping Xiao, Qi Lai, Xin Wang, Bangrong Cao, Qifeng Wang, Fang Liu, Xiaoqin Liu, Tianpeng Xie, Xiaojun Yang, Xiang Zhuang, Zhong Wu, Guowei Che, Qiang Li, Qiuling Shi
Summary: The study evaluated the efficacy and feasibility of patient-reported outcome (PRO)-based symptom management in the early period after lung cancer surgery. Results showed that PRO-based symptom management reduced symptom burden and complications compared to usual care.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Review
Oncology
Ruochong Wang, Guiquan Zhu
Summary: The Hippo-YAP pathway is becoming increasingly important in regulating cancers, with various binary oppositions and contradictory points emerging. While these complexities present challenges for current research, they also offer opportunities for fresh insights and future drug development.
TRANSLATIONAL CANCER RESEARCH
(2022)
Review
Dentistry, Oral Surgery & Medicine
En Long, Dongling You, Shubin Wang, Shun Lu, Peng Xu, Jie Zhou, Lu Li, Jian Wu, Biqin Zhang, Guiquan Zhu, Jinyi Lang
Summary: This study investigates the prognostic factors and treatment of primary intraosseous carcinoma (PIOC). The results suggest that surgery combined with adjuvant therapy is the superior treatment strategy for PIOC, and radiotherapy plays a positive role in the treatment of PIOC.
Article
Oncology
Su Chen, Khaled Alkebsi, Ming Xuan, Xiao-Yi Wang, Long-Jiang Li, Chun-Jie Li, Zhuang Zhang, Gui-Quan Zhu
Summary: Endoscopic parotidectomy is becoming a reliable procedure for benign and low-grade malignant parotid gland tumors, but it requires more precision and experience compared to traditional surgery. Clinicians have summarized a seven-step single incision-plus approach for gasless endoscopic parotidectomy through clinical exploration.
TRANSLATIONAL CANCER RESEARCH
(2022)
Article
Genetics & Heredity
Xiaoxia Wen, Guishu Yang, Yongcheng Dong, Liping Luo, Bangrong Cao, Birga Anteneh Mengesha, Ruiling Zu, Yulin Liao, Chang Liu, Shi Li, Yao Deng, Kaijiong Zhang, Xin Ma, Jian Huang, Dongsheng Wang, Keyan Zhao, Ping Leng, Huaichao Luo
Summary: Many studies have shown that certain messenger RNA (mRNA) in platelets can serve as biomarkers for diagnosing pan-cancer. This study used bioinformatics and functional analysis to identify and validate reference genes for pan-cancer diagnosis based on platelet transcript analysis. The results confirmed that GAPDH gene was the most suitable reference gene for this purpose, providing a platform for molecular diagnosis of pan-cancer using platelets.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Chang Sun, Shubin Wang, Wenjing Ye, RanLin Wang, Mingyu Tan, Hanyi Zhang, Jie Zhou, Minglun Li, Lichun Wei, Peng Xu, Guiquan Zhu, Jinyi Lang, Shun Lu
Summary: This study aimed to investigate the relationship between prognostic and tumor parameters of cervical cancer patients, and found that tumor size, tumor volume, and tumor volume reduction rate are associated with patients' survival rates.
FRONTIERS IN ONCOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Guiquan Zhu, Fan Yang, Hongxuan Wei, Wanrong Meng, Jianguo Gan, Linlin Wang, Chuanshi He, Shun Lu, Bangrong Cao, Huaichao Luo, Bo Han, Ling Li
Summary: Using mass spectrometry-based high-throughput proteomics, researchers discovered a membrane protein called 90 K on extracellular vesicles (EVs), which is associated with poor overall survival of head and neck cancer patients. Levels of 90 K in serum EVs can independently predict poor prognosis. Tumor-derived EVs (TDEs) pre-treatment in immune competent mice creates an immune-suppressive micro-environment for tumor cells regulated by 90 K.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Wei Zhang, Hongyuan Jia, Zhuzhong Cheng, Wei Diao, Yi Wang, Bangrong Cao, Ying Kou, Qifeng Wang
Summary: This study assessed the prognostic value of PET/CT parameters in patients with locally advanced ESSC. The results showed that TLG, MTV, and SUVmax were correlated with overall survival, with SUVmax being the only independent prognostic factor.
NUCLEAR MEDICINE COMMUNICATIONS
(2022)
Article
Oncology
Jie Zhu, Yongtao Han, Wenjie Ni, Xiao Chang, Lei Wu, Yi Wang, Li Jiang, Yan Tan, Zefen Xiao, Qifeng Wang, Lin Peng
Summary: This study aimed to develop a prognostic nomogram, quantify survival benefit, and guide risk-dependent adjuvant therapy for locally advanced esophageal squamous cell carcinoma (LA-ESCC) after esophagectomy. The nomogram showed superior discriminative capacity than TNM stage and provided risk-dependent and individualized adjuvant treatment recommendations. The survival improvement from adjuvant therapy was quantified and plotted corresponding to nomogram score, with at least 10% 5-year survival improvement expected in almost all patients and patients mainly with high-intermediate risk.
Article
Oncology
Wei Zhang, Hongyuan Jia, Xue Chen, Wei Diao, Xuefeng Leng, Bangrong Cao, Yi Wang, Zhuzhong Cheng, Qifeng Wang
Summary: This study found that preoperative mean platelet volume (MPV) can predict prognosis and guide postoperative chemoradiotherapy in patients with locally advanced esophageal squamous cell carcinoma. Higher MPV is associated with a better survival rate, and postoperative chemoradiotherapy improves survival in patients with low MPV.
FRONTIERS IN ONCOLOGY
(2023)
Article
Surgery
Miao Yu, Li Xia, Bangrong Cao, Meihua Wang, Shuanghua Liu, Shiwei Liu, Exian Mou, Hui Li, Hao Wang
Summary: This study compares the effects of breast-conserving surgery (BCS) and mastectomy on the survival of female patients with multifocal multicenter breast cancer (MIBC). The results show that for early, good prognosis, and treatment-sensitive patients, there is no survival advantage for BCS, and mastectomy provides better survival outcomes.
Article
Oncology
Ruiling Zu, Lin Wu, Rong Zhou, Xiaoxia Wen, Bangrong Cao, Shan Liu, Guishu Yang, Ping Leng, Yan Li, Li Zhang, Xiaoyu Song, Yao Deng, Kaijiong Zhang, Chang Liu, Yuping Li, Jian Huang, Dongsheng Wang, Guiquan Zhu, Huaichao Luo
Summary: This study developed a predictive model based on platelet features to assist in the diagnosis of early stage malignancy, ensuring accurate diagnosis and optimal management.
