Article
Computer Science, Interdisciplinary Applications
Siddharth Narayanan, Nicholas Polys, Ivica Ico Bukvic
Article
Neurosciences
Lin Luo, Mateusz C. Ambrozkiewicz, Fritz Benseler, Cui Chen, Emilie Dumontier, Susanne Falkner, Elisabetta Furlanis, Andrea M. Gomez, Naosuke Hoshina, Wei-Hsiang Huang, Mary Anne Hutchison, Yu Itoh-Maruoka, Laura A. Lavery, Wei Li, Tomohiko Maruo, Junko Motohashi, Emily Ling-Lin Pai, Kenneth A. Pelkey, Ariane Pereira, Thomas Philips, Jennifer L. Sinclair, Jeff A. Stogsdill, Lisa Traunmueller, Jiexin Wang, Joke Wortel, Wenjia You, Nashat Abumaria, Kevin T. Beier, Nils Brose, Harold A. Burgess, Constance L. Cepko, Jean-Francois Cloutier, Cagla Eroglu, Sandra Goebbels, Pascal S. Kaeser, Jeremy N. Kay, Wei Lu, Liqun Luo, Kenji Mandai, Chris J. McBain, Klaus-Armin Nave, Marco A. M. Prado, Vania F. Prado, Jeffrey Rothstein, John L. R. Rubenstein, Gesine Saher, Kenji Sakimura, Joshua R. Sanes, Peter Scheiffele, Yoshimi Takai, Hisashi Umemori, Matthijs Verhage, Michisuke Yuzaki, Huda Yahya Zoghbi, Hiroshi Kawabe, Ann Marie Craig
Article
Environmental Sciences
Sofia Rincon-Gallardo Patino, Srijith Rajamohan, Kathleen Meaney, Eloise Coupey, Elena Serrano, Valisa E. Hedrick, Fabio da Silva Gomes, Nicholas Polys, Vivica Kraak
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2020)
Article
Neurosciences
Josiah D. Zoodsma, Kelvin Chan, Ashwin A. Bhandiwad, David R. Golann, Guangmei Liu, Shoaib A. Syed, Amalia J. Napoli, Harold A. Burgess, Howard Sirotkin, Lonnie P. Wollmuth
JOURNAL OF NEUROSCIENCE
(2020)
Article
Computer Science, Software Engineering
M. Dahshan, N. F. Polys, R. S. Jayne, R. M. Pollyea
COMPUTER GRAPHICS FORUM
(2020)
Article
Cell Biology
Giampaolo Trivellin, Amit Tirosh, Laura C. Hernandez-Ramirez, Tripti Gupta, Chon Hwa Tsai-Morris, Fabio R. Faucz, Harold A. Burgess, Benjamin Feldman, Constantine A. Stratakis
Summary: Both gpr101 loss- and gain-of-function affect fertility, embryonic patterning, growth, and brain development in different ways. Using zebrafish models, the study found that loss of gpr101 led to a significant reduction in body size and subfertility, accompanied by gastrulation and hypothalamic defects. On the other hand, ectopic gpr101 expression perturbed the embryonic body plan but did not affect growth.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Toxicology
Travon Cooman, Sadie A. Bergeron, Rebecca Coltogirone, Eric Horstick, Luis Arroyo
Summary: The study evaluated the effects of fentanyl on the development and metabolism of zebrafish, finding significant impacts on survival and development, as well as notable defects to the tail, yolk, and pericardium. Metabolites of fentanyl were detected in zebrafish larvae, presenting a single in vivo model for assessing the toxicity and metabolism of fentanyl exposure in a vertebrate system.
JOURNAL OF APPLIED TOXICOLOGY
(2022)
Article
Behavioral Sciences
John Hageter, Matthew Waalkes, Jacob Starkey, Haylee Copeland, Heather Price, Logan Bays, Casey Showman, Sean Laverty, Sadie A. Bergeron, Eric J. Horstick
Summary: Innate behavioral biases like human handedness are common forms of inter-individual variation, influenced by genetic and environmental factors. Research on larval zebrafish shows significant individual variation in turning preference, impacted by factors like temperature and pharmacological manipulation of Notch signaling. Results suggest larval zebrafish is a valuable vertebrate model for studying inter-individual variation in behavior and neural development.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Genetics & Heredity
Josiah D. Zoodsma, Emma J. Keegan, Gabrielle R. Moody, Ashwin A. Bhandiwad, Amalia J. Napoli, Harold A. Burgess, Lonnie P. Wollmuth, Howard Sirotkin
Summary: This study used CRISPR-Cas9 technology to generate zebrafish lacking GluN2B, showing similar structural and functional properties to humans, and revealing a specific deficit in social behavior. Despite the lack of GluN2B not resulting in broad disruption of neurodevelopment in zebrafish, there are significant differences in specific behaviors.
Article
Multidisciplinary Sciences
Ashwin A. Bhandiwad, Nickolas C. Chu, Svetlana A. Semenova, George A. Holmes, Harold A. Burgess
Summary: Sudden changes in the environment can trigger defensive behavior, such as tonic immobility, in organisms. This study reveals that a strong vibratory stimulus can induce tonic immobility in larval zebrafish through the regulation of cerebellar granule cells and a cluster of glutamatergic ventral prepontine neurons (vPPNs) that express stress-associated neuropeptides.
Article
Biology
Fatimah Matalkah, Bohye Jeong, Macie Sheridan, Eric Horstick, Visvanathan Ramamurthy, Peter Stoilov
Summary: RNA-binding proteins Musashi 1 and 2 play important roles in the survival and function of photoreceptor cells, regulating splicing and protein expression. Their roles in stem cells are opposite to their roles in mature photoreceptor cells, but they are still essential.
COMMUNICATIONS BIOLOGY
(2022)
Review
Neurosciences
Jacob Starkey, Eric J. Horstick, Sarah D. Ackerman
Summary: Animal behavior relies on the accurate wiring of neurons into neural circuits, which undergo significant remodeling during critical periods. Environmental experiences during these periods can have lasting effects on circuit function and behavior. Understanding the mechanisms that regulate critical period timing is crucial for studying neurodevelopmental disorders, and glial cells may play a role in this process.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Biochemical Research Methods
John Hageter, Jacob Starkey, Allison Barr, Johnathon R. Huff, Eric J. Horstick
Summary: This article describes a minimally invasive protocol for immobilizing zebrafish during early development to control visual experience. The authors provide detailed instructions on preparing and embedding larvae, building a behavior rig, and analyzing behavioral data.
Review
Sport Sciences
Brian J. Andonian, Nicolas Hardy, Alon Bendelac, Nicholas Polys, William E. Kraus
Summary: CPET is a dynamic clinical tool for determining exercise limitation, providing fundamental knowledge of respiration coupling during exercise. Challenges in data interpretation have led to underuse, but this article reviews fundamental concepts and future directions for best utilizing CPET results in clinical care, aiming to make CPET testing more accessible and useful in medical practice.
CURRENT SPORTS MEDICINE REPORTS
(2021)
Article
Computer Science, Information Systems
Ming Wang, John Wenskovitch, Leanna House, Nicholas Polys, Chris North
Summary: This paper discusses the Two Black Boxes problem in interactive machine learning systems and cognitive gaps, proposing methods to open both black boxes through usability improvements. The redesigned Andromeda system performs well in high-dimensional data analysis tasks.
VISUAL INFORMATICS
(2021)