Avidity and Bystander Suppressive Capacity of Human Regulatory T Cells Expressing De Novo Autoreactive T-Cell Receptors in Type 1 Diabetes

Generation of human islet-specific regulatory T cells by TCR gene transfer

(2017) Caroline M. Hull et al.   JOURNAL OF AUTOIMMUNITY

Autoimmunity against a defective ribosomal insulin gene product in type 1 diabetes

(2017) Maria J L Kracht et al.   NATURE MEDICINE

Development of CAR T cells designed to improve antitumor efficacy and safety

(2017) Janneke E. Jaspers et al.   PHARMACOLOGY & THERAPEUTICS

Expansion of Human Tregs from Cryopreserved Umbilical Cord Blood for GMP-Compliant Autologous Adoptive Cell Transfer Therapy

(2017) Howard R. Seay et al.   Molecular Therapy-Methods & Clinical Development

Current approaches to increase CAR T cell potency in solid tumors: targeting the tumor microenvironment

(2017) Irene Scarfò et al.   Journal for ImmunoTherapy of Cancer

Aberrant Accumulation of the Diabetes Autoantigen GAD65 in Golgi Membranes in Conditions of ER Stress and Autoimmunity

(2016) Edward A. Phelps et al.   DIABETES

Islet-Derived CD4 T Cells Targeting Proinsulin in Human Autoimmune Diabetes

(2016) Aaron W. Michels et al.   DIABETES

Antithymocyte globulin therapy for patients with recent-onset type 1 diabetes: 2 year results of a randomised trial

(2016) Stephen E. Gitelman et al.   DIABETOLOGIA

Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes

(2016) Sarah J. Richardson et al.   DIABETOLOGIA

Efficacy and safety of otelixizumab use in new-onset type 1 diabetes mellitus

(2016) Chiara Guglielmi et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Genetically modified human CD4+T cells can be evaluatedin vivowithout lethal graft-versus-host disease

(2016) Riyasat Ali et al.   IMMUNOLOGY

Regulatory T cell therapy for type 1 diabetes: May the force be with you

(2016) Stephen E. Gitelman et al.   JOURNAL OF AUTOIMMUNITY

Long-Term Insulin Independence in Type 1 Diabetes Mellitus Using a Simplified Autologous Stem Cell Transplant

(2016) Olga Graciela Cantú-Rodríguez et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion

(2016) T. Delong et al.   SCIENCE

Domain-swapped T cell receptors improve the safety of TCR gene therapy

(2016) Michael T Bethune et al.   eLife

Generation of β cell-specific human cytotoxic T cells by lentiviral transduction and their survival in immunodeficient human leucocyte antigen-transgenic mice

(2015) J. Babad et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

A combination dual-sized microparticle system modulates dendritic cells and prevents type 1 diabetes in prediabetic NOD mice

(2015) Jamal S. Lewis et al.   CLINICAL IMMUNOLOGY

Micro and nanoparticle drug delivery systems for preventing allotransplant rejection

(2015) James D. Fisher et al.   CLINICAL IMMUNOLOGY

Islet autoantibody phenotypes and incidence in children at increased risk for type 1 diabetes

(2015) Eleni Z. Giannopoulou et al.   DIABETOLOGIA

Alefacept provides sustained clinical and immunological effects in new-onset type 1 diabetes patients

(2015) Mark R. Rigby et al.   JOURNAL OF CLINICAL INVESTIGATION

Divergent Phenotypes of Human Regulatory T Cells Expressing the Receptors TIGIT and CD226

(2015) Christopher A. Fuhrman et al.   JOURNAL OF IMMUNOLOGY

Immune Interventions to Preserve β Cell Function in Type 1 Diabetes

(2015) Mario R. Ehlers   JOURNAL OF INVESTIGATIVE MEDICINE

Type 1 diabetes immunotherapy using polyclonal regulatory T cells

(2015) Jeffrey A. Bluestone et al.   Science Translational Medicine

Autologous Nonmyeloablative Hematopoietic Stem Cell Transplantation in New-Onset Type 1 Diabetes: A Multicenter Analysis

(2014) F. D'Addio et al.   DIABETES

Going viral: chimeric antigen receptor T-cell therapy for hematological malignancies

(2014) Saar Gill et al.   IMMUNOLOGICAL REVIEWS

Regulatory T Cells Prevent Transfer of Type 1 Diabetes in NOD Mice Only When Their Antigen Is Present In Vivo

(2014) D. R. Tonkin et al.   JOURNAL OF IMMUNOLOGY

Autoreactive T cells specific for insulin B:11-23 recognize a low-affinity peptide register in human subjects with autoimmune diabetes

(2014) J. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Improving the safety of cell therapy products by suicide gene transfer

(2014) Benjamin S. Jones et al.   Frontiers in Pharmacology

Anti-CD3 clinical trials in type 1 diabetes mellitus

(2013) Anastasia G. Daifotis et al.   CLINICAL IMMUNOLOGY

B-Lymphocyte Depletion With Rituximab and  -Cell Function: Two-Year Results

(2013) M. D. Pescovitz et al.   DIABETES CARE

Efficacy and safety of low-dose otelixizumab anti-CD3 monoclonal antibody in preserving C-peptide secretion in adolescent type 1 diabetes: DEFEND-2, a randomized, placebo-controlled, double-blind, multi-centre study

(2013) P. Ambery et al.   DIABETIC MEDICINE

Exploiting the curative potential of adoptive T-cell therapy for cancer

(2013) Christian S. Hinrichs et al.   IMMUNOLOGICAL REVIEWS

Combinatorial delivery of immunosuppressive factors to dendritic cells using dual-sized microspheres

(2013) Jamal S. Lewis et al.   Journal of Materials Chemistry B

Antithymocyte globulin treatment for patients with recent-onset type 1 diabetes: 12-month results of a randomised, placebo-controlled, phase 2 trial

(2013) Stephen E Gitelman et al.   Lancet Diabetes & Endocrinology

Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients

(2012) Ken T. Coppieters et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Structural basis for the killing of human beta cells by CD8+ T cells in type 1 diabetes

(2012) Anna M Bulek et al.   NATURE IMMUNOLOGY

Genetic engineering with T cell receptors

(2011) Ling Zhang et al.   ADVANCED DRUG DELIVERY REVIEWS

Long-Term Outcome of Individuals Treated With Oral Insulin: Diabetes Prevention Trial-Type 1 (DPT-1) oral insulin trial

(2011) K. Vehik et al.   DIABETES CARE

Multiple Injections of Electroporated Autologous T Cells Expressing a Chimeric Antigen Receptor Mediate Regression of Human Disseminated Tumor

(2010) Y. Zhao et al.   CANCER RESEARCH

Naturally Arising Human CD4 T-Cells That Recognize Islet Autoantigens and Secrete Interleukin-10 Regulate Proinflammatory T-Cell Responses via Linked Suppression

(2010) T. I. M. Tree et al.   DIABETES

Human Antigen-Specific Regulatory T Cells Generated by T Cell Receptor Gene Transfer

(2010) Todd M. Brusko et al.   PLoS One

Transfer of mRNA encoding recombinant immunoreceptors reprograms CD4+ and CD8+ T cells for use in the adoptive immunotherapy of cancer

(2009) K Birkholz et al.   GENE THERAPY

Regulatory T cells: how do they suppress immune responses?

(2009) S. Sakaguchi et al.   INTERNATIONAL IMMUNOLOGY

Restricted Autoantigen Recognition Associated with Deletional and Adaptive Regulatory Mechanisms

(2009) J. A. Gebe et al.   JOURNAL OF IMMUNOLOGY