Graphene and the Immune System: A Romance of Many Dimensions

Graphene and carbon nanotubes activate different cell surface receptors on macrophages before and after deactivation of endotoxins

(2017) Mohamed H. Lahiani et al.   JOURNAL OF APPLIED TOXICOLOGY

An emerging role for neutrophil extracellular traps in noninfectious disease

(2017) Selina K Jorch et al.   NATURE MEDICINE

Biodegradation of Carbon Nanotubes, Graphene, and Their Derivatives

(2017) Ming Chen et al.   TRENDS IN BIOTECHNOLOGY

PEGylated graphene oxide elicits strong immunological responses despite surface passivation

(2017) Nana Luo et al.   Nature Communications

Culture Media Critically Influence Graphene Oxide Effects on Plasma Membranes

(2017) Cyrill Bussy et al.   Chem

Graphene-Induced Pore Formation on Cell Membranes

(2017) Guangxin Duan et al.   Scientific Reports

Spontaneous Protein Adsorption on Graphene Oxide Nanosheets Allowing Efficient Intracellular Vaccine Protein Delivery

(2016) Hui Li et al.   ACS Applied Materials & Interfaces

Regulation of Macrophage Recognition through the Interplay of Nanoparticle Surface Functionality and Protein Corona

(2016) Krishnendu Saha et al.   ACS Nano

The Intracellular Destiny of the Protein Corona: A Study on its Cellular Internalization and Evolution

(2016) Filippo Bertoli et al.   ACS Nano

Stealth Immune Properties of Graphene Oxide Enabled by Surface-Bound Complement Factor H

(2016) Jason N. Belling et al.   ACS Nano

Improved In Vitro and In Vivo Biocompatibility of Graphene Oxide through Surface Modification: Poly(Acrylic Acid)-Functionalization is Superior to PEGylation

(2016) Ming Xu et al.   ACS Nano

Graphene Oxides Decorated with Carnosine as an Adjuvant To Modulate Innate Immune and Improve Adaptive Immunity in Vivo

(2016) Chunchun Meng et al.   ACS Nano

Controlling the Stealth Effect of Nanocarriers through Understanding the Protein Corona

(2016) Susanne Schöttler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Soluble and immobilized graphene oxide activates complement system differently dependent on surface oxidation state

(2016) Peter P. Wibroe et al.   BIOMATERIALS

Endotoxin contamination: a key element in the interpretation of nanosafety studies

(2016) Yang Li et al.   Nanomedicine

Biological interactions of carbon-based nanomaterials: From coronation to degradation

(2016) Kunal Bhattacharya et al.   Nanomedicine-Nanotechnology Biology and Medicine

Functionalized graphene oxide serves as a novel vaccine nano-adjuvant for robust stimulation of cellular immunity

(2016) Ligeng Xu et al.   Nanoscale

Protein adsorption is required for stealth effect of poly(ethylene glycol)- and poly(phosphoester)-coated nanocarriers

(2016) Susanne Schöttler et al.   Nature Nanotechnology

Detection of Endotoxin Contamination of Graphene Based Materials Using the TNF-α Expression Test and Guidelines for Endotoxin-Free Graphene Oxide Production

(2016) Sourav P. Mukherjee et al.   PLoS One

Nanoparticles size-dependently initiate self-limiting NETosis-driven inflammation

(2016) Luis E. Muñoz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vitro and in vivo comparison of the immunotoxicity of single- and multi-layered graphene oxides with or without pluronic F-127

(2016) Young Chol Cho et al.   Scientific Reports

Graphene Oxide Nanosheets Stimulate Ruffling and Shedding of Mammalian Cell Plasma Membranes

(2016) Chao Sun et al.   Chem

Surface-Engineered Graphene Navigate Divergent Biological Outcomes toward Macrophages

(2015) Nana Luo et al.   ACS Applied Materials & Interfaces

Crucial Role of Lateral Size for Graphene Oxide in Activating Macrophages and Stimulating Pro-inflammatory Responses in Cells and Animals

(2015) Juan Ma et al.   ACS Nano

Graphene Induces Formation of Pores That Kill Spherical and Rod-Shaped Bacteria

(2015) Vy T. H. Pham et al.   ACS Nano

Vacuolization in Cytoplasm and Cell Membrane Permeability Enhancement Triggered by Micrometer-Sized Graphene Oxide

(2015) Congyu Wu et al.   ACS Nano

Use of a Pro-Fibrogenic Mechanism-Based Predictive Toxicological Approach for Tiered Testing and Decision Analysis of Carbonaceous Nanomaterials

(2015) Xiang Wang et al.   ACS Nano

Reduced Cytotoxicity of Graphene Nanosheets Mediated by Blood-Protein Coating

(2015) Yu Chong et al.   ACS Nano

Postulates for validating TLR4 agonists

(2015) Mateja Manček-Keber et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

It takes two to tango: Understanding the interactions between engineered nanomaterials and the immune system

(2015) Consol Farrera et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Protein corona mitigates the cytotoxicity of graphene oxide by reducing its physical interaction with cell membrane

(2015) Guangxin Duan et al.   Nanoscale

Science and technology roadmap for graphene, related two-dimensional crystals, and hybrid systems

(2015) Andrea C. Ferrari et al.   Nanoscale

Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis

(2015) A. Warnatsch et al.   SCIENCE

NADPH Oxidase-Dependent NLRP3 Inflammasome Activation and its Important Role in Lung Fibrosis by Multiwalled Carbon Nanotubes

(2015) Bingbing Sun et al.   Small

Molecular and Genomic Impact of Large and Small Lateral Dimension Graphene Oxide Sheets on Human Immune Cells from Healthy Donors

(2015) Marco Orecchioni et al.   Advanced Healthcare Materials

Graphene Oxide Attenuates Th2-Type Immune Responses, but Augments Airway Remodeling and Hyperresponsiveness in a Murine Model of Asthma

(2014) Michael R. Shurin et al.   ACS Nano

Protein Corona Fingerprinting Predicts the Cellular Interaction of Gold and Silver Nanoparticles

(2014) Carl D. Walkey et al.   ACS Nano

Potential Toxicity of Graphene to Cell Functions via Disrupting Protein–Protein Interactions

(2014) Binquan Luan et al.   ACS Nano

Classification Framework for Graphene-Based Materials

(2014) Peter Wick et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cutting Edge: Alum Adjuvant Stimulates Inflammatory Dendritic Cells through Activation of the NALP3 Inflammasome

(2014) M. Kool et al.   JOURNAL OF IMMUNOLOGY

Extracellular HMGB1 regulates multi-walled carbon nanotube-induced inflammationin vivo

(2014) Forrest Jessop et al.   Nanotoxicology

Neutrophils sense microbe size and selectively release neutrophil extracellular traps in response to large pathogens

(2014) Nora Branzk et al.   NATURE IMMUNOLOGY

Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines

(2014) Christine Schauer et al.   NATURE MEDICINE

Exploring the Interface of Graphene and Biology

(2014) K. Kostarelos et al.   SCIENCE

Functionalization of Graphene Oxide Generates a Unique Interface for Selective Serum Protein Interactions

(2013) Xiaofang Tan et al.   ACS Applied Materials & Interfaces

Single-Walled Carbon Nanotube Surface Control of Complement Recognition and Activation

(2013) Alina J. Andersen et al.   ACS Nano

Surface Polyethylene Glycol Conformation Influences the Protein Corona of Polyethylene Glycol-Modified Single-Walled Carbon Nanotubes: Potential Implications on Biological Performance

(2013) Cristiano Sacchetti et al.   ACS Nano

Graphene Oxide Induces Toll-like Receptor 4 (TLR4)-Dependent Necrosis in Macrophages

(2013) Guangbo Qu et al.   ACS Nano

Engineering an Effective Immune Adjuvant by Designed Control of Shape and Crystallinity of Aluminum Oxyhydroxide Nanoparticles

(2013) Bingbing Sun et al.   ACS Nano

Mechanisms of carbon nanotube-induced toxicity: Focus on pulmonary inflammation

(2013) Kunal Bhattacharya et al.   ADVANCED DRUG DELIVERY REVIEWS

Prospects and Challenges of Graphene in Biomedical Applications

(2013) Dimitrios Bitounis et al.   ADVANCED MATERIALS

Interference of silica nanoparticles with the traditional Limulus amebocyte lysate gel clot assay

(2013) Melanie Kucki et al.   Innate Immunity

Evidencing the mask effect of graphene oxide: a comparative study on primary human and murine phagocytic cells

(2013) Julie Russier et al.   Nanoscale

Rapid formation of plasma protein corona critically affects nanoparticle pathophysiology

(2013) Stefan Tenzer et al.   Nature Nanotechnology

Destructive extraction of phospholipids from Escherichia coli membranes by graphene nanosheets

(2013) Yusong Tu et al.   Nature Nanotechnology

Graphene microsheets enter cells through spontaneous membrane penetration at edge asperities and corner sites

(2013) Y. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functionalization of Carbon Nanoparticles Modulates Inflammatory Cell Recruitment and NLRP3 Inflammasome Activation

(2013) Marie Yang et al.   Small

A Natural Vanishing Act: The Enzyme-Catalyzed Degradation of Carbon Nanomaterials

(2012) Gregg P. Kotchey et al.   ACCOUNTS OF CHEMICAL RESEARCH

Decisions About Dendritic Cells: Past, Present, and Future

(2012) Ralph M. Steinman   Annual Review of Immunology

Simultaneous induction of autophagy and toll-like receptor signaling pathways by graphene oxide

(2012) Guan-Yu Chen et al.   BIOMATERIALS

Designing the nanoparticle–biomolecule interface for “targeting and therapeutic delivery”

(2012) Eugene Mahon et al.   JOURNAL OF CONTROLLED RELEASE

Biomolecular coronas provide the biological identity of nanosized materials

(2012) Marco P. Monopoli et al.   Nature Nanotechnology

Contamination of nanoparticles by endotoxin: evaluation of different test methods

(2012) Stijn Smulders et al.   Particle and Fibre Toxicology

Graphene Oxide, But Not Fullerenes, Targets Immunoproteasomes and Suppresses Antigen Presentation by Dendritic Cells

(2012) Alexey V. Tkach et al.   Small

Long, Needle-like Carbon Nanotubes and Asbestos Activate the NLRP3 Inflammasome through a Similar Mechanism

(2011) Jaana Palomäki et al.   ACS Nano

Differential Uptake of Functionalized Polystyrene Nanoparticles by Human Macrophages and a Monocytic Cell Line

(2011) Oleg Lunov et al.   ACS Nano

Macrophages and Tissue Injury: Agents of Defense or Destruction?

(2011) Debra L. Laskin et al.   Annual Review of Pharmacology and Toxicology

Factors Controlling Nanoparticle Pharmacokinetics: An Integrated Analysis and Perspective

(2011) S.M. Moghimi et al.   Annual Review of Pharmacology and Toxicology

Biological Interactions of Graphene-Family Nanomaterials: An Interdisciplinary Review

(2011) Vanesa C. Sanchez et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Alum interaction with dendritic cell membrane lipids is essential for its adjuvanticity

(2011) Tracy L Flach et al.   NATURE MEDICINE

Binding of blood proteins to carbon nanotubes reduces cytotoxicity

(2011) C. Ge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Particle size and activation threshold: a new dimension of danger signaling

(2010) L. Rettig et al.   BLOOD

Complement activation cascade triggered by PEG–PL engineered nanomedicines and carbon nanotubes: The challenges ahead

(2010) S.M. Moghimi et al.   JOURNAL OF CONTROLLED RELEASE

Carbon Nanotube-Based Nanocarriers: The Importance of Keeping It Clean

(2010) Lucia G. Delogu et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Graphene Oxide Sheets at Interfaces

(2010) Jaemyung Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ambiguities in applying traditionalLimulusAmebocyte Lysate tests to quantify endotoxin in nanoparticle formulations

(2010) Marina A Dobrovolskaia et al.   Nanomedicine

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Complement: a key system for immune surveillance and homeostasis

(2010) Daniel Ricklin et al.   NATURE IMMUNOLOGY

Lipid Rafts As a Membrane-Organizing Principle

(2010) D. Lingwood et al.   SCIENCE

The chemistry of graphene oxide

(2009) Daniel R. Dreyer et al.   CHEMICAL SOCIETY REVIEWS

Wettability and Surface Free Energy of Graphene Films

(2009) Shiren Wang et al.   LANGMUIR

Evaluation of nanoparticle immunotoxicity

(2009) Marina A. Dobrovolskaia et al.   Nature Nanotechnology

NETs: a new strategy for using old weapons

(2009) Venizelos Papayannopoulos et al.   TRENDS IN IMMUNOLOGY

Alum adjuvanticity: Unraveling a century old mystery

(2008) Ennio De Gregorio et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

(2008) Stephanie C. Eisenbarth et al.   NATURE

Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts

(2008) M. Lundqvist et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA