Article
Microbiology
Kirsten Freitag, Sara Hamdan, Matthias J. Reddehase, Rafaela Holtappels
Summary: CD8(+) T-cell responses to pathogens mainly target infected cells presenting pathogen-encoded peptides, with only a few peptides qualifying as epitopes. IDEs are preferred in vaccine design and CD8(+) T-cell immunotherapy.
Article
Immunology
Rosa Sottile, M. Kazim Panjwani, Colleen M. Lau, Anthony F. Daniyan, Kento Tanaka, Juliet N. Barker, Renier J. Brentjens, Joseph C. Sun, Jean-Benoit Le Luduec, Katharine C. Hsu
Summary: CD8(+) T cells expressing NKG2C exhibit properties of both innate and adaptive immunity, with a strong effector function against leukemia cells and HCMV-infected fibroblasts. These cells do not up-regulate PD-1 even with persistent activation, suggesting a potential for cellular therapy including CAR T cell-based therapies.
SCIENCE IMMUNOLOGY
(2021)
Review
Virology
Eva-Maria Schilling, Myriam Scherer, Thomas Stamminger
Summary: Cellular restriction factors act as important innate immune barriers against viruses, including HCMV. Multiple RFs have been identified to counteract HCMV infection, affecting different steps of the viral replication cycle. Understanding the interplay between host RFs and viral antagonists is essential for developing new approaches to combat HCMV infection.
Article
Immunology
Florence Bettens, Zuleika Calderin Sollet, Stephane Buhler, Jean Villard
Summary: Direct allorecognition in transplantation involves a complex interplay between T-cell receptors and HLA molecules. The repertoire of alloreactive cytotoxic T-cells is influenced by HLA disparities and inflammatory status. Predicting alloreactive T-cell repertoires remains a major challenge in HLA mismatched HSCT.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Yang Liu, Jun Lei, Dan San, Yi Yang, Chonil Paek, Zixiong Xia, Yongshun Chen, Lei Yin
Summary: This study investigates how T18A TCR recognizes TL9 epitope restricted by HLA-B*81:01 and provides insights into the engagement of CD8(+) T cells in HIV-mediated T cell response.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Pablo Juanes-Velasco, Alicia Landeira-Vinuela, Vanessa Acebes-Fernandez, Angela-Patricia Hernandez, Marina L. Garcia-Vaquero, Carlota Arias-Hidalgo, Halin Bareke, Enrique Montalvillo, Rafael Gongora, Manuel Fuentes
Summary: Genetic variability in HLA genes can impact susceptibility to diseases, and understanding immune responses across different populations requires sensitive methods for deciphering peptides loaded on MHC molecules. Developing novel strategies and databases could aid in vaccine development and identifying high-risk HLA types for prioritization in vaccination programs.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Immunology
Peter A. Barry, Smita S. Iyer, Laura Gibson
Summary: Traditionally, vaccine development for Human cytomegalovirus (HCMV) has focused on viral antigens that are identified as key targets of neutralizing antibody and/or T cell responses in healthy adults. However, there is currently no licensed HCMV vaccine that reduces the risk of infection in pregnant women. This study suggests that HCMV proteins recognized by only a small minority of participants may contain important vaccine antigens.
Article
Immunology
Marion Griessl, Angelique Renzaho, Kirsten Freitag, Christof K. Seckert, Matthias J. Reddehase, Niels A. W. Lemmermann
Summary: This study investigated the transcription of viral genes during latent infection of murine cytomegalovirus, revealing that the transcription of antigenic peptides driving memory inflation rarely coincides with the transcription of immune evasion proteins. The stochastic transcription hypothesis explains why immune evasion does not interfere with memory inflation in latently infected cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Da-Hua Liu, Fei-Fei Mou, Min An, Pu Xia
Summary: Malignant tumors pose a serious threat to human health and life, as well as hinder economic development. Human leukocyte antigen (HLA) is the most complex known polymorphic system, which has been shown to be associated with tumor occurrence and development. HLA molecules can regulate tumor cell proliferation and inhibit anti-tumor immunity. This review summarizes the structure and function of HLA molecules, the polymorphism and expression of HLA in tumor tissue, the roles of HLA in tumor cells and tumor immunity, and the potential clinical application of HLA in tumor immunotherapy, aiming to provide relevant information for the development of anti-tumor immunotherapies involving HLA in the clinic.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2023)
Article
Immunology
Meenal Chand, Jae-Yeon Choi, Anasuya C. Pal, Pallavi Singh, Vandana Kumari, Jose Thekkiniath, Jacqueline Gagnon, Sushma Timalsina, Gauri Gaur, Scott Williams, Michel Ledizet, Choukri Ben Mamoun
Summary: The rise in tick-borne diseases poses a significant threat to global public health. This study provides a comprehensive characterization of BmGPI12, an antigen related to human babesiosis, and identifies five unique epitopes recognized by a set of monoclonal antibodies, which can be used for the detection of B. microti infection.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Microbiology
Hidetaka Sadanari, Masaya Takemoto, Tomoki Ishida, Hikaru Otagiri, Tohru Daikoku, Tsugiya Murayama, Shuichi Kusano
Summary: PLSCR1 negatively regulates HCMV replication by repressing the transcription from viral MIE and early promoters, and PLSCR1 expression may contribute to the IFN-mediated suppression of HCMV infection.
MICROBIOLOGY SPECTRUM
(2022)
Article
Immunology
Ping Liu, Minya Yao, Yu Gong, Yunjie Song, Yanan Chen, Yizhou Ye, Xiao Liu, Fugen Li, Hua Dong, Rui Meng, Hao Chen, Aiwen Zheng
Summary: With advancements in NGS technology, HLA typing accuracy has increased while costs have decreased. Comparing three HLA assays and seven NGS-based HLA algorithms, HISAT-genotype and HLA-HD showed the highest accuracy, making them recommended choices for HLA genotyping. Capture-based NGS HLA typing may be more suitable than whole exome sequencing in clinical practice due to lower costs and higher sequencing depth.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Anais Redruello-Romero, Maria S. Benitez-Cantos, David Lopez-Perez, Jesus Garcia-Rubio, Francisco Tamayo, Daniel Perez-Bartivas, Sara Moreno-SanJuan, Isabel Ruiz-Palmero, Jose D. Puentes-Pardo, Jose R. Vilchez, Miguel A. Lopez-Nevot, Federico Garcia, Carlos Cano, Josefa Leon, Angel Carazo
Summary: The study reveals that human omental white adipose tissue (oWAT) is a major reservoir of CMV-specific T cells and plays an important role in controlling latent viral reactivation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Robert J. Fontana, Yi-Ju Li, Elizabeth Phillips, Naba Saeed, Huiman Barnhart, David Kleiner, Jay Hoofnagle
Summary: Allopurinol hepatotoxicity is associated with systemic hypersensitivity, short latency to onset, particularly in African Americans, and three HLA risk alleles: HLA-B*58:01, HLA-B*53:01, and HLA-A*34:02. Testing for 58:01 may help confirm a diagnosis of hepatotoxicity in allopurinol-treated patients.
LIVER INTERNATIONAL
(2021)
Article
Cardiac & Cardiovascular Systems
Ahad Firoz, Mohammed Kashem, Huaqing Zhao, Steven Geier, Yoshiya Toyoda
Summary: This study found that HLA mismatch is associated with the development of bronchiolitis obliterans syndrome (BOS), and a decrease in overall survival is only apparent when there are 6 mismatches. HLA-A and -DR mismatches are associated with an increased risk of mortality and BOS development. Lung transplantation offers an extended lifespan and improved quality of life for many patients with advanced refractory lung disease.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Multidisciplinary Sciences
Dae-Hee Sohn, Hyun-Jung Sohn, Hyun-Joo Lee, Seon-Duk Lee, Sueon Kim, Seung-Joo Hyun, Hyun-Il Cho, Seok-Goo Cho, Suk-Kyeong Lee, Tai-Gyu Kim
Article
Oncology
Sueon Kim, Hyun-Jung Sohn, Hyun-Joo Lee, Dae-Hee Sohn, Seung-Joo Hyun, Hyun-Il Cho, Tai-Gyu Kim
JOURNAL OF IMMUNOTHERAPY
(2017)
Article
Hematology
Ji-Young Maeng, Su-Yeon Kim, Bo-Young An, Sueon Kim, Jung-Lim Lee, Il-Hoan Oh, Tai-Gyu Kim
TRANSFUSION AND APHERESIS SCIENCE
(2019)
Article
Immunology
Sunho Lee, Sueon Kim, Hyunwoo Chung, Ji Hwan Moon, Seong Jun Kang, Chung-Gyu Park
IMMUNOLOGY LETTERS
(2020)
Article
Immunology
Yeongwon Kim, Sueon Kim, Cheol-Hwa Hong, You-Seok Hyun, In-Cheol Baek, Tai-Gyu Kim
Summary: Artificial antigen-presenting cells (aAPCs) have been developed to stimulate T cells effectively. Membrane vesicles derived from aAPCs (AP-CIMVs) show similar antigen-presenting functions as a cell-free system, but the stimulating effect of AP-CIMVs on endogenously processed antigen presentation is limited.
Article
Materials Science, Biomaterials
Sueon Kim, Yeongwon Kim, You-Seok Hyun, Haeyoun Choi, Su-Yeon Kim, Tai-Gyu Kim
Summary: Exosomes are important in transferring natural cargo molecules to neighboring or distant cells, playing a crucial role in wound healing. The study of wound healing potential of proteins in human cord blood plasma exosomes revealed that they have better wound healing effects compared to adult blood plasma exosomes. The use of artificial CBPexo may potentially overcome limitations related to exosome production from cord blood.
BIOMATERIALS SCIENCE
(2021)
Article
Medicine, Research & Experimental
Sueon Kim, Ji-young Maeng, Seung-Joo Hyun, Hyun-Jung Sohn, Su-Yeon Kim, Cheol-Hwa Hong, Tai-Gyu Kim
Article
Immunology
Mi-Young Park, Bang-Geul Lim, Su-Yeon Kim, Hyun-Jung Sohn, Sueon Kim, Tai-Gyu Kim
FRONTIERS IN IMMUNOLOGY
(2019)
Meeting Abstract
Immunology
Sueon Kim, Jin-Young Shin, Yong-Hee Kim, Chung-Gyu Kim
JOURNAL OF IMMUNOLOGY
(2011)