Review
Biochemistry & Molecular Biology
Carol Imbriano, Viviana Moresi, Silvia Belluti, Alessandra Renzini, Giorgia Cavioli, Eleonora Maretti, Susanna Molinari
Summary: Epitranscriptomics is a process of post-transcriptional regulation that affects gene expression through RNA modifications and editing. It has functional roles in the skeletal muscle system and potential therapeutic applications for human diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Peter T. Ajayi, Prasanna Katti, Yingfan Zhang, T. Bradley Willingham, Ye Sun, Christopher K. E. Bleck, Brian Glancy
Summary: This study reveals three mechanisms that regulate muscle cell connectivity. The authors identified the presence of a myofibrillar matrix in fruit fly muscles and found that the loss of the transcription factor H15 increases sarcomere branching frequency. They also demonstrated that misexpression of neurochondrin leads to myofibrillar connectivity in flight muscles.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Fabian Montecino, Natalia Gonzalez, Natasha Blanco, Manuel J. Ramirez, Adrian Gonzalez-Martin, Alejandra R. Alvarez, Hugo Olguin
Summary: The study reveals the role of c-Abl in regulating myogenic progression in satellite cells (SCs) by controlling Pax7 function and expression, affecting the activity and muscle regeneration of SCs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Daniely Messias Costa, Joao da Cruz- Filho, Alan Bruno Silva Vasconcelos, Joao Victor Gomes- Santos, Luis Carlos Reis, Waldecy de Lucca Jr, Enilton Aparecido Camargo, Sandra Lauton- Santos, Neusa Maria Zanon, Isis do Carmo Kettelhut, Luiz Carlos Navegantes, Andre de Souza Mecawi, Daniel Badaue Passos, Danilo Lustrino
Summary: The study found that oxytocin (OT) directly inhibits proteolytic activities in rat oxidative skeletal muscle by activating the Akt/FoxO signaling pathway, suppressing atrogene expression, and promoting muscle mass gain without affecting protein synthesis.
Review
Medicine, Research & Experimental
Lilei Zhang, Mukesh K. Jain
Summary: The circadian rhythm allows organisms to coordinate physiological functions in anticipation of environmental changes. The disruption of this rhythm leads to cardiometabolic disorders, affecting not only shift workers but also most individuals in modern society. Understanding circadian biology in cardiac metabolism is essential for developing novel chronotherapeutic strategies.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Biochemistry & Molecular Biology
Danesh H. Sopariwala, Neah Likhite, Gungsheng Pei, Fnu Haroon, Lisa Lin, Vikas Yadav, Zhongming Zhao, Vihang A. Narkar
Summary: ERR alpha is induced in skeletal muscle by hindlimb ischemia or hypoxia, and its overexpression can drive a switch in myofiber type and activate gene programs related to angiogenesis in muscle. This leads to increased baseline capillarity and arterioles, as well as improved perfusion recovery in ischemic muscle, suggesting ERR alpha as a potential target for treating PAD/CLI.
Article
Biochemistry & Molecular Biology
Kenta Yoh, Kazuhiro Ikeda, Saki Nagai, Kuniko Horie, Satoru Takeda, Satoshi Inoue
Summary: Estrogen signaling potentiates exercise endurance in skeletal muscle through modulating the expression of metabolism-associated genes.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Claudia Camerino
Summary: The Oxytocin/Vasopressin system originated around 600 million years ago and regulates various physiological functions. Invertebrate models may be useful for studying functions of Oxytocin not related to pregnancy. Oxytocin affects uteri contractility, milk ejection, metabolism, energy homeostasis, skeletal muscle tonicity, and body temperature.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell & Tissue Engineering
Congshan Sun, Suraj Kannan, In Young Choi, HoTae Lim, Hao Zhang, Grace S. Chen, Nancy Zhang, Seong-Hyun Park, Carlo Serra, Shama R. Iyer, Thomas E. Lloyd, Richard M. Lovering, Su Bin Lim, Peter Andersen, Kathryn R. Wagner, Gabsang Lee, Chulan Kwon
Summary: Human pluripotent stem cell (hPSC)-derived myogenic progenitor cell (MPC) transplantation can contribute to muscle fiber regeneration in mice, providing a proof of principle for future hPSC-based cell therapy for muscle disorders.
Review
Biochemistry & Molecular Biology
Kenta Yoh, Kazuhiro Ikeda, Kuniko Horie, Satoshi Inoue
Summary: Estrogen is an essential hormone that primarily functions in the female reproductive system and has pleiotropic effects in various tissues and organs. Low estrogen levels, such as in postmenopausal women, can lead to disorders like cardiovascular disease, dementia, metabolic syndrome, osteoporosis, sarcopenia, and frailty. Estrogen receptors (ERs) and estrogen-related receptors (ERRs) play crucial roles in muscle physiology, including muscle mass maintenance, exercise physiology, and regeneration, particularly in relation to mitochondrial function and metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Jingbao Kan, Yifang Hu, Yaoqi Ge, WenSong Zhang, Shan Lu, Cuiping Zhao, Rihua Zhang, Yun Liu
Summary: The research revealed that the reduced expression of mitochondrial functional genes may be the main cause of skeletal muscle aging, with CYCS and ESRRA potentially playing significant roles in this process.
Article
Cell Biology
Cheuk Wang Fung, Shaopu Zhou, Han Zhu, Xiuqing Wei, Zhenguo Wu, Angela Ruohao Wu
Summary: This study provides insights into the role of Pax7 lineage during embryonic development, using lineage tracing and single-cell transcriptomics. It reveals transcription factors and differentiation events, and identifies a bipotent progenitor population in early stages.
Article
Multidisciplinary Sciences
Ricardo Laranjeiro, Girish Harinath, Amelia K. Pollard, Christopher J. Gaffney, Colleen S. Deane, Siva A. Vanapalli, Timothy Etheridge, Nathaniel J. Szewczyk, Monica Driscoll
Summary: The study found that in spaceflight conditions, worm neurons exhibited hyper-branching and an accumulation of neuronal waste in surrounding tissues, indicating impaired transcellular degradation of neuronal debris. The results highlight the significant impact of spaceflight on adult neuronal morphology and trash clearance, emphasizing the importance of assessing risks and developing countermeasures for safe long-duration space exploration.
Article
Genetics & Heredity
Yue Ai, Yaning Zhu, Linli Wang, Xiaosheng Zhang, Jinlong Zhang, Xianlei Long, Qingyi Gu, Hongbing Han
Summary: Sheep growth, particularly skeletal muscle growth, brings direct economic benefits to the animal husbandry industry. However, the genetic mechanisms underlying different breeds remain unclear. Transcriptomic analysis revealed that the gene expression patterns of the cross-bred sheep were more similar to Dorper sheep, possibly explaining the differences in muscle growth among the three breeds. This study identified several candidate genes related to skeletal muscle growth, providing valuable insights into the molecular basis of muscle growth and development in sheep.
Article
Cell Biology
Nobuko Katoku-Kikyo, Ellen Paatela, Daniel L. Houtz, Britney Lee, Dane Munson, Xuerui Wang, Mohammed Hussein, Jasmeet Bhatia, Seunghyun Lim, Ce Yuan, Yoko Asakura, Atsushi Asakura, Nobuaki Kikyo
Summary: This study demonstrates that the circadian master regulators Per1 and Per2 play essential roles in regulating myoblast differentiation and muscle regeneration by controlling the activation of Igf2 and key genes in the differentiation process. The circadian epigenetic priming creates a preferred time window for initiating myoblast differentiation, with muscle regeneration being faster when initiated at night due to higher expression of Per1, Per2, and Igf2 compared to morning.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
S. Divari, F. De Lucia, E. Berio, A. Sereno, B. Biolatti, F. T. Cannizzo
DOMESTIC ANIMAL ENDOCRINOLOGY
(2020)
Article
Agriculture, Dairy & Animal Science
L. Starvaggi Cucuzza, S. Divari, B. Biolatti, F. T. Cannizzo
DOMESTIC ANIMAL ENDOCRINOLOGY
(2020)
Article
Agriculture, Dairy & Animal Science
D. Giannuzzi, B. Biolatti, E. Longato, S. Divari, L. Starvaggi Cucuzza, P. Pregel, F. E. Scaglione, A. Rinaldi, L. M. Chiesa, F. T. Cannizzo
Summary: This study analyzed the gene expression patterns of poultry treated with different antimicrobials through RNA sequencing and identified potential new biomarkers to differentiate treatments. The liver was found to be a valuable target organ for screening antimicrobial administration.
Article
Veterinary Sciences
Laura Starvaggi Cucuzza, Paola Pregel, Bartolomeo Biolatti, Francesca Tiziana Cannizzo
RESEARCH IN VETERINARY SCIENCE
(2020)
Article
Agriculture, Dairy & Animal Science
Arturo Nicoletti, Paola Pregel, Laura Starvaggi Cucuzza, Francesca Tiziana Cannizzo, Alessandra Sereno, Frine Eleonora Scaglione
Summary: This study aimed to identify a reliable and cost-effective method for tissue preservation in field sampling, suitable for both histological and molecular analysis. Comparison of preservation methods showed that vacuum-sealed samples had good preservation quality for up to 48 hours, while samples preserved with silica beads showed promising results in terms of RNA integrity.
Article
Infectious Diseases
Matteo Cuccato, Selene Rubiola, Diana Giannuzzi, Elena Grego, Paola Pregel, Sara Divari, Francesca Tiziana Cannizzo
Summary: The use of antimicrobials significantly affects the composition and diversity of gut microbiota in broilers, particularly impacting the Enterobacteriaceae family in the ileum. Withdrawal periods are insufficient for the restoration of original gut microbiota, indicating a need for further research on the negative effects of altered gut microbiota in broilers.
Article
Veterinary Sciences
Matteo Cuccato, Frine Eleonora Scaglione, Cinzia Centelleghe, Sara Divari, Bartolomeo Biolatti, Paola Pregel, Francesca Tiziana Cannizzo
Summary: This study investigates the role of different antimicrobial prophylaxis protocols in the modulation of gut barrier in broilers. Results show that antimicrobial treatments may harm the gut health of broilers, inducing an inflammatory response and epithelial lesions. However, the expression of gut barrier proteins was not affected by different antimicrobial treatments. Further research is needed to clarify the role of antimicrobial treatments in the modulation of gut barrier in broilers.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Multidisciplinary Sciences
Sara Divari, Matteo Cuccato, Antonella Fanelli, Francesca Tiziana Cannizzo
Summary: A study has developed an indirect screening method to detect the biological effect of long-term administration of low doses of dexamethasone and prednisolone on livestock, in order to identify animals illegally treated with glucocorticoids.
Article
Engineering, Environmental
Pengyun Liu, Zhilin Wu, Francesca Tiziana Cannizzo, Stefano Mantegna, Giancarlo Cravotto
Summary: This study investigates the use of ozonation in a vortex reactor for removing antibiotic residues from milk. It finds that stronger vortexing and hydrodynamic cavitation can enhance the efficiency of antibiotic removal. The degradation kinetics and pathways of antibiotics are affected by various factors, such as initial concentration, ozone concentration, reaction temperature, and milk components.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Agriculture, Dairy & Animal Science
Riccardo Moretti, Stefania Chessa, Stefano Sartore, Dominga Soglia, Daniele Giaccone, Francesca Tiziana Cannizzo, Paola Sacchi
Summary: This study examined the application of genomic tools in animal selection on farms and found that well-managed farms rear animals with better genomic indexes. Selecting heifers based on their wellness genomic indexes can improve their economic value and disease resistance. Genomic selection is a fast and cost-effective method for animal evaluation, although it is mainly used for sire line and performance traits.
Article
Multidisciplinary Sciences
Andrea Laconi, Roberta Tolosi, Lapo Mughini-Gras, Matteo Cuccato, Francesca Tiziana Cannizzo, Alessandra Piccirillo
Summary: This study aimed to assess the dynamics of microbial communities and antimicrobial resistance genes (ARGs) in the chicken gut following amoxicillin and thiamphenicol treatments and potential co-selection of ARGs. Results showed that the administered antimicrobials changed the composition of the gut microbiome, with certain bacteria being enriched after treatment. The abundance of ARGs also increased, possibly due to interaction between the two antimicrobials.
SCIENTIFIC REPORTS
(2022)
Article
Veterinary Sciences
Matteo Cuccato, Sara Divari, Paola Sacchi, Flavia Girolami, Francesca Tiziana Cannizzo
Summary: This study applied MALDI-TOF mass spectrometry to analyze milk samples from cows with different SCC, and found significant differences in polypeptide/protein profiles between the two groups. Classification algorithms were used to classify new spectra into the two classes, supporting MALDI-TOF mass spectrometry profiling as a tool to detect mastitic milk samples.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Immunology
Angela Maria Catania, Pierluigi Di Ciccio, Ilario Ferrocino, Tiziana Civera, Francesca Tiziana Cannizzo, Alessandra Dalmasso
Summary: Food processing lines are suitable environments for the formation of bacterial biofilms, with Bacillus being one of the most common biofilm-forming genera in dairy processing plants. This study evaluated the biofilm-forming ability and molecular characteristics of dairy Bacillus spp. isolates (B. cereus and B. subtilis), including reference strains. The biofilm formation was higher on polystyrene than stainless steel, and the presence of selected genes involved in biofilm formation correlated with higher biofilm production. Furthermore, enterotoxin genes were detected in B. cereus strains.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Veterinary Sciences
Hamidreza Sohrabi, Francesca Tiziana Cannizzo, Paola Pregel, Frine Eleonora Scaglione, Chiara Beltramo, Pier Luigi Acutis, Alessandra Dalmasso, Bartolomeo Biolatti
VETERINARIA ITALIANA
(2020)
Article
Agriculture, Dairy & Animal Science
Sara Divari, Paola Pregel, Stefania Zanet, Ezio Ferroglio, Francesca Giannini, Frine Eleonora Scaglione, Alex Grinberg, Bartolomeo Biolatti, Enrico Bollo