Article
Multidisciplinary Sciences
Yazhe Wang, Shipra Malik, Hee-Won Suh, Yong Xiao, Yanxiang Deng, Rong Fan, Anita Huttner, Ranjit S. Bindra, Vijender Singh, W. Mark Saltzman, Raman Bahal
Summary: In this study, we developed functionalized nanoparticles loaded with anti-seed s gamma PNAs to target oncomiRs 10b and 21 in tumor cells. Combined with temozolomide, these nanoparticles significantly improved the survival of orthotopic mouse models of GBM. This study provides a promising approach to personalized treatment of GBM based on tumor-specific oncomiRs.
Article
Chemistry, Physical
Qinyuan Zhang, Jiali Cai, Zhiyong Wang, Zhe Wang, Bingling Lin, Junya Zhao, Jiaji Mao, Yunhua Li, Jianing Li, Xieqing Yang, Xintao Shuai, Liejing Lu, Jun Shen
Summary: In this study, an innovative treatment approach was developed to enhance the survival of neural stem cells (NSCs) for stroke treatment. By delivering superparamagnetic iron oxide (SPIO) nanoparticles and miR-210 into NSCs, the therapeutic nanomedicine not only promotes cell survival but also allows for in vivo cell tracking using MRI. The improved NSCs survivability significantly enhances the recovery after stroke onset, highlighting the potential of this multifunctional nanomedicine for stroke treatment.
Article
Chemistry, Multidisciplinary
Tao Zheng, Wentao Wang, Mohsen Mohammadniaei, Jon Ashley, Ming Zhang, Ninglin Zhou, Jian Shen, Yi Sun
Summary: This study developed a targeted delivery system for miRNA-21 using ligand-modified nanoparticles, which temporarily opened the blood-tumor barrier to achieve effective transportation and controlled release in glioblastoma treatment, leading to the inhibition of tumor growth and angiogenesis.
Article
Biochemistry & Molecular Biology
Xiaoli Zhao, Yifan Yang, Xuerong Su, Ying Xie, Yiyao Liang, Tong Zhou, Yangqian Wu, Liuqing Di
Summary: In this study, a transferrin-modified Triptolide (TP) liposome was developed for the treatment of hepatocellular carcinoma. The results showed that the liposome had good physicochemical properties and drug loading, and effectively inhibited tumor growth in vitro and in vivo. The modification with transferrin enhanced the drug targeting to the tumor tissues and reduced its toxic effects in normal tissues.
Article
Medicine, Research & Experimental
Anja Geisler, Babette Dieringer, Leslie Elsner, Karin Klingel, Robert Klopfleisch, Hans-Peter Vornlocher, Jens Kurreck, Henry Fechner
Summary: This study demonstrates the effectiveness of stabilized small interfering RNA (siRNA) encapsulated in lipid nanoparticles (LNPs) for inhibiting hepatic adenovirus 5 (hAd5) infection. The siRNA effectively reduced viral titers, liver injury, and inflammation. This research provides a new strategy for the treatment of hAd infections.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Article
Oncology
Mairah T. Khan, Joely J. Irlam-Jones, Ronnie Rodrigues Pereira, Brian Lane, Helen R. Valentine, Kai Aragaki, Lars Dyrskjot, David J. McConkey, Peter J. Hoskin, Ananya Choudhury, Catharine M. L. West
Summary: A 14-miRNA hypoxia signature was derived and found to be prognostic for overall survival in bladder cancer patients, showing similar performance to a 24-gene mRNA signature. Combining the miRNA and mRNA signatures improved performance and identified patients who benefitted most from carbogen and nicotinamide with radiotherapy. Interaction tests also showed significance for local relapse-free survival.
BRITISH JOURNAL OF CANCER
(2021)
Article
Biochemistry & Molecular Biology
Ahmed M. Abdelaal, Ikjot S. Sohal, Shreyas Iyer, Kasireddy Sudarshan, Harish Kothandaraman, Nadia A. Lanman, Philip S. Low, Andrea L. Kasinski
Summary: Altered by defects in p53, epigenetic silencing, and genomic loss, the microRNA miR-34a is one of the most clinically relevant tumor-suppressive microRNAs. A fully modified version of miR-34a (FM-miR-34a) can overcome the challenges of stability, delivery specificity, and toxicity. When conjugated to folate (FM-FolamiR-34a), FM-miR-34a can inhibit tumor growth and even lead to complete cures in some mice.
Article
Clinical Neurology
Xiao-Bin Zhang, Yang Song, Yan-Ting Lai, Shao-Zhao Qiu, An-Ke Hu, Dai-Xi Li, Nai-Shan Zheng, Hui-Qing Zeng, Qi-Chang Lin
Summary: This study investigated the role of miR-210-3p in the relationship between intermittent hypoxia (IH) and tumor function. It was found that high levels of miR-210-3p were positively correlated with polysomnographic variables in patients with lung adenocarcinoma and obstructive sleep apnea (OSA). IH enhanced tumor viability, proliferation, migration, and invasion while downregulating E2F3 expression and increasing miR-210-3p levels. MiR-210-3p inhibition reversed these changes in vitro, and miR-210-3p antagomir injection reversed them in vivo. These findings suggest that miR-210-3p may be a potential therapeutic target for patients with concomitant cancer and OSA.
SLEEP AND BREATHING
(2023)
Review
Biotechnology & Applied Microbiology
Jiahui Wang, Ning Guo, Weiliang Hou, Huanlong Qin
Summary: Therapeutic bacteria have shown great potential in anti-tumor therapy, offering unique advantages compared to traditional strategies. Bacteria exhibit high targeting ability and excellent colonization in the tumor microenvironment with hypoxic and nutrient-rich conditions. However, the low therapeutic effect and biosafety concerns have limited the clinical application of bacterial-mediated antitumor therapy. Coating living bacteria with suitable materials has drawn widespread attention in material science for achieving synergistic tumor therapy.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Cell & Tissue Engineering
Lucile Bansard, Oceane Bouvet, Elisa Moutin, Gaetan Le Gall, Alessandro Giammona, Elodie Pothin, Marion Bacou, Cedric Hassen-Khodja, Benoit Bordignon, Jean Francois Bourgaux, Michel Prudhomme, Frederic Hollande, Julie Pannequin, Jean Marc Pascussi, Chris Planque
Summary: This study identifies miR-148a as a targetable element upstream of PXR signaling in CSCs, which can decrease PXR expression and impair tumor relapse after chemotherapy. The anti-helminthic drug niclosamide is identified as an inducer of miR-148a expression, which decreases PXR expression and CSC numbers, and synergizes with chemotherapeutic agents to prevent tumor relapse.
Article
Cell Biology
Pengfei Yan, Jia Wang, Hongya Liu, Xia Liu, Rong Fu, Jun Feng
Summary: A large amount of clinical and experimental evidence suggests that M1 macrophages can inhibit tumor progression and expansion. However, the molecular mechanism by which macrophage-derived exosomes inhibit glioblastoma cell proliferation is not yet fully understood. In this study, it was found that M1 macrophage-derived exosomes carrying miR-150 can inhibit glioma cell proliferation by targeting MMP16. This dynamic interaction between glioblastoma cells and M1 macrophages provides new therapeutic opportunities for glioma treatment.
CELLULAR SIGNALLING
(2023)
Article
Engineering, Biomedical
Xuan Meng, Lin Wang, Ning Zhao, Delong Zhao, Yongli Shen, Yuan Yao, Wenjie Jing, Shuli Man, Yujie Dai, Yanjun Zhao
Summary: This study reports a hybrid nanocarrier that targets glycolysis and redox balance simultaneously for cancer therapy. The nanocarrier, composed of pH-and ATP-responsive ZIF-8 core and poloxamer 407 coating, delivers glucose oxidase and 3-bromopyruvate to liver hepatocellular carcinoma cells, effectively inhibiting cellular energy metabolism and reducing cell viability. This approach enriches the available strategies for anti-tumor treatment.
ACTA BIOMATERIALIA
(2023)
Article
Biochemistry & Molecular Biology
Yu Huang, Longxiang Wang, Yingxuan Chen, Haobo Han, Quanshun Li
Summary: The study demonstrates that the LA-OEI derivative as a carrier exhibits superior transfection efficiency, effectively delivering miR-34a to increase its expression level, resulting in anti-proliferation and anti-migration effects on human cervical carcinoma cells. This delivery method has the potential to be an effective approach in tumor gene therapy.
Article
Engineering, Biomedical
Weilin Zhou, Sibei Lei, Mei Liu, Dan Li, Yong Huang, Xiaoyi Hu, Jinrong Yang, Jing Li, Mengxi Zhang, Fengling Wang, Jiaqian Li, Ke Men, Wei Wang
Summary: This study demonstrates the potential of an injectable and photocurable Gelatin Methacryloyl hydrogel as a delivery system for CAR-T cells, showing enhanced anti-tumor effect and extended survival in mouse models. This therapeutic strategy holds promise for the treatment of patients with unresectable tumors.
Article
Genetics & Heredity
Heba Alkhatib, Ariel M. Rubinstein, Swetha Vasudevan, Efrat Flashner-Abramson, Shira Stefansky, Sangita Roy Chowdhury, Solomon Oguche, Tamar Peretz-Yablonsky, Avital Granit, Zvi Granot, Ittai Ben-Porath, Kim Sheva, Jon Feldman, Noa E. Cohen, Amichay Meirovitz, Nataly Kravchenko-Balasha
Summary: This study developed an information-theoretic single-cell quantification strategy to accurately assess the composition and evolutionary changes of distinct tumor cell subpopulations in response to anticancer treatments. The strategy uses cell barcodes and cell-specific signaling signatures to reveal and map evolving subpopulations within the tumor, and assign targeted drug combinations to optimize tumor response to therapy. It has shown promising results in preventing cancer treatment resistance and has potential for clinical use.
Article
Oncology
Alanna R. Kaplan, Ha Pham, Yanfeng Liu, Stanley Oyaghire, Raman Bahal, Donald M. Engelman, Peter M. Glazer
MOLECULAR CANCER RESEARCH
(2020)
Article
Medicine, Research & Experimental
Alexander A. Svoronos, Raman Bahal, Mohan C. Pereira, Francisco N. Barrera, John C. Deacon, Marcus Bosenberg, Daniel DiMaio, Peter M. Glazer, Donald M. Engelman
MOLECULAR PHARMACEUTICS
(2020)
Review
Biochemistry & Molecular Biology
Nicholas G. Economos, Stanley Oyaghire, Elias Quijano, Adele S. Ricciardi, W. Mark Saltzman, Peter M. Glazer
Review
Biochemistry & Molecular Biology
Aniket Wahane, Akaash Waghmode, Alexander Kapphahn, Karishma Dhuri, Anisha Gupta, Raman Bahal
Article
Multidisciplinary Sciences
Ravinder Reddy Gaddam, Veronica Peotta Jacobsen, Young-Rae Kim, Mohanad Gabani, Julia S. Jacobs, Karishma Dhuri, Santosh Kumar, Modar Kassan, Qiuxia Li, Raman Bahal, Robert Roghair, Kaikobad Irani, Ajit Vikram
SCIENTIFIC REPORTS
(2020)
Review
Chemistry, Medicinal
Shipra Malik, Anisha Gupta, Xiaobo Zhong, Theodore P. Rasmussen, Jose E. Manautou, Raman Bahal
Article
Oncology
Supriya K. Singh, Raman Bahal, Theodore P. Rasmussen
EXPERIMENTAL CELL RESEARCH
(2020)
Review
Pharmacology & Pharmacy
M. May Zhang, Raman Bahal, Theodore P. Rasmussen, Jose E. Manautou, Xiao-bo Zhong
Summary: After more than twenty years since the discovery of the natural gene-silencing mechanism of RNA interference, siRNA-based therapeutics have entered the pharmaceutical market with three approved drugs and many others in advanced stages of development. The majority of late-stage candidates are targeted towards rare diseases or patients who have not responded to current treatments, while some have potential for a wider patient population. This review provides an overview of siRNA mechanisms, barriers to delivery, and profiles of approved drugs and candidates in Phase 3 clinical trials.
BIOCHEMICAL PHARMACOLOGY
(2021)
Review
Cell Biology
Nayanthara U. Dharmaratne, Alanna R. Kaplan, Peter M. Glazer
Summary: pHLIPs offer a promising approach for targeted drug delivery to tumors based on the acidic environment of hypoxic tumors, highlighting their potential applications in cancer therapy.
Review
Biochemistry & Molecular Biology
Thomas J. Hayman, Peter M. Glazer
Summary: Research on disease treatment has focused on DNA repair pathways, with potential for enhanced efficacy with novel immunotherapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Susan E. Gueble, Ranjit S. Bindra
Summary: Oncometabolites have emerged as a new mechanism impacting DNA damage response and repair, offering the opportunity for tumor-selective chemo- and radio-sensitization.
SEMINARS IN RADIATION ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nicholas G. Economos, Elias Quijano, Kelly E. W. Carufe, J. Dinithi R. Perera, Peter M. Glazer
Summary: This study describes a method using synthetic peptide nucleic acids (PNAs) as a tool to modulate the binding and activity of CRISPR-Cas9 in a sequence-specific manner. They demonstrate that PNAs can efficiently and rapidly target complex gRNA spacer sequences, and achieve on-target specificity by modifying gRNA affinity.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Multidisciplinary Sciences
Shipra Malik, Frank J. Slack, Raman Bahal
Article
Chemistry, Multidisciplinary
Shipra Malik, Jihoon Lim, Frank J. Slack, Demetrios T. Braddock, Raman Bahal
JOURNAL OF CONTROLLED RELEASE
(2020)
Article
Chemistry, Multidisciplinary
Armin Tahmasbi Rad, Shipra Malik, Lin Yang, Tripat Kaur Oberoi-Khanuja, Mu-Ping Nieh, Raman Bahal