期刊
CELLS
卷 10, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/cells10030541
关键词
hypoxia; acidity; pHLIP; tumor targeting; peptide nucleic acids; toxins; nanoparticles; imaging
类别
资金
- NIH [R35CA197574, F30CA221065]
pHLIPs offer a promising approach for targeted drug delivery to tumors based on the acidic environment of hypoxic tumors, highlighting their potential applications in cancer therapy.
The delivery of cancer therapeutics can be limited by pharmacological issues such as poor bioavailability and high toxicity to healthy tissue. pH-low insertion peptides (pHLIPs) represent a promising tool to overcome these limitations. pHLIPs allow for the selective delivery of agents to tumors on the basis of pH, taking advantage of the acidity of the hypoxic tumor microenvironment. This review article highlights the various applications in which pHLIPs have been utilized for targeting and treating diseases in hypoxic environments, including delivery of small molecule inhibitors, toxins, nucleic acid analogs, fluorescent dyes, and nanoparticles.
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