Article
Multidisciplinary Sciences
Menglin Jiang, Jin Yang, Linlin Yang, Lina Wang, Ting Wang, Shengna Han, Ye Cheng, Zihua Chen, Yu Su, Lirong Zhang, Fanping Yang, Sheng-an Chen, Jin Zhang, Hao Xiong, Lanting Wang, Zhen Zhang, Li Ma, Xiaoqun Luo, Qinghe Xing
Summary: An association study was conducted to investigate the relationship between human leukocyte antigen (HLA) alleles and levofloxacin-induced severe cutaneous adverse drug reactions (LEV-SCARs). The study found that the carrier frequencies of HLA-B*13:01, HLA-B*13:02, and serotype B13 were significantly higher in patients with LEV-SCARs compared to levofloxacin-tolerant individuals. Molecular docking analysis and mass spectrometry provided insights into the binding and structural changes between levofloxacin and HLA-B*13:01/HLA-B*13:02. Prospective screening for serotype B13 and alternative drug treatment for carriers may reduce the incidence of LEV-SCARs.
Article
Pharmacology & Pharmacy
Pansakon Wattanachai, Warayuwadee Amornpinyo, Parinya Konyoung, Danklai Purimart, Usanee Khunarkornsiri, Oranuch Pattanacheewapull, Wichittra Tassaneeyakul, Nontaya Nakkam
Summary: This study extensively characterizes the associations between HLA genetic polymorphisms and several phenotypes of beta-lactam antibiotics-related severe cutaneous adverse reactions (SCARs).
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Dermatology
C-B Chen, Y-E Chen, M-T Chu, C-W Wang, R. C-Y Hui, C-W Lu, Y-P Hsiao, C-Y Chu, M. M. Chang, C. M-T Cheung, C-Y Cheng, Y-W Wang, Y-J Lin, C-J Chang, S- Hung, W-H Chung
Summary: Research in Taiwan and Hong Kong focused on characterizing patients with AOA-SCAR, investigating the HLA association, and examining the utility of in vitro diagnostic methods. The study identified strontium ranelate as the most common causality of AOA-SCAR in Asian populations, with HLA-A*33:03 genetic allele being significantly associated with SR-SJS. The sensitivity of lymphocyte activation test (LAT) for identifying the culprit drug of SR-SJS was 83.3%.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Article
Health Care Sciences & Services
Shobana John, Karuppiah Balakrishnan, Chonlaphat Sukasem, Tharmarajan Chinnathambi Vijay Anand, Bhutorn Canyuk, Sutthiporn Pattharachayakul
Summary: This study investigated the association of genetic variants of the HLA B gene and CYP2C9*3 with PHT-CADRs in South Indian epileptic patients. The findings revealed significant associations of CYP2C9*3 with overall PHT-CADRs, and identified HLA B*51:01, CYP2C9*3, and HLA B*55:01 as risk factors for PHT-CADRs in the South Indian Tamil population. Further research with larger sample sizes is needed to validate the clinical relevance of these alleles.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Kanoot Jaruthamsophon, Paul J. Thomson, Chonlaphat Sukasem, Dean J. Naisbitt, Munir Pirmohamed
Summary: This review explores the translational progress of using HLA as a key susceptibility factor for immune ADRs and highlights gaps in our knowledge. Additionally, it covers relevant findings of HLA-mediated drug-specific T cell activation.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY
(2022)
Article
Dermatology
Mehak Singh, Manoj Pawar, Shashank Bhargava, Prakhar Gupta, Pankaj Adhicari
Summary: A study was conducted on HIV patients on antiretroviral therapy, showing a significant association between HLA-DRB1*03:01 and efavirenz-induced severe cutaneous adverse reactions. This genetic marker may help prevent serious rashes caused by efavirenz. The study provides a novel insight into the immunological basis of antiretroviral drug reactions.
DERMATOLOGIC THERAPY
(2021)
Review
Health Care Sciences & Services
Ali Fadhel Ahmed, Chonlaphat Sukasem, Majeed Arsheed Sabbah, Nur Fadhlina Musa, Dzul Azri Mohamed Noor, Nur Aizati Athirah Daud
Summary: This review highlights the immune mechanisms and genetic risk factors involved in severe cutaneous adverse reactions caused by antiepileptic drugs, emphasizing the importance of pharmacogenetic markers in predicting and preventing such reactions.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Kanyawan Tiwattanon, Shobana John, Napatrupron Koomdee, Pimonpan Jinda, Jiratha Rachanakul, Thawinee Jantararoungtong, Nutthan Nuntharadthanaphong, Chiraphat Kloypan, Mohitosh Biswas, Apisit Boongird, Chonlaphat Sukasem
Summary: This study found that pre-pharmacogenomics (PGx) testing for HLA-B*15:02 can significantly reduce the incidence of cutaneous adverse drug reactions (CADRs) induced by carbamazepine (CBZ)/oxcarbazepine (OXC). HLA-B pharmacogenetics testing influences clinical decisions in the selection of appropriate anti-epileptic drugs.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Yi-Shin Huang, Chen-Yi Wu, Ting-Tsung Chang, Cheng-Yuan Peng, Gin-Ho Lo, Chao-Wei Hsu, Chi-Tan Hu, Yi-Hsiang Huang
Summary: DILI patients combined with SCAR are common and have a high mortality rate in Taiwan. Allopurinol is the main culprit drug. Jaundice, acute kidney injury, and SJS/TEN are independent risk factors for mortality. HLA-B*5801, chronic kidney disease, and high drug dosage also contribute to the high mortality in cases of allopurinol-induced DILI with SCAR.
LIVER INTERNATIONAL
(2021)
Editorial Material
Dermatology
T. Shiohara
Summary: The linked article is written by C.-B. Chen et al. and published in the Journal of the European Academy of Dermatology and Venereology in 2021, focusing on the topics from page 712 to 720.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Article
Chemistry, Medicinal
Jiahao Zhu, Jieluan Lu, Yaodong He, Xianhuan Shen, Hanbing Xia, Wenzhou Li, Jianping Zhang, Xiaomei Fan
Summary: This study found that the polymorphisms of the ABCB1 gene are associated with the treatment outcomes of valproic acid in Chinese children with epilepsy. The TT genotype of rs1128503 is more likely to lead to persistent seizures after treatment, while the CC genotype of rs3789243 may be protective against gastrointestinal adverse drug reactions but increase the risk of cutaneous adverse drug reactions. However, the CT genotype of rs3789243 is associated with a lower risk of cutaneous adverse drug reactions. Additionally, carriers of the CC haplotype tend to respond better to valproic acid treatment.
Article
Geriatrics & Gerontology
Li-Ju Chen, Thi Ngoc Mai Nguyen, Dana Clarissa Laetsch, Jenny Chang-Claude, Michael Hoffmeister, Hermann Brenner, Ben Schoettker
Summary: The study found that the quality of combined medication in older colorectal cancer patients is significantly associated with overall and CRC-specific survival, with potentially inappropriate medication use and overuse having negative impacts. The results suggest that improved cancer medication management in this patient population may prolong survival.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Immunology
Patompong Satapornpong, Jirawat Pratoomwun, Pawinee Rerknimitr, Jettanong Klaewsongkram, Nontaya Nakkam, Thanyada Rungrotmongkol, Parinya Konyoung, Niwat Saksit, Ajanee Mahakkanukrauh, Warayuwadee Amornpinyo, Usanee Khunarkornsiri, Therdpong Tempark, Kittipong Wantavornprasert, Pimonpan Jinda, Napatrupron Koomdee, Thawinee Jantararoungtong, Ticha Rerkpattanapipat, Chuang-Wei Wang, Dean Naisbitt, Wichittra Tassaneeyakul, Manasalak Ariyachaipanich, Thapana Roonghiranwat, Munir Pirmohamed, Wen-Hung Chung, Chonlaphat Sukasem
Summary: The HLA-B*13:01 allele has been significantly associated with dapsone-induced severe cutaneous adverse reactions (SCARs), highlighting the importance of specific genotyping before initiating dapsone therapy in the Asian population.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Ning Jiang, Yue Yu, Min Zhang, Yu Tang, Dawei Wu, Shuhang Wang, Yuan Fang, Yu Zhang, Lin Meng, Yingying Li, Huilei Miao, Peiwen Ma, Huiyao Huang, Ning Li
Summary: This study found that specific HLA types may be associated with irAEs in specific organs and tissues, while HLA heterogeneity does not significantly influence the occurrence of irAEs.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Nontaya Nakkam, Parinya Konyoung, Warayuwadee Amornpinyo, Niwat Saksit, Somsak Tiamkao, Usanee Khunarkornsiri, Kanyarat Khaeso, Oranuch Pattanacheewapull, Teekayu Plangkoon Jorns, Pansu Chumworathayi, Wichittra Tassaneeyakul
Summary: The study found significant associations between the HLA-B*15:02 and HLA-B75 alleles and CBZ-induced SJS/TEN, serving as strong genetic markers for predicting SCARs caused by CBZ in the Thai population.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Allergy
Chuang-Wei Wang, Sherrie Jill Divito, Wen-Hung Chung, Shuen-Iu Hung
IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA
(2022)
Letter
Allergy
Po-Chien Wu, I-Hsin Huang, Chuang-Wei Wang, Wen-Hung Chung, Chun-Bing Chen
Article
Immunology
Yu Liu, Chuang-Wei Wang, Chun-Bing Chen, Kuang-Hui Yu, Yeong-Jian Wu, Siew-Eng Choon, Wan-Chun Chang, Fanping Yang, Xiao-Qun Luo, Wen-Hung Chung, Ming Zhao, Qian-Jin Lu
Summary: This study identifies ITGB2 as a differentially methylated gene in allopurinol-induced SCAR patients, regardless of the presence of HLA-B*58:01 allele, which improves the prediction accuracy of genetic testing.
CLINICAL IMMUNOLOGY
(2023)
Article
Dermatology
Chun-Wei Lu, Jong-Hwei Su Pang, Yu-Shien Ko, Chih-Jung Chang, Chuang-Wei Wang, Wei-Ti Chen, Chun-Bing Chen, Rosaline Chung-yee Hui, Shuen-Iu Hung, Lai-Ying Lu, Kun Lin Lu, Chih-Liang Wang, Chiao-En Wu, Ping-Chih Hsu, Yueh-Fu Fang, Shih-Hong Li, How-Wen Ko, Li-Chuan Tseng, Feng-Ya Shih, Mei-Jun Chen, Wen-Hung Chung
Summary: This study investigated the role of zinc deficiency in EGFR-TKI-induced skin toxicities and found that zinc supplementation can ameliorate skin impairment following EGFR-TKI therapy.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Zhengrong Li, Zhenhu Lv, Chuangwei Wang, Lei Liu, Kaiyu Cui, Zhengzhi Zhao
Summary: This study investigates the strengthening effect of Ti microalloying on weathering steel used in building. It analyzes the microstructure and performance at different coiling temperatures and explores the relationship between cooling rate and hardness. The results show that decreasing the coiling temperature increases the strength and yield ratio of the steel.
Article
Immunology
Chuang-Wei Wang, Ming-Ying Wu, Chun-Bing Chen, Wei-Chen Lin, Jennifer Wu, Chun-Wei Lu, Wei-Ti Chen, Fang-Ying Wang, Rosaline Chung-Yee Hui, Min-Hui Chi, Tsu-Man Chiu, Ya-Ching Chang, Jing Yi Lin, Yang Yu-Wei Lin, Wan-Ting Tsai, Shuen-Iu Hung, Wen-Hung Chung
Summary: This study found that immune-mediated alopecia can occur following COVID-19 vaccinations, and it is associated with T cell-mediated cytotoxicity.
CLINICAL IMMUNOLOGY
(2023)
Letter
Dermatology
Po-Chien Wu, Wen-Hung Chung, Yi-Teng Hung, Chun-Bing Chen
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ya-Ching Chang, Lung-An Hsu, Yu-Lin Ko
Summary: This study investigates the association between PCSK9 E670G polymorphism and Lp(a) levels, and confirms a causal relationship between plasma PCSK9 levels and Lp(a) concentrations through MR analysis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Letter
Dermatology
Yu-Wen Huang, Wen-Hung Chung, Chun-Bing Chen
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Microbiology
Ya-Zhu Ko, Wasantha Kumara Liyanage, Huei-Chuan Shih, Min-Nan Tseng, Meng-Shin Shiao, Yu-Chung Chiang
Summary: This study investigated the diversity and genetic variation of Lasiodiplodia species in Taiwan and identified several new infection records. The study found that the diversity of Lasiodiplodia in Taiwan had been underestimated, and L. theobromae exhibited high genetic diversity and low gene flow. The high genetic diversity and host-associated differentiation of Lasiodiplodia species indicate their powerful evolutionary potential in Taiwan.
Review
Biochemistry & Molecular Biology
Ching-Ya Wang, Chuang-Wei Wang, Chun-Bing Chen, Wei-Ti Chen, Ya-Ching Chang, Rosaline Chung-Yee Hui, Wen-Hung Chung
Summary: The efficacy and safety of psoriasis medications have been proven in trials, but suboptimal responses and side effects are observed in clinical practice. Genetic predisposition plays a role in the development of psoriasis, suggesting the potential for pharmacogenomics to predict individual treatment response. This review emphasizes current pharmacogenetic and pharmacogenomic studies of medical therapy in psoriasis. HLA-Cw*06 status remains the most promising predictive marker for treatment response in certain drugs, and various genetic variants have also been associated with treatment response for different medications. The application of high throughput sequencing technologies in clinical settings may enable pharmacogenomic tests prior to treatment in the future. Further research is needed to identify potential genetic markers for psoriasis treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Wen-Kuan Huang, Hung-Chih Hsu, Tsai-Sheng Yang, Chun-Wei Lu, Yi-Ru Pan, Chiao-En Wu, Wen-Hung Chung, Shuen-Iu Hung, Chun-Nan Yeh
Summary: This study investigated the impact of zinc supplementation on the severity of regorafenib-induced HFSR. The results have important clinical implications for the management and prevention of HFSR.
EUROPEAN JOURNAL OF CANCER
(2023)