Article
Infectious Diseases
Li Wei, Yu Feng, Hongxia Wen, Hu Ya, Fu Qiao, Zhiyong Zong
Summary: This study identified a common carbapenem-resistant Klebsiella pneumoniae (CRKP) lineage in neonates that caused various infections and had been circulating in multiple hospitals for several years. The emergence of this lineage was likely due to the acquisition of a self-transmissible carbapenemase-encoding gene. The findings highlight the potential differences between CRKP lineages in neonates and adults.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Article
Biochemistry & Molecular Biology
Hao Guo, Yuye Wu, Lirong Li, Jianfeng Wang, Juan Xu, Fang He
Summary: The study investigated the global dissemination trends of carbapenem-resistant Klebsiella pneumoniae (CRKP) strains that co-carry multiple carbapenemases. A CRKP strain, KP424, co-carrying blaNDM-1 and blaKPC-2, was identified and sequenced. Genome sequences of CRKP strains carrying multiple carbapenemase genes were retrieved from the NCBI GenBank database. The prevalence of CRKP strains co-carrying two carbapenemase genes has significantly increased over time, with strains carrying both blaNDM and blaOXA-48-like being the most common worldwide. Further research is needed to understand the mechanisms of multiple carbapenemase gene occurrence and prevent their global dissemination.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Infectious Diseases
Mykhailo Savin, Gabriele Bierbaum, Nico T. Mutters, Ricarda Maria Schmithausen, Judith Kreyenschmidt, Isidro Garcia-Menino, Silvia Schmoger, Annemarie Kaesbohrer, Jens Andre Hammerl
Summary: This study characterizes carbapenem-resistant Klebsiella spp. in wastewater and surface water in Germany. The isolates showed resistance to multiple antibiotics and a high diversity of antibiotic-resistance genes. Virulence factors were also present in most isolates. The findings suggest the possible dissemination of resistant bacteria in the environment and the risk of colonization and infection in humans, livestock, and wildlife.
Article
Infectious Diseases
Jozef Ficik, Michal Andrezal, Hana Drahovska, Miroslav Bohmer, Tomas Szemes, Adriana Liptakova, Livia Slobodnikova
Summary: The COVID-19 era has significantly increased the incidence of carbapenem-resistant Klebsiella pneumoniae (CRKP) in hospitals. It is vital to monitor the global and local incidence of CRKP and its antimicrobial resistance. The study highlighted the importance of rational antibiotic policy and strict anti-epidemic precautions.
Article
Microbiology
Yali Gong, Yifei Lu, Dongdong Xue, Yu Wei, Qimeng Li, Gang Li, Shuguang Lu, Jing Wang, Yunying Wang, Yizhi Peng, Yan Zhao
Summary: This study describes the emergence of a carbapenem-resistant Klebsiella pneumoniae (CRKP) strain, KP2e, in a Chinese hospital. The strain, recovered from a fatal septic shock case, carried the NDM-6 gene and exhibited resistance to almost all beta-lactams except for monobactam. It belonged to sequence type 4024 and had a genome composed of one chromosome and three plasmids. Coexistence of bla(NDM-6) on two self-transmissible plasmids, belonging to types IncFIB and IncN, was observed. The study highlights the importance of monitoring and detecting bla(NDM)-harbouring plasmids.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Sanjay Singh, Ashutosh Pathak, Mohibur Rahman, Avinash Singh, Soumyabrata Nag, Chinmoy Sahu, Kashi Nath Prasad
Summary: The study identified that colistin resistance in Klebsiella pneumoniae is mainly mediated by mcr-1. The co-existence of colistin, carbapenem, and other drug-resistant genes along with efflux pumps suggests significant genomic plasticity in K. pneumoniae, potentially leading to the emergence of super-spreaders of drug resistance.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Microbiology
Arnon Chukamnerd, Rattanaruji Pomwised, Kongpop Jeenkeawpiam, Chanida Sakunrang, Sarunyou Chusri, Komwit Surachat
Summary: This study elucidates the genetic features of carbapenem-resistant Klebsiella pneumoniae (CRKP) clinical isolates from a university hospital in Thailand, indicating the presence of various antimicrobial resistance and virulence genes, as well as genomic diversity. The findings highlight the importance of whole-genome sequencing (WGS) in the rapid and accurate genomic analysis of clinical isolates of CRKP.
MICROBIOLOGICAL RESEARCH
(2022)
Article
Microbiology
Yujiao Wang, Bo Zhu, Min Liu, Xiutao Dong, Jianping Ma, Xiaofeng Li, Fang Cheng, Jianzhuang Guo, Sumei Lu, Furong Wan, Yingying Hao, Wanshan Ma, Mingju Hao, Liang Chen
Summary: The study reported three Klebsiella species strains carrying TmexCD2-ToprJ2, indicating the spread of this novel plasmid-mediated tigecycline resistance mechanism to different Klebsiella species. The co-occurrence of bla(NDM-1) and TmexCD2-ToprJ2 in the same plasmid is of particular public health concern.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
Min Yi Lau, Fui Enn Teng, Kek Heng Chua, Sasheela Ponnampalavanar, Chun Wie Chong, Kartini Abdul Jabar, Cindy Shuan Ju Teh
Summary: The study reported the epidemiology of carbapenem-resistant Klebsiella pneumoniae (CRKP) in a Malaysian teaching hospital, with bla(OXA-48) identified as the predominant carbapenemase gene. Infection or colonization by CRKP, especially NDM-producers, central venous catheter usage, and stoma were associated with higher in-hospital mortality. Early detection of CRKP isolates was crucial due to the potential high mortality rate associated with infection.
Article
Microbiology
Jiankang Zhao, Danni Pu, Ziyao Li, Xinmeng Liu, Yulin Zhang, Yongli Wu, Feilong Zhang, Chen Li, Xianxia Zhuo, Binghuai Lu, Bin Cao
Summary: This study evaluated the in vitro activity of cefiderocol against hypervirulent Klebsiella pneumoniae (hvKp) isolates and found that cefiderocol might be less effective against CR-hvKp compared with CR-cKp isolates, highlighting the need for caution regarding the prevalence of cefiderocol-resistant K. pneumoniae strains, particularly in CR-hvKp isolates.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Microbiology
Ziyao Li, Xinmeng Liu, Zichen Lei, Chen Li, Feilong Zhang, Yongli Wu, Xinrui Yang, Jiankang Zhao, Yulin Zhang, Yanning Hu, Fangfang Shen, Pingbang Wang, Junwen Yang, Yulei Liu, Binghuai Lu
Summary: In this study, 662 nonduplicate CRKP strains were collected from across China to identify carbapenemase and polymyxin resistance genes and epidemiological features. The study revealed that mgrB inactivation is the main mechanism of polymyxin resistance in PR-CRKP strains, and its deletion or splicing mutations are associated with ST11 and KL47. Various mutations of the ramR gene were also identified. This study provides important insights into antibiotic resistance in China.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Xinmiao Jia, Peiyao Jia, Ying Zhu, Wei Yu, Xue Li, Jingyuan Xi, Xiaoyu Liu, Kang Liao, Yingchun Xu, Bin Cheng, Qiwen Yang
Summary: We identified a novel hybrid plasmid carrying both bla(NDM-1) and bla(IMP-4) genes, and characterized its genetic and phenotypic features. The plasmid showed potential for horizontal transfer and high stability, without exerting significant growth pressure on bacteria.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Infectious Diseases
Po-Han Huang, Yi-Hsiang Cheng, Wen-Yin Chen, Chih-Han Juan, Sheng-Hua Chou, Jin-Town Wang, Chien Chuang, Fu-Der Wang, Yi-Tsung Lin
Summary: This study investigated the risk factors and mechanisms for in vivo emergence of colistin resistance in CRKP, revealing colistin exposure as a significant factor predisposing to resistance. Alterations in the mgrB gene were identified as the predominant mechanism for emergent colistin resistance.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2021)
Article
Infectious Diseases
Wenjing Wu, Yongmei Jiang, Wei Zhou, Linghan Kuang
Summary: This study analyzed the molecular epidemiology and drug resistance mechanism of carbapenem-resistant Klebsiella pneumoniae (CRKP) isolated from neonatal patients in Sichuan, Southwest China. The dominant carbapenemase resistance gene was blaNDM, and the ST789 CRKP strains carrying blaNDM-5 were a tremendous menace to neonates.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Immunology
Xi Li, Weizhong Wang, Xi Jin, Xiaofan Zhang, Xuehan Zou, Qiang Ma, Qingfeng Hu, Haijun Huang, Yuexing Tu
Summary: In this study, two NDM-1-producing CRKP ST11 strains carrying tmexCD2-toprJ2 gene clusters were identified. These gene clusters are likely to spread into clinical high-risk CRKP clones, exacerbating the antimicrobial resistance crisis. In addition, the co-occurrence of bla(NDM-1), bla(KPC-2), and tmexCD2-toprJ2 in a single strain was found, which will undoubtedly accelerate the formation of superdrug-resistant bacteria. Therefore, effective control measures should be implemented to prevent the further dissemination of such organisms in clinical settings.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Ophthalmology
Ebru Esen, Selcuk Sizmaz, Ferit Kuscu, Cansu Demircan, Yesim Tasova, Ilker Unal, Nihal Demircan
Summary: This study evaluated retinal and choroidal microvascular blood flow in patients with HIV infection using optical coherence tomography angiography (OCTA). The results showed that HIV-positive patients had reduced microvascular blood flow in the macula, which was associated with HIV RNA plasma level and CD4 + T cell count.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Immunology
Hakan Demirhindi, Burak Mete, Ferdi Tanir, Ertan Kara, Filiz Kibar, Salih Cetiner, Aslihan Candevir, Sukriye Ece Akti
Summary: This study evaluated the mixed application of the inactivated SARS-CoV-2 vaccine CoronaVac and the mRNA vaccine BNT162b2. The results showed that after 6 months, a portion of participants in the Cohort-I did not produce antibodies, and the antibody levels of those who had antibodies decreased by 60% compared to the levels at the 3rd month. However, the antibody concentrations in the Cohort-II and Cohort-III increased by 5.13 times and 20.4 times, respectively, compared to the 3rd-month levels. Therefore, the heterologous vaccination strategy of CoronaVac and BNT162b2 can induce a stronger immune response.
Article
Pediatrics
Ummuhan Cay, Derya Alabaz, Ozlem Ozgur Gundeslioglu, Filiz Kibar, Ceren Cetin, Kadir Oktay
Summary: This study investigated the clinical and microbiological characteristics, predisposing factors, and prognosis in pediatric patients with enterococcal meningitis/ventriculitis (EMV). Neurosurgical conditions are the most common predisposing factors for EMV, while preterm birth is an important predisposing factor in children. EMV should be considered when there is an underlying CNS disorder and empirical treatment should begin in this direction.
PEDIATRICS INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Suzan Dinkci, Filiz Kibar, Erkan Demir, Saime Paydas, Seyda Erdogan, Akgun Yaman
Summary: This study investigated the frequency of cytomegalovirus (CMV), BK virus (BKV), and bacterial infections in kidney transplant recipients before and in the first six months after transplantation. The results showed a gradual decrease in infection rates over time. The most common bacterial infections were caused by Escherichia coli, Klebsiella pneumoniae, and Candida nonalbicans.
CUKUROVA MEDICAL JOURNAL
(2022)
Article
Medicine, General & Internal
Gulsen Hascelik, Guner Soyletir, Zeynep Gulay, Banu Sancak, Akgun Yaman, Nezahat Gurler, Sabire Sohret Aydemir, Gulcin Bayramoglu, Faruk Aydin, Yesim Cekin, Asuman Birinci, Cuneyt Ozakin, Nezahat Akpolat, Betil Ozhak Baysan, Meral Gultekin, Yasemin Zer, Laser Sanal, Cigdem Arabaci, Yasemin Ay Altintop, Candan Ozturk, Mehmet Ceyhan
Summary: This study evaluated the serotype distribution and antibiotic resistance in pneumococcal infections in adults. The results showed that the current PCV13 vaccine might not provide sufficient coverage, and there was a high prevalence of antibiotic resistance. The findings suggest the need to expand the serotype coverage of vaccines and to continue surveillance in pneumococcal diseases.
ANNALS OF MEDICINE
(2023)
Article
Geriatrics & Gerontology
Ertugrul Bayram, Didem Karaduman, Bulent Kaya, Burak Mete, Suleyman Ozbek, Akgun Yaman
Summary: This study confirmed the effectiveness of serum beta-2 microglobulin as a marker for frailty assessment in geriatric patients and found a significant relationship between increased beta-2 microglobulin levels and decreased quality of life.
TURKISH JOURNAL OF GERIATRICS-TURK GERIATRI DERGISI
(2022)
Article
Infectious Diseases
Damla Erturk, Aslihan Candevir, Suheyla Komur, Ferit Kuscu, Ayse Seza Inal, Behice Kurtaran, Yesim Tasova, Mustafa Balal, Yusuf Dogus, Onur Acar, Ozlem Gorurolu Ozturk
Summary: The number of HIV-infected individuals is increasing, and with the use of HAART, life expectancy is prolonged. However, as individuals age, chronic diseases that may cause renal dysfunction become more prevalent. This study aimed to evaluate nephropathy in HIV-infected individuals by assessing cystatin C and NGAL levels in serum, and KIM1 and NGAL levels in urine. Early detection of nephropathy and preventive measures are important due to the social and medical problems caused by HIV.
MEDITERRANEAN JOURNAL OF INFECTION MICROBES AND ANTIMICROBIALS
(2023)
Article
Public, Environmental & Occupational Health
Emel Azak, Ahmet Sertcelik, Gulden Ersoz, Guven Celebi, Fatma Eser, Ayse Batirel, Yasemin Cag, Zeynep Ture, Derya Engin, Meltem Arzu Yetkin, Sedat Kaygusuz, Aslihan Candevir, Ermira Tartari, Jordi Rello, Emine Alp, THIRG, Turkish Hosp Infection Res Grp
Summary: This study examined the implementation of WHO infection prevention and control core components in a developing country, as well as the prevalence of healthcare-associated infections and antimicrobial resistance in intensive care units. Most healthcare facilities had advanced levels of implementation, but workload, staffing, and occupancy were the areas with the lowest scores. Increasing the number of nurses and reducing workload can prevent healthcare-associated infections and antimicrobial resistance.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2023)
Article
Medicine, General & Internal
Figen Sarigul Yildirim, Aslihan Candevir, Sila Akhan, Selcuk Kaya, Mehmet Cabalak, Gulden Ersoz, Dilara Inan, Nurgul Ceren, Ilkay Karaoglan, Tuba Damar Cakirca, Safak Ozer Balin, Sevil Alkan, Ozlem Kandemir, Ulku User, Oguz Karabay, Mustafa Kemal Celen
Summary: This study aimed to determine whether rapid initiation of antiretroviral therapy (ART) is effective compared to standard ART treatment. The results showed that virological suppression rates at 12 months were high in all groups, over 90% on average. However, there were no statistically significant differences in HIV-1 RNA suppression rates, CD+4 T cell count, and CD4/CD8 ratio normalization during the study period.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2023)
Article
Infectious Diseases
Aslihan Candevir, Damla Erturk, Ferit Kuscu, Sueheyla Komur, Yasemin Saygideger, A. Seza Inal, Ezgi Ozyilmaz, Behice Kurtaran, Yesim Tasova
Summary: A retrospective single-center cohort study was conducted to investigate the characteristics of exposure to SARS-CoV-2 among healthcare workers and determine the risk of COVID-19 development. The study found that exposure to SARS-CoV-2-positive healthcare workers posed a greater risk compared to contact with patients.
JOURNAL OF INFECTION IN DEVELOPING COUNTRIES
(2023)
Article
Medicine, General & Internal
Aslihan Candevir, Ferit Kuscu, Behice Kurtaran, Suheyla Komur, Ayse Seza Inal, Damla Erturk, Yesim Tasova
Summary: Late presentation for HIV care remains a challenge in Turkey, with a high rate of late diagnosis and an increase in late diagnoses during the COVID-19 pandemic. Older age, poor virological response, higher mortality rates, and disruption of health services during the pandemic were identified as risk factors for late diagnosis in HIV patients.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2023)
Article
Microbiology
Ozlem Ozkan Kuscu, Sinem Bayrakci, Pinar Etiz, Emre Karakoc, Ozlem Gorurolu Ozturk, Ezgi Ozyilmaz, Aslihan Candevir
Summary: Hospital-acquired pneumonia and ventilator-associated pneumonia are major causes of death in hospitalized patients. This study aimed to provide an early diagnosis of pneumonia with alfa-defensin and calprotectin as inflammation biomarkers. The results showed higher levels of alpha defensin and calprotectin in patients with pneumonia compared to those without. However, larger-scale studies are needed to confirm the clinical utility and benefits.
FLORA INFEKSIYON HASTALIKLARI VE KLINIK MIKROBIYOLOJI DERGISI
(2023)
Article
Medicine, General & Internal
Husnu Umit Luleyap, Gokhan Karacaoglan, Aysegul Tahiroglu, Akgun Yaman, Percin Pazarci, Salih Cetiner, Davut Alptekin, Yasar Sertdemir, Gulsah Evyapan, Doga Luleyap
Summary: This study aimed to investigate the relationship between childhood onset OCD risk and MHC complex I and II alleles. The results showed that A2, A29, C4, DRB3.1, and DRB1*16 alleles increased the risk of OCD. The relationship between DRB locus and OCD found in this study is remarkable and has implications for the understanding of MHC genes' role in immune response.
TURKISH JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Medicine, General & Internal
Burak Mete, Ferdi Tanir, Hakan Demirhindi, Ertan Kara, Filiz Kibar, Salih Cetiner, Aslihan Candevir, Rabia Dal
Summary: This study investigated the seroconversion rates and short-term adverse events of the inactivated SARS-CoV-2 vaccine in healthcare workers. The results showed that after the second dose of the vaccine, 92.9% of participants developed total anti-spike and anti-nucleocapsid IgG antibodies, 15.2% developed IgM antibodies, and 98.2% developed anti-S-RBD IgG antibodies. Mild adverse events were reported, including pain at the injection site, weakness, fatigue, and headache. Age, natural COVID-19 history, and comorbidity were found to be significant factors in immune response formation.
TURKISH JOURNAL OF MEDICAL SCIENCES
(2022)
