Acetylation- and Methylation-Related Epigenetic Proteins in the Context of Their Targets

Phase II multicentre trial of oral quisinostat, a histone deacetylase inhibitor, in patients with previously treated stage IB-IVA mycosis fungoides/Sézary syndrome

(2016) F. Child et al.   BRITISH JOURNAL OF DERMATOLOGY

Dynamic Competing Histone H4 K5K8 Acetylation and Butyrylation Are Hallmarks of Highly Active Gene Promoters

(2016) Afsaneh Goudarzi et al.   MOLECULAR CELL

Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS Domain

(2016) Yuanyuan Li et al.   MOLECULAR CELL

The Taf14 YEATS domain is a reader of histone crotonylation

(2016) Forest H Andrews et al.   Nature Chemical Biology

BRPF3-HBO1 regulates replication origin activation and histone H3K14 acetylation

(2015) Y. Feng et al.   EMBO JOURNAL

Intracellular Crotonyl-CoA Stimulates Transcription through p300-Catalyzed Histone Crotonylation

(2015) Benjamin R. Sabari et al.   MOLECULAR CELL

Bivalent interaction of the PZP domain of BRPF1 with the nucleosome impacts chromatin dynamics and acetylation

(2015) Brianna J. Klein et al.   NUCLEIC ACIDS RESEARCH

Ctbp2 Modulates NuRD-Mediated Deacetylation of H3K27 and Facilitates PRC2-Mediated H3K27me3 in Active Embryonic Stem Cell Genes During Exit from Pluripotency

(2015) Tae Wan Kim et al.   STEM CELLS

SP140L, an Evolutionarily Recent Member of the SP100 Family, Is an Autoantigen in Primary Biliary Cirrhosis

(2015) Mario Saare et al.   Journal of Immunology Research

Disrupting the Interaction of BRD4 with Diacetylated Twist Suppresses Tumorigenesis in Basal-like Breast Cancer

(2014) Jian Shi et al.   CANCER CELL

AF9 YEATS Domain Links Histone Acetylation to DOT1L-Mediated H3K79 Methylation

(2014) Yuanyuan Li et al.   CELL

BRD7 Regulates XBP1s’ Activity and Glucose Homeostasis through Its Interaction with the Regulatory Subunits of PI3K

(2014) Sang Won Park et al.   Cell Metabolism

ANP32E is a histone chaperone that removes H2A.Z from chromatin

(2014) Arnaud Obri et al.   NATURE

Tyrosine phosphorylation of histone H2A by CK2 regulates transcriptional elongation

(2014) Harihar Basnet et al.   NATURE

Mass-spectrometry-based draft of the human proteome

(2014) Mathias Wilhelm et al.   NATURE

Targeting bromodomains: epigenetic readers of lysine acetylation

(2014) Panagis Filippakopoulos et al.   NATURE REVIEWS DRUG DISCOVERY

The growing landscape of lysine acetylation links metabolism and cell signalling

(2014) Chunaram Choudhary et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

BAF180 Promotes Cohesion and Prevents Genome Instability and Aneuploidy

(2014) Peter M. Brownlee et al.   Cell Reports

Histone H2A Ubiquitination Inhibits the Enzymatic Activity of H3 Lysine 36 Methyltransferases

(2013) Gang Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy

(2013) Cigall Kadoch et al.   NATURE GENETICS

BRD4 Short Isoform Interacts with RRP1B, SIPA1 and Components of the LINC Complex at the Inner Face of the Nuclear Membrane

(2013) Jude Alsarraj et al.   PLoS One

CARM1/PRMT4 is necessary for the glycogen gene expression programme in skeletal muscle cells

(2012) Shu-Ching Mary Wang et al.   BIOCHEMICAL JOURNAL

Phase I study of chidamide (CS055/HBI-8000), a new histone deacetylase inhibitor, in patients with advanced solid tumors and lymphomas

(2012) Mei Dong et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Protein Group Modification and Synergy in the SUMO Pathway as Exemplified in DNA Repair

(2012) Ivan Psakhye et al.   CELL

Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family

(2012) Panagis Filippakopoulos et al.   CELL

A Phase I Pharmacokinetic and Pharmacodynamic Study of CHR-3996, an Oral Class I Selective Histone Deacetylase Inhibitor in Refractory Solid Tumors

(2012) U. Banerji et al.   CLINICAL CANCER RESEARCH

Panobinostat activity in both bexarotene-exposed and -naïve patients with refractory cutaneous T-cell lymphoma: Results of a phase II trial

(2012) Madeleine Duvic et al.   EUROPEAN JOURNAL OF CANCER

Human Histone H3K79 Methyltransferase DOT1L Methyltransferase Binds Actively Transcribing RNA Polymerase II to Regulate Gene Expression

(2012) Seung-Kyoon Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone Lysine Methylation Dynamics: Establishment, Regulation, and Biological Impact

(2012) Joshua C. Black et al.   MOLECULAR CELL

Med5(Nut1) and Med17(Srb4) Are Direct Targets of Mediator Histone H4 Tail Interactions

(2012) Zhongle Liu et al.   PLoS One

Total kinetic analysis reveals how combinatorial methylation patterns are established on lysines 27 and 36 of histone H3

(2012) Y. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hpa2 Required by HrpF To Translocate Xanthomonas oryzae Transcriptional Activator-Like Effectors into Rice for Pathogenicity

(2011) Yu-Rong Li et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Phase I clinical, pharmacokinetic and pharmacodynamic study of SB939, an oral histone deacetylase (HDAC) inhibitor, in patients with advanced solid tumours

(2011) A R A Razak et al.   BRITISH JOURNAL OF CANCER

A Poised Chromatin Platform for TGF-β Access to Master Regulators

(2011) Qiaoran Xi et al.   CELL

Recognition of a Mononucleosomal Histone Modification Pattern by BPTF via Multivalent Interactions

(2011) Alexander J. Ruthenburg et al.   CELL

Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification

(2011) Minjia Tan et al.   CELL

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

NuRD-mediated deacetylation of H3K27 facilitates recruitment of Polycomb Repressive Complex 2 to direct gene repression

(2011) Nicola Reynolds et al.   EMBO JOURNAL

Two-pronged Binding with Bromodomain-containing Protein 4 Liberates Positive Transcription Elongation Factor b from Inactive Ribonucleoprotein Complexes

(2011) Sebastian Schröder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sequential Establishment of Marks on Soluble Histones H3 and H4

(2011) Francisca Alvarez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

H3K36 Methylation Antagonizes PRC2-mediated H3K27 Methylation

(2011) Wen Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phase II Study of Belinostat in Patients With Recurrent or Refractory Advanced Thymic Epithelial Tumors

(2011) Giuseppe Giaccone et al.   JOURNAL OF CLINICAL ONCOLOGY

Mocetinostat for relapsed classical Hodgkin's lymphoma: an open-label, single-arm, phase 2 trial

(2011) Anas Younes et al.   LANCET ONCOLOGY

Structural Basis and Specificity of Acetylated Transcription Factor GATA1 Recognition by BET Family Bromodomain Protein Brd3

(2011) R. Gamsjaeger et al.   MOLECULAR AND CELLULAR BIOLOGY

SAGA and ATAC Histone Acetyl Transferase Complexes Regulate Distinct Sets of Genes and ATAC Defines a Class of p300-Independent Enhancers

(2011) Arnaud R. Krebs et al.   MOLECULAR CELL

Histone Methylation by PRC2 Is Inhibited by Active Chromatin Marks

(2011) Frank W. Schmitges et al.   MOLECULAR CELL

Cecr2 mutations causing exencephaly trigger misregulation of mesenchymal/ectodermal transcription factors

(2010) Nicholas A. Fairbridge et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

A pilot study of the Histone-Deacetylase inhibitor Givinostat in patients with JAK2V617F positive chronic myeloproliferative neoplasms

(2010) Alessandro Rambaldi et al.   BRITISH JOURNAL OF HAEMATOLOGY

Chromatin-Remodeling Components of the BAF Complex Facilitate Reprogramming

(2010) Nishant Singhal et al.   CELL

Conserved DNA methylation inGadd45a-/-mice

(2010) Nora Engel et al.   Epigenetics

The Dnmt3a PWWP Domain Reads Histone 3 Lysine 36 Trimethylation and Guides DNA Methylation

(2010) Arunkumar Dhayalan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HBO1 Histone Acetylase Activity Is Essential for DNA Replication Licensing and Inhibited by Geminin

(2010) Benoit Miotto et al.   MOLECULAR CELL

The Cooperative Function of Nuclear Receptor Coactivator 1 (NCOA1) and NCOA3 in Placental Development and Embryo Survival

(2010) Xian Chen et al.   MOLECULAR ENDOCRINOLOGY

Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency

(2010) Christian Popp et al.   NATURE

Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

(2010) Shinsuke Ito et al.   NATURE

TRIM24 links a non-canonical histone signature to breast cancer

(2010) Wen-Wei Tsai et al.   NATURE

Chromatin methylation activity of Dnmt3a and Dnmt3a/3L is guided by interaction of the ADD domain with the histone H3 tail

(2010) Yingying Zhang et al.   NUCLEIC ACIDS RESEARCH

Transcriptional corepressor SHP recruits SIRT1 histone deacetylase to inhibit LRH-1 transactivation

(2010) Dipanjan Chanda et al.   NUCLEIC ACIDS RESEARCH

Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence

(2010) A. E. Burrows et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Androgen Receptor Transcriptional Activity and Specificity by RNF6-Induced Ubiquitination

(2009) Kexin Xu et al.   CANCER CELL

Valproic Acid at Therapeutic Plasma Levels May Increase 5-Azacytidine Efficacy in Higher Risk Myelodysplastic Syndromes

(2009) M. T. Voso et al.   CLINICAL CANCER RESEARCH

The interaction of xKaiso with xTcf3: a revised model for integration of epigenetic and Wnt signalling pathways

(2009) A. Ruzov et al.   DEVELOPMENT

Structural basis for recognition of H3K4 methylation status by the DNA methyltransferase 3A ATRX–DNMT3–DNMT3L domain

(2009) Junji Otani et al.   EMBO REPORTS

High definition profiling of mammalian DNA methylation by array capture and single molecule bisulfite sequencing

(2009) E. Hodges et al.   GENOME RESEARCH

A phase 2 study of vorinostat in acute myeloid leukemia

(2009) E. W. Schaefer et al.   HAEMATOLOGICA

Cdk2ap1 Is Required for Epigenetic Silencing of Oct4 during Murine Embryonic Stem Cell Differentiation

(2009) Amit M. Deshpande et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study

(2009) Pierre Fenaux et al.   LANCET ONCOLOGY

Selective Anchoring of DNA Methyltransferases 3A and 3B to Nucleosomes Containing Methylated DNA

(2009) S. Jeong et al.   MOLECULAR AND CELLULAR BIOLOGY

TAF12 Recruits Gadd45a and the Nucleotide Excision Repair Complex to the Promoter of rRNA Genes Leading to Active DNA Demethylation

(2009) Kerstin-Maike Schmitz et al.   MOLECULAR CELL

Protein Arginine Methylation in Mammals: Who, What, and Why

(2009) Mark T. Bedford et al.   MOLECULAR CELL

DNA demethylation in hormone-induced transcriptional derepression

(2009) Mi-Sun Kim et al.   NATURE

KDM1B is a histone H3K4 demethylase required to establish maternal genomic imprints

(2009) David N. Ciccone et al.   NATURE

Cooperative binding of two acetylation marks on a histone tail by a single bromodomain

(2009) Jeanne Morinière et al.   NATURE

Reprogramming towards pluripotency requires AID-dependent DNA demethylation

(2009) Nidhi Bhutani et al.   NATURE

Reversible acetylation of the chromatin remodelling complex NoRC is required for non-coding RNA-dependent silencing

(2009) Yonggang Zhou et al.   NATURE CELL BIOLOGY

Neuronal Activity-Induced Gadd45b Promotes Epigenetic DNA Demethylation and Adult Neurogenesis

(2009) D. K. Ma et al.   SCIENCE

Jmjd6 Catalyses Lysyl-Hydroxylation of U2AF65, a Protein Associated with RNA Splicing

(2009) Celia J. Webby et al.   SCIENCE

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

(2009) M. Tahiliani et al.   SCIENCE

The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain

(2009) S. Kriaucionis et al.   SCIENCE

Gcn5- and Elp3-induced histone H3 acetylation regulateshsp70gene transcription in yeast

(2008) Qiuju Han et al.   BIOCHEMICAL JOURNAL

CXXC Domain of Human DNMT1 Is Essential for Enzymatic Activity

(2008) Mihika Pradhan et al.   BIOCHEMISTRY

The Colorful History of Active DNA Demethylation

(2008) Steen K.T. Ooi et al.   CELL

DNA Demethylation in Zebrafish Involves the Coupling of a Deaminase, a Glycosylase, and Gadd45

(2008) Kunal Rai et al.   CELL

A Phase I and Pharmacokinetic Study of the Oral Histone Deacetylase Inhibitor, MS-275, in Patients with Refractory Solid Tumors and Lymphomas

(2008) L. Gore et al.   CLINICAL CANCER RESEARCH

A Phase I Biological Study of MG98, an Oligodeoxynucleotide Antisense to DNA Methyltransferase 1, in Patients with High-Risk Myelodysplasia and Acute Myeloid Leukemia

(2008) R. B. Klisovic et al.   CLINICAL CANCER RESEARCH

Coronary development is regulated by ATP-dependent SWI/SNF chromatin remodeling component BAF180

(2008) Xuling Huang et al.   DEVELOPMENTAL BIOLOGY

Regulation of TIP60 by ATF2 Modulates ATM Activation

(2008) Anindita Bhoumik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BRD7, a Novel PBAF-specific SWI/SNF Subunit, Is Required for Target Gene Activation and Repression in Embryonic Stem Cells

(2008) Matthias D. Kaeser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Transcription Factor NFAT by ADP-Ribosylation

(2008) O. A. Olabisi et al.   MOLECULAR AND CELLULAR BIOLOGY

Activating Signal Cointegrator-2 Is an Essential Adaptor to Recruit Histone H3 Lysine 4 Methyltransferases MLL3 and MLL4 to the Liver X Receptors

(2008) Seunghee Lee et al.   MOLECULAR ENDOCRINOLOGY

WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity

(2008) Andrew Xiao et al.   NATURE

Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism

(2008) Kyohei Arita et al.   NATURE

Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1

(2008) George V. Avvakumov et al.   NATURE

Genome-scale DNA methylation maps of pluripotent and differentiated cells

(2008) Alexander Meissner et al.   NATURE

Requirement of histone deacetylase1 (HDAC1) in signal transducer and activator of transcription 3 (STAT3) nucleocytoplasmic distribution

(2008) S. Ray et al.   NUCLEIC ACIDS RESEARCH

MeCP2, a Key Contributor to Neurological Disease, Activates and Represses Transcription

(2008) M. Chahrour et al.   SCIENCE

GADD45A Does Not Promote DNA Demethylation

(2008) Seung-Gi Jin et al.   PLoS Genetics