Functions of NQO1 in Cellular Protection and CoQ10 Metabolism and its Potential Role as a Redox Sensitive Molecular Switch

Catalytic competence, structure and stability of the cancer-associated R139W variant of the human NAD(P)H:quinone oxidoreductase 1 (NQO1)

(2017) Wolf-Dieter Lienhart et al.   FEBS Journal

Natural Small Molecules as Stabilizers and Activators of Cancer-Associated NQO1 Polymorphisms

(2016) Angel L. Pey et al.   CURRENT DRUG TARGETS

Novel RNA-binding activity of NQO1 promotes SERPINA1 mRNA translation

(2016) Andrea Di Francesco et al.   FREE RADICAL BIOLOGY AND MEDICINE

Recognition of enzymes lacking bound cofactor by protein quality control

(2016) Adrián Martínez-Limón et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NQO1 inhibits proteasome-mediated degradation of HIF-1α

(2016) Eun-Taex Oh et al.   Nature Communications

β-Lapachone suppresses neuroinflammation by modulating the expression of cytokines and matrix metalloproteinases in activated microglia

(2015) Eun-Jung Lee et al.   Journal of Neuroinflammation

Ensembl 2016

(2015) Andrew Yates et al.   NUCLEIC ACIDS RESEARCH

A Mutually Inhibitory Feedback Loop between the 20S Proteasome and Its Regulator, NQO1

(2015) Oren Moscovitz et al.   MOLECULAR CELL

NAD(P)H:Quinone Oxidoreductase 1 Activation Reduces Blood Pressure Through Regulation of Endothelial Nitric Oxide Synthase Acetylation in Spontaneously Hypertensive Rats

(2014) Y.-H. Kim et al.   AMERICAN JOURNAL OF HYPERTENSION

FAD binding overcomes defects in activity and stability displayed by cancer-associated variants of human NQO1

(2014) Angel L. Pey et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Collapse of the native structure caused by a single amino acid exchange in human NAD(P)H:quinone oxidoreductase1

(2014) Wolf-Dieter Lienhart et al.   FEBS Journal

Quinone-induced protein handling changes: Implications for major protein handling systems in quinone-mediated toxicity

(2014) Rui Xiong et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Augmentation of NAD+ by NQO1 attenuates cisplatin-mediated hearing impairment

(2014) H-J Kim et al.   Cell Death & Disease

The human flavoproteome

(2013) Wolf-Dieter Lienhart et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

NQO1 activation regulates angiotensin-converting enzyme shedding in spontaneously hypertensive rats

(2013) Yong-Hoon Kim et al.   CARDIOVASCULAR RESEARCH

Protection of NAD(P)H:quinone oxidoreductase 1 against renal ischemia/reperfusion injury in mice

(2013) Gil-Tae Gang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Enhanced activation of NAD(P)H

(2013) Yong-Hoon Kim et al.   JOURNAL OF HYPERTENSION

Pharmacological activation of NQO1 increases NAD+ levels and attenuates cisplatin-mediated acute kidney injury in mice

(2013) Gi-Su Oh et al.   KIDNEY INTERNATIONAL

The Protein Level of PGC-1 , a Key Metabolic Regulator, Is Controlled by NADH-NQO1

(2013) Y. Adamovich et al.   MOLECULAR AND CELLULAR BIOLOGY

Protective role of NAD(P)H:quinone oxidoreductase 1 (NQO1) in cisplatin-induced nephrotoxicity

(2013) Gil-Tae Gang et al.   TOXICOLOGY LETTERS

Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins

(2012) Alfredo Castello et al.   CELL

β-Lapachone, a substrate of NAD(P)H:quinone oxidoreductase, induces anti-inflammatory heme oxygenase-1 via AMP-activated protein kinase activation in RAW264.7 macrophages

(2012) Seung Jae Byun et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Beta-Lapachone, a Modulator of NAD Metabolism, Prevents Health Declines in Aged Mice

(2012) Jeong-sook Lee et al.   PLoS One

Activation of NAD(P)H:quinone oxidoreductase ameliorates spontaneous hypertension in an animal model via modulation of eNOS activity

(2011) Yong-Hoon Kim et al.   CARDIOVASCULAR RESEARCH

Prevention of salt-induced renal injury by activation of NAD(P)H:quinone oxidoreductase 1, associated with NADPH oxidase

(2011) Yong-Hoon Kim et al.   FREE RADICAL BIOLOGY AND MEDICINE

E3 Ligase STUB1/CHIP Regulates NAD(P)H:Quinone Oxidoreductase 1 (NQO1) Accumulation in Aged Brain, a Process Impaired in Certain Alzheimer Disease Patients

(2011) Peter Tsvetkov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Mechanistic and Structural Analysis of the Inhibition of the 90-kDa Heat Shock Protein by the Benzoquinone and Hydroquinone Ansamycins

(2011) P. Reigan et al.   MOLECULAR PHARMACOLOGY

NAD(P)H Quinone Oxidoreductase Protects TAp63γ from Proteasomal Degradation and Regulates TAp63γ-Dependent Growth Arrest

(2010) Oshrat Hershkovitz Rokah et al.   PLoS One

A two-domain structure for the two subunits of NAD(P)H:quinone acceptor oxidoreductase

(2010) Shiuan Chen et al.   PROTEIN SCIENCE

Activation of NAD(P)H:Quinone Oxidoreductase 1 Prevents Arterial Restenosis by Suppressing Vascular Smooth Muscle Cell Proliferation

(2009) Sun-Yee Kim et al.   CIRCULATION RESEARCH

Pharmacological Stimulation of NADH Oxidation Ameliorates Obesity and Related Phenotypes in Mice

(2009) J. H. Hwang et al.   DIABETES

NAD(P)H quinone oxidoreductase 1 inhibits the proteasomal degradation of the tumour suppressor p33ING1b

(2008) Marco Garate et al.   EMBO REPORTS

Quinone reductase acts as a redox switch of the 20S yeast proteasome

(2008) Sonja Sollner et al.   EMBO REPORTS