The Protein Level of PGC-1 , a Key Metabolic Regulator, Is Controlled by NADH-NQO1

A Mutually Inhibitory Feedback Loop between the 20S Proteasome and Its Regulator, NQO1

(2015) Oren Moscovitz et al.   MOLECULAR CELL

The Role of PGC-1α in the Pathogenesis of Neurodegenerative Disorders

(2012) Krisztina Rona-Voros et al.   CURRENT DRUG TARGETS

Stress-induced NQO1 controls stability of C/EBPα against 20S proteasomal degradation to regulate p63 expression with implications in protection against chemical-induced skin cancer

(2012) B A Patrick et al.   ONCOGENE

Beta-Lapachone, a Modulator of NAD Metabolism, Prevents Health Declines in Aged Mice

(2012) Jeong-sook Lee et al.   PLoS One

PGC-1 coactivators in the control of energy metabolism

(2011) C. Liu et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Intrinsically disordered proteins: regulation and disease

(2011) M Madan Babu et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

RNF34 Is a Cold-Regulated E3 Ubiquitin Ligase for PGC-1  and Modulates Brown Fat Cell Metabolism

(2011) P. Wei et al.   MOLECULAR AND CELLULAR BIOLOGY

Telomere dysfunction induces metabolic and mitochondrial compromise

(2011) Ergün Sahin et al.   NATURE

Disorder-to-order transition underlies the structural basis for the assembly of a transcriptionally active PGC-1 /ERR  complex

(2011) S. Devarakonda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector

(2010) Albena T. Dinkova-Kostova et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network

(2010) Richard C. Scarpulla   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Understanding protein non-folding

(2010) Vladimir N. Uversky et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Ubiquitin Proteasome-dependent Degradation of the Transcriptional Coactivator PGC-1α via the N-terminal Pathway

(2010) Julie Trausch-Azar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The PGC-1 cascade as a therapeutic target for heart failure

(2010) Joel Schilling et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

c-Fos Proteasomal Degradation Is Activated by a Default Mechanism, and Its Regulation by NAD(P)H:Quinone Oxidoreductase 1 Determines c-Fos Serum Response Kinetics

(2010) J. Adler et al.   MOLECULAR AND CELLULAR BIOLOGY

Disruption of NAD(P)H:quinone oxidoreductase 1 gene in mice leads to 20S proteasomal degradation of p63 resulting in thinning of epithelium and chemical-induced skin cancer

(2010) B A Patrick et al.   ONCOGENE

NAD(P)H Quinone Oxidoreductase Protects TAp63γ from Proteasomal Degradation and Regulates TAp63γ-Dependent Growth Arrest

(2010) Oshrat Hershkovitz Rokah et al.   PLoS One

Dynamic regulation of PGC-1α localization and turnover implicates mitochondrial adaptation in calorie restriction and the stress response

(2009) Rozalyn M. Anderson et al.   AGING CELL

Activation of NAD(P)H:Quinone Oxidoreductase 1 Prevents Arterial Restenosis by Suppressing Vascular Smooth Muscle Cell Proliferation

(2009) Sun-Yee Kim et al.   CIRCULATION RESEARCH

PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

(2009) Carles Cantó et al.   CURRENT OPINION IN LIPIDOLOGY

Pharmacological Stimulation of NADH Oxidation Ameliorates Obesity and Related Phenotypes in Mice

(2009) J. H. Hwang et al.   DIABETES

Sensitivity of Lipid Metabolism and Insulin Signaling to Genetic Alterations in Hepatic Peroxisome Proliferator-Activated Receptor-  Coactivator-1  Expression

(2009) J. L. Estall et al.   DIABETES

PGC-1α activation as a therapeutic approach in mitochondrial disease

(2009) Tina Wenz   IUBMB LIFE

Susceptibility of p53 Unstructured N Terminus to 20 S Proteasomal Degradation Programs the Stress Response

(2009) Peter Tsvetkov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PPAR control: it's SIRTainly as easy as PGC

(2009) Mary C Sugden et al.   JOURNAL OF ENDOCRINOLOGY

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

The nanny model for IDPs

(2009) Peter Tsvetkov et al.   Nature Chemical Biology

Intrinsically Disordered Proteins in Human Diseases: Introducing the D2 Concept

(2008) Vladimir N. Uversky et al.   Annual Review of Biophysics

Glucose Restriction Inhibits Skeletal Myoblast Differentiation by Activating SIRT1 through AMPK-Mediated Regulation of Nampt

(2008) Marcella Fulco et al.   DEVELOPMENTAL CELL

NAD(P)H quinone oxidoreductase 1 inhibits the proteasomal degradation of the tumour suppressor p33ING1b

(2008) Marco Garate et al.   EMBO REPORTS

Quinone reductase acts as a redox switch of the 20S yeast proteasome

(2008) Sonja Sollner et al.   EMBO REPORTS

SCFCdc4 acts antagonistically to the PGC-1  transcriptional coactivator by targeting it for ubiquitin-mediated proteolysis

(2008) B. L. Olson et al.   GENES & DEVELOPMENT

Tight Regulation of Unstructured Proteins: From Transcript Synthesis to Protein Degradation

(2008) J. Gsponer et al.   SCIENCE