Article
Physiology
Myriam Paquette, Francois Bieuzen, Francois Billaut
Summary: This study compared the performance and physiological adaptations of sprint kayakers undergoing HIIT and SIT training, finding that HIIT led to greater improvements in performance compared to SIT. Training did not alter VO2peak, but increased muscle maximal deoxygenation, indicating peripheral adaptations were elicited by both HIIT and SIT.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Review
Sport Sciences
Daniel Boullosa, Boris Dragutinovic, Joshua F. Feuerbacher, Stefano Benitez-Flores, Edward F. Coyle, Moritz Schumann
Summary: The study suggests that short sprint interval training (sSIT) is highly effective in improving maximal oxygen consumption (V?O(2)max), aerobic, and anaerobic performances in physically active young healthy adults and athletes. Various exercise modes, such as cycling, running, paddling, and punching, can benefit from sSIT protocols.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2022)
Article
Multidisciplinary Sciences
Zahra Saadatian, Yaser Mansoori, Lida Nariman-Saleh-Fam, Abdolreza Daraei, Sepideh Zununi Vahed, Shadan Navid, Ziba Nariman-Saleh-Fam
Summary: This study evaluated the alteration of miR-200c, miR-125b, miR-27b, miR-203, and miR-155 in patients with coronary artery stenosis and insignificant coronary artery stenosis compared to healthy individuals. The results showed that three of these miRNAs have the potential to differentiate between coronary artery stenosis patients and healthy individuals, suggesting they could be novel diagnostic biomarkers.
SCIENTIFIC REPORTS
(2023)
Article
Physiology
Ian A. J. Darragh, Tom P. P. Aird, Aifric O'Sullivan, Brendan Egan, Brian P. P. Carson
Summary: This study investigated the response of a targeted fraction of the resting serum metabolome to short-term sprint interval training. The results showed that the training had limited effect on the serum metabolome at rest, but certain fatty acids were potentially sensitive to the training.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Hamish Ferguson, Chris Harnish, Sebastian Klich, Kamil Michalik, Anna Katharina Dunst, Tony Zhou, J. Geoffrey Chase
Summary: The current convention that peak power is the main determinant of sprint cycling performance is challenged by this study. It compares two common durations of sprint cycling performance, not only based on peak power but also power over 20 minutes. Despite the belief that longer maximal efforts could hinder sprint cycling performance, the study finds strong relationships between 1-second power and longer durations up to 20 minutes, suggesting the importance of training durations from 1 second to 20 minutes to improve competition performance.
Article
Sport Sciences
Moises D. Germano, Marcio A. G. Sindorf, Alex H. Crisp, Tiago V. Braz, Felipe A. Brigatto, Ana G. Nunes, Rozangela Verlengia, Marlene A. Moreno, Marcelo S. Aoki, Charles R. Lopes
Summary: This study aimed to investigate the impact of different recovery methods during HIIT exercises on metabolic, cardiorespiratory responses, and sprint performance in healthy men. The results showed that short active recovery and long active recovery significantly reduced blood lactate concentration during recovery, while long passive recovery consumed more oxygen. All recovery methods allowed participants to reach high percentages of maximum oxygen consumption.
JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
(2022)
Article
Environmental Sciences
Fabian Herold, Tom Behrendt, Caroline Meissner, Notger G. Mueller, Lutz Schega
Summary: The study shows that a single bout of SSREHIT can improve specific aspects of attentional performance, but does not affect other measures of attentional or working memory performance. Additionally, the increase in peripheral blood lactate levels after exercise is associated with changes in attentional performance.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Physiology
Ema Juskeviciute, Elmo Neuberger, Nerijus Eimantas, Tomas Venckunas, Sigitas Kamandulis, Perikles Simon, Marius Brazaitis
Summary: Short interval training (SIT) leads to an increase in post-exercise cfDNA levels, which is correlated with an increase in LFF in both groups. Three weeks of SIT resulted in an improvement in aerobic capacity (VO2max) for the young group, while decreasing baseline cfDNA values and improving the recovery of LFF for the older group.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Andreas Schober, Richard M. Blay, Saffiyeh Saboor Maleki, Farima Zahedi, Anja E. Winklmaier, Mati Y. Kakar, Isabelle M. Baatsch, Mengyu Zhu, Claudia Geissler, Anja E. Fusco, Anna Eberlein, Nan Li, Remco T. A. Megens, Ramin Banafsche, Jorg Kumbrink, Christian Weber, Maliheh Nazari-Jahantigh
Summary: The molecular clock in atherosclerotic lesions induces a diurnal rhythm of apoptosis, regulated by circadian Mir21 expression in macrophages, leading to an increase in necrotic core size.
Review
Cardiac & Cardiovascular Systems
Ruhan Xu, Wei Yuan, Zhongqun Wang
Summary: Glycolysis is an important energy acquisition pathway for various cells, and it plays a role in regulating lipid deposition, calcification, and angiogenesis in atherosclerosis. Lactate and lactylation modifications are widely present in inflammatory diseases and may be a new approach for targeted therapy in atherosclerosis.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2023)
Article
Sport Sciences
Seth F. Mccarthy, Emily J. Ferguson, Claudia Jarosz, Kenji A. Kenno, Tom J. Hazell
Summary: This study compared the effects of different exercise modes on postexercise hypotension in middle-age adults and found that moderate-intensity continuous training (MICT), high-intensity interval training (HIIT), and sprint interval training (SIT) have similar effects on systolic blood pressure (SBP), but have smaller effects on diastolic blood pressure (DBP), and these effects are not sustained over 24 hours.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Article
Physiology
Claire Thomas, Remi Delfour-Peyrethon, Karen Lambert, Cesare Granata, Thomas Hobbs, Christine Hanon, David J. J. Bishop
Summary: The purpose of this study was to evaluate the effect of pre-exercise alkalosis, induced via ingestion of sodium bicarbonate, on changes to lactate/pH regulatory proteins and mitochondrial function induced by a sprint-interval exercise session in humans. The results showed that ingestion of sodium bicarbonate increased blood bicarbonate and pH levels after exercise, and led to increases in lactate/pH regulatory proteins. Additionally, mitochondrial respiration was found to decrease after 24 hours of recovery in the sodium bicarbonate condition.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Haoyang Zhou, Dafeng Yang, Henry S. Cheng, Michael G. McCoy, Daniel Perez-Cremades, Stefan Haemmig, Danny Wong, Lei Chen, Mark W. Feinberg
Summary: The study uncovers an important role of miR-181b in regulating vascular endothelial aging through the MAP3K3-MAPK signaling pathway, revealing potential therapeutic targets for anti-aging therapy in cardiovascular disease.
Article
Biology
Seung-Bo Park, Da-Sol Park, Minjun Kim, Eunseok Lee, Doowon Lee, Jaewoo Jung, Seong Jun Son, Junggi Hong, Woo-Hwi Yang
Summary: The study found that a high-intensity warm-up (HIW) increases anaerobic system contributions in a 100-m sprint compared to a low-intensity warm-up (LIW), but has no significant effect on sprint time trials, although it may improve times.
Article
Endocrinology & Metabolism
Panyun Wu, Tengteng Zhu, Yiyuan Huang, Zhenfei Fang, Fei Luo
Summary: Research in recent decades has revealed the presence and function of lactate in the body. Lactate, primarily produced through glycolysis, plays important roles in tissue and organ regulation, especially in the cardiovascular system. The heart, as both a net consumer and the organ with the highest lactate consumption, contributes to cardiovascular homeostasis through energy supply and signal regulation. Lactate also affects the occurrence, development, and prognosis of various cardiovascular diseases. This article aims to explore the regulation of the cardiovascular system by lactate under physiological and pathological conditions, provide a better understanding of the lactate-cardiovascular health relationship, and propose new ideas for preventing and treating cardiovascular diseases. Additionally, it summarizes the current progress in treatments targeting lactate metabolism, transport, and signaling in cardiovascular diseases.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Sport Sciences
Katharina Minnebeck, Elena Vorona, Sarah Zinn, Reinhold Gellner, Jens Hinder, Stefan-Martin Brand, Iyad Kabar, Florian Alten, Boris Schmitz
Summary: The study found that a four-week HIIT intervention had positive effects on the cardiometabolic risk profile, physical fitness, and health-related quality of life in T1DM patients. Particularly, the beneficial effects of HIIT on the cardiometabolic risk profile may be larger in overweight T1DM patients.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2021)
Letter
Ophthalmology
Florian Alten, Boris Schmitz
CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE
(2021)
Article
Peripheral Vascular Disease
Florian Alten, Nicole Eter, Boris Schmitz
Summary: The study found that after four weeks of HIIT training, healthy participants showed improved perfusion of the choriocapillaris, while T1DM patients did not exhibit the same effect, suggesting impaired choriocapillaris adaptation in T1DM individuals.
MICROVASCULAR RESEARCH
(2021)
Review
Nutrition & Dietetics
Melina Heimer, Marc Teschler, Boris Schmitz, Frank C. Mooren
Summary: The effects of probiotics on the immune system, URTI, and GI symptoms in athletes, healthy adults, and recreationally active individuals remain inconclusive. Further research is needed to draw definitive conclusions.
FRONTIERS IN NUTRITION
(2022)
Meeting Abstract
Psychiatry
W. Kop, B. Schmitz, D. Gatsios, C. Pena-Gil, J. Gonzalez Juanatey, D. Cantarero Prieto, V. Tsakanikas, S. Hubert, M. Habibovic, M. Schmidt, M. Kleber, G. de Bruijn, H. Malberg, F. Mooren, J. Widdershoven, D. Fotiadis, W. Marz, J. Bosch
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2022)
Review
Physiology
Maryam Balke, Marc Teschler, Hendrik Schaefer, Pantea Pape, Frank C. Mooren, Boris Schmitz
Summary: There is evidence that ICU treatment and invasive ventilation can cause a decline in muscle mass and function, known as ICU-acquired weakness. Electromyostimulation may improve the condition of critically ill patients, but more research is needed for conclusive results.
FRONTIERS IN PHYSIOLOGY
(2022)
Correction
Nutrition & Dietetics
Melina Heimer, Marc Teschler, Boris Schmitz, Frank C. C. Mooren
FRONTIERS IN NUTRITION
(2022)
Review
Oncology
Franziska Lioba Breulmann, Luan Phelipe Hatt, Boris Schmitz, Esther Wehrle, Robert Geoff Richards, Elena Della Bella, Martin James Stoddart
Summary: This systematic review aimed to identify common miRNAs involved in fracture healing or non-union fractures. Out of 151 miRNAs, miR-21, miR-140 and miR-214 were the most investigated miRNAs in fracture healing in general, while miR-31-5p, miR-221 and miR-451-5p were identified to be regulated specifically in non-union fractures. Despite heterogeneity between studies, these miRNAs have the potential to serve as biomarkers for non-union fractures.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Physiology
Sinje Biss, Marc Teschler, Melina Heimer, Thomas Thum, Christian Baer, Frank C. Mooren, Boris Schmitz
Summary: This study aimed to evaluate the long-term effects of EMS on circulating miRNA levels. The results showed that a single EMS session induces specific long-lasting changes in miR-206 and miR-133a involved in muscle proliferation and differentiation, but does not affect cardiovascular miRNAs.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Melina Heimer, Sandra Schmitz, Marc Teschler, Hendrik Schaefer, Emma R. Douma, Mirela Habibovic, Willem J. Kop, Thorsten Meyer, Frank C. Mooren, Boris Schmitz
Summary: This study provides a quantitative analysis of the effects of eHealth-supported interventions on health outcomes in cardiovascular rehabilitation maintenance phase III for patients with coronary artery disease (CAD). The results suggest that eHealth interventions can increase physical activity and exercise capacity, improve quality of life, and lower systolic blood pressure. Effective behavioral change techniques include self-monitoring of behavior, goal setting, and behavior feedback.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Peripheral Vascular Disease
Hendrik Schaefer, Marc Teschler, Frank C. Mooren, Boris Schmitz
Summary: In patients with post COVID-19 syndrome (PCS), the rate of tissue oxygen consumption is persistently altered, leading to slower decline in tissue oxygenation during occlusion. These observations may help explain PCS-specific symptoms such as physical impairment and fatigue.
MICROVASCULAR RESEARCH
(2023)
Article
Multidisciplinary Sciences
Frank C. Mooren, Irina Boeckelmann, Melina Waranski, Mona Kotewitsch, Marc Teschler, Hendrik Schaefer, Boris Schmitz
Summary: Post-COVID-19 Syndrome (PCS) is a condition characterized by persistent alterations in heart rate variability (HRV) and sympathetic overstimulation, resembling findings in patients with coronary artery disease (CAD). PCS patients show disturbed diurnal adjustment of HRV, with impaired parasympathetic activity at night. HRV variables may have prognostic value in PCS and further studies are needed to investigate their potential role as biomarkers of successful interventions.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Johanna M. Mooren, Rene Garbsch, Hendrik Schaefer, Mona Kotewitsch, Melina Waranski, Marc Teschler, Boris Schmitz, Frank C. Mooren
Summary: This study compared the effects of different modes of aerobic endurance training on patients with Post-COVID-19 syndrome (PCS). The results showed that both continuous training and interval training improved physical exercise capacity and disease perception in PCS patients, with similar outcomes to coronary artery disease (CAD) patients undergoing rehabilitation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Boris Schmitz
Summary: The role of scientific research is crucial in modern society for driving innovation, informing policies, and shaping public opinion. However, communicating scientific findings to the general public can be challenging due to its technicality and complexity. Lay abstracts, generated by artificial intelligence language models, can provide easily understandable summaries of key findings and implications, increasing the visibility and impact of scientific research.
Meeting Abstract
Cardiac & Cardiovascular Systems
B. Schmitz, S. Wirtz, M. Sestayo-Fernandez, H. Schaefer, E. R. Douma, M. Alonso, V. Gonzalez-Salvado, M. Habibovic, W. J. Kop, C. Pena-Gil, F. C. Mooren
EUROPEAN HEART JOURNAL
(2022)