Review
Cell Biology
Yu-Feng Long, Simon Kwoon-Ho Chow, Can Cui, Ronald Man Yeung Wong, Ning Zhang, Ling Qin, Sheung-Wai Law, Wing-Hoi Cheung
Summary: This systematic review explores the potential relationships among physical exercise, mitochondrial function, and microRNAs in muscle. It reveals that effective physical exercise can improve mitochondrial functions by regulating microRNAs, ultimately enhancing muscle performance.
AGEING RESEARCH REVIEWS
(2023)
Article
Physiology
Carina Zink-Rueckel, Oliver Chaudry, Klaus Engelke, Mansour Ghasemikaram, Matthias Kohl, Michael Uder, Wolfgang Kemmler
Summary: The study showed that once-weekly WB-EMS significantly affects muscle quality in the mid-thigh of moderately active, healthy men aged 18-70, reducing fatty muscle infiltration and increasing muscle tissue volume.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sarah U. Morton, Christopher R. Sefton, Huanqing Zhang, Manhong Dai, David L. Turner, Michael D. Uhler, Pankaj B. Agrawal
Summary: miRNAs play a key role in regulating mRNA during processes like muscle differentiation. Understanding miRNA targets can provide insights into muscle biology and gene expression changes caused by diseases. The study found that differentially expressed miRNAs are enriched for functions related to calcium signaling and sarcomere formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Donato A. Rivas, Fei Peng, Townsend Benard, Adelino Sanchez Ramos da Silva, Roger A. Fielding, Lee M. Margolis
Summary: The study found that miR-19b-3p plays a crucial role in regulating muscle synthesis, contributing to understanding the varied responses of mobility-limited older adults to anabolic stimuli.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Article
Biology
Luiz Rodrigues-Santana, Jose Carmelo Adsuar, Angel Denche-Zamorano, Alejandro Vega-Munoz, Guido Salazar-Sepulveda, Nicolas Contreras-Barraza, Carmen Galan-Arroyo, Hugo Louro
Summary: This work presents a bibliometric analysis on WB-EMS to provide an overview of the research status in this field. The results indicate that Germany is the leading country in terms of scientific knowledge production on WB-EMS, and Wolfgang Kemmler is the most relevant author. The study also reveals a growing trend in WB-EMS research, with German and Spanish researchers leading collaborations in this field.
Review
Physiology
Wolfgang Kemmler, Mahdieh Shojaa, James Steele, Joshua Berger, Michael Frohlich, Daniel Schoene, Simon von Stengel, Heinz Kleinoder, Matthias Kohl
Summary: This study found significant effects of whole-body electromyostimulation (WB-EMS) on body composition and strength parameters in non-athletic cohorts. Muscle mass and strength changes were important, while changes in body fat mass were not significant.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Nutrition & Dietetics
Dejan Reljic, Hans J. Herrmann, Markus F. Neurath, Yurdagul Zopf
Summary: The study concludes that traditional resistance training (RT) has superior effects on cardiometabolic health, skeletal muscle mass, and quality of life in obese metabolic syndrome (MetS) patients undergoing caloric restriction (CR) compared to whole body electromyostimulation (WB-EMS).
Article
Geriatrics & Gerontology
Jiling Liang, Hu Zhang, Zhengzhong Zeng, Jun Lv, Jielun Huang, Xiaowen Wu, Minghui Wang, Jiahao Xu, Jingjing Fan, Ning Chen
Summary: Exercise interventions may serve as a potential treatment for sarcopenia by modulating molecular mechanisms associated with muscle atrophy.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Biology
Holger Stephan, Thorsten Hagedorn, Udo Frank Wehmeier, Fabian Tomschi, Thomas Hilberg
Summary: The study found that running with electromyostimulation may result in lower maximum running speed, increased exertion, and, in some cases, higher metabolic demands. The use of electromyostimulation can enhance running training, helping to reduce training volume or speed, providing an interesting training tool for runners.
Article
Geriatrics & Gerontology
Marc Teschler, Melina Heimer, Boris Schmitz, Wolfgang Kemmler, Frank C. Mooren
Summary: The study investigates the effects of EMS on muscle strength and function during 4 weeks of inpatient medical rehabilitation. Results suggest that EMS, when included in a rehabilitation program with dynamic movements, can improve muscle function and strength in patients.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Energy & Fuels
Myeongcheol Kim, Jaegyun Im, Junsul Park, Kyung-Bum Kim, Jaegeun Lee
Summary: We have developed a carbon nanotube pad to replace carbon black, which shows better EMS performance with lower concentration and resistance.
Review
Cell & Tissue Engineering
Wei Huang, Xiaoyue Wu, Shuaixi Xiang, Mingxin Qiao, Hanfei Li, Yujie Zhu, Zhou Zhu, Zhihe Zhao
Summary: MicroRNAs (miRNAs) play a vital role in the differentiation of C3H10T1/2 cells, directly regulating targeted genes and indirectly modulating differentiation through various signaling pathways. Understanding the balance effect of miRNAs on C3H10T1/2 tri-lineage differentiation can provide promising therapeutic methods for bone defects, osteoporosis, and other diseases.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cell Biology
Anurag Kumar Singh, Amrita Rai, Anja Weber, Guido Posern
Summary: Myoblast fusion is crucial for skeletal muscle formation and growth. This study identifies the critical role of Cyclase-Associated Protein 1 (CAP1) in cytoskeletal remodeling during myoblast fusion. The study also reveals the regulation of Cap1 expression by microRNAs during myogenic differentiation. These findings contribute to a better understanding of the molecular mechanisms underlying myoblast fusion.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Green & Sustainable Science & Technology
Luiz Rodrigues-Santana, Angel Denche-Zamorano, Carmen Galan-Arroyo, Jose Carmelo Adsuar, Nicolas Contreras-Barraza, Sandra Vera-Ruiz, Hugo Louro
Summary: Physical activity is important for people's health, but sedentary lifestyles pose a serious risk to global health. The likelihood of engaging in physical activity depends on perceived benefits and barriers. Whole-body electrostimulation training (WB-EMS) helps minimize barriers. A study found no significant gender differences in barriers and perceived benefits of WB-EMS, with enjoyment and improved physical health being the most prominent benefits and time constraints being the main barriers.
Article
Endocrinology & Metabolism
John M. Jakicic, Renee J. Rogers, Timothy S. Church
Summary: Contemporary antiobesity medications are effective, but lifestyle factors should focus on enhancing holistic patient health and well-being rather than just weight loss. Physical activity is an important lifestyle behavior that has many health benefits, whether or not weight loss is achieved.
Review
Cardiac & Cardiovascular Systems
Hannah J. Hunkler, Sonja Gross, Thomas Thum, Christian Baer
Summary: Myocardial infarction leads to the loss of cardiomyocytes and heart failure. The only curative treatment for heart failure currently is heart transplantation, but it has limitations. Cellular reprogramming and defined differentiation protocols offer new possibilities for cell therapy, and non-coding RNAs have been shown to regulate these processes.
CARDIOVASCULAR RESEARCH
(2022)
Review
Nutrition & Dietetics
Melina Heimer, Marc Teschler, Boris Schmitz, Frank C. Mooren
Summary: The effects of probiotics on the immune system, URTI, and GI symptoms in athletes, healthy adults, and recreationally active individuals remain inconclusive. Further research is needed to draw definitive conclusions.
FRONTIERS IN NUTRITION
(2022)
Meeting Abstract
Psychiatry
W. Kop, B. Schmitz, D. Gatsios, C. Pena-Gil, J. Gonzalez Juanatey, D. Cantarero Prieto, V. Tsakanikas, S. Hubert, M. Habibovic, M. Schmidt, M. Kleber, G. de Bruijn, H. Malberg, F. Mooren, J. Widdershoven, D. Fotiadis, W. Marz, J. Bosch
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2022)
Review
Physiology
Maryam Balke, Marc Teschler, Hendrik Schaefer, Pantea Pape, Frank C. Mooren, Boris Schmitz
Summary: There is evidence that ICU treatment and invasive ventilation can cause a decline in muscle mass and function, known as ICU-acquired weakness. Electromyostimulation may improve the condition of critically ill patients, but more research is needed for conclusive results.
FRONTIERS IN PHYSIOLOGY
(2022)
Correction
Nutrition & Dietetics
Melina Heimer, Marc Teschler, Boris Schmitz, Frank C. C. Mooren
FRONTIERS IN NUTRITION
(2022)
Review
Cardiac & Cardiovascular Systems
Dimyana Neufeldt, Sarah Cushman, Christian Baer, Thomas Thum
Summary: Considerable progress has been made in managing cancer, but the discovery of previously unknown adverse events poses challenges to treatment. The close relationship between cardiovascular diseases and cancer underscores the need for interdisciplinary study. Non-coding RNAs, particularly circular RNAs, are emerging as potential targets for the simultaneous treatment of cardiac dysfunction and cancer in the field of cardio-oncology.
CARDIOVASCULAR RESEARCH
(2023)
Review
Oncology
Franziska Lioba Breulmann, Luan Phelipe Hatt, Boris Schmitz, Esther Wehrle, Robert Geoff Richards, Elena Della Bella, Martin James Stoddart
Summary: This systematic review aimed to identify common miRNAs involved in fracture healing or non-union fractures. Out of 151 miRNAs, miR-21, miR-140 and miR-214 were the most investigated miRNAs in fracture healing in general, while miR-31-5p, miR-221 and miR-451-5p were identified to be regulated specifically in non-union fractures. Despite heterogeneity between studies, these miRNAs have the potential to serve as biomarkers for non-union fractures.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Melina Heimer, Sandra Schmitz, Marc Teschler, Hendrik Schaefer, Emma R. Douma, Mirela Habibovic, Willem J. Kop, Thorsten Meyer, Frank C. Mooren, Boris Schmitz
Summary: This study provides a quantitative analysis of the effects of eHealth-supported interventions on health outcomes in cardiovascular rehabilitation maintenance phase III for patients with coronary artery disease (CAD). The results suggest that eHealth interventions can increase physical activity and exercise capacity, improve quality of life, and lower systolic blood pressure. Effective behavioral change techniques include self-monitoring of behavior, goal setting, and behavior feedback.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Peripheral Vascular Disease
Hendrik Schaefer, Marc Teschler, Frank C. Mooren, Boris Schmitz
Summary: In patients with post COVID-19 syndrome (PCS), the rate of tissue oxygen consumption is persistently altered, leading to slower decline in tissue oxygenation during occlusion. These observations may help explain PCS-specific symptoms such as physical impairment and fatigue.
MICROVASCULAR RESEARCH
(2023)
Article
Multidisciplinary Sciences
Frank C. Mooren, Irina Boeckelmann, Melina Waranski, Mona Kotewitsch, Marc Teschler, Hendrik Schaefer, Boris Schmitz
Summary: Post-COVID-19 Syndrome (PCS) is a condition characterized by persistent alterations in heart rate variability (HRV) and sympathetic overstimulation, resembling findings in patients with coronary artery disease (CAD). PCS patients show disturbed diurnal adjustment of HRV, with impaired parasympathetic activity at night. HRV variables may have prognostic value in PCS and further studies are needed to investigate their potential role as biomarkers of successful interventions.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Johanna M. Mooren, Rene Garbsch, Hendrik Schaefer, Mona Kotewitsch, Melina Waranski, Marc Teschler, Boris Schmitz, Frank C. Mooren
Summary: This study compared the effects of different modes of aerobic endurance training on patients with Post-COVID-19 syndrome (PCS). The results showed that both continuous training and interval training improved physical exercise capacity and disease perception in PCS patients, with similar outcomes to coronary artery disease (CAD) patients undergoing rehabilitation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Boris Schmitz
Summary: The role of scientific research is crucial in modern society for driving innovation, informing policies, and shaping public opinion. However, communicating scientific findings to the general public can be challenging due to its technicality and complexity. Lay abstracts, generated by artificial intelligence language models, can provide easily understandable summaries of key findings and implications, increasing the visibility and impact of scientific research.
Meeting Abstract
Cardiac & Cardiovascular Systems
B. Schmitz, S. Wirtz, M. Sestayo-Fernandez, H. Schaefer, E. R. Douma, M. Alonso, V. Gonzalez-Salvado, M. Habibovic, W. J. Kop, C. Pena-Gil, F. C. Mooren
EUROPEAN HEART JOURNAL
(2022)