Review
Immunology
Jie Huang
Summary: This review discusses the current status and applications of molecule-based positron emission tomography (PET) imaging in neuroinflammation. Despite certain limitations, neuroinflammation PET imaging is considered a promising approach to understanding the pathophysiological process of Alzheimer's disease (AD) and mild cognitive impairment (MCI).
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Clinical Neurology
Anna Pink, Janina Krell-Roesch, Jeremy A. Syrjanen, Maria Vassilaki, Val J. Lowe, Prashanthi Vemuri, Gorazd B. Stokin, Teresa J. Christianson, Walter K. Kremers, Clifford R. Jack, David S. Knopman, Ronald C. Petersen, Yonas E. Geda
Summary: This study found that cortical amyloid deposition, anxiety, and depression independently increased the risk of incident mild cognitive impairment. Additionally, anxiety modified the association between cortical amyloid deposition and incident mild cognitive impairment.
ALZHEIMERS & DEMENTIA
(2022)
Article
Neurosciences
Hyejin Ahn, Dahyun Yi, Kyungjin Chu, Haejung Joung, Younghwa Lee, Gijung Jung, Kiyoung Sung, Dongkyun Han, Jun Ho Lee, Min Soo Byun, Dong Young Lee
Summary: This study investigated the neural correlates of semantic verbal fluency test (SVFT) scores in subjects with mild cognitive impairment (MCI) and Alzheimer's disease (AD) dementia using FDG-PET. The results showed that the total score (TS) of SVFT was positively correlated with cerebral glucose metabolism in various brain regions. However, the strategy scores of switching (SW) and cluster switching (CSW) were found to be better indicators of specific language and executive functions. Furthermore, the associations between strategy scores and regional glucose metabolism varied based on the severity of the disease.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Clinical Neurology
Dallah Yoo, Jee-Young Lee, Yu Kyeong Kim, Eun Jin Yoon, Heejung Kim, Ryul Kim, Hyunwoo Nam, Beomseok Jeon
Summary: MCI is common in isolated RBD, with 45% of iRBD patients having MCI and a 27% risk of significant cognitive deterioration. Cognitive decline in iRBD-MCI group is particularly pronounced in verbal memory and executive function domains.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Biochemistry & Molecular Biology
Shanshan Chen, Yu Song, Huimin Wu, Honglin Ge, Wenzhang Qi, Yue Xi, Jiayi Wu, Yuxiang Ji, Kexin Chen, Xingjian Lin, Jiu Chen
Summary: In patients with amnestic mild cognitive impairment (aMCI), anosognosia is associated with increased tau accumulation in specific brain regions, disrupted functional connectivity, and accelerates progression to Alzheimer's disease dementia.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Ophthalmology
Kallene Summer Moreira Vidal, Diego Decleva, Mirella Telles Salgueiro Barboni, Balazs Vince Nagy, Paulo Augusto Hidalgo de Menezes, Avinash Aher, Artur Martins Coutinho, Paula Squarzoni, Daniele de Paula Faria, Fabio Luis de Souza Duran, Carlos Alberto Buchpiguel, Jan Kremers, Geraldo Busatto Filho, Dora Fix Ventura
Summary: This study evaluated color vision changes and retinal processing in patients with AD and MCI, finding that both groups showed acquired color vision deficiency, which may be related to impaired brain metabolism.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Psychology, Multidisciplinary
Kimberly D. Mueller, Lianlian Du, Davide Bruno, Tobey Betthauser, Bradley Christian, Sterling Johnson, Bruce Hermann, Rebecca Langhough Koscik
Summary: This study demonstrates that the Logical Memory (LM) task is effective in discriminating ability levels and amyloid status, and that individual items vary in difficulty and discrimination based on amyloid status. These findings can inform the development of sensitive tasks or composite scores for early detection of cognitive decline.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Geriatrics & Gerontology
Hyun Jeong Lee, Eun-Chong Lee, Seongho Seo, Kwang-Pil Ko, Jae Myeong Kang, Woo-Ram Kim, Ha-Eun Seo, Sang-Yoon Lee, Yeong-Bae Lee, Kee Hyung Park, Byeong Kil Yeon, Nobuyuki Okamura, Duk L. Na, Joon-Kyung Seong, Young Noh
Summary: Using cluster analyses with [F-18]THK5351 retention patterns, it is possible to identify clinically-distinct subgroups of MCI patients and those at greater risk of progression to dementia. These subgroups show significant differences in cognitive function and risk of dementia progression.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Geriatrics & Gerontology
Andrea M. Weinstein, Swathi Gujral, Meryl A. Butters, Christopher R. Bowie, Corinne E. Fischer, Alastair J. Flint, Nathan Herrmann, James L. Kennedy, Linda Mah, Shima Ovaysikia, Bruce G. Pollock, Tarek K. Rajji, Benoit H. Mulsant
Summary: This study compared diagnostic rates and clinical predictors between NIA-AA criteria and DSM-5 criteria, finding that discrepancies were more likely in individuals with a history of MDD or carrying at least one ApoE4 allele. Detailed neuropsychological testing and NIA-AA criteria identified a greater prevalence of cognitive impairment compared to DSM-5 criteria and the Montreal Cognitive Assessment.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Article
Neurosciences
Eric Cao, Da Ma, Siddharth Nayak, Tim Q. Duong
Summary: This study presents a novel deep learning approach to predict the conversion from mild cognitive impairment (MCI) to Alzheimer's dementia (AD) using whole-brain FDG-PET and cognitive scores (CS). The results show that a combination of FDG-PET, age, and neurocognitive data yields the best model for predicting MCI conversion to AD.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Cell Biology
Eun-Hye Lee, Myung-Hoon Han, Jungsoon Ha, Hyun-Hee Park, Seong-Ho Koh, Seong Hye Choi, Jae-Hong Lee
Summary: The study indicated a negative association between age and telomere length, with individuals with Alzheimer's disease showing a greater rate of telomere shortening per year compared to healthy individuals and those with mild cognitive impairment. Additionally, women experienced more significant telomere shortening per year than men.
Article
Clinical Neurology
HyunChul Youn, Won Seok William Hyung, Junhyung Kim, Eun Seong Lee, Jae Seon Eo, Cheol E. Han, Changsu Han, Seung-Hyun Kim, Hyun-Ghang Jeong
Summary: This study investigated the 1-year changes in neuropsychological test results in older adults with late-life depression and mild cognitive impairment, based on the presence or absence of brain amyloidopathy. The findings showed differences in the extent of change depending on the severity of depressive symptoms and amyloidopathy status. Clinicians should consider exploring neuropathology when assessing older adults with depression and cognitive impairment.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Biochemistry & Molecular Biology
Yuuki Sasaki, Noriyuki Kimura, Yasuhiro Aso, Kenichi Yabuuchi, Miki Aikawa, Etsuro Matsubara
Summary: The study found that CSF levels of MMP-2 were negatively correlated with brain amyloid deposition, especially in the parietotemporal lobe and posterior cingulate gyrus, and that CSF levels of MMP-7 were positively correlated with the severity of WMLs. These findings provide insights into the role of MMPs in amyloid beta catabolism and blood-brain barrier integration at the MCI stage.
Article
Clinical Neurology
Andrea Horta-Barba, Saul Martinez-Horta, Jesus Perez-Perez, Arnau Puig-Davi, Natascia de Lucia, Giuseppe de Michele, Elena Salvatore, Stefanie Kehrer, Josef Priller, Simone Migliore, Ferdinando Squitieri, Anna Castaldo, Caterina Mariotti, Veronica Mananes, Jose Luis Lopez-Sendon, Noelia Rodriguez, Asuncion Martinez-Descals, Filipa Julio, Cristina Januario, Marianna Delussi, Marina de Tommaso, Sandra Noguera, Jesus J. Ruiz-Idiago, Emilia Sitek, Renata Wallner, Angela Nuzzi, Javier Pagonabarraga, Jaime Kulisevsky
Summary: This study developed a specific assessment tool, the Parkinson's Disease-Cognitive Rating Scale (PD-CRS), to evaluate the cognitive status of Huntington's disease patients and monitor the progression of cognitive impairment. Through evaluating 180 gene-positive patients, criteria for classifying normal cognition, mild cognitive impairment, and dementia were established, and the PD-CRS demonstrated good sensitivity and specificity. Additionally, the PD-CRS captured cognitive progression in different cognitive groups and showed sensitivity to change in mild cognitive impairment and dementia.
JOURNAL OF NEUROLOGY
(2023)
Article
Neurosciences
Kinjal Doshi, Stacey L. Henderson, Qianqian Fan, Kian F. Wong, Julian Lim
Summary: The study found that a cognition-focused mindfulness-based intervention had significant improvements in global cognition and delayed memory in MCI patients, although it did not show advantages over usual treatment. Depression did not change in the MBT group, and only reductions in depression were associated with improvements in cognitive functioning in this group.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Correction
Multidisciplinary Sciences
Gisela Pattarone, Laura Acion, Marina Simian, Roland Mertelsmann, Marie Follo, Emmanuel Iarussi
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Natalia Mena-Vazquez, Rocio Redondo-Rodriguez, Jose Rioja, Francisco Gabriel Jimenez-Nunez, Sara Manrique-Arija, Jose Manuel Lisbona-Montanez, Laura Cano-Garcia, Marta Rojas-Gimenez, Inmaculada Urena, Pedro Valdivielso, Antonio Fernandez-Nebro
Summary: Postprandial lipidemia is more frequent in patients with rheumatoid arthritis and is associated with subclinical atherosclerosis and inflammation.
Article
Geriatrics & Gerontology
Andrea Weber, Alison Lynch, Benjamin Miskle, Stephan Arndt, Laura Acion
Summary: The percentage of older adults entering substance use treatment for the first time continues to increase, particularly in the use of illicit drugs. Opioid and methamphetamine use has also increased among older adults entering treatment. As the population ages and substance use trends change, treatment programs must adapt to meet the needs of older adults.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Article
Psychology, Clinical
Pablo Cresta Morgado, Martin Carusso, Laura Alonso Alemany, Laura Acion
Summary: Machine learning provides a variety of tools to explore addiction data, requiring careful implementation for reproducibility and transparency. Key issues in applying machine learning include training a model, avoiding overfitting, and determining an adequate sample size. Researchers in addiction must be aware of the limitations and seek solutions when applying machine learning techniques.
AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE
(2022)
Article
Psychology, Clinical
Pablo Cresta Morgado, Martin Carusso, Laura Alonso Alemany, Laura Acion
Summary: The two-part review introduces machine learning tools and concepts to addiction researchers, providing them with the knowledge and understanding to incorporate these methods into their projects. The first part covers supervised and unsupervised methods, with examples of their application in addiction research.
AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE
(2022)
Editorial Material
Biochemical Research Methods
Rocio Joo, Andrea Sanchez-Tapia, Sara Mortara, Yanina Bellini Saibene, Heather Turner, Dorothea Hug Peter, Natalia Soledad Morandeira, Matt Bannert, Batool Almazrouq, Elizabeth Hare, Laura Acion, Juan Pablo Narvaez-Gomez, Marcela Alfaro Cordoba, Federico Marini, Rita Giordano, Silvia Canelon, Anicet Ebou, Adithi R. Upadhya, Joselyn Chavez, Janani Ravi
Summary: This article introduces ten simple rules for hosting inclusive conferences, based on the authors' experience organizing the useR! statistical computing conference in 2021. These rules and practical tips aim to make various events more accessible and inclusive, providing a starting point for efforts to build more inclusive conferences worldwide.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Article
Substance Abuse
Anees Bahji, Laura Acion, Anne-Marie Laslett, Bryon Adinoff
Summary: This study examines the predominance of English in scientific addiction literature and proposes suggestions for making this literature more accessible to non-English speakers, including increasing the availability of translation services.
NORDIC STUDIES ON ALCOHOL AND DRUGS
(2023)
Article
Psychiatry
Peter B. Barr, Travis T. Mallard, Sandra Sanchez-Roige, Holly E. Poore, Richard Karlsson Linner, Irwin D. Waldman, Abraham A. Palmer, K. Paige Harden, Danielle M. Dick
Summary: In this study, multivariate GWAS was used to identify genetic variants associated with problematic alcohol use. These variants were found to be related to either shared risk factors for externalizing or specific risk factors for alcohol use disorders. SNPs associated with specific risk factors were primarily related to alcohol metabolism.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Substance Abuse
Andrea Weber, Benjamin Miskle, Alison Lynch, Stephan Arndt, Laura Acion
Summary: The study found that 65% of SUD treatment facilities provided at least one pharmacotherapy, while 35% did not. Facilities offering pharmacotherapy also provided, on average, 6 additional treatment options. The most commonly available pharmacotherapy was psychiatric medications, followed by buprenorphine/naloxone and naltrexone.
SUBSTANCE ABUSE AND REHABILITATION
(2022)
Article
Pharmacology & Pharmacy
Jose Rioja, Maria Jose Ariza, Maria Jose Benitez-Toledo, Javier Espildora-Hernandez, Inmaculada Coca-Prieto, Teresa Arrobas-Velilla, Ana Camacho, Gunilla Olivecrona, Miguel Angel Sanchez-Chaparro, Pedro Valdivielso
Summary: This study aimed to establish and validate cut-off points for the diagnosis of familial chylomicronemia syndrome (FCS) based on the ROC curve. The results showed that all FCS patients had post-heparin plasma lipoprotein lipase (LPL) activity below 25.1 mU/mL, with no overlap between FCS and multifactorial chylomicronemia syndrome (MCS) groups. Therefore, in addition to genetic testing, LPL activity in subjects with severe hypertriglyceridemia can serve as a reliable criterion for FCS diagnosis with a cut-off of 25.1 mU/mL.
JOURNAL OF CLINICAL LIPIDOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Belen Murcia Casas, Juan Luis Carrillo Linares, Isabel Baquero Aranda, Jose Rioja Villodres, Vicente Merino Bohorquez, Andres Gonzalez Jimenez, Miguel Angel Rico Corral, Ricardo Bosch, Miguel Angel Sanchez Chaparro, Maria Garcia Fernandez, Pedro Valdivielso
Summary: Pseudoxanthoma elasticum (PXE) is a condition characterized by low levels of inorganic pyrophosphate (PPi) and high activity of tissue-nonspecific alkaline phosphatase (TNAP). This study investigated the effect of lansoprazole, a partial inhibitor of TNAP, on plasma PPi levels in PXE patients. The results showed that 30 mg/day of lansoprazole significantly increased plasma PPi levels in PXE patients, indicating the potential therapeutic role of lansoprazole in PXE.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Natalia Mena-Vazquez, Francisco Javier Godoy-Navarrete, Jose Manuel Lisbona-Montanez, Rocio Redondo-Rodriguez, Sara Manrique-Arija, Jose Rioja, Arkaitz Mucientes, Patricia Ruiz-Limon, Aimara Garcia-Studer, Fernando Ortiz-Marquez, Begona Oliver-Martos, Laura Cano-Garcia, Antonio Fernandez-Nebro
Summary: This study aimed to identify inflammatory factors and soluble cytokines that act as biomarkers in the diagnosis and prognosis of rheumatoid arthritis-associated interstitial lung disease (RA-ILD). The study found that patients with RA-ILD had higher inflammatory activity and certain cytokines were associated with both diagnosis and poorer prognosis in these patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
John Nurnberger Jr, Yumin Wang, Yong Zang, Dongbing Lai, Leah Wetherill, Howard J. Edenberg, Fazil Aliev, Martin H. Plawecki, David Chorlian, Grace Chan, Kathleen Bucholz, Lance Bauer, Chella Kamarajan, Jessica E. Salvatore, Manav Kapoor, Victor Hesselbrock, Danielle Dick, Laura Bierut, Vivia McCutcheon, Jacquelyn L. Meyers, Bernice Porjesz, John Kramer, Samuel Kuperman, Sivan Kinreich, Andrey P. Anokhin
Summary: This study found that European ancestry subjects with higher PRS were more likely to develop AUD, with predictive power primarily driven by clinical variables. In a high-risk sample, European ancestry subjects with PRS in the highest quartile showed a higher risk for developing AUD.
BIOLOGICAL PSYCHIATRY: GLOBAL OPEN SCIENCE
(2022)
Article
Neurosciences
Richard Karlsson Linner, Travis T. Mallard, Peter B. Barr, Sandra Sanchez-Roige, James W. Madole, Morgan N. Driver, Holly E. Poore, Ronald de Vlaming, Andrew D. Grotzinger, Jorim J. Tielbeek, Emma C. Johnson, Mengzhen Liu, Sara Brin Rosenthal, Trey Ideker, Hang Zhou, Rachel L. Kember, Joelle A. Pasman, Karin J. H. Verweij, Dajiang J. Liu, Scott Vrieze, Henry R. Kranzler, Joel Gelernter, Kathleen Mullan Harris, Elliot M. Tucker-Drob, Irwin D. Waldman, Abraham A. Palmer, K. Paige Harden, Philipp D. Koellinger, Danielle M. Dick
Summary: Research shows that persistent difficulties in self-regulation may be conceptualized as a neurodevelopmental trait with complex and far-reaching social and health correlates. By leveraging genetic correlations, over 500 genetic loci related to externalizing traits were identified, enriched for genes expressed in the brain and related to nervous system development.
NATURE NEUROSCIENCE
(2021)
Article
Substance Abuse
Alison C. Lynch, Andrea N. Weber, Suzy Hedden, Sayeh Sabbagh, Stephan Arndt, Laura Acion
Summary: The study demonstrates that a care model based on easy and flexible access, as well as strategies to improve treatment retention, can increase recovery capital, reduce illegal drug use and cravings, and retain individuals in treatment.
SUBSTANCE ABUSE TREATMENT PREVENTION AND POLICY
(2021)