Temporal Expression of Apelin/Apelin Receptor in Ischemic Stroke and its Therapeutic Potential

The Metalloprotease Neprilysin Degrades and Inactivates Apelin Peptides

(2016) Shaun M. K. McKinnie et al.   CHEMBIOCHEM

Development of Potent and Metabolically Stable APJ Ligands with High Therapeutic Potential

(2016) Cathleen Juhl et al.   ChemMedChem

Apelin-13 exerts antidepressant-like and recognition memory improving activities in stressed rats

(2016) E. Li et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Angiotensin-Converting Enzyme 2 Metabolizes and Partially Inactivates Pyr-Apelin-13 and Apelin-17Novelty and Significance

(2016) Wang Wang et al.   HYPERTENSION

Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015

(2016) Haidong Wang et al.   LANCET

Apelin-13 Protects PC12 Cells from Corticosterone-Induced Apoptosis Through PI3K and ERKs Activation

(2016) Yunjun Zou et al.   NEUROCHEMICAL RESEARCH

Apelin-13 protects neurovascular unit against ischemic injuries through the effects of vascular endothelial growth factor

(2016) Chuyi Huang et al.   NEUROPEPTIDES

The emerging role of signal transducer and activator of transcription 3 in cerebral ischemic and hemorrhagic stroke

(2016) Zhenxing Liang et al.   PROGRESS IN NEUROBIOLOGY

Effect of apelin hormone on renal ischemia/reperfusion induced oxidative damage in rats

(2016) Burak Bircan et al.   RENAL FAILURE

Apelinergic system in endothelial cells and its role in angiogenesis in myocardial ischemia

(2016) Vera Novakova et al.   VASCULAR PHARMACOLOGY

Evaluation of Gene Therapy as an Intervention Strategy to Treat Brain Injury from Stroke

(2016) Amanda J. Craig et al.   Frontiers in Molecular Neuroscience

Intranasal Delivery of Apelin-13 Is Neuroprotective and Promotes Angiogenesis After Ischemic Stroke in Mice

(2015) Dongdong Chen et al.   ASN Neuro

Autophagy and oxidative stress in cardiovascular diseases

(2015) Yu Mei et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Structural apelin analogues: mitochondrial ROS inhibition and cardiometabolic protection in myocardial ischaemia reperfusion injury

(2015) Oleg Pisarenko et al.   BRITISH JOURNAL OF PHARMACOLOGY

Heart Disease and Stroke Statistics—2016 Update

(2015) Dariush Mozaffarian et al.   CIRCULATION

Apelin/APJ signaling in hypoxia-related diseases

(2015) Lu He et al.   CLINICA CHIMICA ACTA

Lateral intracerebroventricular injection of Apelin-13 inhibits apoptosis after cerebral ischemia/reperfusion injury

(2015) Bo Bai et al.   Neural Regeneration Research

Neuroprotective effects of apelin-13 on experimental ischemic stroke through suppression of inflammation

(2015) Qing Xin et al.   PEPTIDES

Genetic targeting of sprouting angiogenesis using Apln-CreER

(2015) Qiaozhen Liu et al.   Nature Communications

Elabela-Apelin Receptor Signaling Pathway is Functional in Mammalian Systems

(2015) Zhi Wang et al.   Scientific Reports

Apelin is transcriptionally regulated by ER stress-induced ATF4 expression via a p38 MAPK-dependent pathway

(2014) Kwon Jeong et al.   APOPTOSIS

The apelin receptor: physiology, pathology, cell signalling, and ligand modulation of a peptide-activated class A GPCR

(2014) Nigel A. Chapman et al.   Biochemistry and Cell Biology

Lys203 and Lys382 are Essential for the Proteasomal Degradation of BACE1

(2014) Rong Wang et al.   Current Alzheimer Research

Down-regulation of MIF by NFκB under hypoxia accelerated neuronal loss during stroke

(2014) Si Zhang et al.   FASEB JOURNAL

Identification of Serine 348 on the Apelin Receptor as a Novel Regulatory Phosphorylation Site in Apelin-13-induced G Protein-independent Biased Signaling

(2014) Xiaoyu Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Apelin inhibits the proliferation and migration of rat PASMCsviathe activation of PI3K/Akt/mTOR signal and the inhibition of autophagy under hypoxia

(2014) Hongyu Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Apelin-13 Attenuates Traumatic Brain Injury-Induced Damage by Suppressing Autophagy

(2014) Hai-Jun Bao et al.   NEUROCHEMICAL RESEARCH

Endoplasmic reticulum stress in cerebral ischemia

(2014) Qing Xin et al.   NEUROCHEMISTRY INTERNATIONAL

Apelin-13 protects the brain against ischemia/reperfusion injury through activating PI3K/Akt and ERK1/2 signaling pathways

(2014) Yi Yang et al.   NEUROSCIENCE LETTERS

Synthetic retinoid Am80 up-regulates apelin expression by promoting interaction of RARα with KLF5 and Sp1 in vascular smooth muscle cells

(2013) Xin-rui Lv et al.   BIOCHEMICAL JOURNAL

ELABELA: A Hormone Essential for Heart Development Signals via the Apelin Receptor

(2013) Serene C. Chng et al.   DEVELOPMENTAL CELL

Apelin Attenuates Oxidative Stress in Human Adipocytes

(2013) Aung Than et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The apelin receptor APJ: journey from an orphan to a multifaceted regulator of homeostasis

(2013) Anne-Marie O'Carroll et al.   JOURNAL OF ENDOCRINOLOGY

Apelin-36, a potent peptide, protects against ischemic brain injury by activating the PI3K/Akt pathway

(2013) Qin Gu et al.   NEUROCHEMISTRY INTERNATIONAL

Neuroprotective Effect of Kaempferol Glycosides against Brain Injury and Neuroinflammation by Inhibiting the Activation of NF-κB and STAT3 in Transient Focal Stroke

(2013) Lu Yu et al.   PLoS One

The Role of Apelins in the Physiology of the Heart

(2013) Suna Aydin et al.   PROTEIN AND PEPTIDE LETTERS

Mechanism underlying the inhibitory effect of Apelin-13 on glucose deprivation-induced autophagy in rat cardiomyocytes

(2013) HUI JIAO et al.   Experimental and Therapeutic Medicine

Loss of Apelin Exacerbates Myocardial Infarction Adverse Remodeling and Ischemia‐reperfusion Injury: Therapeutic Potential of Synthetic Apelin Analogues

(2013) Wang Wang et al.   Journal of the American Heart Association

Preferential apelin-13 production by the proprotein convertase PCSK3 is implicated in obesity

(2013) Kyungsoo Shin et al.   FEBS Open Bio

Autophagy regulates endoplasmic reticulum stress in ischemic preconditioning

(2012) Rui Sheng et al.   Autophagy

Both PI3K/Akt and ERK1/2 pathways participate in the protection by dexmedetomidine against transient focal cerebral ischemia/reperfusion injury in rats

(2012) Yong-Man Zhu et al.   BRAIN RESEARCH

Apelin-13 Protects the Brain Against Ischemic Reperfusion Injury and Cerebral Edema in a Transient Model of Focal Cerebral Ischemia

(2012) Mehdi Khaksari et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Apelin-13 protects the heart against ischemia-reperfusion injury through inhibition of ER-dependent apoptotic pathways in a time-dependent fashion

(2011) Jianping Tao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Sequential Activation of Hypoxia-Inducible Factor 1 and Specificity Protein 1 is Required for Hypoxia-Induced Transcriptional Stimulation of Abcc8

(2011) Seung Kyoon Woo et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Identification and Characterization of Apelin Peptides in Bovine Colostrum and Milk by Liquid Chromatography–Mass Spectrometry

(2011) Cédric Mesmin et al.   JOURNAL OF PROTEOME RESEARCH

Translational and transcriptional control of Sp1 against ischaemia through a hydrogen peroxide-activated internal ribosomal entry site pathway

(2011) Shiu Hwa Yeh et al.   NUCLEIC ACIDS RESEARCH

GSK-3 as a Target for Lithium-Induced Neuroprotection Against Excitotoxicity in Neuronal Cultures and Animal Models of Ischemic Stroke

(2011) De-Maw Chuang et al.   Frontiers in Molecular Neuroscience

Apelin and APJ regulation in adipose tissue and skeletal muscle of type 2 diabetic mice and humans

(2010) Cédric Dray et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Effect of Apelin-Apelin Receptor System in Postischaemic Myocardial Protection: A Pharmacological Postconditioning Tool?

(2010) Raffaella Rastaldo et al.   ANTIOXIDANTS & REDOX SIGNALING

The Science of Stroke: Mechanisms in Search of Treatments

(2010) Michael A. Moskowitz et al.   NEURON

Endoplasmic Reticulum Stress Plays Critical Role in Brain Damage After Cerebral Ischemia/Reperfusion in Rats

(2009) Venkata Prasuja Nakka et al.   NEUROTOXICITY RESEARCH

Ontogeny of apelin and its receptor in the rodent gastrointestinal tract

(2009) Guiyun Wang et al.   REGULATORY PEPTIDES

Involvement of a Stat3 binding site in inflammation-induced enteric apelin expression

(2008) Song Han et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

A new penumbra: transitioning from injury into repair after stroke

(2008) Eng H Lo   NATURE MEDICINE

In vivo genetic profiling and cellular localization of apelin reveals a hypoxia-sensitive, endothelial-centered pathway activated in ischemic heart failure

(2007) Ahmad Y. Sheikh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY