Cisplatin as an Anti-Tumor Drug: Cellular Mechanisms of Activity, Drug Resistance and Induced Side Effects

A Better Platinum-Based Anticancer Drug Yet to Come?

(2012) Ulrike Olszewski et al.   Anti-Cancer Agents in Medicinal Chemistry

Status of Bi- and Multi-Nuclear Platinum Anticancer Drug Development

(2012) Jinchao Zhang et al.   Anti-Cancer Agents in Medicinal Chemistry

Cisplatin as an Anti-Tumor Drug: Cellular Mechanisms of Activity, Drug Resistance and Induced Side Effects

(2011) Ana-Maria Florea et al.   Cancers

The relationship between cisplatin-induced reactive oxygen species, glutathione, and BCL-2 and resistance to cisplatin

(2010) Anamaria Brozovic et al.   CRITICAL REVIEWS IN TOXICOLOGY

Novel Metals and Metal Complexes as Platforms for Cancer Therapy

(2010) Michael Frezza et al.   CURRENT PHARMACEUTICAL DESIGN

Alterations of microRNAs and their targets are associated with acquired resistance of MCF-7 breast cancer cells to cisplatin

(2010) Igor P. Pogribny et al.   INTERNATIONAL JOURNAL OF CANCER

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(2010) Kirti Bhatt et al.   MOLECULAR MEDICINE

miRNA-regulated expression of oncogenes and tumor suppressor genes in the cisplatin-inhibited growth of K562 cells

(2010) Xie   ONCOLOGY REPORTS

Mitochondria as targets for chemotherapy

(2009) Vladimir Gogvadze et al.   APOPTOSIS

Metal complexes in medicine with a focus on enzyme inhibition

(2009) Chi-Ming Che et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Metal Complexes, their Cellular Targets and Potential for Cancer Therapy

(2009) Di Chen et al.   CURRENT PHARMACEUTICAL DESIGN

Cisplatin Overdose

(2009) Roger Y. Tsang et al.   DRUG SAFETY

New-generation platinum agents for solid tumors

(2009) Neel Shah et al.   Future Oncology

Mitochondria as targets for cancer therapy

(2009) Stephen J. Ralph et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Targeting of cancer energy metabolism

(2009) Sara Rodríguez-Enríquez et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Anti-cancer drugs interfere with intracellular calcium signaling

(2009) Ana-Maria Florea et al.   NEUROTOXICOLOGY

Cisplatin enhances the antitumor effect of tumor necrosis factor-related apoptosis-inducing ligand gene therapy via recruitment of the mitochondria-dependent death signaling pathway

(2008) S Shamimi-Noori et al.   CANCER GENE THERAPY

Cancer chemoprevention and mitochondria: Targeting apoptosis in transformed cellsviathe disruption of mitochondrial bioenergetics/redox state

(2008) Numsen Hail et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Co-application of arsenic trioxide (As2O3) and cisplatin (CDDP) on human SY-5Y neuroblastoma cells has differential effects on the intracellular calcium concentration ([Ca2+]i) and cytotoxicity

(2008) Dennis Alexander Günes et al.   NEUROTOXICOLOGY

Mitochondrial off targets of drug therapy

(2008) Kendall B. Wallace   TRENDS IN PHARMACOLOGICAL SCIENCES

Experimental Evidence That a DNA Polymerase Can Incorporate N7-Platinated Guanines To Give Platinated DNA

(2007) Michele Benedetti et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Role of Cellular Accumulation in Determining Sensitivity to Platinum-Based Chemotherapy

(2007) Matthew D. Hall et al.   Annual Review of Pharmacology and Toxicology

[Pt(O,O′-acac)(γ-acac)(DMS)], a new Pt compound exerting fast cytotoxicity in MCF-7 breast cancer cells via the mitochondrial apoptotic pathway

(2007) A Muscella et al.   BRITISH JOURNAL OF PHARMACOLOGY

IP3 receptor antagonist, 2-APB, attenuates cisplatin induced Ca2+-influx in HeLa-S3 cells and prevents activation of calpain and induction of apoptosis

(2007) F Splettstoesser et al.   BRITISH JOURNAL OF PHARMACOLOGY