Astaxanthin Protects Primary Hippocampal Neurons against Noxious Effects of Aβ-Oligomers

Resveratrol Protects β Amyloid-Induced Oxidative Damage and Memory Associated Proteins in H19-7 Hippocampal Neuronal Cells

(2015) Shraddha Rege et al.   Current Alzheimer Research

Short-term modern life-like stress exacerbates Aβ-pathology and synapse loss in 3xTg-AD mice

(2015) David Baglietto-Vargas et al.   JOURNAL OF NEUROCHEMISTRY

Marine Carotenoids against Oxidative Stress: Effects on Human Health

(2015) Maria Gammone et al.   Marine Drugs

Astaxanthin as a Potential Neuroprotective Agent for Neurological Diseases

(2015) Haijian Wu et al.   Marine Drugs

The antioxidant effect of astaxanthin is higher in young mice than aged: a region specific study on brain

(2015) Md. Mamun Al-Amin et al.   METABOLIC BRAIN DISEASE

Neuroprotective effect of astaxanthin against glutamate-induced cytotoxicity in HT22 cells: Involvement of the Akt/GSK-3β pathway

(2015) X. Wen et al.   NEUROSCIENCE

Astaxanthin rescues neuron loss and attenuates oxidative stress induced by amygdala kindling in adult rat hippocampus

(2015) Yan Lu et al.   NEUROSCIENCE LETTERS

Inhibition of inflammation by astaxanthin alleviates cognition deficits in diabetic mice

(2015) Xiaoyan Zhou et al.   PHYSIOLOGY & BEHAVIOR

Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer’s disease

(2015) Sergio T. Ferreira et al.   Frontiers in Cellular Neuroscience

Astaxanthin prevents and reverses diet-induced insulin resistance and steatohepatitis in mice: A comparison with vitamin E

(2015) Yinhua Ni et al.   Scientific Reports

Contribution of Ca2+ Release Channels to Hippocampal Synaptic Plasticity and Spatial Memory: Potential Redox Modulation

(2014) Andrea C. Paula-Lima et al.   ANTIOXIDANTS & REDOX SIGNALING

Alzheimer disease: Epidemiology, diagnostic criteria, risk factors and biomarkers

(2014) Christiane Reitz et al.   BIOCHEMICAL PHARMACOLOGY

Strategy to reduce free radical species in Alzheimer’s disease: an update of selected antioxidants

(2014) Fabio Di Domenico et al.   Expert Review of Neurotherapeutics

Nuclear Translocation Uncovers the Amyloid Peptide Aβ42 as a Regulator of Gene Transcription

(2014) Christian Barucker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alzheimer's Disease-Like Pathology Induced by Amyloid-β Oligomers in Nonhuman Primates

(2014) Leticia Forny-Germano et al.   JOURNAL OF NEUROSCIENCE

N-acetylcysteine in psychiatry: current therapeutic evidence and potential mechanisms of action

(2014) Olivia Dean et al.   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

Extrasynaptic NMDA Receptor Involvement in Central Nervous System Disorders

(2014) Matthew P. Parsons et al.   NEURON

Oxidative Stress in Alzheimer’s Disease: Why Did Antioxidant Therapy Fail?

(2014) Torbjörn Persson et al.   Oxidative Medicine and Cellular Longevity

Astaxanthin Treatment Confers Protection against Oxidative Stress in U937 Cells Stimulated with Lipopolysaccharide Reducing O2− Production

(2014) Sara Franceschelli et al.   PLoS One

Small molecule SIRT1 activators for the treatment of aging and age-related diseases

(2014) Basil P. Hubbard et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Amyloid-beta neuroprotection mediated by a targeted antioxidant

(2014) Courtney R. Giordano et al.   Scientific Reports

Accelerating neuronal aging in in vitro model brain disorders: a focus on reactive oxygen species

(2014) Priscila Britto Campos et al.   Frontiers in Aging Neuroscience

Ryanodine receptor-mediated Ca2+ release underlies iron-induced mitochondrial fission and stimulates mitochondrial Ca2+ uptake in primary hippocampal neurons

(2014) Carol D. SanMartín et al.   Frontiers in Molecular Neuroscience

Astaxanthin and omega-3 fatty acids individually and in combination protect against oxidative stress via the Nrf2–ARE pathway

(2013) Constance Lay Lay Saw et al.   FOOD AND CHEMICAL TOXICOLOGY

Deregulation of excitatory neurotransmission underlying synapse failure in Alzheimer's disease

(2013) Andrea C. Paula-Lima et al.   JOURNAL OF NEUROCHEMISTRY

Nuclear calcium signalling in the regulation of brain function

(2013) Hilmar Bading   NATURE REVIEWS NEUROSCIENCE

Amyloid β-Peptide (1–42)-Induced Oxidative Stress in Alzheimer Disease: Importance in Disease Pathogenesis and Progression

(2012) D. Allan Butterfield et al.   ANTIOXIDANTS & REDOX SIGNALING

Sub-lethal levels of amyloid β-peptide oligomers decrease non-transferrin-bound iron uptake and do not potentiate iron toxicity in primary hippocampal neurons

(2012) C. D. SanMartín et al.   BIOMETALS

Distinct Activation Properties of the Nuclear Factor of Activated T-cells (NFAT) Isoforms NFATc3 and NFATc4 in Neurons

(2012) Jason D. Ulrich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid-β Oligomers Induce Differential Gene Expression in Adult Human Brain Slices

(2012) Adriano Sebollela et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of the NFAT Pathway Alleviates Amyloid Beta Neurotoxicity in a Mouse Model of Alzheimer's Disease

(2012) E. Hudry et al.   JOURNAL OF NEUROSCIENCE

Scavenging Capacity of Marine Carotenoids against Reactive Oxygen and Nitrogen Species in a Membrane-Mimicking System

(2012) Eliseu Rodrigues et al.   Marine Drugs

The Metal Cation Chelating Capacity of Astaxanthin. Does This Have Any Influence on Antiradical Activity?

(2012) Elizabeth Hernández-Marin et al.   MOLECULES

The Antioxidant N-Acetylcysteine Prevents the Mitochondrial Fragmentation Induced by Soluble Amyloid-F Peptide Oligomers

(2012) C.D. SanMartin et al.   Neurodegenerative Diseases

Vitamin E: supplement versus diet in neurodegenerative diseases

(2012) Liang Shen et al.   TRENDS IN MOLECULAR MEDICINE

Basic Principles and Emerging Concepts in the Redox Control of Transcription Factors

(2011) Regina Brigelius-Flohé et al.   ANTIOXIDANTS & REDOX SIGNALING

Antioxidant effect of astaxanthin on phospholipid peroxidation in human erythrocytes

(2011) Kiyotaka Nakagawa et al.   BRITISH JOURNAL OF NUTRITION

A Role for Calcineurin in Alzheimers Disease

(2011) Lindsay C. Reese et al.   Current Neuropharmacology

Role of calcineurin in neurodegeneration produced by misfolded proteins and endoplasmic reticulum stress

(2011) Abhisek Mukherjee et al.   CURRENT OPINION IN CELL BIOLOGY

Amyloid  -Induced Impairments in Hippocampal Synaptic Plasticity Are Rescued by Decreasing Mitochondrial Superoxide

(2011) T. Ma et al.   JOURNAL OF NEUROSCIENCE

Alzheimer's disease

(2011) Clive Ballard et al.   LANCET

Involvement of ryanodine receptors in neurotrophin-induced hippocampal synaptic plasticity and spatial memory formation

(2011) T. Adasme et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid β-Peptide Oligomers Stimulate RyR-Mediated Ca2+ Release Inducing Mitochondrial Fragmentation in Hippocampal Neurons and Prevent RyR-Mediated Dendritic Spine Remodeling Produced by BDNF

(2010) Andrea C. Paula-Lima et al.   ANTIOXIDANTS & REDOX SIGNALING

Astaxanthin upregulates heme oxygenase-1 expression through ERK1/2 pathway and its protective effect against beta-amyloid-induced cytotoxicity in SH-SY5Y cells

(2010) Hong-Quan Wang et al.   BRAIN RESEARCH

Astaxanthine Secured Apoptotic Death of PC12 Cells Induced by β-Amyloid Peptide 25–35: Its Molecular Action Targets

(2010) Chi-Huang Chang et al.   JOURNAL OF MEDICINAL FOOD

Amyloid   Induces the Morphological Neurodegenerative Triad of Spine Loss, Dendritic Simplification, and Neuritic Dystrophies through Calcineurin Activation

(2010) H.-Y. Wu et al.   JOURNAL OF NEUROSCIENCE

Potential in vivo amelioration by N-acetyl-L-cysteine of oxidative stress in brain in human double mutant APP/PS-1 knock-in mice: Toward therapeutic modulation of mild cognitive impairment

(2010) Quanzhen Huang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Potential health-promoting effects of astaxanthin: A high-value carotenoid mostly from microalgae

(2010) Jian-Ping Yuan et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Astaxanthin reduces ischemic brain injury in adult rats

(2009) Hui Shen et al.   FASEB JOURNAL

Cognitive Decline in Alzheimer's Disease Is Associated with Selective Changes in Calcineurin/NFAT Signaling

(2009) H. M. Abdul et al.   JOURNAL OF NEUROSCIENCE

Neural Activity Regulates Synaptic Properties and Dendritic Structure In Vivo through Calcineurin/NFAT Signaling

(2009) Neil Schwartz et al.   NEURON

Calcium hypothesis of Alzheimer’s disease

(2009) Michael J. Berridge   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

N-acetylcysteine for antioxidant therapy: pharmacology and clinical utility

(2008) Seetal Dodd et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Human apolipoprotein A–I binds amyloid-β and prevents Aβ-induced neurotoxicity

(2008) Andréa C. Paula-Lima et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Linking Calcium to Aβ and Alzheimer's Disease

(2008) Kim N. Green et al.   NEURON

From Synapse to Nucleus: Calcium-Dependent Gene Transcription in the Control of Synapse Development and Function

(2008) Paul L. Greer et al.   NEURON

Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease

(2008) Ilya Bezprozvanny et al.   TRENDS IN NEUROSCIENCES