Article
Multidisciplinary Sciences
Mao Hagihara, Tadashi Ariyoshi, Yasutoshi Kuroki, Shuhei Eguchi, Seiya Higashi, Takeshi Mori, Tsunemasa Nonogaki, Kenta Iwasaki, Makoto Yamashita, Nobuhiro Asai, Yusuke Koizumi, Kentaro Oka, Motomichi Takahashi, Yuka Yamagishi, Hiroshige Mikamo
Summary: CBM 588 enhances the antibacterial activity against C. difficile, reduces colon epithelial damage, and improves immunity through upregulating pathogen specific immunoglobulin A and enhancing gut epithelial barrier function to protect colon tissue from CDI.
SCIENTIFIC REPORTS
(2021)
Review
Medicine, General & Internal
Ibrahim A. Al-Zahrani
Summary: Clostridioides difficile (C. difficile) infection is a global threat to many healthcare settings. Excessive use of antimicrobials, lack of optimal antibiotic policies, and suboptimal infection control practices have fueled the development of this health issue. Prudent use of antimicrobials and simple infection control measures can significantly reduce infection rates.
SAUDI MEDICAL JOURNAL
(2023)
Article
Surgery
Elisa Morales-Marroquin, Luyu Xie, Madhuri Uppuluri, Jaime P. Almandoz, Nestor de la Cruz-Munoz, Sarah E. Messiah
Summary: The study found that patients using immunosuppressants after metabolic and bariatric surgery are at higher risk of developing Clostridioides difficile infection. Patients who underwent laparoscopic Roux-en-Y gastric bypass surgery had a higher odds of infection compared to those who underwent laparoscopic sleeve gastrectomy. Patients using immunosuppressants should be closely monitored both pre and post procedure.
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2021)
Article
Biotechnology & Applied Microbiology
Peng An Khun, Long Duc Phi, Huong Thi Thu Bui, Nguyen Thi Bui, Quyen Thi Huyen Vu, Luong Duy Trinh, Deirdre A. Collins, Thomas Riley
Summary: This study investigated the prevalence, molecular type, and antimicrobial susceptibility of Clostridioides difficile in the environment in Vietnam. It found that the overall contamination rate of C. difficile was 24.5%, with the highest prevalence in pig farm and hospital soils. C. difficile was also found in pig feces and potato surfaces. These findings highlight the importance of environmental sources in the epidemiology of C. difficile infection in Vietnam.
JOURNAL OF APPLIED MICROBIOLOGY
(2023)
Review
Microbiology
Matthew L. Jenior, Jason A. Papin
Summary: The progress of Clostridioides difficile infection is influenced by metabolic cues encountered during colonization of the gastrointestinal tract. Computational systems have provided insights into the metabolic elements of infection, ranging from virulence regulation to interactions with the gut microbiota.
CURRENT OPINION IN MICROBIOLOGY
(2022)
Review
Infectious Diseases
Keeley O'Grady, Daniel R. Knight, Thomas Riley
Summary: This review discusses the genetics of AMR in Clostridioides difficile as well as the factors affecting the clear determination of AMR burden in this bacterium and its impact on CDI treatment.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2021)
Review
Microbiology
Jennifer Venhorst, Jos M. B. M. van der Vossen, Valeria Agamennone
Summary: The pathogenic bacteria Clostridioides difficile and Clostridium perfringens pose a major threat to human and animal health. The increasing antibiotic resistance has led to the pursuit of novel strategies to combat these infections, including the use of bacteriophages. However, there are limitations to the use of bacteriophages that need to be considered and further research is necessary to optimize their potential.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biology
Daniel R. Knight, Korakrit Imwattana, Brian Kullin, Enzo Guerrero-Araya, Daniel Paredes-Sabja, Xavier Didelot, Kate E. Dingle, David W. Eyre, Cesar Rodriguez, Thomas Riley
Summary: Research on over 12,000 C. difficile genomes revealed major taxonomic incoherence and clear species boundaries for the recently described cryptic clades CI-III. This discovery has significant implications for the global population structure of C. difficile and the Peptostreptococcaceae taxonomy as a whole. Additionally, the unique toxin gene architecture of these newly identified genomospecies may impact the diagnosis of CDI.
Review
Microbiology
Aritri Majumdar, Revathi Govind
Summary: Clostridioides difficile produces toxins TcdA and TcdB during infection, and the severity of the illness is directly correlated with the toxin production level. Recent advancements in genetics and mutagenesis technologies have greatly improved our understanding of the regulatory mechanisms involved in toxin production. The current research suggests that the toxin regulatory network overlaps with the regulatory networks of sporulation, motility, and key metabolic pathways, indicating that toxin production is a complex process initiated by bacteria in response to various host factors during infection. This review summarizes the existing knowledge about the toxin gene regulatory network.
CURRENT OPINION IN MICROBIOLOGY
(2022)
Article
Microbiology
Brintha P. Girinathan, Nicholas DiBenedetto, Jay N. Worley, Johann Peltier, Mario L. Arrieta-Ortiz, Selva Rupa Christinal Immanuel, Richard Lavin, Mary L. Delaney, Christopher K. Cummins, Maria Hoffman, Yan Luo, Narjol Gonzalez-Escalona, Marc Allard, Andrew B. Onderdonk, Georg K. Gerber, Abraham L. Sonenshein, Nitin S. Baliga, Bruno Dupuy, Lynn Bry
Summary: Different species of Clostridia can protect against or worsen Clostridioides difficile infection in mice by modulating the pathogen's colonization, growth, and virulence through altering the gut-nutrient environment. This research lays the groundwork for mechanistically informed therapies to counter C. difficile disease using systems biology approaches to define host-commensal-pathogen interactions in vivo.
CELL HOST & MICROBE
(2021)
Article
Microbiology
Nana Y. D. Ankrah, David B. Bernstein, Matthew Biggs, Maureen Carey, Melinda Engevik, Beatriz Garcia-Jimenez, Meiyappan Lakshmanan, Alan R. Pacheco, Snorre Sulheim, Gregory L. Medlock
Summary: Genome-scale metabolic models (GEMs) are well-established systems biology approach that can predict metabolic and growth phenotypes, providing mechanistic insight into microbial ecological processes. GEMs offer exciting opportunities in microbiome research, but face current challenges for trustworthy application that need to be addressed for further advancement in the field.
Review
Public, Environmental & Occupational Health
Peng An Khun, Thomas V. Riley
Summary: This review provides an overview of Clostridium difficile infection (CDI) in southeast Asia, including its prevalence, detection methods, antimicrobial susceptibility profiles, and the potential significance of a One Health approach. CDI is a common cause of hospital-acquired gastroenteritis worldwide, with higher rates observed in high-income countries. Lack of knowledge and awareness about CDI, along with antimicrobial abuse and inadequate education on appropriate usage, contribute to its evolution. Underreporting of CDI rates and misuse of antimicrobial agents pose a significant threat in regions like Indochina, while C. difficile RT 017 strain is endemic in southeast Asia.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2022)
Article
Ecology
Yannick D. N. Tremblay, Benjamin A. R. Durand, Audrey Hamiot, Isabelle Martin-Verstraete, Marine Oberkampf, Marc Monot, Bruno Dupuy
Summary: Clostridioides difficile infection is a leading cause of hospital-acquired diarrhea, and successful infection relies on the absence of specific microbiota-produced metabolites. The study found that in the presence of deoxycholate, extracellular pyruvate induces biofilm formation, which may play a key role in driving C. difficile persistence in the gut.
Article
Biotechnology & Applied Microbiology
Vivienne Mol, Martyn Bennett, Benjamin J. Sanchez, Beata K. Lisowska, Markus J. Herrgard, Alex Toftgaard Nielsen, David J. Leak, Nikolaus Sonnenschein
Summary: This study presents p-thermo, the most comprehensive genome-scale model to date of Parageobacillus thermoglucosidasius NCIMB 11955, which accurately predicts the metabolism of this bacteria and resolves an uncharacterized bottleneck in anaerobic metabolism.
METABOLIC ENGINEERING
(2021)
Article
Microbiology
Vanessa Lang, Katrin Gunka, Jan Rudolf Ortlepp, Ortrud Zimmermann, Uwe Gross
Summary: Nosocomial infections with Clostridioides difficile have emerged as a serious health threat. This study aimed to identify risk factors for C. difficile infection beyond the well-known factors. It found that regular consumption of proton pump inhibitors, low vegetable intake, and the use of the diuretic agent torasemid were additional risk factors for CDI.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Melanie Zischka, Carsten T. Kuenne, Jochen Blom, Dominique Wobser, Tuekan Sakinc, Kerstin Schmidt-Hohagen, P. Wojtek Dabrowski, Andreas Nitsche, Johannes Huebner, Torsten Hain, Trinad Chakraborty, Burkhard Linke, Alexander Goesmann, Sonja Voget, Rolf Daniel, Dietmar Schomburg, Ruediger Hauck, Hafez M. Hafez, Petra Tielen, Dieter Jahn, Margrete Solheim, Ewa Sadowy, Jesper Larsen, Lars B. Jensen, Patricia Ruiz-Garbajosa, Dianelys Quinones Perez, Theresa Mikalsen, Jennifer Bender, Matthias Steglich, Ulrich Nuebel, Wolfgang Witte, Guido Werner
Article
Microbiology
Meina Neumann-Schaal, Julia Danielle Hofmann, Sabine Eva Will, Dietmar Schomburg
Article
Biochemistry & Molecular Biology
Hanne Vorwerk, Claudia Huber, Juliane Mohr, Boyke Bunk, Sabin Bhuju, Olga Wensel, Cathrin Sproeer, Angelika Fruth, Antje Flieger, Kerstin Schmidt-Hohagen, Dietmar Schomburg, Wolfgang Eisenreich, Dirk Hofreuter
MOLECULAR MICROBIOLOGY
(2015)
Article
Microbiology
Kathleen Trautwein, Sabine Eva Will, Reiner Hulsch, Uwe Maschmann, Katharina Wiegmann, Michael Hensler, Victoria Michael, Hanna Ruppersberg, Daniel Wuensch, Christoph Feenders, Meina Neumann-Schaal, Sabine Kaltenhaeuser, Marcus Ulbrich, Kerstin Schmidt-Hohagen, Bernd Blasius, Joern Petersen, Dietmar Schomburg, Ralf Rabus
ENVIRONMENTAL MICROBIOLOGY
(2016)
Article
Microbiology
Sarah Kleist, Marcus Ulbrich, Nelli Bill, Kerstin Schmidt-Hohagen, Robert Geffers, Dietmar Schomburg
ENVIRONMENTAL MICROBIOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Jacqueline Wolf, Helge Stark, Katharina Fafenrot, Andreas Albersmeier, Trong K. Pham, Katrin B. Mueller, Benjamin H. Meyer, Lena Hoffmann, Lu Shen, Stefan P. Albaum, Theresa Kouril, Kerstin Schmidt-Hohagen, Meina Neumann-Schaal, Christopher Braesen, Joern Kalinowski, Phillip C. Wright, Sonja-Verena Albers, Dietmar Schomburg, Bettina Siebers
MOLECULAR MICROBIOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Sandra Placzek, Ida Schomburg, Antje Chang, Lisa Jeske, Marcus Ulbrich, Jana Tillack, Dietmar Schomburg
NUCLEIC ACIDS RESEARCH
(2017)
Article
Ecology
Meinhard Simon, Carmen Scheuner, Jan P. Meier-Kolthoff, Thorsten Brinkhoff, Irene Wagner-Doebler, Marcus Ulbrich, Hans-Peter Klenk, Dietmar Schomburg, Joern Petersen, Markus Goeker
Article
Microbiology
Henning Dannheim, Thomas Riedel, Meina Neumann-Schaal, Boyke Bunk, Isabel Schober, Cathrin Sproeer, Cynthia Maria Chibani, Sabine Gronow, Heiko Liesegang, Joerg Overmann, Dietmar Schomburg
JOURNAL OF MEDICAL MICROBIOLOGY
(2017)
Article
Multidisciplinary Sciences
Sabine Eva Will, Meina Neumann-Schaal, Raymond Leopold Heydorn, Pascal Bartling, Joern Petersen, Dietmar Schomburg
Article
Biochemistry & Molecular Biology
Sebastian Laass, Sarah Kleist, Nelli Bill, Katharina Drueppel, Sebastian Kossmehl, Lars Woehlbrand, Ralf Rabus, Johannes Klein, Manfred Rohde, Annekathrin Bartsch, Christoph Wittmann, Kerstin Schmidt-Hohagen, Petra Tielen, Dieter Jahn, Dietmar Schomburg
JOURNAL OF BIOLOGICAL CHEMISTRY
(2014)
Article
Biochemistry & Molecular Biology
Hanne Vorwerk, Juliane Mohr, Claudia Huber, Olga Wensel, Kerstin Schmidt-Hohagen, Eugenia Gripp, Christine Josenhans, Dietmar Schomburg, Wolfgang Eisenreich, Dirk Hofreuter
MOLECULAR MICROBIOLOGY
(2014)
Article
Biochemistry & Molecular Biology
Antje Chang, Ida Schomburg, Sandra Placzek, Lisa Jeske, Marcus Ulbrich, Mei Xiao, Christoph W. Sensen, Dietmar Schomburg
NUCLEIC ACIDS RESEARCH
(2015)
Article
Microbiology
Anna M. Vetter, Julia Helmecke, Dietmar Schomburg, Meina Neumann-Schaal
ARCHAEA-AN INTERNATIONAL MICROBIOLOGICAL JOURNAL
(2019)