The role of gut microbiota in the modulation of drug action: a focus on some clinically significant issues

Assumption versus evidence: the case of digoxin in atrial fibrillation and heart failure

(2017) Udo Bavendiek et al.   EUROPEAN HEART JOURNAL

Elderberry and Elderflower Extracts, Phenolic Compounds, and Metabolites and Their Effect on Complement, RAW 264.7 Macrophages and Dendritic Cells

(2017) Giang Ho et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Glucuronides in the gut: Sugar-driven symbioses between microbe and host

(2017) Samuel J. Pellock et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemical transformation of xenobiotics by the human gut microbiota

(2017) Nitzan Koppel et al.   SCIENCE

Gut microbiome interactions with drug metabolism, efficacy, and toxicity

(2017) Ian D. Wilson et al.   Translational Research

Anthraquinones As Pharmacological Tools and Drugs

(2016) Enas M. Malik et al.   MEDICINAL RESEARCH REVIEWS

Flavonoid metabolite 3-(3-hydroxyphenyl)propionic acid formed by human microflora decreases arterial blood pressure in rats

(2016) Iveta Najmanová et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The microbial pharmacists within us: a metagenomic view of xenobiotic metabolism

(2016) Peter Spanogiannopoulos et al.   NATURE REVIEWS MICROBIOLOGY

The chemistry of gut microbial metabolism of polyphenols

(2016) Jan F. Stevens et al.   PHYTOCHEMISTRY REVIEWS

3,4-Dihydroxyphenylacetic acid, a microbiota-derived metabolite of quercetin, attenuates acetaminophen (APAP)-induced liver injury through activation of Nrf-2

(2016) Huiting Xue et al.   XENOBIOTICA

Revised Estimates for the Number of Human and Bacteria Cells in the Body

(2016) Ron Sender et al.   PLOS BIOLOGY

Effect of co-administration of probiotics with polysaccharide based colon targeted delivery systems to optimize site specific drug release

(2015) G. Prudhviraj et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

3,4-dihydroxyphenylacetic acid, a microbiota-derived metabolite of quercetin, protects against pancreatic β-cells dysfunction induced by high cholesterol

(2015) Catalina Carrasco-Pozo et al.   EXPERIMENTAL CELL RESEARCH

Metabolism of Rutin and Poncirin by Human Intestinal Microbiota and Cloning of Their Metabolizing ��-L-Rhamnosidase from Bifidobacterium dentium

(2015) Seo-Hyeon Bang et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Isolation and characterization of human intestinalEnterococcus aviumEFEL009 converting rutin to quercetin

(2015) N.R. Shin et al.   LETTERS IN APPLIED MICROBIOLOGY

Role of intestinal microbiota in the generation of polyphenol-derived phenolic acid mediated attenuation of Alzheimer's disease β-amyloid oligomerization

(2015) Dongjie Wang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Constipation and Botanical Medicines: An Overview

(2015) Carla Cirillo et al.   PHYTOTHERAPY RESEARCH

Old Drug New Use--Amoxapine and Its Metabolites as Potent Bacterial  -Glucuronidase Inhibitors for Alleviating Cancer Drug Toxicity

(2014) R. Kong et al.   CLINICAL CANCER RESEARCH

Determination of Metabolites of Diosmetin-7-O-glucoside by a Newly Isolated Escherichia coli from Human Gut Using UPLC-Q-TOF/MS

(2014) Min Zhao et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Safety, tolerability, and pharmacokinetics of a single ascending dose of baicalein chewable tablets in healthy subjects

(2014) Min Li et al.   JOURNAL OF ETHNOPHARMACOLOGY

On the Colonic Bacterial Metabolism of Azo-Bonded Prodrugsof 5-Aminosalicylic Acid

(2014) Tiago Sousa et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Confirmation of diosmetin 3-O-glucuronide as major metabolite of diosmin in humans, using micro-liquid-chromatography–mass spectrometry and ion mobility mass spectrometry

(2013) Luigi Silvestro et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Therapeutic Targeting of CPT-11 Induced Diarrhea: A Case for Prophylaxis

(2013) Umang Swami et al.   CURRENT DRUG TARGETS

Predicting and Manipulating Cardiac Drug Inactivation by the Human Gut Bacterium Eggerthella lenta

(2013) H. J. Haiser et al.   SCIENCE

Bacterial β-glucuronidase inhibition protects mice against enteropathy induced by indomethacin, ketoprofen or diclofenac: mode of action and pharmacokinetics

(2013) Kyle S. Saitta et al.   XENOBIOTICA

Nonsteroidal anti-inflammatory drugs and upper and lower gastrointestinal mucosal damage

(2013) Carlos Sostres et al.   ARTHRITIS RESEARCH & THERAPY

Protocatechuic Acid and Human Disease Prevention: Biological Activities and Molecular Mechanisms

(2012) R. Masella et al.   CURRENT MEDICINAL CHEMISTRY

Pharmacokinetic study of baicalein after oral administration in monkeys

(2012) Shuo Tian et al.   FITOTERAPIA

NSAID enteropathy: could probiotics prevent it?

(2012) Massimo Montalto et al.   JOURNAL OF GASTROENTEROLOGY

Promotion of Intestinal Peristalsis by Bifidobacterium spp. Capable of Hydrolysing Sennosides in Mice

(2012) Mitsuharu Matsumoto et al.   PLoS One

Multiple NSAID-Induced Hits Injure the Small Intestine: Underlying Mechanisms and Novel Strategies

(2012) Urs A. Boelsterli et al.   TOXICOLOGICAL SCIENCES

The influence of probiotic treatment on sulfasalazine metabolism in rat

(2012) Hee Ji Lee et al.   XENOBIOTICA

Haemoglobin decreases in NSAID users over time: an analysis of two large outcome trials

(2011) J. L. Goldstein et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Pharmacological effects and pharmacokinetics properties of Radix Scutellariae and its bioactive flavones

(2011) Chenrui Li et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Proton Pump Inhibitors Exacerbate NSAID-Induced Small Intestinal Injury by Inducing Dysbiosis

(2011) John L. Wallace et al.   GASTROENTEROLOGY

Route of administration determines the anxiolytic activity of the flavonols kaempferol, quercetin and myricetin — are they prodrugs?

(2011) Cica Vissiennon et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Enterotypes of the human gut microbiome

(2011) Manimozhiyan Arumugam et al.   NATURE

Synthesis of uronic-Noeurostegine – a potent bacterial β-glucuronidase inhibitor

(2011) Tina S. Rasmussen et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The Human Gut Microbiome: Ecology and Recent Evolutionary Changes

(2010) Jens Walter et al.   Annual Review of Microbiology

β-Glucuronidase from Helix pomatia origin is not suitable for diosmetin analysis

(2010) E. Werner et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Alleviating Cancer Drug Toxicity by Inhibiting a Bacterial Enzyme

(2010) B. D. Wallace et al.   SCIENCE

Reaction mechanism of azoreductases suggests convergent evolution with quinone oxidoreductases

(2010) Ali Ryan et al.   Protein & Cell

Time Trends and Impact of Upper and Lower Gastrointestinal Bleeding and Perforation in Clinical Practice

(2009) Angel Lanas et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

In vitro catabolism of rutin by human fecal bacteria and the antioxidant capacity of its catabolites

(2009) Indu B. Jaganath et al.   FREE RADICAL BIOLOGY AND MEDICINE

Rutin metabolites: Novel inhibitors of nonoxidative advanced glycation end products

(2009) Srinath Pashikanti et al.   FREE RADICAL BIOLOGY AND MEDICINE

Bacterial Community Variation in Human Body Habitats Across Space and Time

(2009) E. K. Costello et al.   SCIENCE

Quercetin: potentials in the prevention and therapy of disease

(2008) Stephan C Bischoff   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

The gastrointestinal microbiota as a site for the biotransformation of drugs

(2008) Tiago Sousa et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS