Article
Public, Environmental & Occupational Health
Benjamin J. Varley, Amanda Henry, Lynne Roberts, Gregory Davis, Michael R. Skilton, Maria E. Craig, Megan L. Gow
Summary: This study investigated the vascular health of children exposed to intrauterine preeclampsia and found no major adverse differences in vascular health, which contrasts with existing studies. This suggests that exposure to intrauterine preeclampsia may result in a less severe cardiovascular phenotype in young children.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Daniel Goeder, Renate Oberhoffer-Fritz, Leon Brudy, Laura Willinger, Michael Meyer, Peter Ewert, Jan Mueller
Summary: The study found that patients with Tetralogy of Fallot (ToF) have reduced endothelial function, indicating cardiovascular risk, but no changes in vascular structure. Therefore, long-term management of these patients should include evaluation of vascular parameters.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pediatrics
Doaa M. Mahrous, Asmaa N. Moustafa, Mahmoud M. Higazi, Aliaa M. Higazi, Reem A. AbdelAziz
Summary: The prolonged use of antiseizure medications has been found to increase plasma homocysteine levels, leading to an increased risk of cardiovascular disease. Children with epilepsy on old generation and polytherapy antiseizure medications are at a higher risk and require early intervention.
Article
Nutrition & Dietetics
Maria Abellaneda Millan, Juan Maria Morillas-Ruiz, Raul Ballester Sajardo, Daniel Guillen Martinez, Isabel Morales Moreno, Juan Jose Hernandez Morante
Summary: This study aimed to analyze the effect of a nutritional and physical exercise program on obesity comorbidities in young children. The results showed that the program significantly improved anthropometrical parameters and triglyceride levels, as well as reducing the percentage of children with liver steatosis and carotid intima-media thickness.
Article
Pediatrics
Luisa Semmler, Heidi Weberruss, Lisa Baumgartner, Raphael Pirzer, Renate Oberhoffer-Fritz
Summary: Arterial alterations in children, including intima-media thickness and vascular diameter enlargement, are important hemodynamic parameters that correlate with higher cardiovascular risk in adults. This study provides values for vascular diameter, intima-media thickness/diameter ratio, and tensile stress in children, with differences observed between sexes and body mass index influencing these parameters. Systolic and diastolic blood pressure also significantly impact these vascular parameters.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Multidisciplinary Sciences
Angela Yu, Maria A. C. Jansen, Geertje W. Dalmeijer, Patricia Bruijning-Verhagen, Cornelis K. van der Ent, Diederick E. Grobbee, David P. Burgner, Cuno S. P. M. Uiterwaal
Summary: Recent use of antibiotics is associated with adverse vascular phenotypes in early childhood, while non-hospitalized infections are not related to vascular phenotypes.
Article
Medicine, General & Internal
Haiping Xia, Biao Jin, Cen Su, Kangren Zhao, Rui Ma
Summary: This study evaluated the diagnostic value of the combination of D-dimer and Doppler Intima-Media Thickness (IMT) based on clinical data for vascular dementia (VaD). The results showed that D-dimer and IMT were highly correlated with the onset of VaD. The combination diagnosis had a higher sensitivity and specificity for early VaD compared to using IMT or D-dimer alone.
Article
Peripheral Vascular Disease
Line Sletner, Sarah R. Crozier, Hazel M. Inskip, Keith M. Godfrey, Pamela Mahon, Scott T. Chiesa, Marietta Charakida, Cyrus Cooper, Mark Hanson
Summary: The study found that postnatal linear and abdominal circumference growth were associated with early markers of atherosclerosis and later cardiovascular disease risk, while prenatal growth was not. Faster postnatal growth was related to higher blood pressure and pulse wave velocity, whereas faster growth in early gestation was associated with greater carotid intima-media thickness in children.
JOURNAL OF HYPERTENSION
(2021)
Article
Cardiac & Cardiovascular Systems
Raimund Pechlaner, Nele Friedrich, Anna Staudt, Nina Gande, Benoit Bernar, Katharina Stock, Sophia J. Kiechl, Christoph Hochmayr, Andrea Griesmacher, Astrid Petersmann, Kathrin Budde, Hermann Stuppner, Sonja Sturm, Marcus Dorr, Ulf Schminke, Claire Cannet, Fang Fang, Hartmut Schaefer, Manfred Spraul, Ralf Geiger, Manuel Mayr, Matthias Nauck, Stefan Kiechl, Ursula Kiechl-Kohlendorfer, Michael Knoflach
Summary: This study investigates the differences in lipoprotein subclass profiles between adolescents and adults and their relationships with vascular disease. The results show that adolescents have lower lipid levels compared to adults, and dense LDL subclasses are associated with carotid intima-media thickness (cIMT) in both age groups, with greater effect in adults. Additionally, HDL-related measures are associated with cIMT in adults.
Article
Cardiac & Cardiovascular Systems
Constance G. Weismann, Sara Ljungberg, Anna Akesson, J. Hlebowicz
Summary: Patients with Bicuspid Aortic Valve (BAV) demonstrate increased proximal arterial stiffness and wave reflection, but no significant changes in Pulse Wave Velocity (PWV), common carotid intima media thickness (cIMT), or endothelial function when compared to controls. Diastolic function is mildly reduced in BAV patients, with moderate-strong correlations between arterial stiffness parameters, diastolic dysfunction, and age. Ascending aortic distensibility shows the strongest correlation with diastolic dysfunction in the BAV group, suggesting a different mechanism of arterial and cardiac stiffening compared to acquired heart diseases.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, General & Internal
Anna Dieden, Leone Malan, Catharina M. C. Mels, Leandi Lammertyn, Annemarie Wentzel, Peter M. Nilsson, Petri Gudmundsson, Amra Jujic, Martin Magnusson
Summary: In this observational study, a multiplex proteomic platform was used to explore associations between 92 targeted proteins and deteriorating vascular health phenotypes in a cohort of black and white African school teachers. The study revealed significant associations between hypertension, carotid intima-media thickness (cIMT), pulse wave velocity (PWV) and specific proteins related to inflammation, chemotaxis, coagulation or proteolysis. Additionally, ethnicity played a role in some of these associations, highlighting the complexity of the relationships between proteins and vascular health markers.
Article
Physiology
Maria Karolina Ferreira de Sousa, Raissa de Melo Silva, Yuri Alberto Freire, Gabriel Costa Souto, Marcyo Camara, Ludmila Lucena Pereira Cabral, Geovani Araujo Dantas Macedo, Eduardo Caldas Costa, Ricardo Santos Oliveira
Summary: This study examined the associations between physical activity and cardiorespiratory fitness with vascular health phenotypes in older adults. The results showed that poor cardiorespiratory fitness, but not physical activity, was associated with the unhealthiest vascular health phenotype in older adults.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Lisa Baumgartner, Heidi Weberruss, Tobias Engl, Thorsten Schulz, Renate Oberhoffer-Fritz
Summary: The study revealed that training duration and intensity were associated with vascular structure and function in children and adolescents, with higher intensity training contributing to thicker cIMT but also increased vascular elasticity.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Fabio Mangiacapra, Edoardo Bressi, Michele Mattia Viscusi, Antonio Creta, Giuseppe Di Gioia, Marialessia Capuano, Iginio Colaiori, Germano Di Sciascio, Gian Paolo Ussia, Francesco Grigioni
Summary: The combined evaluation of FMD and IMT has significant value in predicting the presence of CAD, with the combination of low FMD and high IMT being the strongest predictor. Adding FMD and IMT to the traditional risk factors model improves the predictive power for CAD presence and correctly reclassifies a portion of patients.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Endocrinology & Metabolism
Linda Litwin, Johnny K. M. Sundholm, Jelena Meinila, Janne Kulmala, Tuija H. Tammelin, Kristiina Rono, Saila B. Koivusalo, Johan G. Eriksson, Taisto Sarkola
Summary: Although there was no direct association found between child and maternal ideal cardiovascular health, specific metrics such as total cholesterol, BMI, diastolic blood pressure, and diet quality showed correlations. Child arterial phenotype was not related to child or maternal ideal cardiovascular health. Maternal carotid intima-media thickness was found to predict child carotid intima-media thickness, while maternal subclinical atherosclerosis was associated with local carotid arterial stiffness in early childhood.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Review
Sport Sciences
Emilio Villa-Gonzalez, Yaira Barranco-Ruiz, Antonio Garcia-Hermoso, Avery D. Faigenbaum
Summary: This systematic review and meta-analysis investigated the efficacy of school-based exercise interventions for improving muscular fitness in children. The findings showed that exercise interventions, especially those conducted at least 3 times a week, were associated with significant improvements in local muscular endurance, muscular strength, and muscular power in children.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2023)
Article
Sport Sciences
Mairena Sanchez-Lopez, Antonio Garcia-Hermoso, Francisco B. Ortega, Diego Moliner-Urdiales, Idoia Labayen, Jose Castro-Pinero, Pedro J. Benito, German Vicente-Rodriguez, Joaquin Sanchis-Moysi, Jaume Cantallops, Enrique G. Artero, Vicente Martinez-Vizcaino
Summary: The study aims to examine the validity and reliability of the parent-reported IFIS in preschoolers. The results indicate that there is poor concordance between parent-reported fitness levels and objective assessment, suggesting that parents may not be able to correctly classify preschoolers according to their fitness level.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2023)
Review
Endocrinology & Metabolism
Robinson Ramirez-Velez, Arantxa Gonzalez, Antonio Garcia-Hermoso, Inigo Latasa Amezqueta, Mikel Izquierdo, Javier Diez
Summary: Exercise intolerance remains a major unmet medical need in patients with heart failure, and skeletal myopathy is considered as the major limiting factor. Recent studies have suggested that circulating myokines synthesized and secreted by skeletal muscle may provide new insights into the pathophysiology and classification of HF-related skeletal myopathy. These myokines may also serve as biomarkers to personalize physical training for patients with HF and exercise intolerance. Furthermore, the production and secretion of myokines in patients with HF may interact with systemic alterations and affect cardiac structure and function, which can influence adverse cardiac remodeling and clinical outcomes in HF patients.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2023)
Letter
Cardiac & Cardiovascular Systems
Robinson Ramirez-Velez, Nora Garcia-Alonso, Julio Oteiza, Mikel Izquierdo
REVISTA ESPANOLA DE CARDIOLOGIA
(2023)
Article
Sport Sciences
Robinson Ramirez-Velez, Mikel Izquierdo, Jose Francisco Lopez-Gil, David Rincon-Pabon, Edwar Nicolas Martinez-Jamioy, Rosemberg Rivera-Ruiz, Sebastian Castellanos-Montana, Miguel Alejandro Atencio-Osorio, Hugo Alejandro Carrillo-Arango, Alicia M. M. Alonso-Martinez, Antonio Garcia-Hermoso
Summary: The aim of this study was to determine whether Colombian preschool-aged children meet all three 24-hour movement guidelines and to explore the associations between socio-ecological correlates and meeting these guidelines. A cross-sectional study was conducted with data from the National Survey of Nutritional Situation (ENSIN-2015) in Colombia, 2015-2016. The sample consisted of 3002 low-income preschoolers (3-4 years old, 50.7% boys). Data on physical activity, screen time, and sleep time were collected using a questionnaire reported by parents. The prevalence of preschoolers meeting all three 24-hour movement guidelines was 4.8%, and the prevalence of not meeting any of the guidelines was 16.6%. Boys and children without a television in their bedroom were more likely to meet all three movement guidelines. Strategies to promote adherence to these guidelines in low-income preschoolers should consider the importance of sex and home environment changes.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2023)
Review
Hospitality, Leisure, Sport & Tourism
Antonio Garcia-Hermoso, Robinson Ramirez-Velez, Javier Diez, Arantxa Gonzalez, Mikel Izquierdo
Summary: This study investigates the effects of exercise training on exerkines in patients with type 2 diabetes mellitus and determines the optimal exercise prescription. The results show that exercise training can induce changes in exerkine levels, with positive effects on glycated hemoglobin, fasting glucose, waist circumference, and body mass. Therefore, exercise training is an important therapeutic approach for patients with type 2 diabetes mellitus.
JOURNAL OF SPORT AND HEALTH SCIENCE
(2023)
Review
Sport Sciences
Adria Muntaner-Mas, Javier S. Morales, Oscar Martinez-de-Quel, David R. Lubans, Antonio Garcia-Hermoso
Summary: Physical activity can have positive acute effects on academic outcomes in school-aged youth, especially in mathematics and language. Behavior change techniques play an important role in this relationship.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2023)
Article
Geriatrics & Gerontology
Robinson Ramirez-Velez, Maria Iriarte-Fernandez, Guzman Santafe, Armando Malanda, John R. Beard, Antonio Garcia-Hermoso, Mikel Izquierdo
Summary: The concept of intrinsic capacity (IC) is proposed by the World Health Organization as central for healthy ageing. This study examines the association between IC and cardiovascular disease (CVD) incidence and mortality in middle- and older-aged adults. The results indicate that IC deficit score is a powerful predictor of CVD incidence and premature death.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Pediatrics
Antonio Garcia-Hermoso, Yasmin Ezzatvar, Alicia M. Alonso-Martinez, Robinson Ramirez-Velez, Mikel Izquierdo, Jose Francisco Lopez-Gil
Summary: This study analyzed data from a nationally representative US cohort and found that adherence to the 24-h movement guidelines during adolescence is associated with lower risk of abdominal obesity in adulthood. Adolescents who met screen time recommendation alone or combined with physical activity, as well as those who met all three recommendations, had lower waist circumference in adulthood. In addition, adhering to the 24-h movement guidelines during adolescence was also associated with lower risk of abdominal obesity in adulthood.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Review
Endocrinology & Metabolism
Ignacio Hormazabal-Aguayo, Yasmin Ezzatvar, Nidia Huerta-Uribe, Robinson Ramirez-Velez, Mikel Izquierdo, Antonio Garcia-Hermoso
Summary: The aim of this study was to determine the global incidence of type 1 diabetes mellitus (T1DM) in children and adolescents under 20 years of age from 2000 to 2022. The study included 126 studies from 55 countries and 18 regions. The incidence rate (IR) of T1DM from 2000 to 2022 was 14.07 per 100,000 person-years, with significant variations among different regions and an increase during the pandemic period.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Nutrition & Dietetics
Robinson Ramirez-Velez, Sergio Oscoz-Ochandorena, Yesenia Garcia-Alonso, Nora Garcia-Alonso, Gaizka Legarra-Gorgonon, Julio Oteiza, Ander Ernaga Lorea, Mikel Izquierdo, Maria Correa-Rodriguez
Summary: This study assessed the differences in skeletal muscle energy metabolism between patients with long COVID syndrome (LCS) and healthy controls, and explored the mediating role of muscle power output in the relationship between COVID-19 and skeletal muscle energy metabolism. The results showed that patients with LCS had lower peak fat oxidation rates during exercise compared with healthy controls, potentially indicating impaired skeletal muscle function. Muscle power output predominantly mediated the relationship between peak fat oxidation and LCS.
CLINICAL NUTRITION ESPEN
(2023)
Article
Sport Sciences
Hector Gutierrez Espinoza, Felipe Araya-Quintanilla, Sebastian Pinto-Concha, Juan Valenzuela-Fuenzalida, Jose Francisco Lopez-Gil, Robinson Ramirez-Velez
Summary: This study compares the short-term effects of a specific exercise programme and a general exercise programme on shoulder function in patients with subacromial impingement syndrome (SIS). The results show that specific exercises have a larger effect than general exercises, although most differences did not reach the clinically important threshold.
BMJ OPEN SPORT & EXERCISE MEDICINE
(2023)
