标题
Role and mechanism of action of leucine-rich repeat kinase 1 in bone
作者
关键词
-
出版物
Bone Research
Volume 5, Issue -, Pages 17003
出版商
Springer Nature
发表日期
2017-03-14
DOI
10.1038/boneres.2017.3
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Leucine-rich repeat kinase-1 regulates osteoclast function by modulating RAC1/Cdc42 Small GTPase phosphorylation and activation
- (2016) Canjun Zeng et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Identification of biallelicLRRK1mutations in osteosclerotic metaphyseal dysplasia and evidence for locus heterogeneity
- (2016) Aritoshi Iida et al. JOURNAL OF MEDICAL GENETICS
- Structural model of the dimeric Parkinson’s protein LRRK2 reveals a compact architecture involving distant interdomain contacts
- (2016) Giambattista Guaitoli et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- LRRK1 is critical in the regulation of B-cell responses and CARMA1-dependent NF-κB activation
- (2016) Keiko Morimoto et al. Scientific Reports
- Death Associated Protein Kinase 1 (DAPK1): A Regulator of Apoptosis and Autophagy
- (2016) Pratibha Singh et al. Frontiers in Molecular Neuroscience
- Deletion of Rac in Mature Osteoclasts Causes Osteopetrosis, an Age-Dependent Change in Osteoclast Number, and a Reduced Number of Osteoblasts In Vivo
- (2015) Meiling Zhu et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Death-associated protein kinase 1 promotes growth of p53-mutant cancers
- (2015) Jing Zhao et al. JOURNAL OF CLINICAL INVESTIGATION
- Leucine-Rich Repeat Kinase 1 Regulates Autophagy through Turning On TBC1D2-Dependent Rab7 Inactivation
- (2015) Toshihiko Toyofuku et al. MOLECULAR AND CELLULAR BIOLOGY
- PLK1-dependent activation of LRRK1 regulates spindle orientation by phosphorylating CDK5RAP2
- (2015) Hiroshi Hanafusa et al. NATURE CELL BIOLOGY
- LRRK2 localizes to endosomes and interacts with clathrin-light chains to limit Rac1 activation
- (2014) A. M. Schreij et al. EMBO REPORTS
- A defect in the CLIP1 gene (CLIP-170) can cause autosomal recessive intellectual disability
- (2014) Farzaneh Larti et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- Novel LRRK2 GTP-binding inhibitors reduced degeneration in Parkinson's disease cell and mouse models
- (2014) T. Li et al. HUMAN MOLECULAR GENETICS
- LRRK1-phosphorylated CLIP-170 regulates EGFR trafficking by recruiting p150Glued to microtubule plus ends
- (2014) S. Kedashiro et al. JOURNAL OF CELL SCIENCE
- DAPK1-p53 Interaction Converges Necrotic and Apoptotic Pathways of Ischemic Neuronal Death
- (2014) L. Pei et al. JOURNAL OF NEUROSCIENCE
- Leucine-Rich Repeat Kinase 2 Binds to Neuronal Vesicles through Protein Interactions Mediated by Its C-Terminal WD40 Domain
- (2014) G. Piccoli et al. MOLECULAR AND CELLULAR BIOLOGY
- Discovery of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1: Optimization of kinase selectivity and pharmacokinetics
- (2013) Keith R. Hornberger et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- MASL1 induces erythroid differentiation in human erythropoietin-dependent CD34+ cells through the Raf/MEK/ERK pathway
- (2013) C. Kumkhaek et al. BLOOD
- Targeted disruption of leucine-rich repeat kinase 1 but not leucine-rich repeat kinase 2 in mice causes severe osteopetrosis
- (2013) Weirong Xing et al. JOURNAL OF BONE AND MINERAL RESEARCH
- NF-κB RelB Negatively Regulates Osteoblast Differentiation and Bone Formation
- (2013) Zhenqiang Yao et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Expression Analysis of Lrrk1, Lrrk2 and Lrrk2 Splice Variants in Mice
- (2013) Florian Giesert et al. PLoS One
- Protein kinase C (PKC) isozyme-specific substrates and their design
- (2012) Jeong-Hun Kang et al. BIOTECHNOLOGY ADVANCES
- Integrin-linked kinase at a glance
- (2012) M. Widmaier et al. JOURNAL OF CELL SCIENCE
- c-Src Links a RANK/ v 3 Integrin Complex to the Osteoclast Cytoskeleton
- (2012) T. Izawa et al. MOLECULAR AND CELLULAR BIOLOGY
- TAK1 Is Essential for Osteoclast Differentiation and Is an Important Modulator of Cell Death by Apoptosis and Necroptosis
- (2012) Betty Lamothe et al. MOLECULAR AND CELLULAR BIOLOGY
- Biochemical Characterization of Highly Purified Leucine-Rich Repeat Kinases 1 and 2 Demonstrates Formation of Homodimers
- (2012) Laura Civiero et al. PLoS One
- Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations
- (2012) B. K. Gilsbach et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Delivery of endosomes to lysosomes via microautophagy in the visceral endoderm of mouse embryos
- (2012) Nobuyuki Kawamura et al. Nature Communications
- GTP binding and intramolecular regulation by the ROC domain of Death Associated Protein Kinase 1
- (2012) Joseph D. Jebelli et al. Scientific Reports
- Disorders of Bone Remodeling
- (2011) Xu Feng et al. Annual Review of Pathology-Mechanisms of Disease
- GTP binding to the ROC domain of DAP-kinase regulates its function through intramolecular signalling
- (2011) Rodrigo Carlessi et al. EMBO REPORTS
- Rac1 Protein Rescues Neurite Retraction Caused by G2019S Leucine-rich Repeat Kinase 2 (LRRK2)
- (2011) Diane Chan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Rac deletion in osteoclasts causes severe osteopetrosis
- (2011) M. Croke et al. JOURNAL OF CELL SCIENCE
- MLK3 regulates bone development downstream of the faciogenital dysplasia protein FGD1 in mice
- (2011) Weiguo Zou et al. JOURNAL OF CLINICAL INVESTIGATION
- LRRK2 Kinase Activity Is Dependent on LRRK2 GTP Binding Capacity but Independent of LRRK2 GTP Binding
- (2011) Jean-Marc Taymans et al. PLoS One
- Leucine-rich repeat kinase LRRK1 regulates endosomal trafficking of the EGF receptor
- (2011) Hiroshi Hanafusa et al. Nature Communications
- Effects of Altered Bone Remodeling and Retention of Cement Lines on Bone Quality in Osteopetrotic Aged c-Src-Deficient Mice
- (2010) Hiroto Nakayama et al. CALCIFIED TISSUE INTERNATIONAL
- DAPK1 Interaction with NMDA Receptor NR2B Subunits Mediates Brain Damage in Stroke
- (2010) Weihong Tu et al. CELL
- Cdk5rap2 regulates centrosome function and chromosome segregation in neuronal progenitors
- (2010) S. B. Lizarraga et al. DEVELOPMENT
- Epidermal growth factor receptor plays an anabolic role in bone metabolism in vivo
- (2010) Xianrong Zhang et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Osteoclast-specific inactivation of the integrin-linked kinase (ILK) inhibits bone resorption
- (2010) Tanya Dossa et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Cdc42 regulates bone modeling and remodeling in mice by modulating RANKL/M-CSF signaling and osteoclast polarization
- (2010) Yuji Ito et al. JOURNAL OF CLINICAL INVESTIGATION
- LRRK2 G2019S Mutation Induces Dendrite Degeneration through Mislocalization and Phosphorylation of Tau by Recruiting Autoactivated GSK3
- (2010) C.-H. Lin et al. JOURNAL OF NEUROSCIENCE
- Novel functions for NFκB: inhibition of bone formation
- (2010) Susan A. Krum et al. Nature Reviews Rheumatology
- Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of -synuclein, and apoptotic cell death in aged mice
- (2010) Y. Tong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A complex interplay between Akt, TSC2 and the two mTOR complexes: Figure 1
- (2009) Jingxiang Huang et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- The function of ROCO proteins in health and disease
- (2009) Patrick A. Lewis BIOLOGY OF THE CELL
- Adhesion signaling - crosstalk between integrins, Src and Rho
- (2009) S. Huveneers et al. JOURNAL OF CELL SCIENCE
- Protinfo PPC: A web server for atomic level prediction of protein complexes
- (2009) Weerayuth Kittichotirat et al. NUCLEIC ACIDS RESEARCH
- The WD40 Domain Is Required for LRRK2 Neurotoxicity
- (2009) Nathan D. Jorgensen et al. PLoS One
- 2-Alkylamino- and alkoxy-substituted 2-amino-1,3,4-oxadiazoles—O-Alkyl benzohydroxamate esters replacements retain the desired inhibition and selectivity against MEK (MAP ERK kinase)
- (2008) Joseph S. Warmus et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Advances in osteoclast biology resulting from the study of osteopetrotic mutations
- (2008) T. Segovia-Silvestre et al. HUMAN GENETICS
- Epidermal growth factor receptor regulates osteoclast differentiation and survival through cross-talking with RANK signaling
- (2008) TacGhee Yi et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Mixed-Lineage Kinase 1 and Mixed-Lineage Kinase 3 Subtype-Selective Dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: Optimization, Mixed-Lineage Kinase 1 Crystallography, and Oral in Vivo Activity in 1-Methyl-4-phenyltetrahydropyridine Models
- (2008) Robert L. Hudkins et al. JOURNAL OF MEDICINAL CHEMISTRY
- Developmental regulation of leucine-rich repeat kinase 1 and 2 expression in the brain and other rodent and human organs: Implications for Parkinson’s disease
- (2008) M. Westerlund et al. NEUROSCIENCE
- Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase
- (2008) J. Deng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Become a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get StartedAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started