Design, synthesis and antiviral evaluation of novel heteroarylcarbothioamide derivatives as dual inhibitors of HIV-1 reverse transcriptase-associated RNase H and RDDP functions

Synthesis, biological evaluation and molecular modeling of 2-Hydroxyisoquinoline-1,3-dione analogues as inhibitors of HIV reverse transcriptase associated ribonuclease H and polymerase

(2017) Jing Tang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

New insights into the interaction between pyrrolyl diketoacids and HIV-1 integrase active site and comparison with RNase H

(2016) Angela Corona et al.   ANTIVIRAL RESEARCH

Inhibition of HIV-1 Reverse Transcriptase Dimerization by Small Molecules

(2016) Cristina Tintori et al.   CHEMBIOCHEM

Isatin thiazoline hybrids as dual inhibitors of HIV-1 reverse transcriptase

(2016) Rita Meleddu et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Design, Synthesis, and Biological Evaluations of Hydroxypyridonecarboxylic Acids as Inhibitors of HIV Reverse Transcriptase Associated RNase H

(2016) Jayakanth Kankanala et al.   JOURNAL OF MEDICINAL CHEMISTRY

Global epidemiology of drug resistance after failure of WHO recommended first-line regimens for adult HIV-1 infection: a multicentre retrospective cohort study

(2016) John Gregson et al.   LANCET INFECTIOUS DISEASES

Synthesis and Anti-HIV-1 Activity Evaluation for Novel 3a,6a-Dihydro-1H-pyrrolo[3,4-c]pyrazole-4,6-dione Derivatives

(2016) Guan-Nan Liu et al.   MOLECULES

Ribonuclease H/DNA Polymerase HIV-1 Reverse Transcriptase Dual Inhibitor: Mechanistic Studies on the Allosteric Mode of Action of Isatin-Based Compound RMNC6

(2016) Angela Corona et al.   PLoS One

Pyrroloaryls and pyrroloheteroaryls: Inhibitors of the HIV fusion/attachment, reverse transcriptase and integrase

(2015) Rahul V. Patel et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Identification of a novel type of small molecule inhibitor against HIV-1

(2015) Byung Soo Kim et al.   BMB Reports

(3Z)-3-(2-[4-(aryl)-1,3-thiazol-2-yl]hydrazin-1-ylidene)-2,3-dihydro-1H-indol-2-one derivatives as dual inhibitors of HIV-1 reverse transcriptase

(2015) Rita Meleddu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structure–Activity Relationship of Pyrrolyl Diketo Acid Derivatives as Dual Inhibitors of HIV-1 Integrase and Reverse Transcriptase Ribonuclease H Domain

(2015) Giuliana Cuzzucoli Crucitti et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pyrazolo-Piperidines Exhibit Dual Inhibition of CCR5/CXCR4 HIV Entry and Reverse Transcriptase

(2015) Bryan D. Cox et al.   ACS Medicinal Chemistry Letters

Identification of Highly Conserved Residues Involved in Inhibition of HIV-1 RNase H Function by Diketo Acid Derivatives

(2014) Angela Corona et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inhibition of Foamy Virus Reverse Transcriptase by Human Immunodeficiency Virus Type 1 RNase H Inhibitors

(2014) Angela Corona et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Can the ever-promising target HIV reverse transcriptase-associated RNase H become a success story for drug development?

(2014) Angela Corona et al.   Future Virology

Basic Quinolinonyl Diketo Acid Derivatives as Inhibitors of HIV Integrase and their Activity against RNase H Function of Reverse Transcriptase

(2014) Roberta Costi et al.   JOURNAL OF MEDICINAL CHEMISTRY

In VitroandIn VivoActivities of AIC292, a Novel HIV-1 Nonnucleoside Reverse Transcriptase Inhibitor

(2013) Steffen Wildum et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Molecular Aspects of the RT/drug Interactions. Perspective of Dual Inhibitors

(2013) Simona Distinto et al.   CURRENT PHARMACEUTICAL DESIGN

Active site and allosteric inhibitors of the ribonuclease H activity of HIV reverse transcriptase

(2013) Angela Corona et al.   Future Medicinal Chemistry

Exploiting Drug-Resistant Enzymes as Tools To Identify Thienopyrimidinone Inhibitors of Human Immunodeficiency Virus Reverse Transcriptase-Associated Ribonuclease H

(2013) Takashi Masaoka et al.   JOURNAL OF MEDICINAL CHEMISTRY

6-Benzoyl-3-hydroxypyrimidine-2,4-diones as dual inhibitors of HIV reverse transcriptase and integrase

(2011) Jing Tang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Alizarine derivatives as new dual inhibitors of the HIV-1 reverse transcriptase-associated DNA polymerase and RNase H activities effective also on the RNase H activity of non-nucleoside resistant reverse transcriptases

(2011) Francesca Esposito et al.   FEBS Journal

Identification of Alternative Binding Sites for Inhibitors of HIV-1 Ribonuclease H Through Comparative Analysis of Virtual Enrichment Studies

(2011) Anthony K. Felts et al.   Journal of Chemical Information and Modeling

Synthesis, Activity, and Structural Analysis of Novel α-Hydroxytropolone Inhibitors of Human Immunodeficiency Virus Reverse Transcriptase-Associated Ribonuclease H

(2011) Suhman Chung et al.   JOURNAL OF MEDICINAL CHEMISTRY

Lersivirine, a Nonnucleoside Reverse Transcriptase Inhibitor with Activity against Drug-Resistant Human Immunodeficiency Virus Type 1

(2010) R. Corbau et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structural Basis for the Inhibition of RNase H Activity of HIV-1 Reverse Transcriptase by RNase H Active Site-Directed Inhibitors

(2010) H.-P. Su et al.   JOURNAL OF VIROLOGY

Pyrazole NNRTIs 1: Design and initial optimisation of a novel template

(2009) Charles E. Mowbray et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The spread, treatment, and prevention of HIV-1: evolution of a global pandemic

(2008) Myron S. Cohen et al.   JOURNAL OF CLINICAL INVESTIGATION

Design, Synthesis, and Biological Evaluation of a Series of 2-Hydroxyisoquinoline-1,3(2H,4H)-diones as Dual Inhibitors of Human Immunodeficiency Virus Type 1 Integrase and the Reverse Transcriptase RNase H Domain

(2008) Muriel Billamboz et al.   JOURNAL OF MEDICINAL CHEMISTRY