Article
Biochemistry & Molecular Biology
Marika Cordaro, Angela Trovato Salinaro, Rosalba Siracusa, Ramona D'Amico, Daniela Impellizzeri, Maria Scuto, Maria Laura Ontario, Roberto Crea, Salvatore Cuzzocrea, Rosanna Di Paola, Roberta Fusco, Vittorio Calabrese
Summary: Traumatic brain injuries are a significant public health issue with long-term consequences such as cerebral atrophy and increased risk of dementia and Alzheimer's Disease. Hidrox (R) treatment has shown benefits in reducing TBI-induced neurodegeneration and improving cognitive function and memory impairment.
Article
Neurosciences
Ryan J. Worthen, Eleonore Beurel
Summary: Postpartum depression is a common psychiatric complication associated with pregnancy and childbirth, negatively impacting the mother's quality of life and potentially affecting the child's development. It shares similarities with major depressive disorder and is linked to inflammation theory, with dysregulation and hyperactivation of the body's immune response to stress as contributing factors. The stress and changes faced by new mothers can harm critical brain systems, impair neuronal growth and repair, and alter mood and cognition.
NEUROBIOLOGY OF DISEASE
(2022)
Review
Biochemistry & Molecular Biology
Maria Podbielska, Joan O'Keeffe, Anna Pokryszko-Dragan
Summary: Multiple sclerosis (MS) is a central nervous system disease characterized by immune-mediated inflammatory demyelination and progressive degeneration. Lipids are believed to play a key role in the immunopathogenesis of MS and are a promising area for investigation. Understanding lipid-related mechanisms may offer potential utility in predicting or monitoring the course of MS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Maria Podbielska, Toshio Ariga, Anna Pokryszko-Dragan
Summary: This review summarizes the significant role of sphingolipids (SLs) in central nervous system diseases, particularly multiple sclerosis (MS). It highlights the alterations of SL profile in MS, the involvement of SLs in autoimmune response, and the potential diagnostic and therapeutic implications of SLs in MS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Rekha Raghunathan, Kathleen Turajane, Li Chin Wong
Summary: Neurodegenerative diseases such as ALS and PD lack biomarkers for diagnosis and treatment efficacy. Proteomic studies have identified potential biomarker proteins in ALS and PD and explored disease-related post-translational modifications. Comparative analysis of relative and absolute quantitative proteomic approaches and recent technological advancements may help identify suitable biomarkers for early diagnosis and treatment efficacy of these diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Maria C. Tanzer
Summary: Efferocytosis is the process of phagocytes removing dead or dying cells, which is considered anti-inflammatory. However, it can induce inflammatory signaling pathways under certain conditions. The mechanisms and molecules involved in this response are not well understood. This article discusses the influence of dead cell cargo, ingestion type, and digestion efficiency on phagocyte programming in disease contexts, presents recent findings, identifies knowledge gaps, and proposes experimental approaches to fill them.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Food Science & Technology
Abdul-Hamid M. Emwas, Nahla Al-Rifai, Kacper Szczepski, Shuruq Alsuhaymi, Saleh Rayyan, Hanan Almahasheer, Mariusz Jaremko, Lorraine Brennan, Joanna Izabela Lachowicz
Summary: The relationship between health and nutrition is closely linked, with poor nutrition potentially leading to various metabolic diseases. Metabolomics, as an emerging field of science, has broad research applications and potential for further advancement.
Article
Clinical Neurology
Rachel E. James Bates, Eleanor Browne, Renee Schalks, Heather Jacobs, Li Tan, Puja Parekh, Roberta Magliozzi, Massimiliano Calabrese, Nicholas D. Mazarakis, Richard Reynolds
Summary: This study suggests that persistent increased levels of lymphotoxin-alpha in the cerebral meninges can lead to the formation of lymphoid-like structures and subsequent neurodegenerative and demyelinating pathology, similar to that seen in the progressive multiple sclerosis brain.
Article
Materials Science, Biomaterials
Hongchi Yu, Zhe Hou, Nuoya Chen, Rifang Luo, Li Yang, Michael Miao, Xiaoyi Ma, Lifeng Zhou, Fugui He, Yang Shen, Xiaoheng Liu, Yunbing Wang
Summary: This study found that Mg alloy can inhibit the Hippo pathway and promote the activation of YAP in endothelial cells, leading to the occurrence of inflammation. YAP can aggravate inflammation by regulating the transcription and mRNA methylation of inflammation-related genes. This study provides a potential therapeutic target for alleviating inflammation after Mg alloy stent implantation.
REGENERATIVE BIOMATERIALS
(2022)
Article
Multidisciplinary Sciences
Jared T. Hinkle, Jaimin Patel, Nikhil Panicker, Senthilkumar S. Karuppagounder, Devanik Biswas, Bonn Belingon, Rong Chen, Saurav Brahmachari, Olga Pletnikova, Juan C. Troncoso, Valina L. Dawson, Ted M. Dawson
Summary: This study reveals that pathological alpha Syn aggregates in idiopathic Parkinson's disease can cause STING-dependent neuroinflammation and dopaminergic neurodegeneration. Microglial STING activation plays a crucial role in the development of alpha-synudeinopathies, including Parkinson's disease.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biochemistry & Molecular Biology
Run Jin, Aidan Kai Yeung Chan, Jingsong Wu, Tatia Mei Chun Lee
Summary: The review discusses the potential mechanisms and strategies for ameliorating age-related neurocognitive changes associated with inflammation, providing important insights for understanding the pathophysiological mechanisms of neurocognitive disorders and developing preventative measures.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Computer Science, Information Systems
Floris Devriendt, Jeroen Berrevoets, Wouter Verbeke
Summary: Uplift modeling has gained attention in predictive analytics, with the introduction of a new evaluation metric called the maximum profit uplift that helps assess the potential profit of uplift models. This measure allows for comparison of customer churn prediction models and uplift models, and has been applied in a case study in the financial industry.
INFORMATION SCIENCES
(2021)
Article
Geriatrics & Gerontology
Sean Tanabe, Maggie Parker, Richard Lennertz, Robert A. Pearce, Matthew Banks, Robert D. Sanders
Summary: Delirium is associated with a decrease in cortical complexity as measured by Lempil-Ziv Complexity (LZC), showing reduced brain information processing with increasing delirium severity. The negative correlation between LZC and delirium severity was observed widely across the scalp, while LZC normalized to a phase-shuffled distribution showed weaker correlations primarily in midline posterior regions. The study suggests that peripheral inflammation, as represented by monocyte chemoattractant protein-1, does not fully explain the decreased cortical complexity associated with delirium, indicating additional pathogenic mechanisms may be at play.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Daniel J. Klionsky, Giulia Petroni, Ravi K. Amaravadi, Eric H. Baehrecke, Andrea Ballabio, Patricia Boya, Jose Manuel Bravo-San Pedro, Ken Cadwell, Francesco Cecconi, Augustine M. K. Choi, Mary E. Choi, Charleen T. Chu, Patrice Codogno, Maria Isabel Colombo, Ana Maria Cuervo, Vojo Deretic, Ivan Dikic, Zvulun Elazar, Eeva-Liisa Eskelinen, Gian Maria Fimia, David A. Gewirtz, Douglas R. Green, Malene Hansen, Marja Jaattela, Terje Johansen, Gabor Juhasz, Vassiliki Karantza, Claudine Kraft, Guido Kroemer, Nicholas T. Ktistakis, Sharad Kumar, Carlos Lopez-Otin, Kay F. Macleod, Frank Madeo, Jennifer Martinez, Alicia Melendez, Noboru Mizushima, Christian Munz, Josef M. Penninger, Rushika M. Perera, Mauro Piacentini, Fulvio Reggiori, David C. Rubinsztein, Kevin M. Ryan, Junichi Sadoshima, Laura Santambrogio, Luca Scorrano, Hans-Uwe Simon, Anna Katharina Simon, Anne Simonsen, Alexandra Stolz, Nektarios Tavernarakis, Sharon A. Tooze, Tamotsu Yoshimori, Junying Yuan, Zhenyu Yue, Qing Zhong, Lorenzo Galluzzi, Federico Pietrocola
Summary: Autophagy is crucial for maintaining cellular and organismal homeostasis, and dysfunction in autophagy is implicated in the pathogenesis of major human disorders across various organ systems.
Article
Immunology
Vinicius O. Boldrini, Ana M. Marques, Raphael P. S. Quintiliano, Adriel S. Moraes, Carla R. A. V. Stella, Ana Leda F. Longhini, Irene Santos, Marilia Andrade, Breno Ferrari, Alfredo Damasceno, Rafael P. D. Carneiro, Carlos Otavio Brandao, Alessandro S. Farias, Leonilda M. B. Santos
Summary: This study found that CD19(+) B cells in the peripheral blood of multiple sclerosis (MS) patients may express serine-protease granzyme-B (GzmB), resembling cytotoxic CD8(+) T lymphocytes. This finding may provide important clues for investigating the pathogenesis of MS and for the development of new therapeutic interventions.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Clinical Neurology
Hongmin Li, Suliman Khan, Rabeea Siddique, Qian Bai, Yang Liu, Ruiyi Zhang, Yan Zhang, V. Wee Yong, Mengzhou Xue
Summary: This article analyzes the relationship between obesity and the prognosis of acute ischaemic stroke patients treated with IVT. Obesity is an independent predictor for ischaemic stroke, but its impact on IVT treatment has not reached a consensus.
NEUROLOGICAL RESEARCH
(2023)
Article
Immunology
Emily Wuerch, Manoj Mishra, Helvira Melo, Vincent Ebacher, V. Wee Yong
Summary: The study introduces a quantitative whole slide imaging immunofluorescence method for investigating the extent of neuroinflammation, axonal loss, and myelin density in the thoracic spinal cord of EAE. This method is expected to strengthen histological comparisons in EAE and impact research on multiple sclerosis.
JOURNAL OF NEUROIMMUNOLOGY
(2022)
Review
Clinical Neurology
Heather Y. F. Yong, V. Wee Yong
Summary: Despite significant progress in developing disease-modifying therapies for relapsing-remitting MS, the options remain limited for progressive MS. Early treatment, antagonism of neuroaxonal injury mediators, remediation of oxidative stress, and promotion of neuroprotection are crucial for successful therapy in progressive MS.
NATURE REVIEWS NEUROLOGY
(2022)
Letter
Clinical Neurology
Heather Y. F. Yong, Jodie Roberts, Carlos R. Camara-Lemarroy
ACTA NEUROLOGICA BELGICA
(2022)
Letter
Clinical Neurology
Heather Y. F. Yong, Carlos R. Camara-Lemarroy, Katayoun Alikhani
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2023)
Editorial Material
Clinical Neurology
Heather Y. F. Yong, Carlos R. Camara-Lemarroy
JOURNAL OF CLINICAL NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Zhe Li, Yang Liu, Ruixue Wei, V. Wee Yong, Mengzhou Xue
Summary: Zinc is an abundant metal ion in the CNS, playing a crucial role in physiological and pathological brain functions. It promotes antioxidant effects, neurogenesis, and immune system responses. Zinc regulates gene expression, activates enzymes, and acts as a regulator of synaptic activity and neuronal plasticity. Changes in zinc status can impact neurological diseases, including stroke, neurodegenerative diseases, traumatic brain injuries, and depression. This review explores the mechanisms of brain zinc balance, the role of zinc in neurological diseases, and strategies for prevention and treatment.
Review
Clinical Neurology
Heather Y. F. Yong, Daniel M. Pastula, Ronak K. Kapadia
Summary: This review provides an updated clinical approach to diagnosing viral encephalitis and discusses recent advancements in the field. It does not cover the neurological effects of coronaviruses, including COVID-19, and the management of encephalitis. Diagnostic tools for viral encephalitis are rapidly evolving, with multiplex PCR panels being widely used for rapid pathogen detection and metagenomic next-generation sequencing offering potential in diagnosing challenging and rare causes. In addition, emerging infections such as arboviruses, monkeypox virus, and measles are also discussed.
CURRENT OPINION IN NEUROLOGY
(2023)
Review
Clinical Neurology
Albert M. Isaacs, Runze Yang, Magalie Cadieux, David Ben-Israel, Nicholas Sader, Michael Opoku-Darko, Leonardo Frizon, Heather Yong, Zahra Premji, Sean Nagel, Mark G. Hamilton
Summary: This systematic review and meta-analysis aimed to investigate the shunt failure rate and etiologies in adult patients with hydrocephalus. The overall shunt failure rate in adults was found to be at least 32% after 2 years. The most common causes of shunt failure in adults were infection and obstruction, with the distal catheter being the most common site of failure.
NEUROSURGICAL FOCUS
(2023)
Article
Clinical Neurology
Heather Y. F. Yong, Carlos R. Camara-Lemarroy
Summary: This is a case report describing an atypical case of prolonged TGA, highlighting our current lack of knowledge about this disease entity and its pathophysiology. The patient's clinical and imaging features were consistent with TGA, although her symptoms persisted for 72 hours, which remains controversial.
Meeting Abstract
Clinical Neurology
Heather Yong, Carlos Camara-Lemarroy, Katayoun Alikhani
Meeting Abstract
Clinical Neurology
Heather Yong, Carla Wallace, Ronak Kapadia
Article
Clinical Neurology
P. Johnson, J. K. Chan, I. M. Vavasour, S. Abel, L. E. Lee, H. Yong, C. Laule, D. K. B. Li, R. Tam, A. Traboulsee, R. L. Carruthers, S. H. Kolind
Summary: This study used quantitative MRI to evaluate non-lesional white matter demyelination changes in Susac Syndrome (SuS), and compared them with multiple sclerosis (MS) and healthy controls (HC). The results showed evidence of myelin damage, particularly in the corpus callosum, and more extensive microstructural injury in non-lesional white matter in SuS, supporting the hypothesis of widespread microstructural changes and diffuse demyelination in SuS syndrome.
MULTIPLE SCLEROSIS JOURNAL-EXPERIMENTAL TRANSLATIONAL AND CLINICAL
(2022)
Review
Immunology
Rajiv W. Jain, V. Wee Yong
Summary: Although B cells constitute a minor cell population in the central nervous system (CNS), they can contribute to CNS pathology, especially in multiple sclerosis, through secretion of antibodies and effector molecules and presentation of antigens. Jain and Yong discuss the roles of B cells in the CNS and the potential for targeting these cells in various neurological conditions.
NATURE REVIEWS IMMUNOLOGY
(2022)
Review
Clinical Neurology
Brian M. Lozinski, V. Wee Yong
Summary: People with multiple sclerosis were previously advised to avoid exercise, but now they are encouraged to remain active. Exercise has been shown to improve physical well-being, cognition, mental health, and cause positive changes in the brain's structure and function.
MULTIPLE SCLEROSIS JOURNAL
(2022)
