Article
Chemistry, Multidisciplinary
Mingda Zhao, Ruiling Xu, Yuedi Yang, Lei Tong, Jie Liang, Qing Jiang, Yujiang Fan, Xingdong Zhang, Yong Sun
Summary: In this study, a hybridized cross-linked hydrogel scaffold (HG) was created using tissue-affinity mercapto gelatin (GelS) and dopamine-modified hyaluronic acid (HAD). The scaffold integrated reduction-responsive nano-micelles loaded with doxorubicin (DOX) via click reaction, resulting in a bioabsorbable nano-micelle hybridized hydrogel scaffold (HGMP). The HGMP slowly released DOX and targeted B16F10 cells, effectively inhibiting tumor formation in mouse models and reducing postoperative melanoma recurrence.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Engineering, Biomedical
Yunfan Zhang, Xueyu Dou, Lingyun Zhang, Hufei Wang, Ting Zhang, Rushui Bai, Qiannan Sun, Xing Wang, Tingting Yu, Decheng Wu, Bing Han, Xuliang Deng
Summary: In this study, a semi-interpenetrating network composite gel was prepared to fulfill the mechanical and cell compatibility requirements of hydrogels. The gel successfully encapsulated ASA via electrostatic interactions and achieved sustained release, promoting stem cell proliferation and differentiation. In vivo studies confirmed the potential of this gel in bone tissue engineering.
BIOACTIVE MATERIALS
(2022)
Article
Biophysics
Qiu-yue Wang, Yali-Xiang, Qiu-hui Hu, Shuang-hui Huang, Juan Lin, Qing-han Zhou
Summary: This study developed smart charge switchable nano-micelles for co-delivery of doxorubicin (DOX) and paclitaxel (PTX) in the treatment of lung adenocarcinoma. The nano-micelles exhibited a surface charge-switch from negative to positive in the tumor microenvironment, leading to improved cellular internalization. The nano-micelles also successfully achieved endosome escape in the acidic environment. The co-delivery of DOX/PTX showed enhanced solid tumor inhibition compared to mono-chemotherapy in mice models.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Engineering, Environmental
Zeou Dou, Maria Vitoria Bini Farias, Wensi Chen, Dongjing He, Yuhang Hu, Xing Xie
Summary: This study presents a controlled-release fertilizer excipient based on chitosan and montmorillonite, which can reduce fertilizer loss, improve soil water retention, and has high degradability with minimal impact on long-term soil fertility.
FRONTIERS OF ENVIRONMENTAL SCIENCE & ENGINEERING
(2023)
Article
Chemistry, Inorganic & Nuclear
Chen Li, Fayong Li, Ke Wang, Qing Wang, Hailu Liu, Xiaoyan Sun, Dong Xie
Summary: In this study, a functionalized carboxymethyl chitosan-graphene oxide-gelatin composite hydrogel with excellent swelling property, high biocompatibility, and drug delivery efficiency was prepared by ionic crosslinking. The composite hydrogel exhibited porous structures with randomly distributed but regularly arranged pores in the cross section. The thermal stability and swelling ratio of the composite hydrogel were improved, leading to improved drug delivery efficiency and prolonged drug administration.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Katherine R. Jinkins, Shupeng Li, Hany Arafa, Hyoyoung Jeong, Young Joong Lee, Changsheng Wu, Elizabeth Campisi, Xinchen Ni, Donghwi Cho, Yonggang Huang, John A. Rogers
Summary: Continuous health monitoring is crucial for clinical care, but traditional methods can cause irritation and injury. Researchers propose a materials strategy that utilizes wireless triggering to reduce adhesive strength and prevent harm. The approach involves silicone composites loaded with crystallizable oils, which, when heated, result in decreased adhesion.
Article
Chemistry, Physical
Niloufar Khosravi, Leila Youseftabar-Miri, Faten Divsar, Sara Hallajian, Kaynaz Hafezi
Summary: A biocompatible and biodegradable hydrogel nanocomposite was synthesized for controlled and sustained release of gabapentin. The hydrogel composite exhibited high drug encapsulation and loading efficiency, and the drug release followed the Higuchi kinetics model and Fick-ian diffusion mechanism. The chitosan-based hydrogel showed excellent biocompatibility and thermosensitive properties, making it a promising drug carrier.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Polymer Science
Muhammad Umar Aslam Khan, Zahida Yaqoob, Mohamed Nainar Mohamed Ansari, Saiful Izwan Abd Razak, Mohsin Ali Raza, Amna Sajjad, Sajjad Haider, Fauzi Mh Busra
Summary: Composite hydrogels of CS/PVA and GO/CS/PVA were successfully synthesized and analyzed using various techniques, showing good swelling and drug release properties. The study also revealed better antibacterial and cell viability behaviors of the composite materials, indicating their potential as biomaterials in biomedical applications.
Article
Materials Science, Multidisciplinary
Zhe Wang, Shuai Hou, Shiyu Yao, Yuli Shang, Shu Deng, Yang Peng, Weiwei Zhou, Xiaofei Lv, Bo Ren, Cheng Peng, Jie Yang, Zhaohui Huang
Summary: This article reports the fabrication of a novel Tilapia Collagen/Hydroxyapatite-based tissue engineering scaffold that imitates functional extracellular matrix. By embedding Aspirin-PLGA microspheres in the scaffold, the osteoinductive activity was improved. The scaffold demonstrated ideal pore structure, mechanical strength, chemical stability, and controlled release of aspirin. The enhanced cell proliferation and mineralization capacity make it an ideal biomaterial for bone tissue engineering.
JOURNAL OF MATERIALS SCIENCE
(2022)
Article
Nanoscience & Nanotechnology
Ankan Kumar Sarkar, Koushik Debnath, Himali Arora, Pankaj Seth, Nihar R. Jana, Nikhil R. Jana
Summary: The direct cytosolic delivery of large biomolecules bypassing endocytic pathways is a promising strategy for therapeutic applications. Recent research has shown that surface chemistry of carriers, nanoscale assembly, colloidal stability, and low surface charge are critical for non-endocytic uptake processes. The guanidinium-terminated polyaspartic acid micelle can deliver protein/DNA directly to the cytosol by forming a nano-assembly with <200 nm size and near-zero surface charge, highlighting the importance of size and colloidal properties for efficient cytosolic delivery of large biomolecules.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Applied
Minquan Xia, Zhaoyu Cui, Tao Zeng, LiZhi Lu, Long Sheng, Zhaoxia Cai
Summary: This work achieved pH-responsive oral delivery of IgY-Fab fragments using cellulose based multi-network composite hydrogels, demonstrating stability and interactions between Fab and the hydrogel matrix.
Article
Chemistry, Multidisciplinary
Julie Tzu-Wen Wang, Ana C. Rodrigo, Anna K. Patterson, Kirsten Hawkins, Mazen M. S. Aly, Jia Sun, Khuloud T. Al Jamal, David K. Smith
Summary: The study demonstrates the use of a self-assembling hydrogel as a delivery vehicle for the Parkinson's disease drug l-DOPA, showing promising results for nasal drug delivery strategies.
Article
Chemistry, Multidisciplinary
Jiaxin Li, Yang Long, Rong Guo, Kebai Ren, Zhengze Lu, Man Li, Xuhui Wang, Jiaxin Li, Yashi Wang, Zhirong Zhang, Qin He
Summary: A novel anti-inflammatory strategy based on neutrophils has been developed, showing significant therapeutic efficacy for rheumatoid arthritis by using LMWH-TOS nanoparticles.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Polymer Science
Fengrong Gong, Lihui Jiang, Yanni Gao, Juan Xu, Ting Wang
Summary: To enhance the solubility of ethinylestradiol (EE) in water, researchers prepared diethylenetriamine-beta-cyclodextrin/ethinylestradiol (DETA-beta-CD/EE) complex and designed core-shell composite hydrogel capsules with aldocellulose and hydroxyethyl cellulose as the core and sodium alginate as the shell. The prepared hydrogel capsules exhibited controlled and sustained release of soluble DETA-beta-CD/EE, pH-responsiveness to intestinal fluid, and non-toxicity to normal human cells.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Nanoscience & Nanotechnology
Xianwen Song, Zequn Zhang, Zhaolong Shen, Jun Zheng, Xi Liu, Yaqiong Ni, Jun Quan, Xiaorong Li, Gui Hu, Yi Zhang
Summary: This study successfully prepared supramolecular hydrogels by evaporating ethanol to drive the formation of hydrogen bonds between hydrophilic poly(vinyl alcohol) and certain hydrophobic compounds. The gelation performance of these hydrogels changed regularly with the changing sequence of hydrophobic compounds, showing good plasticity and self-healing properties. In a rat model, the prepared hydrogels demonstrated high efficiency and safety in preventing postsurgical adhesion.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Polymer Science
Daichi Takahashi, Annadanam Venkata Sesha Sainath, Junko Ikeda, Kulisara Budpud, Tatsuo Kaneko, Mika Kawai, Tetsu Mitsumata
Summary: The study investigated the magnetorheological response of magnetic elastomers containing CI particles coated with PMMA. By analyzing the thickness of the PMMA layer and the decrease in storage modulus, the diameter of secondary particles and aggregation behavior in the polyurethane matrix were determined.
Article
Chemistry, Physical
Agman Gupta, Rajashekar Badam, Aniruddha Nag, Tatsuo Kaneko, Noriyoshi Matsumi
Summary: Graphite has been commonly used as the conventional lithium-ion anode, but faces challenges of exfoliation leading to capacity fade. This study introduces an n-type conjugated copolymer BP as a substitute binder for graphite anodes, showing superior performance and cycle stability.
ACS APPLIED ENERGY MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Kenji Takada, Katsuaki Yasaki, Sakshi Rawat, Kosuke Okeyoshi, Amit Kumar, Hideyuki Murata, Tatsuo Kaneko
Summary: Cinnamate-based polyesters were synthesized and processed into membranes which showed different photodeformation behaviors under UV light, with PdHCA membranes visibly contracting while P3HCA membranes exhibited unique photoexpansion behavior. Time-resolution infrared spectroscopy revealed trans-to-cis isomerism in the polymer main chains of the P3HCA film, leading to convex bending in UV-irradiated regions.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Green & Sustainable Science & Technology
Mohammad Asif Ali, Tatsuo Kaneko
Summary: The production of novel chiral dicarboxylic acids from renewable feedstock has been reported in this study. By synthesizing chiral polyamides with heterocyclic diacid monomers, it was found that the interaction between polymer chains of different chiralities affects the crystallization degree and performance of the composite.
ADVANCED SUSTAINABLE SYSTEMS
(2022)
Article
Chemistry, Physical
Gargi Joshi, Kosuke Okeyoshi, Fitri Adila Amat Yusof, Tetsu Mitsumata, Maiko K. Okajima, Tatsuo Kaneko
Summary: By exploring the fluidic geometry of a liquid crystalline polysaccharide solution containing micron-sized rod and platelet units, it was found that the presence of platelet units contributes lateral capillary interactions and helps rod units form a wider self-assembled structure with high viscosity.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Saranyoo Sornkamnerd, Shuhei Sasaki, Tetsu Mitsumata, Kenji Takada, Tomohiro Okada, Shinji Ando, Tatsuo Kaneko
Summary: By synthesizing bio-polyimides using renewable materials, transparent films with high heat resistance and good electrical resistance were prepared, suitable for applications in the field of electric insulators.
Article
Chemistry, Multidisciplinary
Yasuyoshi Funahashi, Yohei Yoshinaka, Kenji Takada, Tatsuo Kaneko
Summary: In this study, self-standing nanomembranes with high toughness were developed by spin-casting super-tough polyamides over dimethylformamide solution. These nanomembranes, which have ultra-high toughness and can be peeled off without breaking, could be applied to flexible devices in the future.
Article
Materials Science, Multidisciplinary
Isamu Saito, Leijie Wu, Mitsuo Hara, Yuka Ikemoto, Tatsuo Kaneko, Kosuke Okeyoshi
Summary: This study designs reordered polysaccharide materials with cation selectivity and anisotropic responses by controlling the drying process of an aqueous pectin dispersion. The membrane, based on the egg-box model, exhibits anisotropic responses to cations and can swell as a hydrogel. It shows potential for application in tissue engineering in physiological environments.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Chemistry, Physical
Yue Jiang, Shuai Wang, Weifu Dong, Tatsuo Kaneko, Mingqing Chen, Dongjian Shi
Summary: The authors developed a high-performance, degradable, and recyclable bio-based epoxy resin by reacting the lignin derivative vanillin with 4-amino cyclohexanol via Schiff base. This resin exhibited higher Young's modulus and tensile strength compared to bisphenol A epoxy. It also showed good degradation in an acidic environment and recoverability through heat treatment. Additionally, the resin could be used to prepare carbon fiber-reinforced composites, with the carbon fiber being completely recyclable. This study provides a pathway for the preparation of high-performance epoxy resin and the effective recycling of carbon fiber.
Article
Chemistry, Applied
Maninder Singh, Gargi Joshi, Han Qiang, Maiko K. Okajima, Tatsuo Kaneko
Summary: Synthetic materials cause damage over time, so the use of naturally-derived polymers for sustainable material fabrication is gaining recognition. We created hybrid hydrogel sheets using polysaccharides and nanocellulose as wound dressings. Antibacterial properties were added through silver nanoparticles in the polysaccharide blend, and the films were crosslinked via thermal annealing to avoid the use of harmful chemicals. The resulting silver nanoparticle-polysaccharide hydrogels effectively reduce bacterial viability and have potential as on-demand dressings.
CARBOHYDRATE POLYMER TECHNOLOGIES AND APPLICATIONS
(2023)
Article
Nanoscience & Nanotechnology
Jianbing Cui, Ruisheng Xu, Weifu Dong, Tatsuo Kaneko, Mingqing Chen, Dongjian Shi
Summary: Flexible and stretchable materials with ionic conductivity are crucial in the development of flexible electronic devices. In this study, a biomimetic hydrogel with strain-stiffening capability was fabricated by embedding a stiff array of poly(acrylic acid) (PAAc) in a soft polyacrylamide (PAAm) hydrogel. The resulting patterned hydrogel exhibited nonlinear mechanical properties, high strength, and protonic conductivity without the need for additional ionic salts. This hydrogel has the potential to serve as a strain sensor for monitoring human motion.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Physical
Rio Urano, Pruetsakorn Saosamniang, Tatsuo Kaneko, Mika Kawai, Tetsu Mitsumata
Summary: The relationship between the magnetorheological effect and the void ratio in a polyurethane magnetic elastomer with voids was investigated by dynamic viscoelastic measurement under a magnetic field. It was found that the void ratio had a significant impact on the storage modulus of the elastomer, allowing movement of magnetic particles within the material.
Article
Polymer Science
Jiabei Zhou, Xianzhu Zhong, Aniruddha Nag, Yang Liu, Kenji Takada, Tatsuo Kaneko
Summary: Porous polybenzimidazole derivative films were prepared using a silica template method, resulting in ultrahigh thermoresistant films with improved elongation properties and enhanced strength and hardness. Microscopic analysis confirmed the formation of pores and observed craters with swollen edges and hardened surfaces.
Article
Chemistry, Multidisciplinary
Xianzhu Zhong, Aniruddha Nag, Jiabei Zhou, Kenji Takada, Fitri Adila Amat Yusof, Tetsu Mitsumata, Kenji Oqmhula, Kenta Hongo, Ryo Maezono, Tatsuo Kaneko
Summary: In this study, ultrahigh thermoresistant bio-based terpolymers with a low dielectric constant were successfully synthesized. These materials showed great potential for various applications.
Article
Chemistry, Multidisciplinary
Kottisa Sumala Patnaik, Rajashekar Badam, Yueying Peng, Koichi Higashimine, Tatsuo Kaneko, Noriyoshi Matsumi
Summary: A highly nitrogen-doped carbon material was synthesized through easy pyrolysis of bio-based poly(2,5-benzimidazole), showing fast charging capability at 18.6 A g(-1) and excellent long-term cyclability of 3000 cycles with 90% capacity retention. Full cell studies demonstrated the commercial potential of this novel material.
CHEMICAL COMMUNICATIONS
(2021)
Article
Materials Science, Biomaterials
Izabela Stupka, Artur P. Biela, Bernard Piette, Agnieszka Kowalczyk, Karolina Majsterkiewicz, Kinga Borzecka-Solarz, Antonina Naskalska, Jonathan G. Heddle
Summary: Artificial protein cages, such as TRAP-cages, have potential applications in vaccines and drug delivery. TRAP-cages have the ability to control the disassembly conditions by modifying the interface between their building blocks. By using TRAP rings with different numbers of monomers, it is possible to predict the formation of other cages.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Guo Zhang, Yu Wang, Hua Qiu, Lei Lu
Summary: This study presents a one-pot synthesis method for flower-like AMPs@EAMP particles by combining antimicrobial peptides with ellagic acid, offering enlarged surface area, excellent biocompatibility, and broad-spectrum antibacterial activity. In vivo studies indicate their potential for tissue repair and immune barrier reconstruction.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Jiamei Zhang, Lingshuang Wang, Cheng Xu, Yingui Cao, Shengsheng Liu, Rui L. Reis, Subhas C. Kundu, Xiao Yang, Bo Xiao, Lian Duan
Summary: Pluronic F127 modified silk fibroin film with different types of antibacterial agents could accelerate wound recovery by promoting fibroblast adhesion, eradicating bacteria, and facilitating angiogenesis and re-epithelialization.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Yinsheng Liu, Mingyue Wang, Yinfei Hui, Lei Sun, Yanrui Hao, Henlong Ren, Hao Guo, Wu Yang
Summary: In this study, a rare-earth hybrid luminescent material was developed for the detection of a biomarker for anthrax. The material showed excellent selectivity and high sensitivity, allowing for the determination of the biomarker in saliva and urine. Additionally, a convenient point-of-care testing method using fluorescent test paper and a smartphone was established for the initial diagnosis of anthrax.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Review
Materials Science, Biomaterials
Wenshuai Yang, Jingsi Chen, Ziqian Zhao, Meng Wu, Lu Gong, Yimei Sun, Charley Huang, Bin Yan, Hongbo Zeng
Summary: Injectable hydrogels with shear-thinning and/or in situ formation properties offer distinct advantages in bioengineering applications, as they can be directly delivered to target sites, possess self-healing abilities, and simplify the implantation process.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)