Article
Biochemistry & Molecular Biology
Yunfei Tan, Lei Ma, Xiangyu Chen, Yaqin Ran, Qiulan Tong, Liwen Tang, Xudong Li
Summary: The interfacial mismatch between rigid hydroxyapatite and soft polysaccharide phase in natural polysaccharide/hydroxyapatite hydrogels remains a challenge in bone tissue engineering. In this study, hyaluronic acid was used as a template for biological mineralization to synthesize hyaluronic acid/hydroxyapatite hybrid particles. These particles were then introduced into hydroxyapatite composite hydrogels, which showed increased storage modulus and excellent cytocompatibility. The self-healing hydrogels, suitable for cell encapsulation, hold promise for bone defect repair.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Materials Science, Multidisciplinary
Xingzhu Liu, Yajie Zhang, Zahid Hussain, Penghui Zheng, Mingsheng Xu, Hongbo Zhao, Yuanshan Liu, Yi Cao, Ismat Ullah, Akiyoshi Osaka, Renjun Pei
Summary: This study developed an injectable polymer-based hydrogel that can fill irregular defects and promote tissue regeneration. The hydrogel, embedded with calcium sulfate nanorods, showed the ability for self-biomineralization and controlled release of calcium ions, facilitating cell adhesion, proliferation, and in situ bone growth.
APPLIED MATERIALS TODAY
(2023)
Article
Biochemistry & Molecular Biology
Ali Mousavi, Shohreh Mashayekhan, Nafiseh Baheiraei, Ali Pourjavadi
Summary: The study presents the optimization of a newly-developed hydrogel derived from biological macromolecules with improved mechanical properties and electrical conductivity for cardiac tissue engineering. Functionalized reduced graphene oxide was added to enhance the electromechanical properties of the hydrogel, showing potential for providing a desirable platform in this field.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Engineering, Environmental
Xingge Yu, Xiuhui Wang, Dejian Li, Ruilong Sheng, Yifeng Qian, Rui Zhu, Xudong Wang, Kaili Lin
Summary: This study developed an injectable organic-inorganic nanocomposite GelMA/Sr-CSH hydrogel system, which improved the mechanical properties of GelMA hydrogels by incorporating Sr-CSH nanofibers. In vitro and in vivo experiments demonstrated that GelMA/Sr-CSH hydrogels facilitated cell adhesion, proliferation, and expression of osteogenic genes, accelerating bone regeneration. This research is of great significance for in-situ bone regeneration.
CHEMICAL ENGINEERING JOURNAL
(2022)
Review
Biotechnology & Applied Microbiology
Senbo Zhu, Yong Li, Zeju He, Lichen Ji, Wei Zhang, Yu Tong, Junchao Luo, Dongsheng Yu, Qiong Zhang, Qing Bi
Summary: This paper reviews the research progress on advanced injectable hydrogels for repairing cartilage defects. It thoroughly discusses the cross-linking method and structure of injectable hydrogels, and reviews the commonly used polymers, cells, and stimulators in their preparation. Finally, it summarizes the research progress of the latest advanced hydrogels for cartilage repair and the future challenges for injectable hydrogels.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Jing Ye, Gang Yang, Jing Zhang, Zhenghua Xiao, Ling He, Han Zhang, Qi Liu
Summary: This study aimed to construct composite hydrogels based on natural polymers for tissue engineering. Results showed that these composite hydrogels have good cell viability and mechanical properties, promoting cell proliferation and adhesion of ADSCs.
Review
Chemistry, Multidisciplinary
Mithun Rajendra Dethe, A. Prabakaran, Hafiz Ahmed, Mukta Agrawal, Upal Roy, Amit Alexander
Summary: Stimuli-responsive hydrogels have been extensively studied in biomedical applications due to their biodegradability and biocompatibility. The emergence of in situ stimuli-responsive hydrogels is the result of advancements in synthetic chemistry and materials science. The copolymer PCL-PEG, recognized by the FDA, can form thermosensitive injectable hydrogels that exhibit rapid and reversible gelation behavior.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Pharmacology & Pharmacy
Mojgan Ghanbari, Masoud Salavati-Niasari, Fatemeh Mohandes
Summary: In this study, thermosensitive injectable hydrogels were fabricated using oxidized alginate, gelatin, and carbon nitride quantum dots (CNQDs) for tissue engineering. The addition of CNQDs improved the mechanical strength and durability of the nanocomposite hydrogels, while reducing biodegradation and swelling ratio. Additionally, the nanocomposite hydrogels showed good biocompatibility (>88%) and cell adhesion to MG63 osteosarcoma cells depending on the presence of CNQDs.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Eduardo Anitua, Mar Zalduendo, Maria Troya, Itsasne Erezuma, Izeia Lukin, Raquel Hernaez-Moya, Gorka Orive
Summary: The study investigated the potential of three different bioinks based on gelatin and alginate for regenerative medicine. The bioinks containing hydroxyapatite and PRGF showed the highest cell compatibility and promoted osteogenic differentiation.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Chemistry, Applied
Baharak Divband, Marziyeh Aghazadeh, Zahraa Haleem Al-qaim, Mohammad Samiei, Falah H. Hussein, Alireza Shaabani, Shahriar Shahi, Roya Sedghi
Summary: Injectable hydrogels loaded with VEGF and BMP-2 promote proliferation and osteogenic differentiation of DPSCs, showing potential for bone defect treatment.
CARBOHYDRATE POLYMERS
(2021)
Article
Materials Science, Multidisciplinary
Aleksandra Krajcer, Joanna Klara, Wojciech Horak, Joanna Lewandowska-Lancucka
Summary: Novel bioactive injectable composites based on biopolymeric hydrogels reinforced with insulin-functionalized silica particles were synthesized and their potential for bone defect regeneration was demonstrated through in vitro experiments.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2022)
Article
Polymer Science
Lea Melzener, Sergio Spaans, Nicolas Hauck, Andre J. G. Potgens, Joshua E. Flack, Mark J. Post, Arin Dogan
Summary: Cultivated meat is an emerging technology that aims to create an environmentally and animal-friendly alternative to traditional meat. Alginate, a biomaterial, can support muscle formation but has limitations in its mechanical properties. By adding electrospun short-stranded zein fibers, the characteristics of the hydrogel can be improved, leading to higher quality and stability of cultivated meat.
Article
Polymer Science
Ting Wu, Haiying Liu, Hongcai Wang, Yanan Bu, Jiayi Liu, Xiuqiong Chen, Huiqiong Yan, Qiang Lin
Summary: In this study, alginate/sericin/cellulose nanocrystalline (ALG/SS/CNCS) composite hydrogels were constructed to overcome the shortcomings of alginate hydrogels and enhance their mechanical strength and degradation properties. The incorporation of sericin and cellulose nanocrystals significantly improved the attachment, proliferation, and differentiation of MC3T3-E1 cells on the composite hydrogels.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Review
Engineering, Biomedical
Chaojie Yu, Fanglian Yao, Junjie Li
Summary: Recently, injectable conducting polymer-based hydrogels have gained attention in tissue engineering due to their controlled conductivity and minimally invasive procedures. Functional CPs play a crucial role in designing these hydrogels and have potential applications in neurological treatment, myocardial repair, and skeletal muscle regeneration.
ACTA BIOMATERIALIA
(2022)
Article
Biochemistry & Molecular Biology
Hongcai Wang, Ruhong Yin, Xiuqiong Chen, Ting Wu, Yanan Bu, Huiqiong Yan, Qiang Lin
Summary: The mechanical strength and cell adhesion of alginate hydrogel were enhanced by grafting the RGD polypeptide sequence onto the alginate molecular chain. Composite hydrogels with cellulose nanocrystals reinforcement were fabricated through physical mixture and ion cross-linking. The addition of cellulose nanocrystals and polyvinyl alcohol affected the morphology, properties, degradation rate, and cell compatibility of the composite hydrogels.
Article
Engineering, Biomedical
Zhi Wu, Dan He, Haiyan Li
Summary: The study demonstrates that BG ion products can significantly enhance the production of exosomes from MSCs and modulate their biological function by influencing relevant pathways, thereby providing a feasible approach to improve the practical application of exosomes in regenerative medicine.
BIOACTIVE MATERIALS
(2021)
Article
Engineering, Biomedical
Yunlong Yang, Zhaochen Zhu, Renzhi Gao, Ji Yuan, Juntao Zhang, Haiyan Li, Zongping Xie, Yang Wang
Summary: In this study, an injectable Diels-Alder crosslinked hyaluronic acid/PEG (DAHP) hydrogel was developed as a delivery platform for mesenchymal stem cell-derived small extracellular vesicles (MSC-sEVs) for osteoarthritis (OA) treatment. The hydrogel displayed sustained release properties and enhanced the efficacy of MSC-sEVs, providing a promising delivery system for OA therapy.
ACTA BIOMATERIALIA
(2021)
Article
Cell & Tissue Engineering
Yating Huang, Zhijie Ma, Xiaojun Kuang, Qiuwan Zhang, Haiyan Li, Dongmei Lai
Summary: The study demonstrates that SA-BG-encapsulated hAECs or CM can treat chemotherapy-induced POF by protecting granulosa cell function and enhancing ovarian vascularization, providing a novel strategy for delivering hAECs for POF treatment.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Medicine, Research & Experimental
Huakun Zhao, Lingzhi Kong, Ji Shen, Yanhong Ma, Zhi Wu, Haiyan Li, Yaohua He
Summary: The study demonstrated that TET protected the normal reticular structure of the capsule during the freezing period and prevented the development of FS by inhibiting inflammation, angiogenesis, and fibrosis in a rat FS model.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Engineering, Biomedical
Pengfei Zhao, Yan Han, Holly Nguyen, Eva Corey, Xiaohu Gao
Summary: A simple yet effective cancer treatment method involves repurposing clinically approved magnetic nanoparticles and utilizing static parallel magnetic fields for intracellular nanoparticle self-assembly, leading to targeted cell death while preserving other cells and organs intact. This approach opens up a new avenue for cancer treatment by utilizing nanosciences and nanoparticle design principles accumulated over the past decades.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Engineering, Biomedical
Ying Li, Xin Zhang, Dan He, Zhijie Ma, Ke Xue, Haiyan Li
Summary: Regulating excessive inflammation and inhibiting MMP-9 overexpression are effective strategies for improving diabetic wound healing. The ionic products of 45S5 Bioglass and chitosan nanoparticles can reduce MMP-9 expression, enhance extracellular matrix protein synthesis, and promote angiogenesis, thereby accelerating the healing process of diabetic wounds.
ACTA BIOMATERIALIA
(2022)
Article
Cell Biology
Dan He, Zhijie Ma, Ke Xue, Haiyan Li
Summary: JM2 inhibits breast tumor growth by inducing apoptosis and inhibiting proliferation, stimulating mitochondrial aggregation and regulating cell cycle. The JM2 grafted hyaluronic acid hydrogel effectively suppresses malignant proliferation of tumor cells and reduces breast tumor recurrence.
CELL DEATH & DISEASE
(2022)
Article
Engineering, Biomedical
Yuhang Guo, Guowen Hu, Yuguo Xia, HaiYan Li, Ji Yuan, Juntao Zhang, Yu Chen, Hua Guo, Yunlong Yang, Yang Wang, Zhifeng Deng
Summary: This study established a saponin-mediated cargo elimination strategy to eliminate the intrinsic risks of original proteins and RNAs in tumor cell-derived small extracellular vesicles (GBM-sEVs), and confirmed its effectiveness in GBM suppression.
BIOACTIVE MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Qing Li, Xinyu Niu, Yan Yi, Yu Chen, Ji Yuan, Juntao Zhang, Haiyan Li, Yuguo Xia, Yang Wang, Zhifeng Deng
Summary: This study demonstrates that inducible pluripotent stem cell-derived small extracellular vesicles (iPSC-sEVs) can alleviate blood-brain barrier (BBB) senescence and improve stroke outcomes in aged mice.
Article
Chemistry, Multidisciplinary
Huiyan Li, Huilin Zhang, Xiaofang He, Peiran Zhao, Tong Wu, Jinxuan Xiahou, Yelin Wu, Yanyan Liu, Yang Chen, Xingwu Jiang, Guanglei Lv, Zhenwei Yao, Jian Wu, Wenbo Bu
Summary: A communication interception strategy is developed to block spatiotemporal crosstalk between lysosomes and endoplasmic reticulum (ER) using amorphous-core@crystalline-shell Fe@Fe3O4 nanoparticles (ACFeNPs). This strategy induces autophagy and ER stress, leading to a significant therapeutic effect for cancer treatment.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Yanlun Zhu, Yiwei Wang, Guanggai Xia, Xuerao Zhang, Shuai Deng, Xiaoyu Zhao, Yanteng Xu, Guozhu Chang, Yu Tao, Mingqiang Li, Haiyan Li, Xinyu Huang, Hon Fai Chan
Summary: Resolving inflammation and promoting intestinal tissue regeneration are critical for inflammatory bowel disease (IBD) treatment. Bioactive glass (BG), a clinically approved bone graft material, attenuates pro-inflammatory response and reduces inflammatory damage to intestinal organoids in vitro. Zein/sodium alginate-based core-shell microspheres (Zein/SA/BG) are developed for oral delivery of BG to prevent its premature dissolution in the stomach.
Review
Engineering, Biomedical
Haiyan Li, Keerthi Subramanian Iyer, Lei Bao, Jiali Zhai, Jiao Jiao Li
Summary: Granular microporous hydrogels made of non-spherical microgels show enhanced characteristics compared to traditional nanoporous hydrogels, promoting cell viability, migration, and tissue regeneration. These hydrogels have higher macroporosity and improved mechanical properties, allowing for better alignment and differentiation of cells in anisotropic tissue. The development of these hydrogels is gaining increasing interest in regenerative medicine.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Materials Science, Biomaterials
Juan Du, Linpeng Fan, Joselito M. Razal, Sihao Chen, Hongmei Zhang, Hongjun Yang, Haiyan Li, Jingliang Li
Summary: Tissue engineered skin and its substitutes show potential for wound healing, but the challenge lies in enabling fast blood vessel formation. This study fabricated active mesoporous bioglass nanoparticles doped with strontium (Sr) for rapid microvascularization and wound healing. In vitro experiments showed that the Sr-ion containing bioglass nanoparticles significantly promoted fibroblast proliferation and microvascularization of human umbilical vein endothelial cells. In vivo, silk fibroin sponges encapsulating the nanoparticles accelerated wound healing by promoting blood vessel and epithelium formation. This work provides a strategy for designing active biomaterials that enhance wound healing by rapid vascularization and epithelial reconstruction.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Review
Cell & Tissue Engineering
Alissa Olga Lukomskyj, Nikitha Rao, Lei Yan, Jasmine Sarah Pye, Haiyan Li, Bin Wang, Jiao Jiao Li
Summary: Burn wounds are severe skin injuries with significant impacts on patients and the healthcare system. Current treatment methods are inadequate, driving the need for tissue engineered solutions. Stem cell-based strategies show promise for improving burn wound treatment. A comprehensive review of research studies on stem cell-based tissue engineering treatments in preclinical burn wound models demonstrated favorable results in animal models, suggesting the potential of these treatments as improved therapies for burn wounds.
STEM CELL REVIEWS AND REPORTS
(2022)
Article
Materials Science, Biomaterials
Haiyan Li, Wenrui Wang, Jiang Chang
Summary: This study found that the ionic products of calcium silicate (CS), a representative BSCs, can enhance the immunosuppressive function of human bone marrow mesenchymal stem cells (HBMSCs) by up-regulating the expression of immunosuppressive factors via NF-kappa B pathway. Additionally, CS-activated HBMSCs have stronger stimulatory effects on M2 polarization of macrophages and early osteogenic differentiation of HBMSCs compared to CS ionic products, providing insights into the mechanism of BSCs enhancing bone regeneration and the importance of considering the effects of biomaterials on the immunomodulatory function of tissue forming cells.
REGENERATIVE BIOMATERIALS
(2021)
Article
Materials Science, Biomaterials
Izabela Stupka, Artur P. Biela, Bernard Piette, Agnieszka Kowalczyk, Karolina Majsterkiewicz, Kinga Borzecka-Solarz, Antonina Naskalska, Jonathan G. Heddle
Summary: Artificial protein cages, such as TRAP-cages, have potential applications in vaccines and drug delivery. TRAP-cages have the ability to control the disassembly conditions by modifying the interface between their building blocks. By using TRAP rings with different numbers of monomers, it is possible to predict the formation of other cages.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Guo Zhang, Yu Wang, Hua Qiu, Lei Lu
Summary: This study presents a one-pot synthesis method for flower-like AMPs@EAMP particles by combining antimicrobial peptides with ellagic acid, offering enlarged surface area, excellent biocompatibility, and broad-spectrum antibacterial activity. In vivo studies indicate their potential for tissue repair and immune barrier reconstruction.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Jiamei Zhang, Lingshuang Wang, Cheng Xu, Yingui Cao, Shengsheng Liu, Rui L. Reis, Subhas C. Kundu, Xiao Yang, Bo Xiao, Lian Duan
Summary: Pluronic F127 modified silk fibroin film with different types of antibacterial agents could accelerate wound recovery by promoting fibroblast adhesion, eradicating bacteria, and facilitating angiogenesis and re-epithelialization.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Yinsheng Liu, Mingyue Wang, Yinfei Hui, Lei Sun, Yanrui Hao, Henlong Ren, Hao Guo, Wu Yang
Summary: In this study, a rare-earth hybrid luminescent material was developed for the detection of a biomarker for anthrax. The material showed excellent selectivity and high sensitivity, allowing for the determination of the biomarker in saliva and urine. Additionally, a convenient point-of-care testing method using fluorescent test paper and a smartphone was established for the initial diagnosis of anthrax.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Review
Materials Science, Biomaterials
Wenshuai Yang, Jingsi Chen, Ziqian Zhao, Meng Wu, Lu Gong, Yimei Sun, Charley Huang, Bin Yan, Hongbo Zeng
Summary: Injectable hydrogels with shear-thinning and/or in situ formation properties offer distinct advantages in bioengineering applications, as they can be directly delivered to target sites, possess self-healing abilities, and simplify the implantation process.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
