Article
Chemistry, Multidisciplinary
Carmen Racles, Mirela-Fernanda Zaltariov, Dragos Peptanariu, Tudor Vasiliu, Maria Cazacu
Summary: Mesoporous silica nanoparticles (MSNs) with different functional groups were synthesized and investigated for the encapsulation and release of anticancer drug Doxorubicin (Dox). The results showed that MSNs with thiol and glucose groups had high loading efficiency and high release rates at pH 5. In vitro experiments demonstrated strong cytotoxic effects of these loaded silica nanoparticles on cancer cells.
Article
Materials Science, Multidisciplinary
Federico Olivieri, Fabio Scherillo, Rachele Castaldo, Mariacristina Cocca, Antonino Squillace, Gennaro Gentile, Marino Lavorgna
Summary: In this study, high-surface-area amino-functionalized mesoporous silica nanoparticles (MSN-NH2) were synthesized and functionalized with benzoyl chloride (MSN-BC) for the release of benzoic acid (BA) in response to acidic and alkaline conditions. These MSN-BC nanoparticles were embedded in acrylic coatings for corrosion protection of aluminum alloys. The coatings showed long-lasting efficiency and were validated through morphological and electrochemical impedance spectroscopy (EIS) measurements, demonstrating their potential for aluminum alloy protection.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Kechen Song, Zhuang Tang, Zhiling Song, Shiyu Meng, Xiaoxue Yang, Hui Guo, Yizhun Zhu, Xiaolin Wang
Summary: In this study, an enzyme-responsive and macrophage-targeting drug delivery system was constructed for precise treatment of atherosclerosis. The results showed that the system had high drug loading efficiency and enzyme-responsive release, as well as robust targeting, anti-inflammatory, and anti-foaming effects, with low cytotoxicity and excellent hemocompatibility.
Article
Pharmacology & Pharmacy
Sang Jun Kim, Youngbo Choi, Khee Tae Min, Surin Hong
Summary: This study proposes radially mesoporous silica nanoparticles as a carrier for dexamethasone, achieving sustained anti-inflammatory effects in rheumatoid arthritis. The nanoparticles demonstrate high-capacity loading and sustained release of the drug, resulting in improved delivery efficiency compared to traditional silica nanoparticles. In vivo evaluation confirms the sustained anti-inflammatory effects and cartilage recovery in a rat model of the disease.
Article
Nanoscience & Nanotechnology
Chun-Feng Lai, Fu-Jia Shiau
Summary: This study presents and investigates pH-triggered drug-eluting contact lenses (DCLs) combined with large-pore mesoporous silica nanoparticles (LPMSNs). LPMSN-laden DCLs can prolong the residence time of glaucoma drugs in an artificial lacrimal fluid (ALF) environment at pH 7.4 compared to reference DCLs. The LPMSN-laden DCLs do not require drug preloading and are compatible with current contact lens manufacturing processes. LPMSN-laden DCLs soaked at pH 6.5 exhibit better drug loading capabilities than reference DCLs due to specific adsorption.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Polymer Science
Dan Eduard Mihaiescu, Daniela Istrati, Alina Morosan, Maria Stanca, Bogdan Purcareanu, Rodica Cristescu, Bogdan Stefan Vasile, Roxana Doina Trusca
Summary: This research focuses on the study of cefotaxime absorption and desorption from different functionalized mesoporous silica supports to obtain new materials with sustained release properties. The MCM-41-type nanostructured mesoporous silica support was synthesized and characterized, showing good micro-structured homogeneity, high surface area, and high silanolic activity. Functionalization of the support was conducted to effectively link the cefotaxime compound. The release experiments revealed significant improved release capacity in the functionalized mesoporous silica support.
Article
Immunology
Weiteng An, Sira Defaus, David Andreu, Pilar Rivera-Gil
Summary: Mesoporous silica nanoparticles are promising candidates for vaccine delivery, especially for peptide-based subunit vaccines. In this study, dendritic mesoporous silica nanoparticles (DMSNs) were shown to effectively release the peptide vaccine and form a protein corona, enhancing the release of the vaccine. These results demonstrate the potential of DMSNs as efficacious nanocarriers for peptide-based vaccine administration.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Inorganic & Nuclear
Israel T. Pulido-Diaz, Alejandro Serrano-Maldonado, Carlos Cesar Lopez-Suarez, Pedro A. Mendez-Ocampo, Benjamin Portales-Martinez, Aida Gutierrez-Alejandre, Karla P. Salas-Martin, Itzel Guerrero-Rios
Summary: The study demonstrates that nicotinamide groups grafted on ordered mesoporous silica (OMS) can serve as stabilizers for RhNPs used as catalysts, forming spherical rhodium nanoparticles with a narrow size distribution. On the contrary, amine-functionalized OMS tends to form RhNP aggregates after catalytic reactions, affecting the reaction efficiency. Supported RhNPs also exhibit selective reduction of different groups and show high activity in reductive amination reactions.
DALTON TRANSACTIONS
(2021)
Article
Nanoscience & Nanotechnology
Emma Ortiz-Islas, Anahi Sosa-Arroniz, Ma Elena Manriquez-Ramirez, C. Ekaterina Rodriguez-Perez, Francisco Tzompantzi, Juan Manuel Padilla
Summary: This study reported the preparation, characterization, and drug release study of mesoporous silica nanoparticles functionalized with folic acid for targeted release of Cis-Pt to kill glioblastoma cancer cells. The MNPSiO2 showed high surface area, large pore size, and proper functionalization, with Higuchi model fitting better to the experimental results. The MNPSiO2-FA were highly biocompatible and enhanced the cytotoxic effect of Cis-Pt.
REVIEWS ON ADVANCED MATERIALS SCIENCE
(2021)
Article
Materials Science, Biomaterials
Nahida Rasool, Deepa Negi, Yashveer Singh
Summary: Osteoporosis is a chronic bone disorder characterized by decreased bone mass and increased fracture risk. This study developed thiolated, bioactive mesoporous silica nanoparticles (MSN-SH) with antioxidant and regenerative properties for potential treatment of osteoporosis. MSN-SH exhibited high antioxidant activity, protected cells from reactive oxygen species-induced damage, and induced osteogenesis. It also inhibited osteoclastogenesis, promoted migration of osteoblast cells, and showed potential as a complementary treatment for osteoporosis. The surface modification of MSN-SH offers a simple and economical method to enhance its properties and introduce new activities.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Nanoscience & Nanotechnology
Jan Grzelak, Jaume Gazquez, Alba Grayston, Mariana Teles, Fernando Herranz, Nerea Roher, Anna Rosell, Anna Roig, Marti Gich
Summary: Multifunctional magnetic nanocomposites based on mesoporous silica have a wide range of potential applications in various fields. By controlling the structure, nanoparticles with different shapes can be prepared to respond to external magnetic fields. The application of these nanoparticles in biomedicine is particularly promising, but research on nanorods is currently limited.
ACS APPLIED NANO MATERIALS
(2022)
Article
Agricultural Engineering
Ximing Zhong, Hongjian Wen, Runxin Zeng, Hongkai Deng, Guofeng Su, Hongjun Zhou, Xinhua Zhou
Summary: In this study, zein was used to modify mesoporous silica as nanocarriers for loading avermectin, resulting in pH and enzyme-responsive nanopesticides. These nanopesticides exhibited high pesticide loading capacity, enhanced photostability, remarkable pesticidal efficacy, and improved wetting and adhesion properties on cucumber foliar surfaces.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Materials Science, Ceramics
Eva Krakor, Sven Saniternik, Isabel Gessner, Robert Frohnhoven, Michael Wilhelm, Marco Drexelius, Nurgul Tosun, Ines Neundorf, Sanjay Mathur
Summary: Intensive and overuse of antibiotics have led to a rise in antibiotic resistance globally, creating a demand for alternative treatments. Metal ions like copper, silver, and zinc have been used to inhibit microorganism growth for centuries. This study focuses on the synthesis of metal and oxide nanoparticles immobilized on hollow mesoporous silica capsules (HMSCs) for efficient antimicrobial effects against both Gram-positive and Gram-negative bacteria. The results show promising potential for metal-loaded capsules as antibacterial delivery vehicles, providing sustained bacterial inhibition over several hours.
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
(2022)
Article
Nanoscience & Nanotechnology
Nora Igaz, Peter Belteky, David Kovacs, Csaba Papp, Andrea Ronavari, Diana Szabo, Attila Gacser, Zoltan Konya, Monika Kiricsi
Summary: The efficient delivery of Rhodamine 123 and Mitomycin C to multidrug-resistant cells via mesoporous silica nanoparticles (MSNs), resulting in increased intracellular drug concentration and enhanced cytotoxic effects, demonstrates the enormous potential of MSNs in overcoming multidrug-resistant cancer.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Rosemeyre Cordeiro, Ana Carvalho, Luisa Duraes, Henrique Faneca
Summary: Mesoporous silica nanoparticles show promise as drug delivery systems with high drug loading capacity and biocompatibility. By conjugating with targeting moieties, these particles can overcome limitations of free drugs and improve therapeutic efficacy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Duc Dung Nguyen, Li-Jyuan Luo, Jui-Yang Lai
ACTA BIOMATERIALIA
(2020)
Article
Engineering, Environmental
Hong-Jyuan Jian, Jiantao Yu, Yu-Jia Li, Binesh Unnikrishnan, Yu-Fen Huang, Li-Jyuan Luo, David Hui-Kang Ma, Scott G. Harroun, Huan-Tsung Chang, Han-Jia Lin, Jui-Yang Lai, Chih-Ching Huang
CHEMICAL ENGINEERING JOURNAL
(2020)
Article
Materials Science, Biomaterials
Duc Dung Nguyen, Li-Jyuan Luo, Jui-Yang Lai
Summary: Understanding the complex interaction between therapeutic nanoparticles and biological entities is crucial for developing effective disease treatments. In this study, different geometrical impacts of silver nanoparticles on their biological activities towards Staphylococcus aureus-induced keratitis were thoroughly assessed. The findings suggest that the geometric effects of therapeutic nanoparticles play a critical role in preclinical treatment of eye-related microbial infections.
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Engineering, Environmental
Hung-Yun Lin, Sin-Wen Wang, Ju-Yi Mao, Huan-Tsung Chang, Scott G. Harroun, Han-Jia Lin, Chih-Ching Huang, Jui-Yang Lai
Summary: In this study, carbonized nanogels synthesized from quercetin and lysine were developed to have antibacterial and antioxidant properties for the treatment of bacterial keratitis. The nanogels showed broad-spectrum bacteriostatic effects against various bacteria and good biocompatibility in vitro and in vivo, making them a potential effective treatment for bacterial ocular diseases.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Biophysics
Duc Dung Nguyen, Shingjiang Jessie Lue, Jui-Yang Lai
Summary: The size of silver nanoparticles plays a crucial role in their therapeutic efficacy in treating Staphylococcus aureus keratitis, with medium-sized particles demonstrating the best treatment outcomes.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Materials Science, Multidisciplinary
Li-Jyuan Luo, Hong-Jyuan Jian, Scott G. Harroun, Jui-Yang Lai, Binesh Unnikrishnan, Chih-Ching Huang
Summary: The study demonstrated a potential nanocomposite for treating AMD through sustained drug release and targeted therapy. The findings suggest a great potential for clinical intervention in AMD treatment with the multifunctional nanocomposite.
APPLIED MATERIALS TODAY
(2021)
Article
Engineering, Biomedical
Pei-Hsuan Lin, Hong-Jyuan Jian, Yu-Jia Li, Yu-Fen Huang, Anisha Anand, Chih-Ching Huang, Han-Jia Lin, Jui-Yang Lai
Summary: In this study, carbonized nanogels (CNGs) were developed as long-lasting eye drops for the treatment of dry eye syndrome (DES). These CNGs show high biocompatibility and anti-inflammatory properties, providing significant therapeutic effects and holding great potential as innovative drugs for the treatment of dry eye disease.
ACTA BIOMATERIALIA
(2022)
Article
Medicine, Research & Experimental
Yi-Jen Hsueh, Yaa-Jyuhn James Meir, Jui-Yang Lai, Chieh-Cheng Huang, Tsai-Te Lu, David Hui-Kang Ma, Chao-Min Cheng, Wei-Chi Wu, Hung-Chi Chen
Summary: In this study, topical application of ascorbic acid (AA) was found to ameliorate benzalkonium chloride-induced rabbit corneal endothelial damage. The mechanism involved the transportation of AA into B4G12 cells via GLUT1, leading to increased ERK phosphorylation and cell proliferation. These findings suggest that CEC proliferation stimulated through the noncanonical AA-GLUT1-ERK axis contributes to AA-enhanced healing of corneal endothelial dysfunction (CED).
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Engineering, Environmental
Li-Jyuan Luo, Duc Dung Nguyen, Chih-Ching Huang, Jui-Yang Lai
Summary: This study reports an advanced therapeutic hydrogel sheet constructed using a functional hydrogel and a ternary drug-carrier system, providing continuous multistage drug release for the treatment of corneal abrasion with significant efficacy, representing over an eight-fold improvement compared to conventional eye drops.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Cell & Tissue Engineering
David Hui-Kang Ma, Yi-Jen Hsueh, Kevin Sheng-Kai Ma, Yueh-Ju Tsai, Shiang-Fu Huang, Hung-Chi Chen, Chi-Chin Sun, Ming-Tse Kuo, An-Shine Chao, Jui-Yang Lai
Summary: The study presented long-term outcomes of two clinical cases of COMET transplantation, demonstrating the promising potential of collagenase-based suspension culture technique for enhancing the long-term survival of transplanted OMECs.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Engineering, Biomedical
Duc Dung Nguyen, Li-Jyuan Luo, Jui-Yang Lai
Summary: This study reports a rational strategy to develop a therapeutic thermogel with prolonged anti-inflammatory and corneal-protective effects, showing great promise for topical treatment of ocular inflammation and advancement of ophthalmic formulations.
MATERIALS TODAY BIO
(2022)
Review
Engineering, Environmental
Duc Dung Nguyen, Jui-Yang Lai
Summary: ITNPs are a special class of nanomaterials with intrinsic therapeutic capabilities, which can be utilized to treat diseases associated with oxidative stress, inflammation, angiogenesis, and infection. Recent advancements in the field of nanotherapeutics have been significantly influenced by ITNPs.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Engineering, Environmental
Yu-Jia Li, Shih-Chun Wei, Han-Wei Chu, Hong-Jyuan Jian, Anisha Anand, Amit Nain, Yu-Fen Huang, Huan-Tsung Chang, Chih-Ching Huang, Jui-Yang Lai
Summary: In this study, a novel nanoVelcro dressing made from quercetin (QNV) was developed, which exhibited antibacterial, anti-oxidative, and anti-inflammatory effects, as well as endotoxin neutralization. The dressing effectively inhibited the growth of various bacteria and accelerated wound closure rate in infected wounds.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Engineering, Environmental
Anisha Anand, Binesh Unnikrishnan, Ju-Yi Mao, Chin-Jung Lin, Jui-Yang Lai, Chih-Ching Huang
Summary: This study demonstrates the use of CNGs/GO nanocomposite membrane for the efficient removal of Gram-negative and Gram-positive bacteria from contaminated water. The membrane shows great potential as a filter without any extra power consumption.
Article
Medicine, Research & Experimental
Li-Jyuan Luo, Duc Dung Nguyen, Jui-Yang Lai
Summary: By controlling the shell thickness of hollow mesoporous ceria nanoparticles (HMCNs), sustained release of Y-27632 was achieved, demonstrating effective treatment for up to 10 days in a rabbit model of glaucoma.
Article
Materials Science, Biomaterials
Izabela Stupka, Artur P. Biela, Bernard Piette, Agnieszka Kowalczyk, Karolina Majsterkiewicz, Kinga Borzecka-Solarz, Antonina Naskalska, Jonathan G. Heddle
Summary: Artificial protein cages, such as TRAP-cages, have potential applications in vaccines and drug delivery. TRAP-cages have the ability to control the disassembly conditions by modifying the interface between their building blocks. By using TRAP rings with different numbers of monomers, it is possible to predict the formation of other cages.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Guo Zhang, Yu Wang, Hua Qiu, Lei Lu
Summary: This study presents a one-pot synthesis method for flower-like AMPs@EAMP particles by combining antimicrobial peptides with ellagic acid, offering enlarged surface area, excellent biocompatibility, and broad-spectrum antibacterial activity. In vivo studies indicate their potential for tissue repair and immune barrier reconstruction.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Jiamei Zhang, Lingshuang Wang, Cheng Xu, Yingui Cao, Shengsheng Liu, Rui L. Reis, Subhas C. Kundu, Xiao Yang, Bo Xiao, Lian Duan
Summary: Pluronic F127 modified silk fibroin film with different types of antibacterial agents could accelerate wound recovery by promoting fibroblast adhesion, eradicating bacteria, and facilitating angiogenesis and re-epithelialization.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Yinsheng Liu, Mingyue Wang, Yinfei Hui, Lei Sun, Yanrui Hao, Henlong Ren, Hao Guo, Wu Yang
Summary: In this study, a rare-earth hybrid luminescent material was developed for the detection of a biomarker for anthrax. The material showed excellent selectivity and high sensitivity, allowing for the determination of the biomarker in saliva and urine. Additionally, a convenient point-of-care testing method using fluorescent test paper and a smartphone was established for the initial diagnosis of anthrax.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Review
Materials Science, Biomaterials
Wenshuai Yang, Jingsi Chen, Ziqian Zhao, Meng Wu, Lu Gong, Yimei Sun, Charley Huang, Bin Yan, Hongbo Zeng
Summary: Injectable hydrogels with shear-thinning and/or in situ formation properties offer distinct advantages in bioengineering applications, as they can be directly delivered to target sites, possess self-healing abilities, and simplify the implantation process.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
