Review
Chemistry, Multidisciplinary
Mike Jeon, Mackenzie Halbert, Zachary R. Stephen, Miqin Zhang
Summary: Gadolinium-based chelates are commonly used contrast agents for MRI, but their toxicity and potential retention in patients' bodies have raised safety concerns. Iron oxide nanoparticles have emerged as a promising alternative due to their non-toxic and biodegradable nature, but their development as T-1 contrast agents is complex and challenging. Progress is being made in exploring IONPs as safe and improved alternatives, but there are still many hurdles to overcome before they can be used clinically.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Qilin Zou, Luan Passini, Laure Gibot, Delphine Lagarde, Jie Hu, Haomiao Zhu, Franck Desmoulin, Pierre Sicard, Nitchawat Paiyabhroma, Marc Verelst, Robert Mauricot, Clement Roux
Summary: This study presents a versatile strategy for synthesizing ultrasmall rare-earth oxysulfide (RE2O2S) nanoparticles ranging from 3 to 10 nm. The stability of PVP-coated Gd0.8Nd1.2O2S nanoparticles with a size of 6 nm in culture medium is investigated. The results demonstrate the potential of these nanoparticles for applications in various imaging techniques, including magnetic resonance, X-ray computed tomography, photoacoustic, ultrasound, and second near-infrared fluorescence imaging. This study lays the foundation for further research on the bioapplications of ultrasmall RE2O2S nanoparticles.
MATERIALS CHEMISTRY FRONTIERS
(2023)
Article
Chemistry, Analytical
Wei Liu, Shengyan Yin, Yingcai Hu, Ting Deng, Jishan Li
Summary: A pH-responsive T2-T1 switchable MRI nanoprobe was constructed by combining the microemulsion method with the biomineralization principle, which can achieve T1-weighted imaging in tumor environments.
ANALYTICAL CHEMISTRY
(2021)
Article
Materials Science, Biomaterials
Pingli Dong, Tingting Zhang, Huijing Xiang, Xue Xu, Yihui Lv, Yi Wang, Chichong Lu
Summary: The study synthesized monodispersed exceptionally small-sized superparamagnetic magnetite nanoparticles (ESM NPs) with tunable size through a simple method. The ESM NPs showed good biocompatibility, high longitudinal relaxivity, and superior contrast effects in MRI imaging.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Materials Science, Biomaterials
M. Zubair Iqbal, Dandan Luo, Ozioma U. Akakuru, Asim Mushtaq, Yike Hou, Israt Ali, Gohar Ijaz, Bilal Khalid, Xiangdong Kong, Aiguo Wu
Summary: Cancer treatment has been enhanced by nanomaterials with diagnostic and therapeutic effects, with a focus on MRI and phototherapy. Fe-TiO2 nanocomposites exhibit promising properties for cancer theranostics, showing potential for safe in vivo applications.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Review
Chemistry, Multidisciplinary
Ruth Antwi-Baah, Yajing Wang, Xiaoqin Chen, Kui Yu
Summary: Metal-based nanoparticles, especially gadolinium, manganese, and iron, have shown potential as MRI contrast agents due to their desirable properties. However, most nanoparticles have not been translated into clinical applications yet.
ADVANCED MATERIALS INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Connor M. Ellis, Daohe Yuan, Ferenc E. Mozes, Jack J. Miller, Jason J. Davis
Summary: Paramagnetically-doped polymer micelles with ionizable poly(acrylic acid) (PAA) block enable high-contrast MR imaging at clinically relevant field strengths with strong pH sensitivity. The reversible switch in polymer strand charge directly affects the local rigidity and rotational correlation time characteristics of the integrated Gd-chelate, resulting in a 50% amplitude switch in positive contrast.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Analytical
Hunter T. Snoderly, Kasey A. Freshwater, Celia Martinez de la Torre, Dhruvi M. Panchal, Jenna N. Vito, Margaret F. Bennewitz
Summary: This study investigates the impact of metal oxide nanoparticle (NP) contrast agents on the innate immune system, particularly on neutrophil extracellular trap (NET) formation, and reveals potential unintended off-target effects of contrast agents that warrant further investigation.
Review
Chemistry, Multidisciplinary
Atiya Fatima, Md. Wasi Ahmad, Abdullah Khamis Ali Al Saidi, Arup Choudhury, Yongmin Chang, Gang Ho Lee
Summary: Gadolinium-based contrast agents represent a significant advancement in MRI technology, with potential for diverse applications and benefits in bioimaging. Future research should focus on establishing the safety, efficacy, and theragnostic capabilities of these agents.
Article
Chemistry, Physical
Jie Zeng, Linlin Huo, Zhenyu Wang, Xin Sun, Yu Guo, Muyao Li, Mingya Tan, Shiqi Zhu, Jingqin Fang, Zhenghuan Zhao
Summary: In recent years, great progress has been made in precisely controlling the structures of magnetic nanoparticles to investigate structure-relaxivity relationships. However, the influence of hollow structures with unique interior structures on the relaxation rate of magnetic nanoparticles has been rarely studied. In this work, we obtained a series of hollow manganese-doped iron oxide nanoparticles (MnIONs) with different void and dopant ratios and investigated the influence of hollow structures on the T-1/T-2 relaxation rate. The results showed that hollow MnIO nanoparticles exhibit increased T-1 relaxivity due to the increased surface-to-volume ratio, while they also show increased T-2 relaxivity attributed to the increased number of magnetic cores per unit volume and magnetic field inhomogeneity induced by hollow structures.
CHEMISTRY OF MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Tingting Zhang, Zhijie Wang, Huijing Xiang, Xue Xu, Jing Zou, Chichong Lu
Summary: This study successfully synthesized water-soluble and biocompatible EuIO NCs with enhanced contrast enhancement in MRI, as well as functionalized EuIO NCs exhibiting excellent fluorescence imaging performance in vivo. The research provides a simple strategy for the design and construction of a novel multifunctional magnetic nanoplatform, offering solutions for the development of multimodal imaging probes and disease diagnosis.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Pharmacology & Pharmacy
Yongkang Gai, Yuying Li, Shuangping Wu, Ling Xu, Yao Lu, Xiaoli Lan, Guangya Xiang, Xiang Ma
Summary: The aim of this study was to synthesize and characterize a new micelle-based TPGS gadolinium chelate as a biocompatible MRI contrast agent for prolonged blood circulation time and good tumor imaging contrast. The successfully prepared TPGS-L-NETA-Gd micelle exhibited improved cellular uptake in HepG2 cells and xenografts and high in vivo safety. The in vitro and in vivo properties of TPGS-L-NETA-Gd make it a favorable macromolecular MRI contrast agent for future in vivo imaging.
Article
Chemistry, Multidisciplinary
Kun Liu, Zhongyuan Cai, Xiaoqin Chi, Bilun Kang, Shengxiang Fu, Xiangjie Luo, Zhi-Wei Lin, Hua Ai, Jinhao Gao, Hongyu Lin
Summary: This study reports a new strategy to improve the performance of nanoparticle-based T1 contrast agents by utilizing the photoinduced super-hydrophilic assistance (PISA) effect. By doping gadolinium into citrate-coated titanium dioxide ellipsoidal nanoparticles (GdTi-SC NPs), the r1 value of the nanoparticles significantly increases upon UV irradiation. The existence of the PISA effect is confirmed by the reduced water contact angle and increased surface hydroxyl groups, leading to enhanced paramagnetic relaxation enhancement (PRE) efficiency and improved imaging performance. In vivo MRI experiments on rats demonstrate that GdTi-SC NPs can serve as a high-performance contrast agent for sensitive imaging of blood vessels and accurate diagnosis of vascular lesions, indicating the success of the proposed strategy.
Article
Materials Science, Biomaterials
Li Yang, Shengxiang Fu, Zhongyuan Cai, Li Liu, Chunchao Xia, Qiyong Gong, Bin Song, Hua Ai
Summary: The T-1-T-2 dual-mode MRI probes can acquire comprehensive information of different tissues simultaneously, showing good stability and non-cytotoxicity. They are suitable for imaging blood vessels and liver tissue.
REGENERATIVE BIOMATERIALS
(2021)
Article
Materials Science, Biomaterials
Mingjie Jia, Xinyu Yang, Yanan Chen, Meie He, Weixiu Zhou, Jiaomin Lin, Lu An, Shiping Yang
Summary: By employing a geometric confinement strategy, Gd chelates are restricted within the channels of a porous metal-organic framework material (MOF-808) to increase their longitudinal relaxivity. This approach resulted in a highly efficient T-1-weighted contrast agent with potential for use in MRI-guided photothermal therapy.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Optics
Tulika Agrawal, Soumyodeep Dey, Shubhayan Bhattacharya, Gurvinder Singh, Prem B. Bisht
Summary: This study conducted a numerical investigation on the microcavity-NP system and found that the shape of metal nanoparticles has a significant impact on the output field strength. The splitting of the dipole mode of the nanoparticles was also observed, and the surface enhanced Raman spectroscopy factor was estimated for the nano-cube dimer NP-microcavity hybrid system.
Article
Engineering, Environmental
Pooria Lesani, Gurvinder Singh, Zufu Lu, Mohammad Mirkhalaf, Elizabeth J. New, Hala Zreiqat
Summary: We report the design and development of a two-photon ratiometric carbon dot-based nanoprobe for real-time monitoring of intracellular pH. The nanoprobe exhibits sensitivity across a wide pH range, remarkable thermal and photo stability, as well as two-photon near-infrared excitation capability.
CHEMICAL ENGINEERING JOURNAL
(2022)
Review
Chemistry, Physical
Matthew Hadden, David Martinez-Martin, Ken-Tye Yong, Yogambha Ramaswamy, Gurvinder Singh
Summary: This review highlights the importance and applications of functional nanoporous materials, and provides recent advances in synthesis strategies and design approaches. It also discusses the working principles, challenges, and limitations associated with nanoporous material fabrication strategies, and explores the potential role of digitally controlled additive manufacturing in developing next-generation nanoporous materials.
Article
Engineering, Chemical
Zeeshan Ali, Jens-Petter Andreassen, Sulalit Bandyopadhyay
Summary: Silica coated iron oxide nanoparticles (SIONPs) have attracted significant attention in biomedicine for their unique properties. The synthesis of SIONPs with tuned size and morphology has been extensively studied, but the effect of solvent, catalyst, and surface chemistry of the iron oxide nanoparticles (IONPs) has not been fully investigated. In this study, we thoroughly investigate the influence of these parameters on the size and morphology of SIONPs. This knowledge is crucial for controlling the magnetic properties and applications of SIONPs.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Hasanain A. Al-Jaber, Agus Arsad, Muhammad Tahir, Mustafa Jawad Nuhma, Sulalit Bandyopadhyay, Abdulmunem R. Abdulmunem, Anis Farhana Abdul Rahman, Zakiah binti Harun, Augustine Agi
Summary: New nano-polymeric materials were synthesized from purple yam and cassava starches, with better performance in oil recovery compared to conventional method using partially hydrolyzed polyacrylamide. The stability and optimal concentration of these nanoparticles were determined through various characterization techniques. This study provides a new technology for polymer flooding in enhanced oil recovery.
Review
Pharmacology & Pharmacy
Yuhang Zhang, Kingsley Poon, Gweneth Sofia P. Masonsong, Yogambha Ramaswamy, Gurvinder Singh
Summary: Significant progress in nanotechnology has led to the development of innovative products that address societal challenges. However, many nanomaterials currently used are unsustainable. Therefore, there is an urgent need to design nanomaterials sustainably. Integrating sustainability with nanotechnology can support the manufacturing of sustainable nanomaterials with optimized performance.
Article
Chemistry, Inorganic & Nuclear
Maria-Cristina Ioncica, Sulalit Bandyopadhyay, Nesrine Bali, Vlad Socoliuc, Sandor I. Bernad
Summary: Based on prior research, iron-oxide nanoparticles (IONPs) of spherical and cubic shapes were synthesized and sized for this study. The magnetic, rheological, and sedimentation properties of PEG-coated IONP suspensions were investigated for potential magnetic targeting applications. The results showed similar shear viscosity behavior of both types of suspensions under different magnetic fields, with shear thinning observed at low shear rates. The study also revealed that spherical IONPs exhibited a higher viscosity at lower shear rates and demonstrated more significant fluctuation in hydrodynamic diameter compared to cubic IONPs. Additionally, cubic-shaped IONPs exhibited greater stability and less tendency to sediment than their spherical counterparts.
Article
Biochemistry & Molecular Biology
Hasanain A. Al-Jaber, Agus Arsad, Sulalit Bandyopadhyay, Muslim Abdurrahman, Mohammad Yasin Abdulfatah, Augustine Agi, Suriatie Mat Yusuf, Abdulmunem R. Abdulmunem, Muhammad Tahir, Mustafa Jawad Nuhma
Summary: This study aimed to improve the efficiency of alkaline-surfactant-polymer (ASP) flooding technique in mature oilfields by introducing suitable materials and special surfactants. Two combinations of ASP formulations resulted in improved oil recovery, with one achieving a progressive recovery rate of 39.17% and the other achieving an incremental oil recovery rate of 35%. These findings highlight the potential of modified ASP flooding in enhancing oil recovery in mature oilfields, offering valuable insights for the oil industry.
Article
Biochemistry & Molecular Biology
Hasanain A. Al-Jaber, Agus Arsad, Sulalit Bandyopadhyay, Mohd Zaidi Jaafar, Muhammad Tahir, Mustafa Jawad Nuhma, Abdulmunem R. Abdulmunem, Mohammad Yasin Abdulfatah, Hajar Alias
Summary: This study explores conventional ASP flooding and compares it with starch-assisted ASP flooding, demonstrating the benefits of adding starch nanoparticles. The study also analyzes the charge stability and crystallinity of starch nanoparticles, emphasizing their importance in the oil recovery industry.
Article
Chemistry, Multidisciplinary
Pierfrancesco Maltoni, Gianni Barucca, Bogdan Rutkowski, Maria Chiara Spadaro, Petra E. Jonsson, Gaspare Varvaro, Nader Yaacoub, Jose A. De Toro, Davide Peddis, Roland Mathieu
Summary: The magnetic coupling of SrFe12O19/CoFe2O4 nanocomposites is investigated. The structural coherence and texture at the interfaces of the nanostructures are evidenced by advanced electron microscopy. The exchange intergranular interaction is evidenced and the critical thickness for uniform reversal of coupled interfaces is quantified.
Review
Green & Sustainable Science & Technology
Usman Saleem, Bhaskar Joshi, Sulalit Bandyopadhyay
Summary: With the increasing demand for energy, batteries play a key role in the energy transition as they are the fastest-growing energy storage technology globally. However, there is a need for innovation to mitigate the environmental impact of battery production and use. Recycling and reusing batteries offer sustainable value creation opportunities, but the lack of control over batteries hinders investment in the reuse market. On the other hand, recycling batteries has great potential for promoting sustainability through closed-loop material recirculation. This review aims to provide insights into industrial processes and the future of battery recycling in the EV battery value chain.
JOURNAL OF SUSTAINABLE METALLURGY
(2023)
Article
Chemistry, Multidisciplinary
Mehran Sedrpooshan, Claudiu Bulbucan, Pau Ternero, Pierfrancesco Maltoni, Calle Preger, Simone Finizio, Benjamin Watts, Davide Peddis, Adam M. Burke, Maria E. Messing, Rasmus Westerstrom
Summary: In this paper, a template-free technique is proposed to produce 1D magnetic nanochains and nanowires directly on substrates and device architectures through the directed self-assembly of gas-phase-generated nanoparticles. It is found that the orientation of the nanochains and the presence of multi-domain particles play a key role in domain formation and magnetization reversal, while the improved magnetic properties of the nanowires can be attributed to the uniform formation of magnetocrystalline anisotropy and the onset of exchange interactions.
Review
Chemistry, Inorganic & Nuclear
Kingsley Poon, Abhishek Gupta, William S. Price, Hala Zreiqat, Gurvinder Singh
Summary: Progress in the development of manganese oxide nanoparticles (MONPs) has provided an alternative for early-stage diagnosis of life-threatening diseases and therapeutic delivery of drugs and genes. The synthesis and characterization of MONPs have enabled the production of multi-functional targeted nanoparticles in various sizes and shapes. The integration of diagnosis and therapeutic capabilities within a single entity, known as nanotheranostics, is promising for real-time monitoring of disease progression and evaluating therapeutic treatment efficacy.
COORDINATION CHEMISTRY REVIEWS
(2024)
Article
Chemistry, Physical
Pierfrancesco Maltoni, Miran Baricic, Gianni Barucca, Maria Chiara Spadaro, Jordi Arbiol, Nader Yaacoub, Davide Peddis, Roland Mathieu
Summary: This study demonstrates an efficient synthetic approach to control the magnetic coupling between a hard-magnetic matrix and nanoparticles in order to produce strongly magnetically coupled nanocomposites. The final extrinsic properties of the composites can be tuned by controlling the agglomeration of the nanoparticles in the matrix and their elemental doping.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Chemistry, Multidisciplinary
Nesrine Bali, Svein J. Brennhaug, Magnar Bjoras, Sulalit Bandyopadhyay, Adeel Manaf
Summary: This study proposes an easy and cost-effective method for synthesizing polyacrylic acid-coated iron oxide nanoparticles (PAA-IONPs) for high-efficiency nucleic acid extraction and size selection. The method shows comparable performance to commercial products and offers flexibility. This research is significant for future molecular biology research and diagnostics.
Article
Materials Science, Biomaterials
Izabela Stupka, Artur P. Biela, Bernard Piette, Agnieszka Kowalczyk, Karolina Majsterkiewicz, Kinga Borzecka-Solarz, Antonina Naskalska, Jonathan G. Heddle
Summary: Artificial protein cages, such as TRAP-cages, have potential applications in vaccines and drug delivery. TRAP-cages have the ability to control the disassembly conditions by modifying the interface between their building blocks. By using TRAP rings with different numbers of monomers, it is possible to predict the formation of other cages.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Guo Zhang, Yu Wang, Hua Qiu, Lei Lu
Summary: This study presents a one-pot synthesis method for flower-like AMPs@EAMP particles by combining antimicrobial peptides with ellagic acid, offering enlarged surface area, excellent biocompatibility, and broad-spectrum antibacterial activity. In vivo studies indicate their potential for tissue repair and immune barrier reconstruction.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Jiamei Zhang, Lingshuang Wang, Cheng Xu, Yingui Cao, Shengsheng Liu, Rui L. Reis, Subhas C. Kundu, Xiao Yang, Bo Xiao, Lian Duan
Summary: Pluronic F127 modified silk fibroin film with different types of antibacterial agents could accelerate wound recovery by promoting fibroblast adhesion, eradicating bacteria, and facilitating angiogenesis and re-epithelialization.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Yinsheng Liu, Mingyue Wang, Yinfei Hui, Lei Sun, Yanrui Hao, Henlong Ren, Hao Guo, Wu Yang
Summary: In this study, a rare-earth hybrid luminescent material was developed for the detection of a biomarker for anthrax. The material showed excellent selectivity and high sensitivity, allowing for the determination of the biomarker in saliva and urine. Additionally, a convenient point-of-care testing method using fluorescent test paper and a smartphone was established for the initial diagnosis of anthrax.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Review
Materials Science, Biomaterials
Wenshuai Yang, Jingsi Chen, Ziqian Zhao, Meng Wu, Lu Gong, Yimei Sun, Charley Huang, Bin Yan, Hongbo Zeng
Summary: Injectable hydrogels with shear-thinning and/or in situ formation properties offer distinct advantages in bioengineering applications, as they can be directly delivered to target sites, possess self-healing abilities, and simplify the implantation process.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
