db/db Mice Exhibit Features of Human Type 2 Diabetes That Are Not Present in Weight-Matched C57BL/6J Mice Fed a Western Diet

Pancreatic β-Cell production of CXCR3 ligands precedes diabetes onset

(2016) Susan J. Burke et al.   BIOFACTORS

Adiponectin, Leptin, and Fatty Acids in the Maintenance of Metabolic Homeostasis through Adipose Tissue Crosstalk

(2016) Jennifer H. Stern et al.   Cell Metabolism

Identifying hyperinsulinaemia in the absence of impaired glucose tolerance: An examination of the Kraft database

(2016) Catherine Crofts et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Evidence of β-Cell Dedifferentiation in Human Type 2 Diabetes

(2016) Francesca Cinti et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Pancreatic Islet Responses to Metabolic Trauma

(2016) Susan J. Burke et al.   SHOCK

Aldehyde dehydrogenase 1a3 defines a subset of failing pancreatic β cells in diabetic mice

(2016) Ja Young Kim-Muller et al.   Nature Communications

IL-1β reciprocally regulates chemokine and insulin secretion in pancreatic β-cells via NF-κB

(2015) Susan J. Burke et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

CCL20 is elevated during obesity and differentially regulated by NF-κB subunits in pancreatic β-cells

(2015) Susan J. Burke et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Insulin demand regulates β cell number via the unfolded protein response

(2015) Rohit B. Sharma et al.   JOURNAL OF CLINICAL INVESTIGATION

Hyperglycemia in rodent models of type 2 diabetes requires insulin-resistant alpha cells

(2014) Y. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fasting insulin concentrations and incidence of hypertension, stroke, and coronary heart disease: a meta-analysis of prospective cohort studies

(2013) Pengcheng Xun et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

The effects of NOD activation on adipocyte differentiation

(2013) Jaanki S. Purohit et al.   Obesity

Nkx6.1 Is Essential for Maintaining the Functional State of Pancreatic Beta Cells

(2013) Brandon L. Taylor et al.   Cell Reports

Mechanisms for Insulin Resistance: Common Threads and Missing Links

(2012) Varman T. Samuel et al.   CELL

Hyperinsulinemia Drives Diet-Induced Obesity Independently of Brain Insulin Production

(2012) Arya E. Mehran et al.   Cell Metabolism

Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover

(2012) Roger H. Unger et al.   JOURNAL OF CLINICAL INVESTIGATION

Inflammatory Mechanisms in Obesity

(2011) Margaret F. Gregor et al.   Annual Review of Immunology

Elevated fasting insulin predicts the future incidence of metabolic syndrome: a 5-year follow-up study

(2011) Ki-Chul C Sung et al.   Cardiovascular Diabetology

The beta cell lesion in type 2 diabetes: there has to be a primary functional abnormality

(2009) S. E. Kahn et al.   DIABETOLOGIA

Carnitine Insufficiency Caused by Aging and Overnutrition Compromises Mitochondrial Performance and Metabolic Control

(2009) Robert C. Noland et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

cAMP Prevents Glucose-Mediated Modifications of Histone H3 and Recruitment of the RNA Polymerase II Holoenzyme to the L-PK Gene Promoter

(2009) Susan J. Burke et al.   JOURNAL OF MOLECULAR BIOLOGY

Metabolic flexibility and insulin resistance

(2008) Jose E. Galgani et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance

(2008) Timothy R. Koves et al.   Cell Metabolism

Newly identified loci highlight beta cell dysfunction as a key cause of type 2 diabetes: Where are the insulin resistance genes?

(2008) J. C. Florez   DIABETOLOGIA

Reinventing Type 2 Diabetes

(2008) Roger H. Unger   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Diazoxide enhances basal metabolic rate and fat oxidation in obese Zucker rats

(2008) Ramin Alemzadeh et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes

(2008) Deborah M. Muoio et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY