Article
Biochemistry & Molecular Biology
Olof Breuer, Ola Brodin, Ali Razaghi, David Brodin, Bente Gammelgaard, Mikael Bjoernstedt
Summary: The study analyzed the selenium species in plasma samples from cancer patients participating in a clinical trial and found that selenite, selenosugars, and unidentified peaks were detected. The identification of selenite even long after administration was unexpected and demonstrates its potential as a chemotherapeutic agent.
Article
Nutrition & Dietetics
Jacqueline K. Evenson, Roger AA. Sunde
Summary: Research has shown rapid metabolism of different selenium compounds into a common intermediate used for synthesis and incorporation into major selenoproteins in various tissues. However, synthesis of selenoproteins is only a part of the complete selenium metabolism story, with different selenium compounds potentially metabolizing into different selenosugar species that may be linked to cancer prevention, disease prevention, and selenium toxicity. Further studies using HPLC-mass spectroscopy are likely needed to fully understand the complete selenium metabolism.
FRONTIERS IN NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Rama Alhasan, Guilherme M. Martins, Pedro P. de Castro, Rahman Shah Zaib Saleem, Ali Zaiter, Isabelle Fries-Raeth, Alexandra Kleinclauss, Caroline Perrin-Sarrado, Patrick Chaimbault, Eufranio N. da Silva Junior, Caroline Gaucher, Claus Jacob
Summary: Decreased selenium levels and increased oxidative stress have been linked to chronic diseases. This study synthesized and evaluated a series of organic selenium compounds for their antioxidant activities. The seleno-hydantoin derivatives exhibited glutathione peroxidase-like activity and show potential for treating chronic diseases.
BIOORGANIC & MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Vasco Branco, Luis Carvalho, Cassia Barboza, Eduarda Mendes, Afonso Cavaco, Cristina Carvalho
Summary: This study found that pregnant women highly exposed to mercury through fish consumption had sub-optimal selenium status, resulting in reduced plasma selenoprotein activity. However, low selenium levels did not affect the activity of thioredoxin reductase. On the other hand, the decrease in thioredoxin activity with an increase in mercury may be a good indicator for preventing fetal susceptibility.
Article
Chemistry, Analytical
Ling-Ling Yang, Wei Zhao, Zhen-Ya Liu, Mengtian Ren, Juan Kong, Xia Zong, Meng-Yao Luo, Bo Tang, Jiahongyi Xie, Dai-Wen Pang, An-An Liu
Summary: In this study, a novel approach to the continuous growth of water-dispersible Ag2Se quantum dots (QDs) was proposed using glutathione (GSH) as the reductant under acidic conditions. The synthesized NIR-II Ag2Se QDs exhibited exceptional stability and photostability due to the passivation of the silver-rich surface with dense GSH, as well as acid resistance. Compared to conventional barium meal-based X-ray imaging, NIR-II fluorescence imaging with the synthesized NIR-II Ag2Se QDs provided clearer visualization of fine intestinal structures.
ANALYTICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Katarzyna Bierla, Joanna Szpunar, Ryszard Lobinski, Roger A. Sunde
Summary: This study found that the metabolism and accumulation of selenomethionine in rats is different from that of selenocysteine. At the selenium requirement for maximal glutathione peroxidase activity, selenocysteine is the major selenium species, while at higher intakes of selenomethionine, it is metabolized into low molecular weight selenosugars and selenosugar-decorated proteins. Additionally, compared to selenite, selenomethionine leads to less binding of inorganic selenium to liver proteins.
Article
Biochemistry & Molecular Biology
Kristell Le Gal, Edward E. Schmidt, Volkan Sayin
Summary: Cellular redox homeostasis is crucial for balancing the reducing and oxidizing reactions within cells, regulating various biological responses and events. Despite the challenges in studying these biochemical reactions, recent advancements in technology have rapidly expanded the redox field, enhancing our understanding of its significance in biology. This short review aims to provide an overview of redox regulation in cellular signaling, development, and disease, as well as introduce some recent discoveries in these areas.
Article
Biochemistry & Molecular Biology
Maria J. Ferreira, Tony A. Rodrigues, Ana G. Pedrosa, Ana R. Silva, Beatriz G. Vilarinho, Tania Francisco, Jorge E. Azevedo
Summary: This article summarizes and compares data on the peroxisome-glutathione topic in several organisms. The results indicate that the repertoire of glutathione-utilizing enzymes in peroxisomes varies widely among different organisms. Furthermore, the data suggest that the kinetic connectivity between the cytosolic and peroxisomal pools of glutathione may also differ among organisms. However, regardless of the differences, it is evident that glutathione is a crucial component of the antioxidative system in peroxisomes across all organisms.
Article
Biochemistry & Molecular Biology
Laura G. Sherlock, Durganili Balasubramaniyan, Lijun Zheng, Miguel Zarate, Thomas Sizemore, Cassidy Delaney, Trent E. Tipple, Clyde J. Wright, Eva Nozik-Grayck
Summary: Maternal selenium deficiency leads to decreased neonatal selenium levels and increased risk for neonatal morbidities. The impact of maternal selenium deficiency varies across different organs and selenoproteins. Research suggests that neonates experience earlier depletion of selenoenzyme activity in the liver and circulation after maternal selenium deficiency, indicating a potential escalation of risk to the neonate with prolonged maternal selenium deficiency.
Article
Clinical Neurology
Qing-Zhang Tuo, Shashank Masaldan, Adam Southon, Celeste Mawal, Scott Ayton, Ashley Bush, Peng Lei, Abdel Ali Belaidi
Summary: The emergence of ferroptosis as a cell death pathway associated with brain disorders highlights the importance of developing therapeutics targeting the brain and protecting neurons. Selenium compounds have shown to be effective in inhibiting ferroptosis, with organic selenium compounds like methylselenocysteine providing protection against neuronal damage in ischemia-reperfusion injury in vivo. This suggests the potential use of ferroptosis inhibitors and specific selenium compounds in preventing neuronal damage in ischemic stroke and other related brain diseases.
Article
Agriculture, Dairy & Animal Science
Zhenxin Wang, Linglian Kong, Lixian Zhu, Xiyi Hu, Pengcheng Su, Zhigang Song
Summary: The study found that adding L-SM had a positive impact on the hatchability of breeder eggs and the selenium content in embryos, and it effectively improved the antioxidant enzyme activity of 1-day-old chicks.
Article
Chemistry, Physical
Jiayi Zhang, Zhengyan Du, Tingyu Yan, Fanda Zeng, Zijin Xu, Jian Xu, Zeshuo Meng, Xiaoying Hu, Jingxiang Zhao, Hongwei Tian
Summary: The energy density of supercapacitors can be improved by rapidly reconstructing the electrode materials' surface in an alkaline medium. Transition metal sulfides (TMSs), such as Co9S8, have excellent structural characteristics and are widely used as energy storage electrode materials. However, the enhancement of Co9S8 reconstruction ability induced by Se doping has not been well studied.
ENERGY STORAGE MATERIALS
(2023)
Article
Engineering, Environmental
Tao Wang, Qiang Bai, Zhiling Zhu, Hailian Xiao, Fuyi Jiang, Fanglin Du, William W. Yu, Manhong Liu, Ning Sui
Summary: The PdFe/GDY nanozyme demonstrates excellent specificity in detecting GSH in bacteria and has an ultra-low detection limit, while also consuming GSH for bacterial disinfection and promoting wound healing without significant toxicity in vitro and in vivo. This work presents the first GDY-based nanozyme biosensor and antibacterial agent, indicating potential applications in clinical diagnosis and sterilization.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Chemistry, Physical
Yongmin Zhang, Meng Mu, Yue Zhou, Huan Xie, Shanjuan Zhao
Summary: By investigating the hydrophilicity change of a selenium-containing alcohol and its effect on the stability of microemulsions, it was found that the redox reaction of this selenium-containing alcohol can efficiently switch the stability of microemulsions, providing a new nanoplatform for the delivery of bioactive substances.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Analytical
Hamzeh Khani, Shahryar Abbasi, Mohammad Tavakkoli Yaraki, Mohammad Bagher Gholivand
Summary: A simple design for a naked-eye colorimetric biosensor for rapid and ultrasensitive detection of GSH in human serum was reported. The biosensor showed a limit of detection of 34 nM and excellent selectivity towards interference substances, making it suitable for practical detection and determination of GSH levels in real samples.
MICROCHEMICAL JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Andrea C. Mesias, Natalia Sasoni, Diego G. Arias, Cecilia Perez Brandan, Oliver C. F. Orban, Conrad Kunick, Carlos Robello, Marcelo A. Comini, Nisha J. Garg, M. Paola Zago
FREE RADICAL BIOLOGY AND MEDICINE
(2019)
Article
Biochemistry & Molecular Biology
Bruno Manta, Matias N. Moller, Mariana Bonilla, Matias Deambrosi, Karin Grunberg, Massimo Bellanda, Marcelo A. Comini, Gerardo Ferrer-Sueta
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Claudia Vanesa Piattoni, Florencia Sardi, Florencia Klein, Sergio Pantano, Mariela Bollati-Fogolin, Marcelo Comini
FREE RADICAL BIOLOGY AND MEDICINE
(2019)
Article
Microbiology
Rachel B. Currier, Kathrin Ulrich, Alejandro E. Leroux, Natalie Dirdjaja, Matias Deambrosi, Mariana Bonilla, Yasar Luqman Ahmed, Lorenz Adrian, Haike Antelmann, Ursula Jakob, Marcelo A. Comini, R. Luise Krauth-Siegel
Article
Biochemistry & Molecular Biology
Feriannys Rivas, Andrea Medeiros, Marcelo Comini, Leopoldo Suescun, Esteban Rodriguez Arce, Marta Martins, Teresa Pinheiro, Fernanda Marques, Dinorah Gambino
JOURNAL OF INORGANIC BIOCHEMISTRY
(2019)
Article
Chemistry, Medicinal
Diego Benitez, Estefania Dibello, Mariana Bonilla, Marcelo A. Comini
Summary: African trypanosomiasis is a major health problem in endemic countries and requires new drugs for treatment. In this study, a simple and economical high-throughput screening assay was developed using a bioluminescent cell line of the trypanosome parasite. The assay showed high sensitivity and accuracy in identifying compounds with potent anti-parasitic activity.
DRUG DEVELOPMENT RESEARCH
(2022)
Article
Chemistry, Medicinal
Jaime Franco, Laura Scarone, Marcelo A. Comini
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2020)
Article
Multidisciplinary Sciences
Sonam Parakh, Sina Shadfar, Emma R. Perri, Audrey M. G. Ragagnin, Claudia V. Piattoni, Mariela B. Fogolin, Kristy C. Yuan, Hamideh Shahheydari, Emily K. Don, Collen J. Thomas, Yuning Hong, Marcelo A. Comini, Angela S. Laird, Damian M. Spencer, Julie D. Atkin
Review
Pharmacology & Pharmacy
Carolina L. Bellera, Manuel Llanos, Melisa E. Gantner, Santiago Rodriguez, Luciana Gavernet, Marcelo Comini, Alan Talevi
Summary: The COVID-19 pandemic has resulted in significant human and economic costs, making drug repurposing an attractive option for finding short-term treatments. Most current clinical trials are examples of drug repurposing, with caution needed to manage expectations and avoid overconfidence in conclusions drawn from scientific reports.
EXPERT OPINION ON DRUG DISCOVERY
(2021)
Article
Medicine, General & Internal
Leticia L. Niborski, Mariana Potenza, Renato G. S. Chirivi, Leandro Simonetti, Micaela S. Ossowski, Vanina Grippo, Maria May, Daniela Staquicini, Adriana Parodi-Talice, Carlos Robello, Marcelo A. Comini, Guillermo D. Alonso, Jos M. H. Raats, Karina A. Gomez
Summary: The study found that a human antibody A2R1 can cross-react with the tubulin of T. cruzi parasite and human neural proteins. This highlights the role of molecular mimicry between host and parasitic antigens in the development of pathological manifestations.
Article
Chemistry, Analytical
Karen Perelmuter, Ines Tiscornia, Marcelo A. Comini, Mariela Bollati-Fogolin
Summary: The study validates the use of cytosolic rxYFP as a tool to monitor redox changes and optimize the production of recombinant proteins. The redox reporter cell lines showed a sensitive and reversible response to different redox stimuli. The results provide guidance for metabolic engineering or intervention strategies.
Article
Chemistry, Inorganic & Nuclear
Feriannys Rivas, Andrea Medeiros, Cristina Quiroga, Diego Benitez, Marcelo Comini, Esteban Rodriguez-Arce, Ignacio Machado, Hugo Cerecetto, Dinorah Gambino
Summary: The study synthesized new Pd-Fe heterobimetallic compounds that showed promising activity against Trypanosoma brucei. A quantitative structure-activity relationships study highlighted the importance of electronic effects, lipophilicity, and metal type in determining the anti-T. brucei activity of compounds.
DALTON TRANSACTIONS
(2021)
Article
Biochemistry & Molecular Biology
Andrea Medeiros, Diego Benitez, Ricarda S. Korn, Vinicius C. Ferreira, Exequiel Barrera, Federico Carrion, Otto Pritsch, Sergio Pantano, Conrad Kunick, Camila de Oliveira, Oliver C. F. Orban, Marcelo A. Comini
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2020)
Article
Chemistry, Multidisciplinary
Diego Benitez, Marcelo A. Comini, Zilvinas Anusevicius, Jonas Sarlauskas, Vale Miliukiene, Egle Miliuviene, Narimantas Cenas